To defeat smallpox in South Asia, public health workers had to navigate the region’s layered cultural ideas about the virus. They also dreamed big. In Episode 1, host Céline Gounder wonders how the U.S. might tap into similar “moral imagination” to prepare for the next public health crisis. To close the episode, Céline Gounder wonders how the U.S. might tap into similar “moral imagination” to prepare for the next public health crisis.