Christina Applegate and Jamie-Lynn Sigler

Summary

Podcast Summary: Conan O’Brien Needs A Friend – Episode with Christina Applegate and Jamie-Lynn Sigler

Release Date: May 5, 2025
Guests: Christina Applegate & Jamie-Lynn Sigler
Host: Conan O’Brien

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1. Warm Reunion and Introduction (00:01 - 10:00)

The episode begins with Conan O’Brien reuniting with his longtime friends, Christina Applegate and Jamie-Lynn Sigler. Highlighting their history, Conan shares heartfelt memories of Christina’s frequent appearances on his Late Night show, emphasizing her role as a consistent and supportive guest.

Conan (10:03): "You were always so funny and great and miraculous, and I think you might hold some record for coming on the show."

Christina reciprocates the sentiment, expressing her admiration for Conan’s interviewing style and the genuine connection they shared.

Christina (10:42): "You were my favorite interviewer ever. I had so much fun there."

2. Discussing Their Podcast "Messy" (10:01 - 17:00)

Conan transitions the conversation to Christina and Jamie-Lynn’s podcast, "Messy," which delves into their personal battles with Multiple Sclerosis (MS). He praises their openness and the healing nature of discussing their struggles publicly.

Conan (15:18): "You're being able to talk about it openly in this forum is probably helpful to you."

Christina explains how their friendship became a pillar of support following her MS diagnosis in 2021, leading to the creation of "Messy" as a platform for mutual healing and community support.

Christina (15:24): "That's how this all came about was when I came out with my diagnosis in 2021."

3. Personal Journeys with MS (17:00 - 33:00)

Both Christina and Jamie-Lynn share their individual experiences with MS, detailing the onset of symptoms, the emotional toll, and the challenges of maintaining their careers while managing the disease.

Jamie-Lynn (33:50): "It's been an exercise in Christina and I getting to know each other and sharing a lot about our lives."

They discuss the misconceptions surrounding MS, the stigma of being a celebrity battling a chronic illness, and the importance of visibility and representation in media.

Conan (20:24): "You have a position and a power now to really try and change the perception around that celebrities can get sick."

4. The Power of Friendship and Support (33:00 - 45:00)

Conan reflects on the significance of friendship in navigating personal challenges. He admires how Christina and Jamie-Lynn have leveraged their friendship to create a supportive environment both for themselves and their audience.

Conan (37:10): "I'm really proud of both of you. Extremely proud of you."

The trio engages in light-hearted banter, showcasing the deep bond and mutual respect that underpins their friendship.

Christina (50:22): "We never really have a plan... sometimes the best plan is to have no plan."

5. Humorous Interlude and Future Collaborations (45:00 - 55:00)

The conversation takes a comedic turn as Conan attempts to invite Christina and Jamie-Lynn onto his podcast, leading to playful negotiations and jokes about appearance fees.

Conan (52:04): "You know, I consider us friends, and I would like to help..."

Christina and Jamie-Lynn respond with humor, reinforcing the light-hearted nature of their friendship despite the serious topics discussed.

6. Closing Remarks and Reflections (55:00 - End)

As the episode winds down, Conan expresses his gratitude for the opportunity to reconnect with Christina and Jamie-Lynn, acknowledging the importance of their conversations in raising awareness about MS and providing support to others facing similar challenges.

Conan (55:16): "I'm your comedy uncle. Your weird comedy uncle."

They exchange final words of appreciation, highlighting the enduring nature of their friendship and the impact of their collective work.

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Notable Quotes with Timestamps

• Conan (10:03): "You were always so funny and great and miraculous, and I think you might hold some record for coming on the show."

• Jamie-Lynn (33:50): "It's been an exercise in Christina and I getting to know each other and sharing a lot about our lives."

• Conan (20:24): "You have a position and a power now to really try and change the perception around that celebrities can get sick."

• Christina (50:22): "We never really have a plan... sometimes the best plan is to have no plan."

• Conan (55:16): "I'm your comedy uncle. Your weird comedy uncle."

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Key Takeaways

• Authentic Conversations: The episode emphasizes the healing power of honest and open discussions about personal struggles, particularly chronic illnesses like MS.

• Importance of Support Systems: Highlighting the role of friendship in coping with adversity, Christina and Jamie-Lynn’s bond serves as a cornerstone for their resilience.

• Raising Awareness: Through their podcast "Messy," Christina and Jamie-Lynn aim to educate the public about MS, challenge stigmas, and provide a platform for others to share their experiences.

• Shared History and Mutual Respect: Conan’s longstanding relationship with Christina and Jamie-Lynn underscores the depth of their interactions, moving beyond celebrity and into genuine friendship.

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This episode of Conan O’Brien Needs A Friend serves as a heartfelt reunion, blending humor with profound discussions on personal health challenges and the sustaining power of friendship.

Transcript

[Conan O'Brien]

Sona, wouldn't you say that life is full of personal wins?

[Sona Movsesian]

I would, Conan.

[Conan O'Brien]

Thanks, Sona. Whether it's cleaning your house, getting that dream car, or checking off your to do list, winning at life is a great feeling. I'm pretty good at winning at life, aren't I? Sona, are you okay? Keep moving. State Farm helps you win by helping you create an affordable price just for you. Doesn't that sound like a win, Sona?

[Sona Movsesian]

That I like? An affordable price just for me.

[Conan O'Brien]

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[Jamie Lynn Sigler]

Hi, I'm Jamie Lynn Sigler, and I feel giddy about being Conan O'Brien's friend.

[Conan O'Brien]

I like that. That's very nice. Some people can get very mean and I know that you're not going to do that, Christina. I know you're not.

[Christina Applegate]

Damn it. I was going to say I feel really stupid being Conan O'Brien. I won't. I will change mine. The nicer part of me.

[Conan O'Brien]

No.

[Christina Applegate]

Hi, I'm Christina Applegate, and I feel awesome to be Conan O'Brien's friend.

[Matt Gourley]

Father's here. Hear the yell back to school, Ring.

[Conan O'Brien]

The bell Brand new shoes Walking loose Climb the fence Books and pens I can tell that we are gonna be.

[Jamie Lynn Sigler]

Friends.

[Conan O'Brien]

I can tell that we are gonna be friends hey, Everybody, it's Conan O'Brien needs a friend. I'm Conan O'Brien. Sona laughing really hard. Oh, God. Matt Gorley Jo as well. And we might as well just talk about this because I just said it. Sona, should you recount what happened? Oh, my.

[Sona Movsesian]

I don't even know if I can, like, say, give it justice because I was talking about something and you were.

[Conan O'Brien]

Talking about something and you were talking. We were talking about Ralph Fiennes and how much we love Ralph Fiennes and how good he is. And then you were going on for a while about how great Ralph Fiennes is. And I said, well, I'm not. I'm not talking right now. So this is boring.

[Sona Movsesian]

Yeah.

[Conan O'Brien]

Meaning there's words are happening, but they're not coming from me. So this is boring. Let's get started.

[Matt Gourley]

Yeah.

[Conan O'Brien]

And you were laughing really hard because it might be the truest thing I've ever said.

[Sona Movsesian]

You're just like, well, I'm not talking. So I. You know, like, you completely checked out. Cause it's not coming out of your mouth.

[Conan O'Brien]

It wasn't, you know what happened? There was this moment where I noticed that the words weren't coming out of my skull. So what good could they be, right? I mean, what could their value possibly be, right?

[Sona Movsesian]

I mean, it's unheard of that anything I would say would have any.

[Conan O'Brien]

Again, it's happening.

[Sona Movsesian]

Yeah.

[Conan O'Brien]

I'm like, what is this? I'm hearing, like, it's like Charlie Brown characters hearing their parents.

[Sona Movsesian]

You don't even have hear words coming out of my mouth.

[Conan O'Brien]

Like, when I'm talking, I'm just counting down. It's like, when do I get to.

[Sona Movsesian]

Go, oh, my God.

[Christina Applegate]

Oh, my God.

[Matt Gourley]

I'm just not even gonna speak.

[Sona Movsesian]

You should.

[Conan O'Brien]

Did you. I just heard croaking over there. Sounds like there's a toad.

[Matt Gourley]

I will say this. Just a teaser for the segment. In this episode, we have some Ralph Fien related content to cover.

[Conan O'Brien]

Oh, good.

[Matt Gourley]

We'll get to that later.

[Conan O'Brien]

Oh, good. And that was un. I didn't know that that was just a coincidence.

[Jamie Lynn Sigler]

Yeah.

[Conan O'Brien]

Yeah.

[Sona Movsesian]

Let's get some refine content.

[Conan O'Brien]

Yeah. You were talking about how he's. He's still got it and he can.

[Sona Movsesian]

He's still got. I said he's still got it and he can. He can get it.

[Conan O'Brien]

He can get it.

[Sona Movsesian]

I don't know.

[Conan O'Brien]

Is that a saying?

[Sona Movsesian]

He can get it.

[Conan O'Brien]

He can get it.

[Sona Movsesian]

Yeah.

[Conan O'Brien]

And he.

[Sona Movsesian]

He can get this.

[Conan O'Brien]

He can get this married.

[Sona Movsesian]

He can. Yeah, I know. I. I'm not gonna fuck Ralph Fiennes. I mean, it's not gonna happen. I shouldn't have said it. So I'm not gonna make love to him.

[Matt Gourley]

Which would it be?

[Conan O'Brien]

Don't make love to him. Do you think if you said he's still got it and he can get it, then you're not talking about making love? Oh, Rafe. Pretty. Come to yon window and let us embrace. Do be gentle. Do be gentle. Rafe.

[Sona Movsesian]

He would be if there was any chance of him coming on. I think I just killed it. Right?

[Conan O'Brien]

Maybe.

[Matt Gourley]

If anything, maybe the odds are better.

[Conan O'Brien]

Y said he's got it and he can get it. You just rang the dinner bell.

[Matt Gourley]

Yeah.

[Sona Movsesian]

Ring a ding.

[Matt Gourley]

Ray finds, for what it's worth. Same here, buddy.

[Sona Movsesian]

That killed it. That killed it. No, no, that killed it.

[Matt Gourley]

You don't know.

[Conan O'Brien]

Yeah, you'd be gentle.

[Matt Gourley]

I would be gentle.

[Conan O'Brien]

I. He's a terrific actor. He's great in everything he's ever done. And I was just remarking that it's hilarious that he always. I mean, it's not hilarious, but when I hosted the Oscars recently, he was in the audience and it was like his, you know, fifth time being nominated and he. He's clearly the. The best actor in the room. Yeah, he's an amazing actor. And they. He. He'll probably never get an Academy Award. I shouldn't say that. I hope he does, but I hope he does. It's just these amazing actors come over from. From the UK and they're insanely incredible and, you know, they don't win and they put a. They're all like, well, you know, still, I enjoyed my visit. Ta ta. And is Sona around? Yeah, is Sona round? I'm told she thinks I have it and I could still get it.

[Sona Movsesian]

I think it's because they're not. They, you know, they don't do enough. Like, he needs to like, hook up with like, you know, Selena Gomez.

[Conan O'Brien]

What?

[Sona Movsesian]

Yeah. Yeah, like something needs to happen.

[Conan O'Brien]

Selena Gomez is with Benny Blanco.

[Sona Movsesian]

I know. I can't believe.

[Conan O'Brien]

I'm sorry, I'm bringing this back again.

[Sona Movsesian]

You really are. But I just realized about Benny Blanco. Any chance you can get.

[Conan O'Brien]

I. The other day I was driving around and we brought this up on the podcast, but I just want to repeat it. The most modern sentence that I can think of to say is, Benny Blancos just slid into my DMs.

[Sona Movsesian]

Yeah.

[Conan O'Brien]

Because I don't know what that means.

[Matt Gourley]

Any of it.

[Conan O'Brien]

Any of it. I don't know what any of it is, but I've memorized it in case I'm ever at a party.

[Sona Movsesian]

Oh, okay.

[Conan O'Brien]

And someone's questioning, hey, man, you seem kind of old, maybe you should move on. I'm going to say, yeah, well, Benny Blanco just slid into my DMs.

[Matt Gourley]

And then that person says, really, I'm Benny Blanco?

[Conan O'Brien]

Yeah. And I'll say, well, I'm here in person and if you've got something to say to me, say it face to face. Let's say it face to face. Benny B. If that's even your real name. What? What? Say it.

[Sona Movsesian]

I love that you're talking about Benny Blanco. Sliding into your DMs while you're talking to Benny Blanco. That just made me laugh.

[Conan O'Brien]

Yeah. And also, I love this.

[Sona Movsesian]

That really made me laugh.

[Conan O'Brien]

I love. It's proof at my age that I'm still. That I'm young.

[Sona Movsesian]

Yeah.

[Conan O'Brien]

So I'll be around you.

[Matt Gourley]

How many of you still got. Is your Hailey Bieber smoothie over there?

[Conan O'Brien]

No, it's not. I threw it out. I was done with it. I love that. I'm trying to. I love anything where someone's like, hey, man, you shouldn't be hanging out at this party. You're too old. And that. I think that me shouting at that moment, Benny Blanco just slid into my DMs. Everyone would be like, whoa, whoa, whoa, whoa, whoa, whoa. He's young.

[Sona Movsesian]

Oh, yeah.

[Conan O'Brien]

That's cool.

[Sona Movsesian]

That's cool. He's cool.

[Conan O'Brien]

Let's disregard his rotting face.

[Sona Movsesian]

Someone would be rude enough to just be like, hey, old guy, why are you at this party?

[Matt Gourley]

You know, let's try this out.

[Conan O'Brien]

Okay. Okay. Go ahead.

[Matt Gourley]

All right.

[Conan O'Brien]

Hey.

[Matt Gourley]

What's up, Granddad? How'd you get in here?

[Conan O'Brien]

What do you mean, how did I get in here? I'm a youngster. Benny Blanco just slid into my DMs.

[Sona Movsesian]

Youngster.

[Conan O'Brien]

What?

[Matt Gourley]

What are you talking about? Do you even know what a DM is?

[Conan O'Brien]

It's the Demilitarized Zone that separates South Korea from North Korea. It was established.

[Matt Gourley]

This guy's cool.

[Conan O'Brien]

He could stay. It was established by the United nations at the end of the Korean conflict. All right. Yeah, yeah, yeah. I've actually been there. I visited the Demilitarized Zone. And Benny Blanco is one of the great architects of the late 19th century.

[Matt Gourley]

Hey, guys, gather round. I'm hearing some crazy wack history stories. This guy's off the hook.

[Sona Movsesian]

Yeah. All the women are undressing.

[Conan O'Brien]

Yes. Yeah, that's right. I have the riz. Oh.

[Matt Gourley]

See, you really got it.

[Conan O'Brien]

Okay. I'm gonna write the wrong.

[Sona Movsesian]

You just shouldn't go to those parties. Just. If someone invites you, just don't go. You're busy.

[Conan O'Brien]

I wouldn't be at those parties. They would find me peering in a window, and they would call the police.

[Sona Movsesian]

I mean, who knows? You could be. You could go to a party where Benny Blanco and Selena are, and then.

[Conan O'Brien]

I would know Selena. I would not know Benny Blanco. Yeah. And I have nothing against Benny Blanco. He's you know, I think Selena Gomez is cool. I love her. I, I, I, I'm. And I'm all for this Benny Blanco, gentlemen. I just came up with that sentence when I was driving my car. Benny Blanco just slid into my DMs, and I said, that's gonna get me out of a sticky situation someday. Or get me into one. I don't know. All right, let's get into it. Enough of my bibble and babble. I think this has been enough tomfoolery and skullduggery and Tom thuggery. My guest today, and that's plural guests today, hosts the podcast Messy, which releases new episodes every Tuesday. Wherever you get your podcasts, I'm very excited they're here today. Christina Applegate and Jamie Lynn Sigler. Welcome.

[Christina Applegate]

Cone bone. Cone bone.

[Conan O'Brien]

Cone bone never stuck. No, it did. My wife calls me cone bone.

[Christina Applegate]

No, because Tom Hanks came around and did cool coo.

[Conan O'Brien]

Oh, yeah.

[Christina Applegate]

And then that became your thing. I was trying to make cone bone happen.

[Conan O'Brien]

I'm kind of glad Coco won, frankly.

[Christina Applegate]

Okay.

[Conan O'Brien]

I'm really happy.

[Jamie Lynn Sigler]

It's never too late. It can happen.

[Conan O'Brien]

Yeah. I was gonna start by, first of all, thanking both of you for being here. And I have very distinct memories of both of you. I'm at that age now where I get very sentimental, and I look back over, I don't know, just things that I've done in the past, people I've met. Christina, I remember very clearly you being such a wonderful friend to me on the show. You came on the show so many times, and you were always so funny and great and miraculous, and I think you might hold some record for coming on the show.

[Christina Applegate]

I think I might.

[Conan O'Brien]

You might. You might.

[Christina Applegate]

It was like, my favorite thing. Anytime I got a call saying, hey, you know, even, like, you sometimes would have, like, a guest, like, fallout or something, they'd be like, will you come in? I'm like, absolutely. I would love nothing more. I really, like. You were my favorite interviewer ever. I had so much fun there.

[Conan O'Brien]

That's sweet of you. And it helped that you lived in an apartment right above our studio in Rockfellow Center. She lived in a.

[Christina Applegate]

It called an apartment. I was outside the bathroom, actually.

[Conan O'Brien]

It was. It was a cleaning closet.

[Christina Applegate]

It was a cleaning closet.

[Conan O'Brien]

There was a cot, and people were like, conan, I can't believe Christina Applegate lives in this shitty.

[Christina Applegate]

And you guys charged me rent.

[Conan O'Brien]

Yeah, no, it wasn't a lot of rent, but I just. I wanted to start by thanking you from the bottom of my heart. For just always being just this light, Always such a great guest, always so fantastic. And I have such a very clear memory. Jamie Lynn. I remembered when the Sopranos first came out and had been on for one season. It was the new thing. Everyone was talking about it. And it's nominated for all these Emmys. We're nominated, too. We're in New York. I go, I get on my American Airlines flight, and I sit in this American Airlines flight. And then the person sits down next to me and it's James Gandolfini, who I had never met. And we talked the whole way and he was just talking about, like, yeah, I don't know what this is. He had such a. Like, what is this? We're going to an award show. And I went, yeah, you're on the biggest show on television, Jim, and you're the star of it. Anyway, he talked about act. We just had a lovely time.

[Jamie Lynn Sigler]

Yeah. Oh, that's so cool.

[Conan O'Brien]

And my memory is they put me up at this hotel, I think it was the Four Seasons Hotel. And I walk out at one point and you are standing there with your co star Robert Iler. And you're just like both standing there and you're kids. I mean, how old would you have been?

[Jamie Lynn Sigler]

17.

[Conan O'Brien]

Yeah. You're just your kids. And you were standing there right outside where the cars pick people up. And you just both looked like you had been beamed to Mars. Like, you're here at the Emmys. And I chatted with you guys for a second and remembered having this weird look at, oh, you're. This crazy ride is just starting for you. And I'm getting a sneak peek. And I remembered you just seeming like, I think she's going to be good. She seems like such a grounded, nice kid. I think you're going to be okay.

[Jamie Lynn Sigler]

That's so nice to say. Well, I can tell you, like, meeting you was like, that you. I probably look like I had just been beamed to Mars because that's how we felt seeing you. That's how we always felt like seeing people that we admired and like Christina, actually. And I have talked about that. You are our favorite show.

[Conan O'Brien]

Oh, that's nice.

[Jamie Lynn Sigler]

Because you just, you set us when.

[Christina Applegate]

We'Re talking to you, when we're talking to Jimmy Kimmel. That's a whole other conversation.

[Jamie Lynn Sigler]

Yeah, we were lying to Jimmy.

[Conan O'Brien]

Yeah, I had dinner with.

[Jamie Lynn Sigler]

But I have a distinct memory. Cause my brothers and I bonded over your show.

[Conan O'Brien]

Right.

[Jamie Lynn Sigler]

Like the bits in your show, we would talk about it all the time. And the first time I did Your show. I was able to get my brother, my oldest brother Adam in the front row there, and that was like. It's one of those, like, I made it moments that you're able to share with the people that were there with you. So that was one of those for me.

[Conan O'Brien]

It's so funny. I have. I don't know if it's the Irish in me or whatever, but I get very nostalgic for all of us floating along on this journey, and then I see these people along the way. And so to get to check in with both of you is very nice. I mean, yes, this is a podcast, and we're doing this, and there's gonna be an ad or something, but I don't. I don't fucking care about that. I feel like I'm talking to you guys. I'm checking in. Both of you have been through so much, and you're doing a beautiful thing, which is you're sharing it, you're talking about it very frankly. You have your own podcast, Messy. And it's all about ms, which you're both dealing with and everything that happens. And I know that it's. I'm. You're helping a lot of people. But the strange thing I found about doing a podcast, and I'm not struggling. I'm struggling with just inherent craziness, but. But not Ms. But what I have found is that it's healing for me to talk to people, and I'm. It's. I imagine there's a component of doing this podcast where both of you are maybe doing some healing for yourselves about having this problem. That you're being able to talk about it openly in this forum is probably helpful to you.

[Christina Applegate]

Well, absolutely. 100%. I mean, that's how this all came about was when I came out with my diagnosis in 2021, our friend Lance said, you gotta talk to Jamie. Cause I'm sure you feel like you're on an island and you don't understand what's happening, and that's the person to talk to. And I had met Jamie a few times over the years, and it was like we got on the phone and we were on the phone for hours, and I felt like, so. Less alone. Yeah, sorry. I get teary when I talk about my James, but it healed me in that moment. And that's how this happened, was. It was like, we're talking about so much information and so much stuff that so many people newly diagnosed or even people who have been diagnosed for years might not know about or want to say. The Things that we say, like the brutal honesty about how painful it can be, how lonely it can feel, how awful it is. And then, you know, that's only coming from my mouth. Cause I'm negative Nellie. And then Jamie will be like, but let's breathe, you know? And I love you, Jamie. No, she. She gets pissed off about it, too.

[Conan O'Brien]

Here's the interesting thing is it's. It's. It's not that one way to go is wrong and one is right. They're both.

[Christina Applegate]

No, no, no. That's. I was totally kidding. You know that, by the way. It's like we have helped each other in the sense that I get to see a different side to all of this because of her. And she gets to be honest about how she feels sometimes about. In ways that you didn't. Right. I don't wanna speak for you, but that's.

[Conan O'Brien]

Cause I was noticing that, Jamie Lynn, you got diagnosed much earlier than even I knew. I was familiar with your diagnosis, but then I was shocked to find out that you got your diagnosis when you were on the Sopranos. You were also working on Broadway at the time. And I just assumed that this came, you know, 10 years later because you didn't talk about it. You were afraid to talk about it because you thought. You thought you could get fired. Is that right?

[Jamie Lynn Sigler]

Yeah, I think there was a lot of reasons. I think the initial, you know, drive to keep it a secret and protect me was the fear of being fired, the fear of not being hireable, not, you know, to feel the fear of what people would think about this and me with this. I also think it allowed me to live in a state of denial for some time, because if I didn't talk about it with anybody, then maybe it wasn't real. But then, you know, over the years, as the disease started to manifest into what it would be for me physically, and I started to have to make up excuses and lies was really difficult. And as much as I could, like, regret that choice, I think it's really informed a lot about me and my life. And, you know, now what's so beautiful like, with Messy and having Christina. And what I've learned about myself through this process is, you know, when you find community and when you. When you talk to somebody else, you can almost witness yourself a little bit, and you can kind of take a step back and really acknowledge what you're going through and acknowledge that it's hard and that it sucks and that it can be unfair and all of those things, but also really see the catalyst of it being the catalyst for a lot of growth and self reflection. And you know, I've lived with the disease for almost 24 years now. I was diagnosed when I was 20. And so I'm, I'm finding my way through and finding sort of the purpose from this pain. And I feel like that's all you can do with situations like this. And messy is really what's propelled me into that way of thinking.

[Conan O'Brien]

Now I think there's an interesting thing that we live in this, as, you know, this weird culture with probably misaligned priorities where, you know, people, if you're a quote, celebrity people expect that you shouldn't have anything to complain about and that you're allowed to have problems. But sometimes I think you're expected to have problems that are self destructive problems like addiction or you're, or you blew all your money, you know, you did stupid things. But I think there's almost like a, a sense that, well, wait a minute, you can get sick, you can get this disease. But you were on television. I know that sounds like I'm saying something that would be painfully obviously true, but I think there is a little bit of a hiccup where you're both beautiful, talented actresses that people know from iconic work. You have a. You got it. You got sick. What do you mean you got sick? What did you do? No, I didn't do anything. I just. It just happened and it happens to a lot of people is that. Does that feel that there's a weird way in which it's not fitting the narrative of being a successful, you know, celebrity?

[Christina Applegate]

Well, I think one of the things that I've come across, you know, I mean, and I don't really leave the house anymore. And I mean, if people saw what my life was like on the daily, they wouldn't be able to do it because I can sometimes not do it. It's really, really hard. But I think that the first thing that I hear from people is how did you get it? Meaning I must have done something wrong in my life to have this disease. I did it to myself. It's like I had breast cancer as well. So. Oh, you must have done something, you know, and it's, and that that stigma is, you know, I'm used to it now, but it was for like, it was so hard to swallow because why the f. Would you think that I would do something to have this? Yes, because this is the worst thing I've ever had in my life. This is the worst thing I've ever gone through.

[Conan O'Brien]

So do you Know.

[Christina Applegate]

Do you know I'm the crybaby of the tourists?

[Conan O'Brien]

Cry all you want and then I'm gonna start crying.

[Christina Applegate]

I'm just having a pissy day today. I'm having a bad MSE day.

[Conan O'Brien]

Oh, I'm sorry. Well, no, but cry and then I'm gonna cry and I'm gonna make my assistant David here and you'll cry. He. I make him cry all the time. Every day. Okay. Every hour. And very verbally abusive.

[Jamie Lynn Sigler]

That's what this podcast.

[Conan O'Brien]

Yeah, but mine is just like me being really verbally abusive. Yeah. If he doesn't make at least five people cry a day. Yeah. I feel like I haven't done my job. Yeah. Those Sweet James billboards are everywhere. You know, everywhere I drive I see, I see them all over. They're everywhere. I've crashed into a few of them. They're hard to avoid. And then I call Sweet James. Yeah, that works out. No, it sounds like I'm joking around and I probably am. But the work they do is pretty serious. When you're hurt in an accident, insurance companies that promise to protect you will try to deny your claim or pay you the least amount possible. We all know that Sweet James Accident Attorney is a world class law firm with over 25 years of experience taking on billion dollar insurance companies on behalf of their injured clients and winning. They've recovered over 1.5 billion billion for injured accident victims with a 98% winning record. That's crazy. That's a high percent. I wish my name was Sweet James. My life would have been different. Sweet Conan. Yeah. Having the right attorney by your side after you've been hurt in a car, a truck or motorcycle accident can mean the difference between $2,000 and $2,000,000. Sweet James have some of the best attorneys in the country. They've been awarded best attorneys in America. I mean, I've never won that award. Well, you're not an attorney. I know. That's probably the reason. Yeah. If you're hurt in an accident, call Sweet James at 809 million. 809 million or visit sweetjames.com oh man. I do a lot of traveling. You know that I do the travel shows. Nothing quite like the feeling of an upgrade when you're traveling. Well, as a T mobile customer, you can take the perks with you. That's good. Isn't that nice? It starts the moments you take off with free in flight Wi Fi so you can stream your favorite show on the go. Obviously that would be this show, I would think.

[Christina Applegate]

Yeah.

[Sona Movsesian]

You go a Plane and then you stream your podcast.

[Conan O'Brien]

If I'm anxious about a flight, the thing that calms me is seeing myself. And then when you land, T Mobile's got you covered with 15% off all Hilton brands. Did you know that?

[Sona Movsesian]

No.

[Conan O'Brien]

Yep. Plus, you're covered with 5 gigabytes, count them, 5 of high speed data in over 215 countries and destinations with Go 5G plus or next plans. And I have to tell you, it's a nice feeling when I travel the globe for my travel work, I like to know that when I land in that other country, I'm covered. I'm there. Yeah. I can text you and say, hey, I got here safely. Yeah, I forgot to feed my cat. Could you feed my cat? You could remind me I don't have a cat.

[Sona Movsesian]

Right.

[Conan O'Brien]

It's all good stuff. Yeah.

[Sona Movsesian]

You FaceTimed me before from another country. And it was crisp. She was clear.

[Conan O'Brien]

Yep. You could see every mark on my face. Find out how you can experience travel better@t mobile.com Travel qualifying plan required. Wi Fi where available on select US airlines terms and conditions apply. I went to a party recently. Was a rager by my friend Rodman.

[Sona Movsesian]

Yeah.

[Conan O'Brien]

Yeah. He had the tunes bumping. It was really fun and it was special to me. Cause when you get together with good friends, good chums, amigos, pals from the past, celebrating important occasions means more moments with the coolest people in your life. For me, that's gotta be Rodman.

[Sona Movsesian]

So many cool people.

[Conan O'Brien]

There's so many cool. Just like, yeah.

[Sona Movsesian]

So cool.

[Conan O'Brien]

I do. I have the coolest friends. Cheers to 50 years of Miller Light. The greatest tasting light beer for people who love beer since 1975. Yeah. You know what I say?

[Jamie Lynn Sigler]

What?

[Conan O'Brien]

I say it's Miller time. I do. It's the 50th anniversary of Miller Light. Did you know that?

[Sona Movsesian]

I didn't.

[Conan O'Brien]

So many times, whether I'd been out at sea.

[Sona Movsesian]

Oh, okay.

[Conan O'Brien]

Yeah. You know, on someone's yacht. And I'll crack open a Miller Light. Or whether I'm scaling a volcano. Oh, yeah, it's about to erupt. Because that's the best time to see a volcano when you can feel the tremors. And I crack open a Miller Light. Miller Light. That's what I'm talking about. It's great taste. It's 96 calories. And I did a study myself. It is 96 calories. Go to millerlight.com kona to find delivery options near you. Or you can pick up some Miller Lite pretty much anywhere they sell beer. It's Miller time. Celebrate responsibly. Miller Brewing Company in Milwaukee, Wisconsin. 96 calories and 3.2 carbs per 12 ounces. I'll tell you, I wore it. I mean, obviously, Christina, where it comes from is, it's terror. It's terrifying to people that shit happens. And so people need to work backwards and say, okay, wait a minute, wait a minute, wait a minute. Did you eat a lot of food with zinc in it? You know? No, I didn't. Oh, did you, did you take, like a lot of escalators? Some people can get Ms. No, no, no, that's stupid. That was online. No, whatever. I'm making shit up, clearly. But it is, it is a.

[Christina Applegate]

You'd be. You'd be surprised at the. The cures that I get told about. Like, I have this holy water and I know it will cure your Ms. I'm like, really? That's amazing because there's millions of us across the globe who still have it.

[Conan O'Brien]

Right, right.

[Christina Applegate]

And have probably, you know, done this with the holy. I mean, come on.

[Conan O'Brien]

Yeah, yeah.

[Jamie Lynn Sigler]

Well, I think that that's, that's.

[Christina Applegate]

But that's part of the fear, part.

[Jamie Lynn Sigler]

Of the gift of the. The position I think that we have that it's, you know, taken me a long time to accept. I think, you know, acceptance is hard for anyone no matter what you're dealing with. I think it's like the huge challenge in your life to accept that a situation is what it is. But I, but what I'm looking now is an opportunity is what I thought would sort of bring me out of this business. And I. And even when I was out about having Ms. And working, and it was always people very helpful, like, oh, we'll just walk around it or we'll get you a walking double when the person walks away, you know, so you look able bodied and normal, you know, now it's at this point where I'm like, no, if you want to cast me in this, this is the body I'm in. Because my life doesn't revolve around Ms. If anything, it could enrich a story. And I think that we don't see enough people like us on camera. We don't see enough people that have disabilities that are not defined by their disability within a story a lot of the time. And so, you know, I think that we do have a position and a power now to really try and change the perception around that celebrities can get sick, but that you can also keep, like, doing what you love and keep living your life, you know, I think that it's very scary for people. And, yeah, you can feel like, you know, people are superhuman when they're a celebrity. But, no, we're just human beings that are doing what we love. It just happens to be in front of a lot of people.

[Conan O'Brien]

Right, right.

[Jamie Lynn Sigler]

And now we can use that power for something else.

[Conan O'Brien]

It's weird. It's an occupational hazard. I always think it's an occupation, like working in a shoe store or anything else. It just has this other side to it, which is people recognize you. They recognize you from working as a.

[Jamie Lynn Sigler]

That's how Jim Gandolfini felt. I'm sure he told you that on that plane.

[Conan O'Brien]

Yeah.

[Jamie Lynn Sigler]

I mean, he was. He's like, why don't you want my plumber's autograph? Like, it just didn't make sense to him why he had to have that piece of this, you know?

[Conan O'Brien]

Right, right. I can completely understand that. One question that came to me is, and this is for both of you, and maybe I'll start with you, Christine, is when did you. What's the first symptom? Or when did you start to think something isn't? Something feels off? Is it subtle, or does it hit you like a ton of brick?

[Christina Applegate]

It was January 2021. My mom had just been diagnosed with cancer for the third time. And there was some other stuff going on in my life, and it was a really stressful, traumatic time. And my toes started to feel numb. Just my toes, you know, like a little bit. I was still hiking. I was still playing tennis. I was still doing all the things I could do, but my toes weren't feeling right. And eventually, over those months, it grew from my toes to my ankles to. From my knees. Down is a whole other ball game.

[Conan O'Brien]

Yeah. Yeah.

[Christina Applegate]

And I was losing balance, and I. But the pain was extraordinary. And when I say numb, you. It's numb, but it hurts.

[Conan O'Brien]

Yeah.

[Christina Applegate]

So it was like these, like, very subtle things that happened. And finally someone was like, well, it was actually Selma Blair said, can you please go to the neurologist?

[Conan O'Brien]

Yeah.

[Christina Applegate]

And I was like, no, there's. I was like, there's no way that the both of us from the same movie have Ms. I was like, you crazy? And it was like, that was the end of it for, you know? And by then, I had gotten so bad, and I was in the middle of shooting dead to me. So we had to really stop for a minute and figure out how to do this. But what's interesting is I look back over time, and probably for like, six years, I was Having weird things happening, like fluorescent lights would bother me and make me dizzy and being up on a platform, I would get afraid of the height. I was never afraid of heights. I'd be playing tennis and, like, my right leg would buckle and I'd be like, ooh, I must be dehydrated or it's too hot out here. I mean, they were like the tiniest little things that you would completely ignore otherwise because there's probably an answer for all of them. But the numbness in my toes and as it started to grow up was very much announced in my fingers. And it just. It starts to, you know, over time, it gets worse, you know, but it's. That's how it happened.

[Conan O'Brien]

And when you say, like, you've referenced, I think twice now that you're having a really bad day, what does that mean? You're having a really bad Ms. Day. How does that manifest itself? Is it in the physical? Is it dealing with. Is it. It's the physical. And that affects you also emotionally too, I imagine.

[Christina Applegate]

Well, yeah. I mean, you know, to go to the bathroom, it's like walking on. On needles and hot lava. So, like, I haven't really been able to get out of my bed today. So I'm having just a bad, symptomatic day. And that can be, you know, from anything from. And I always get scared that this, this is now my new normal. And I get afraid that this is the new normal and then I'll have a day where I'm never good. I'm just less shitty.

[Conan O'Brien]

Yeah.

[Christina Applegate]

So those less shitty days, I'm like, okay, so that was just a symptomatic day. It was like, either I didn't sleep enough or I didn't eat enough or I'm stressed out a lot of times. Stress or, you know, anything like that really affects it can make it much worse. But there isn't a day where I'm like, skipping down, you know, skipped Malou down the street. Although I try sometimes. Right, Jamie, I'll send you videos. I'm like, I'm trying to skip. I'm skipping today.

[Conan O'Brien]

Yeah, exactly.

[Christina Applegate]

And then, like the next, then 10 minutes later, I'm like, I can't move a thing.

[Conan O'Brien]

I can't move. Or else she doesn't have Ms. There's TMZ footage of her skipping down the lane, singing, Skip the movie, making it up. This is.

[Christina Applegate]

Damn, I'm good. Damn, I'm a good actress if I'm making this one up.

[Conan O'Brien]

Applegate is so full of shit. Always was.

[Christina Applegate]

I would Much. Probably get an Oscar for having Tourette's than I would. And I'm not making fun of Tourette's because I love Balon out loud. I don't know if you guys have seen it, but she's real beautiful and I want to be her best friend. But. Yeah, for the casting.

[Conan O'Brien]

But also, I've noticed that you've always had. And I love that you get to do it on Dead to Me. You get to say some of the meanest things on Dead to Me. And you do it where it's like, yes, you're a really good actress, but I can also tell that you're accessing some part of you that wants to tell somebody he's a fuckstick. Yes.

[Christina Applegate]

I don't know how Liz Feldman knew that I existed on the planet. Like, she wrote it. It was already there. And then she was like, oh, my God, this is you. And I'm like, sadly, yes. Sadly.

[Conan O'Brien]

How did you know? I had a filthy mouth and a lot of rage.

[Christina Applegate]

The best acting job I've ever done is being Christina Applegate out in the public. That is my greatest apt.

[Conan O'Brien]

That's your Oscar.

[Christina Applegate]

Small, funny.

[Conan O'Brien]

Yeah, yeah. Everything's good. Cheery.

[Christina Applegate]

And then I'm home and I'm like, fuck this shit.

[Conan O'Brien]

That's what podcasts are for.

[Jamie Lynn Sigler]

That's right.

[Conan O'Brien]

And Jamie Lynn, when did you know that? What happened? How was it for you? Is it the same? Does it start with, like, tingling in the toes or.

[Jamie Lynn Sigler]

Yeah, that was actually pretty similar for me. When I was 19, I had something similar, like, weird numbness in my toes. And then it was rising over a couple of days. And it was actually right before we were starting the third season, and I ended up in the emergency room and then the ICU for 14 days. Nobody could figure out what I had. I had ruled out. They had ruled out Ms. At the time because there was no findings on MRIs or whatever. And I got diagnosed with Lyme's disease actually, initially, and they had had me on a bunch of steroids and antibiotics. And in hindsight, I think the steroids is what, like, picked me up out of it. But a year and a half after that, started to get that numbness again and went to the. I was in the middle of the fourth season, and I started to feel the numbness. I thought I was just gonna kind of ask for more antibiotics. And they redid testing and diagnosed me with Ms. So it was shocking and not at all what I was expecting to hear.

[Conan O'Brien]

And to hear it. I mean, at that age, you've gotta just be. I don't know. Felt like you got hit by a meteor. Like you're standing in a cornfield and a meteor hit you. Like, it's. It doesn't make any.

[Jamie Lynn Sigler]

It's weird. I can. Like, I can remember sitting in the hospital room, and my parents were there, and I had two friends, too, and the doctor was talking. After he said, it became kind of like. Like in a movie where all of the talking just starts sounding, like, muffled and like the room kind of gets dizzy, and I just kind of blocked it out. We went home. I spoke to my family about it. I went to a doctor's appointment for, like, a checkup for the show. Like, you have to get, like, a sign off that you're healthy. And I told him, and he told me I wouldn't repeat that again. And so that's what I did. I just kept it quiet.

[Christina Applegate]

I didn't know that part.

[Jamie Lynn Sigler]

Yeah, I mean, he was trying to protect me and understood, you know, but.

[Christina Applegate]

It'S a hard one to hold in, though, babe. Especially when you are the best at teaching me to advocate for myself and to have boundaries on set and to say, hey, this is what I need. You gave me that power. And for you to have to go every day and take that, pretend this isn't even happening. No, I can't.

[Conan O'Brien]

Even if you can't talk about it.

[Christina Applegate]

It makes me want to. Sad.

[Conan O'Brien]

Well, it's interesting because we have all these fears. There's a terror. It's not, you know, just in our culture. It's. In many cultures, we have a. But particularly we have a terror of people who maybe we've idolized or put up on a pedestal in any way, being sick the same way we do. There's this whole attitude about people getting older, and that's something where people are constantly feeling that they need to scrub how old they are or do things or go through ridiculous procedures to make sure that, no, nobody thinks that they're the age they are. It's another kind of, let's just pretend that this doesn't happen to people. And I've taken the very bold move of having no work done, and I think, so brave. So brave, Conan.

[Jamie Lynn Sigler]

So brave.

[Conan O'Brien]

Thank you. Well, I think of the three of us, I'm the brave one.

[Christina Applegate]

You are.

[Conan O'Brien]

Okay.

[Christina Applegate]

And in a way, you're the hero. You're the hero, Conan.

[Conan O'Brien]

Maybe the one who's been through the most. I. I mean, maybe I'm going out on a limb here, and I'm told I don't have the best sense of the room, but I'm just letting it go as a 44 year old man. I'm just letting it happen. No one is fact checking this. No, there's no Internet. Never was and never will be. So how did you. You guys started talking together and at one point, because it's such, you know, there's a lot of new technology and new kind of types of broadcasting and reaching out to people that can feel invasive and lame. But I do think that podcasting is particularly well suited to what the two of you were talking about, because it's so intimate and people can really hear what both of you are going through. It's a great thing that this medium exists right now for what you're doing and for the message that you're trying to get out. And not even that it's a message, it's conversations that both of you are having that feel very confessional and that feel like there's no topic you're not working through. Okay, we're gonna get to this, then. We're gonna get to this, then. We're gonna get to this. It very much feels like you two are hanging out and there are good days and bad days.

[Christina Applegate]

Yeah, I was gonna say. Well, we never really have a plan. I mean, obviously when we have a guest, we, you know, most of the time there's someone that we know quite well, so that's easy to just talk with them. We don't have a list of questions, really. I mean, you know, there's. If we start to go off the rails, our producer will text, like, hey.

[Jamie Lynn Sigler]

She starts texting us.

[Christina Applegate]

She starts texting and going like, bring it back to something to, like, a subject. But I was going to say that with the podcast, it wasn't like Jamie and I were like, how can we go around talking about this? I mean, it was. I was actually getting my infusion for my Ms. And Jenna Fisher from the office, who's a good friend of mine, she came to hang with me for the six hours that it takes, and she's like. And she knows my humor and the way I talk. She's like, you've got to do a podcast, man. And then it was like, after that, Jamie and I started talking. I was like, oh, my God, this is like our lives. And I feel so much better every time I'm talking. Sorry about that. That's my phone telling me to put my feet in the hot bath with Epsom salts.

[Conan O'Brien]

Your phone tells you to do that?

[Christina Applegate]

Yeah, well, it does. It knows. It knows that I'm in pain and I need to do it. I have an alarm. I have an alarm for 1:30.

[Conan O'Brien]

This is going to lead into a.

[Jamie Lynn Sigler]

What is your phone telling me?

[Conan O'Brien]

I don't even know. My phone tells me to stop going on that site. It's creepy. I'm like, what? What's creepy about it?

[Christina Applegate]

That's the thing. It really came from our conversations. We always wanted to be honest and raw and real and not have a plan, because sometimes the best plan is to have no plan. And then other times I just am told to be quiet and to stop talking so much by our producer.

[Sona Movsesian]

No.

[Christina Applegate]

Yep.

[Jamie Lynn Sigler]

Not by me, not by you. But also too, you know, Ms. Looks different for everybody. It affects everybody differently, whether it's day to day or just, you know, body to body. And I think it's about, you know, giving yourself the grace and the space to express what you need to feel in the ups and downs of it. And also to, you know, not a lot of people know a lot about Ms. Is to also educate. But in general, I think, and we have learned that the more specific you get with your vulnerability, the more universal it becomes for other people. So, you know, we get to hear from a lot of other people that listen to us that don't just have ms, that, you know, hear what we're going through and hear what we're. We're trying to push through and accept and all those things through their own filter and how they sort of apply it to their lives. And so, you know, over the past year, it's really been an exercise in Christina and I getting to know each other and sharing a lot about our lives. And I feel like now it's not fully transitioned, but we've opened ourselves up now to having a lot of people really try to help us, help us individually and where we're at. And, you know, it's. We're, we're still here and we, we, we have children and, and dreams and, and lives and friends and people that we care about. And we're trying to figure out how to, you know, make it the best we can.

[Conan O'Brien]

It's also, and, and that's important to point out. It's not. I think one of the reasons it's such a great idea is that it's not, hey, if you've got ms, you should check out Messy. That's not at all what it's about. Sure, if you do, then, yes, but it really is about people struggling and actually people that, you know, people that, I mean, for both of you, there are A lot of people that grew up watching you and have an emotional connection with you and that's something that's very powerful, that gives you this gift of, oh, they know you, they know you and you are part of their lives, you're part of a part of their life. That they're only gonna be that old once. And you were a big part of their life then. And so now they're getting the gift of perspective, of whatever that means. Everyone has stuff in their life. But I'm constantly, you know, we just had these fires out here in la and I'm, you know, so I'm living in a hotel and people will say to me, oh, I'm so sorry. And I cut them off. And I'm like, I'm living in a hotel. I know a lot of people who lost their homes. So I don't have. I have been inconvenienced, but it's stupid. I feel stupid when anyone says anything to me because I know many people who work here. Two people that work here lost their homes and a lot of my writer friends on the Simpsons lost their homes. And a lot of people in and around my neighborhood lost their home. And so I did not. I'm in a hotel. And so my complaint is they don't make the smoothie quite the way I like it. It's not the way I would do it if I was at home. What's wrong with the world? Why does God hate me? God, why have you.

[Jamie Lynn Sigler]

You need to come on messy and talk about it.

[Christina Applegate]

Yes, talk about whatever you want.

[Conan O'Brien]

Well, first of all, before we go any further, before. Yeah, ladies, I'm here to talk about. There's this guy at this high end hotel, Beverly Hills, who. But no, I think that perspective is not something you get. And then you have like someone gives you a gold pocket watch and you have it in your pocket the rest of your life. I always think it's like stomach crunches or any kind of. You just, you know, unfortunately you've gotta keep doing it or stretching or, you know, any of the rehab or anything of the, of the exercises that you need to do or self care you need to do. You have to keep at it. I think that's way about perspective. We just have to keep at it. Because yes, I am this, but these other people are going through that. And it's always the yin and the yang. It's always gonna be that. And so I think the fact that the two of you are sharing this. And you know, Christina, when you were saying earlier, oh, I'M sorry. I'm getting weepy. I'm having a bad day. The whole point is to tell us that and to let it happen.

[Christina Applegate]

Yeah, I mean, we've covered so many topics, too. I mean, it's not like if we just sat there and talked about Ms. All day, we'd be like. Or probably not. I'd just be crying the whole time. We've had episodes about eating disorders and bitches. You know, like just so.

[Conan O'Brien]

Well, wait a minute. Let's talk about bitch for a second. Let me. Let's. Now you've got my.

[Jamie Lynn Sigler]

I mean, go for it, Christine.

[Conan O'Brien]

I was really liking this, but now it's another level.

[Christina Applegate]

She knows that I get pissed off when I lay back when we're recording. And I like this. My fire, my anger inside of myself. Talking about bitches. Just people who are just bitches. I don't know.

[Conan O'Brien]

Bitches is all genders, right? It's everybody. Of course, you know, it includes me is what you're saying.

[Christina Applegate]

You know, you're my biggest bitch ever.

[Conan O'Brien]

I knew I'd make it.

[Christina Applegate]

You are.

[Conan O'Brien]

I made it to the top.

[Christina Applegate]

Well, I haven't even told Jamie. Cause Jamie and I are probably gonna record next week. Cause, you know, whatever. And I have so much to tell you about some bitches.

[Jamie Lynn Sigler]

I can't wait.

[Christina Applegate]

Mama got vicious in the text messages.

[Conan O'Brien]

Do you drop names? You don't drop names.

[Christina Applegate]

I don't. No, no, no.

[Jamie Lynn Sigler]

I think we should. I mean, why not? Well, you know, what we have had, though, is a lot of, like, past co stars. Like, we had Ed O'Neill, we had Edie Falco. And it was really interesting and wonderful to, like, have these conversations with people that knew us when we were kids, you know, in our, like, formative years, and really get their perspective of us. And for also to like, have a conversation, like with Edie where she forever felt like a mother figure to me because of the way we met. But now to have a conversation as two women, you know, and peers, in a way was. It's been really beautiful to be able to, like, have these deep, personal conversations on the podcast with people that are important to us, that also people, like, relate to us, but to get to see a different side of it.

[Conan O'Brien]

Yes, it's interesting to me too, you know, from my lens of, you know, Christina, those times that you would come on, or Jamie Lynn, the times you would come on, it's. I would see you in this very. I loved that format, but it was, you know, you know, from the Sopranos, you know, for marrying from children. Christina. She wins. Hey, what's going on? And it's this.

[Christina Applegate]

I could listen to you do that all day.

[Conan O'Brien]

I know.

[Jamie Lynn Sigler]

I know. Me, too.

[Conan O'Brien]

I know. I know. But I swear to God, it was 30 years of my life, and it's in my head where I'll be brushing my teeth and I'll be like, all right, we're back. I'm using Crest toothpaste because it gets it white, you know, But I guess it's still a conversation. And I was still getting to know you, and you are these, you know, much younger than me, and. And now I'm checking in on you in this very different way. And it's nice. It feels really nice to speak to both of you. And I'm sorry that you got. Both of you got hit with this sack of shit, because that's what it is for no reason. I'm really sorry about that. And it's.

[Christina Applegate]

I pooped myself yesterday, so that goes and goes on brand with me, too.

[Conan O'Brien]

I'm just saying. But I'm saying it's very nice. I'm grateful for this medium that allows us to talk this way and check in and people, you know, a lot of people can hear it and hear how you're doing and hear about your podcast, which. And it's just. I'm very grateful that we get to do this, you know?

[Jamie Lynn Sigler]

Me too.

[Christina Applegate]

Thank you. I've been this. My favorite moments, honestly, Conan, when I would come on there for, like, the 30th time or whatever, was when we'd go to commercial and you and I would just talk.

[Conan O'Brien]

Yeah.

[Christina Applegate]

It was like. It was like the best thing ever. The show was over. You know, the, like, pre interview, we did our bits. I did my stories, and you and I would just sit and talk during that two and two. Chuck Bullery.

[Conan O'Brien]

Yeah. And I remember.

[Christina Applegate]

I don't know, is it.

[Conan O'Brien]

I remember it in a commercial break, you know, trying to do that with Jamie Lynn. And she said, this interview's over. And.

[Jamie Lynn Sigler]

Yeah, usually.

[Conan O'Brien]

Yeah.

[Jamie Lynn Sigler]

So Jamie, she said.

[Conan O'Brien]

She said, this interview's over. And then she said, my people. And seven people came and took her away. And one of them.

[Jamie Lynn Sigler]

That's exactly what would happen.

[Conan O'Brien]

That is not what happened.

[Jamie Lynn Sigler]

Well, I was actually going to say, I've just never felt very good at, like, that side of this business. It's just always felt like. I don't know, it just.

[Conan O'Brien]

It.

[Jamie Lynn Sigler]

It would bring out insecurities and things in me that weren't great. However, doing your show, and I mean this with every part of Me, there was never an ounce of nerves. You may be the first time, because it was. Because I was such a fan, but it was just you always brought ease and enjoyment. I would leave on a high and so happy. Like, I just had the best, you know, 20 minutes of my life. So thank you.

[Christina Applegate]

You would get 20 minutes. I'd get like, eight to 12.

[Conan O'Brien]

No, you were. You would get.

[Jamie Lynn Sigler]

I was counting commercial breaks.

[Conan O'Brien]

Christina would get, like, five at the most.

[Jamie Lynn Sigler]

That's why she kept coming back.

[Conan O'Brien]

I knew if I was cruel to you, Christina, you'd keep coming back.

[Christina Applegate]

And you did, of course. Yes, well, I did. That's why I got that cleaning closet. But I was gonna say, what was so awesome is that you listened.

[Conan O'Brien]

Yeah, yeah.

[Christina Applegate]

And we sometimes wouldn't even get to the questions, man. Because you were, like, one of the only ones who listened, who didn't have, like, a vacant look on their face waiting for the next. Like, get to the part that you're supposed to say, and let's get to the next question. You had listened, and so you and I would just. It did feel, like, real and loose, and it wasn't a show. I love you. You know that. You know that. I've always absolutely adored you.

[Conan O'Brien]

Well, I am. I mean, I was coming in today. I knew I'd be talking to both of you, and I was thinking, I really want to check in with them because I care about these people, and I'm invested in them because I have this avuncular. Like, you know. Well, I knew them when they were these young ladies that used to come by, and I would make a cookie for them and talk to them, and, you know, and I want to see how they're doing. And I'm so. Again, I'd do anything in the world if I could change this reality for both of you, and I can't. But anything I can do to raise awareness, to do anything. I mean, my father was a scientist who devoted his life to trying to find ways to make people better. And my hope is that science will find ways. And anything we can do. I mean, anything I can do to help both of you. And I'd also like to come on your podcast.

[Christina Applegate]

You know, we would love it, seriously.

[Conan O'Brien]

But here's the thing.

[Jamie Lynn Sigler]

Well, I didn't think Conan was gonna make me cry today, but here's the thing.

[Conan O'Brien]

I want to talk about my fee. Oh, it's $100,000, and it's gotta be in its cash, in a suitcase, or I fucking want.

[Christina Applegate]

It's more than I've even Made doing the podcast.

[Conan O'Brien]

Well, listen, sister. Sister, okay, it's time for me to get tough with you, too, all right? I'm not gonna soften up because of this whole Ms. Thing. I get top dollar, hear the next bitch they're gonna talk about. This bitch wants $100,000 to come on. No, David is right here. And David's the one that does the schedule. He's in charge of my life. But I would love to come on and talk to you on your podcast. Thank you. And do you know, I consider us friends, and I would like to help, so let me know what I can do. And I'm just saying that because this is. Once this is over, I'm not gonna do anything. You know that.

[Christina Applegate]

This is just.

[Jamie Lynn Sigler]

Of course. But this is the image you need to put up.

[Christina Applegate]

It's been recorded.

[Conan O'Brien]

This is what's called performative, you know, this is me is the paparazzi here, and they get a picture of me going to the hospital to visit, you know, the people, and then I go out the back and I shop for a Rolex.

[Christina Applegate]

There you go.

[Conan O'Brien]

Yeah.

[Jamie Lynn Sigler]

Real Hollywood secrets here.

[Conan O'Brien]

I like it. No, I really want to come do yours, and really, I really want to get into the bitches thing, so.

[Christina Applegate]

Oh, yeah, yeah.

[Jamie Lynn Sigler]

Maybe we should save the bitch conversation for when Conan comes on.

[Conan O'Brien]

Yeah.

[Christina Applegate]

That's so bad, you guys. It's so bad. It's almost. This particular thing that happened this week is like. I don't even know if I can even talk about it.

[Conan O'Brien]

Well, I've got my own to talk about, two of whom are in this room.

[Christina Applegate]

Talk about your. Yeah, your.

[Conan O'Brien]

I'm looking at one of them right now. Eduardo.

[Matt Gourley]

Eduardo strays over.

[Conan O'Brien]

No, hey, that's not a stray. That is, you know, what you did, and you're gonna pay for it with my microphone. I love you both. And I love you, too. I haven't even said that. I never said that to my parents, so I shall say it to you. That's not true. I'm kidding. Wait a minute. Hold on. Checking. Nope. 1977, the summer Elvis died. I told them I. I'm in your corner, and let me know what I can do, and I will see you on your podcast. We'll talk about bitches.

[Christina Applegate]

Yes, you will.

[Conan O'Brien]

And I'm thinking about you both and. And sending you whatever crazy Irish Catholic energy is within me, half of which is malevolent, I'm sure, but I'll take it.

[Christina Applegate]

Yeah, you know what? You can send me, because I ask all my very, very, very wealthy friends.

[Conan O'Brien]

Yep.

[Christina Applegate]

$6 million. Just like, not alone.

[Conan O'Brien]

Jesus. I made that today. I mean, okay, just.

[Christina Applegate]

Just six million. Six million. I know it sounds weird.

[Conan O'Brien]

No, I just.

[Christina Applegate]

For 6 million, I ask him every time I talk to him.

[Conan O'Brien]

I just bought and closed an orphanage and I got 6 million.

[Christina Applegate]

Okay, there you go.

[Conan O'Brien]

And then I. I have a lot of investments with defense contracts who make Claymore mines. Those are the minds that. Really. So. Yes, ladies, just have a. Christina, I hope your day gets better. And it is really lovely to talk to both of you. And weird thing to say. Cause I'm not your uncle, but I'm really proud of both of you. Extremely proud of you. So let's just. I'm your comedy uncle. Your weird comedy uncle.

[Christina Applegate]

And we're getting creepers.

[Jamie Lynn Sigler]

The only kind of uncles we want.

[Conan O'Brien]

Okay. Yeah, the weird comedy uncle with the red wig. And that's right. And thank you so much for being here today and sharing with me. I really appreciate it.

[Christina Applegate]

I love you.

[Jamie Lynn Sigler]

Thank you for having us.

[Conan O'Brien]

All right, bye.

[Christina Applegate]

Bye.

[Conan O'Brien]

We drink so much water every day and it's just water. And I'm like, hello, boring. There's gotta be a way to make water more exciting. Well, guess what? Someone cracked it with authentic flavors and lively carbonation. Waterloo sparkling waters bring full flavor artistry. Blay, you're drinking one right now. Drinking right now. I got the raspberry nectarine and it is tasty. Very good. Very tasty. Everyone here in the office has been enjoying them. They're excellent. They are delicious. And you know, you say, what's flavor artistry? Some people think, oh, you're just talking a lot of high class nonsense, Conan. No, it's about custom crafting multi sensorial flavor experiences of aroma, taste and mouthfeel that make you say wow wow to that sentence. Waterloo waters are crafted, not formulated or off the shelf. Just purified sparkling water and non GMO project verified natural flavors, which I insist on. Me too. Zero calories, sugars or sweeteners. I drink water constantly. I just had a couple of glasses of water and it was just regular water upstairs. And I regret that time.

[Christina Applegate]

It was boring.

[Sona Movsesian]

You'll never get that back.

[Conan O'Brien]

I'll never get that time back. Three full glasses of water. I wish it was Waterloo and I could have had. What did you have? Raspberry. You know what, what's that one cracking open a peach right now. Okay, well, you should. You could have offered that to me. You just ate a second when I haven't had one. Oh, sorry. Nice. Thanks a lot. I'm so thirsty. Where Are you working tomorrow? Give Waterloo Sparkling Water a try. Look for Waterloo Sparkling Water next time you shop. Learn more about the flavors from Waterloo sparkling [e-mail] I'm gonna go out on a ledge here and say, in the olden days, people used to go on Amazon to get very specific things. You know, I want to get a cuckoo clock. It's made of caramel, hardened caramel. And they go on Amazon and they'd look it up and they'd order it. But you know what they're forgetting? Amazon is the go to destination for both everyday essentials and those last minute must haves. From detergents to diapers, cookies to pain relievers. Find it all on Amazon and save time. Remember the old days. I gotta get to this store and buy my aspirin. No. Hello, Amazon. Check out Amazon Basics and Amazon Essentials for quality products you'll love next time you run out of coffee, need a new lipstick, or realize you're out of light bulbs. Guess what? Amazon has you covered. Save the everyday with deals from Amazon.

[Matt Gourley]

Okay, I have something very tangentially Oscars related, which I don't think I've said on my cow. How great a job you did on Oscar.

[Conan O'Brien]

Oh, thank you very much. Thank you. I enjoyed myself thoroughly. I had a really good time.

[Matt Gourley]

The Oscars are big in our family. It's like the Super Bowl. And my wife sat down with my daughter to do a little arts and crafts and they decided that they would try to predict what all of the famous people would be wearing at the Oscars.

[Conan O'Brien]

Interesting. Okay.

[Matt Gourley]

And so I just want to show.

[Conan O'Brien]

You because your daughter is quite young.

[Matt Gourley]

She's three and a half.

[Conan O'Brien]

Three and a half. Okay.

[Matt Gourley]

And so is my wife.

[Conan O'Brien]

Yeah. All right.

[Matt Gourley]

And this is what my wife did for Cynthia Erivo and Ariana Grande. Okay. I just want to show this.

[Sona Movsesian]

And so that's pretty close.

[Conan O'Brien]

They were wearing very architectural looks. Look at this. That's insane.

[Matt Gourley]

So now I'm living with a woman who is convinced she's psychic and I don't believe in that kind of stuff. But now I have to say I don't know what's real.

[Conan O'Brien]

Wait a minute. Wait a minute.

[Jamie Lynn Sigler]

Yeah.

[Conan O'Brien]

The fact that your wife did that prior to the Oscars and seeing what.

[Matt Gourley]

They were gonna wear.

[Conan O'Brien]

Okay, I'm gonna say this. That is eerie. That is eerily close. Unless. Is she someone who pays attention to how they normally.

[Matt Gourley]

No, not at all. She had no idea. She just took a guess. I think she was going kind of off their wicked characters.

[Conan O'Brien]

A little bit.

[Matt Gourley]

But isn't this incredible?

[Sona Movsesian]

Do you mean if I say she draws like a 10 year old?

[Conan O'Brien]

Two. Okay.

[Sona Movsesian]

Okay.

[Conan O'Brien]

Yeah, yeah, yeah, yeah.

[Matt Gourley]

Certainly is.

[Sona Movsesian]

Yeah.

[Conan O'Brien]

I thought those were pretty good.

[Sona Movsesian]

Yeah, you do.

[Matt Gourley]

Well, wait till you see how my daughter draws.

[Conan O'Brien]

Oh, I thought those were your daughters.

[Sona Movsesian]

I mean, no offense to Amanda.

[Conan O'Brien]

No, no. But also, we were. You were up close because I got you some seats. I hooked you up.

[Jamie Lynn Sigler]

Yeah, you hooked me over.

[Conan O'Brien]

And you could see Ariana Grande trying to sit in that dress.

[Sona Movsesian]

Yes.

[Conan O'Brien]

And she had to. It was not easy.

[Sona Movsesian]

She had to, I think, sit on the edge of the seat because it was.

[Conan O'Brien]

She couldn't recline.

[Matt Gourley]

No, those are not sitting dresses.

[Conan O'Brien]

No, these ain't sitting dresses.

[Matt Gourley]

Okay.

[Conan O'Brien]

Okay. Anyway, stay on. We'll stay on topic.

[Matt Gourley]

Okay, well, that's it for that. But this is. This came up earlier about Ralph Fiennes. This is my daughter's prediction of what Ralph Fiennes would be wearing.

[Conan O'Brien]

Again, spot on.

[Matt Gourley]

She says that's his little hat.

[Sona Movsesian]

Okay.

[Matt Gourley]

But then this is where it gets pretty interesting. This is Zoe Saldana.

[Sona Movsesian]

Oh, okay.

[Conan O'Brien]

Okay.

[Matt Gourley]

And my favorite here, Adrienne Brody. And she pointed out what all of the pieces are here.

[Conan O'Brien]

Oh, little bow hair, bum bum.

[Matt Gourley]

That's his butt. And a toot coming out.

[Sona Movsesian]

Oh, a fart.

[Matt Gourley]

He poopies and potty. And he does go pee pee.

[Sona Movsesian]

Is it his pee pee or he's pee peeing?

[Matt Gourley]

I think he's. You know, I'm not sure. I'll have to get back to you on that.

[Sona Movsesian]

I'd like that. I'd like to.

[Conan O'Brien]

Can I say I was backstage when all that was going down with Adrien Brody and all of that happened.

[Sona Movsesian]

Yeah.

[Conan O'Brien]

This is hosing. We were hosing that place down.

[Sona Movsesian]

He was pooping in the potty and he had the pee pee.

[Conan O'Brien]

We all heard it the first time. We're good. We don't need your recital of the facts.

[Matt Gourley]

Oh, by the way, if you want to see these, just go to eamcoco podcasts on Instagram.

[Conan O'Brien]

So I think that's a pretty. That's pretty impressive.

[Matt Gourley]

This is crazy, right?

[Conan O'Brien]

I think that's crazy. That's. That your wife was able to do that. Look at that.

[Sona Movsesian]

We should do this. We should predict what people are gonna wear and stuff.

[Conan O'Brien]

I do it here around for certain guests.

[Sona Movsesian]

Oh, that's right.

[Conan O'Brien]

Oh, that's right.

[Matt Gourley]

We should talk about this.

[Conan O'Brien]

Eduardo, please speak your truth. I'm not involved.

[Matt Gourley]

There's kind of like an office pool.

[Conan O'Brien]

That happens for certain guests. Okay.

[Matt Gourley]

I'd say The AAA listers, where the office around here starts to guess and wonder what they're going to come in dressed like. From my recollection, it was Goldie Hawn, Jane Fonda and Al Pacino.

[Conan O'Brien]

That's right, yeah. Yes. So there's guesses. So we already kind of. Now, how close did you come? I'm not good at this game. But there's other people within the office that are.

[Sona Movsesian]

So those aren't the only three AAA listed. No, no, those are the only ones we did.

[Matt Gourley]

Yeah.

[Conan O'Brien]

Yeah.

[Matt Gourley]

But nobody got Goldie Hawn because she came in in like a body glove wetsuit or something like that. Remember, she had like a wetsuit? No, it wasn't a wetsuit, but it was like a sport tank top or something. Yeah.

[Conan O'Brien]

Well, to be fair to her, she came right from deep diving for pearls without a tank. So, I mean, she came right from that and brought us all fresh pearls. Yeah. Yeah, it was pretty. She was amazing. By the way, Goldie Hunt. If you have not listened to her interview, check it out, because I loved talking to her.

[Sona Movsesian]

Yeah.

[Conan O'Brien]

She's incredible. And her memory of things that happened to her when she first moved to New York in the 60s and she didn't have a place to live yet. It was. And she talked about all of it as if it happened yesterday. I know the imagery and everything was incredible.

[Sona Movsesian]

I love her so much anyway. But, yeah, we do that. We talk about. I mean, Ruthie's the one who's kind of spearheading it and she goes around.

[Conan O'Brien]

And makes people gasping.

[Sona Movsesian]

She has a list of what people are gonna dress up.

[Conan O'Brien]

Do people ever guess what I'm gonna be wearing when I come in?

[Sona Movsesian]

No one ever talks about you.

[Conan O'Brien]

That's weird.

[Sona Movsesian]

You just never come up, up.

[Conan O'Brien]

I guess it's because I'm so ubiquitous.

[Sona Movsesian]

I think they forget that you do this podcast sometimes.

[Conan O'Brien]

Also, I tend to wear the same thing a lot.

[Sona Movsesian]

You do?

[Conan O'Brien]

I have kind of a uniform.

[Sona Movsesian]

You're like a Steve Jobs.

[Conan O'Brien]

Yeah. You know, in my ability to lead the world of tech. No, no, no, no.

[Sona Movsesian]

I meant, like, just like wearing the same stuff a lot.

[Conan O'Brien]

Oh. I thought.

[Sona Movsesian]

Yeah.

[Conan O'Brien]

The other way in which this works. Yeah. Sometimes the hoodie with the blazer come in.

[Sona Movsesian]

Yes.

[Matt Gourley]

Oh, that's true.

[Conan O'Brien]

I mean, cartoonishly hyperactive. Yeah. Just versus what scale of one through ten, maybe. Like how. How high out the novel be turned up.

[Christina Applegate]

Yeah.

[Conan O'Brien]

How bitty you might be. Where are we today?

[Matt Gourley]

I think today's like a.

[Conan O'Brien]

You know, I. I find a tendency that when we haven't recorded in a while. Yes. There's like this freshness and there's like.

[Matt Gourley]

A layer that pent up bits. Yeah.

[Conan O'Brien]

But also, like, also just friendlier. That's true. Like, he's happy to see everyone.

[Matt Gourley]

I'm worried about next week because we have four sessions on books and by Friday he's just gonna be beating us.

[Conan O'Brien]

Well, I don't physically. Yes, I do physically beat you. I'm sorry. And that's probably wrong and I shouldn't admit to that on Mike, but yes, it is true. I was away from you guys. I've been up in Seattle visiting my in laws with my wife and love Seattle. Shout out to Seattle. And shout out to Pam and Jake Powell. Seattle. Seattle Powells. You're wearing your Seahawks.

[Matt Gourley]

Starbucks.

[Conan O'Brien]

Oh, that's the Mariners. Yeah. And anyway, yeah, Microsoft. It doesn't work the same way, needles space or otherwise. Amazon. Oops. Anyway, yeah, had a. Had a wonderful time with the Powells, as I always do, and I really love Seattle. But what happened after being away for like eight days is I do miss you guys and I do miss this total assery that we engage in. I don't know what else to call it. That's accurate foolishness. So I come in and I'm doing it's bits right away, but bits right away. Then when we do a bunch of shows in a row towards the end, I feel like one of those, you know, jackpot machines with just that they've been pulling on the handle again and again and again and again. There's no coins left. Then I want everyone to off.

[Matt Gourley]

There he is.

[Conan O'Brien]

There he is. All right. We wrapping it up? Yeah. This was just a segment, so there's no. I just looked down. Am I introducing. I don't know how this podcast works. No, you don't. You've only been doing five years.

[Matt Gourley]

You know, can I talk about something that you don't know? How it works. That would help me in editing is every time when you do the intro and you say, these are my guests, blah, blah, blah, blah, blah, and then you say their name is the last thing you say. I really need a pause there because there's a musical break between that and I always have to find a stranger.

[Conan O'Brien]

Okay. That helps me.

[Matt Gourley]

Yeah.

[Conan O'Brien]

That's constructive criticism.

[Matt Gourley]

That's right. No, it's nothing you're doing wrong. You didn't know. But I just didn't want to try to explain that it's been five years.

[Conan O'Brien]

And you've never, ever, ever thought to maybe just suggest to me you're that.

[Matt Gourley]

Afraid of me, and that's on me.

[Conan O'Brien]

Okay. Yeah. Well, I wish I had a guest that I could introduce right now, because I'm gonna tell you how I'm gonna do it in the future. Okay. Okay.

[Matt Gourley]

Do you wanna just try it again with their names one more time?

[Conan O'Brien]

Sure. With the end of the episode and Jamie Lynn. Sure. My guest today hosts the podcast Messy, which releases new episodes every Tuesday. Wherever you get your podcast, I'm very excited they're here today.

[Sona Movsesian]

Oh, man.

[Conan O'Brien]

Christina Applegate and Jamie Lynn Sigler.

[Matt Gourley]

Perfect.

[Conan O'Brien]

Welcome.

[Matt Gourley]

Conan O'Brien needs a friend. With Conan O'Brien, Sonam of Session and Matt Gourley produced by me, Matt Gourley executive produced by Adam Sachs, Jeff Ross and Nick Leow. Theme song by the White Stripes. Incidental music by Jimmy Vivino. Take it away, Jimmy. Our supervising producer is Aaron Blair and our associate talent producer is Jennifer. Samples, engineering and mixing by Eduardo Perez and Brendan Burns. Additional production support by Mars Mellow Helnick. Talent booking by Paula Davis, Gina Bautista and Brit Kahn. You can rate and review this show on Apple Podcasts and you might find your review red on a future episode. Got a question for Conan? Call the Team Coco hotline at 669-587-2847 and leave a message. It too could be featured on a future episode. You can also get three free months of SiriusXM when you sign [e-mail] conan and if you haven't already ready, please subscribe to Conan O'Brien needs a friend wherever.

[Christina Applegate]

Fine podcasts are [e-mail] we know some.

[Jamie Lynn Sigler]

Travelers crave an ocean breeze. Others don't want to deal with sand. And oftentimes, those two people end up together. Compare properties side by side to find yourself poolside, oceanside, and still in a relationship. Find your perfect somewhere with hotels.

[Conan O'Brien]

You know, one of the hardest parts about B2B marketing is reaching the right audience. You put so much effort into a campaign only for it to get wasted on the wrong people. Do you know what I mean? Yeah, it's ridiculous.

[Jamie Lynn Sigler]

It's crazy.

[Conan O'Brien]

Yeah, it's like, hey, Santa Claus, get your bathing suit over here.

[Jamie Lynn Sigler]

Oh, my God.

[Conan O'Brien]

Hey, he doesn't need a bathing suit. He's up at the North Pole. What did I waste my time for?

[Sona Movsesian]

Yeah, and he's got elves.

[Conan O'Brien]

Exactly.

[Sona Movsesian]

They can make it.

[Conan O'Brien]

Okay, you're ruining the point I was trying to make. Yes. No. One of the hardest parts about B2B marketing is reaching the right audience. You put so much effort into a campaign only for it to get wasted on the wrong people. Fortunately, LinkedIn is a network of over 1 billion businessy people who might actually be interested in your business. You can target your buyers by job title, industry, company role, seniority, skills or company revenue. So stop wasting budget on the wrong audience and start targeting the right professionals with LinkedIn ads. LinkedIn will give you $100 credit on your next campaign, so you can try it yourself. Just go to LinkedIn.com teamcoco that's LinkedIn.com teamcoco Terms and conditions apply only on LinkedIn.