Shaun Bagai, CEO of RenovoRx, has designed a drug-delivery platform to treat hard-to-reach chemo-resistant tumors such as pancreatic cancer by delivering chemotherapy directly to the tumor site. The RenovoCath device increases the drug concentration in the tumor while significantly reducing systemic toxicities and side effects. The technology is not intended to replace the traditional approach using systemic chemotherapy and radiation, but to achieve better results in tumors with low blood supply that prevent drugs from reaching their target in sufficient concentrations.

Shaun explains, "Generally, when we think about oncology therapies, it's really trying to balance the detriment to the patients with the toxicities and hopefully keep the tumor at bay or kill the tumor such that patients live longer. And unfortunately, we often forget about the patient and hyper-focus on the disease. And the challenge we've taken on is, can we take both into account and actually treat both the patient and the disease by limiting systemic toxicities and effects, and then trying to improve survival by keeping the tumors at bay."

"So, when we look at certain tumors in the body, like pancreatic tumors, for example, they don't have a high level of blood supply. Generally, when we think about tumors, we think of balls of blood vessels with tumor cells, and of tumors such as pancreatic tumors. They don't have large tumor feeder vessels that end in a tumor. And what this does is create a level of chemo resistance because the blood can't carry the chemotherapy forward. And what we've developed with TAMP is a mechanism where we push the drug across the wall of a blood vessel to saturate and bathe the tumor in chemotherapy, such that we get almost a hundredfold increase in tissue concentration compared to if you just gave it systemically throughout the entire body."

#RenovoRx #OncologyInnovation #DrugDelivery #CancerCare #MedicalDevices #PancreaticCancer #ClinicalTrials #PatientCare #Interventionalradiology #Oncology #MedicalTechnology #TAMP #Chemotherapy #CancerTreatment #HealthcareInnovatio#TargetedOncology #InnovativeCancerTherapies #PancreaticCancerAwareness #PrecisionOncology

RenovoRx.com

Download the transcript here