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Standard collagen supplements get broken down to individual amino acids during digestion, but specific di- and tripeptides resist digestive enzymes, enter your bloodstream intact, and may act as signaling molecules that stimulate collagen production, fibroblast activity, and hyaluronic acid synthesis
German company Gelita produces target-specific bioactive collagen peptide formulations for joints, skin, and bone, each backed by randomized, placebo-controlled clinical trials
The Japanese company Nitta Gelatin first identified these key bioactive dipeptides from within the collagen peptide molecule over a decade ago, and their Replenwell line contains up to 30 times more bioactive dipeptides than standard collagen
A 2024 five-arm multicenter randomized controlled trial showed that 2.5 grams of concentrated bioactive collagen peptides matched the efficacy of 10 grams of conventional collagen — a four-fold potency advantage
Gelita's consumer-available hydrolysate powder — roughly $40 for a pound — is currently a practical option, though a commonly studied intake is about 10 grams per day