B (37:49)
Yeah, and I'M excited to talk about this with, with you and especially with Kai because we're going into Kai land, the world of intangible value. And honestly, Kai sort of inspired me on some of this thinking because there are certain sectors where you've really got to think about this intangible value, where it really matters and where the financial metrics are less helpful. And so this is my first foray into Kai's world. So it's going to be a fun conversation today. But the reason that we got into biotech or looking into biotech is when we were running multi factor equity models, risk models, return models, you know, we're always looking for places where there are mispricings, where the model isn't working. You know, where are we making mistakes, where are we finding idiosyncratic bad, bad outcomes? And we looked and we realized like 80% of our worst outcomes from a prediction standpoint were coming from biotech, right? And we're like, oh my gosh, like our standard quant factor model does not predict this at all. And we think it does and it's a disaster. And so like we could looked at like chart after chart of like, here's our expected return, here's actual return. There's just like no correlation. And you're like, oh my gosh, like, we gotta turn this off. So like a year and a half ago we just like turned off biotech. Like, we are not trading biotech until we figure this out. And then we started saying, okay, now we need to figure it out. And so the first, the first challenge was trying to make what we could of the financial metrics. So, you know, let's start with the easy stuff, like how do we just fix our financial thinking around biotech? And I think there are certain things that are true about biotech. Like biotech companies are small. Biotech companies are very high volatility. We sort of know that. And they're biotech, right? Like those risk factors, the size, the volatility and the fact they're biotech. Like, yeah, we agree on like that our model was getting right and then everything else it was getting wrong. And so the first thing is to say, okay, let's keep our understanding of them as small and volatile, but like, we need something that spreads returns from a financial perspective. And the first thing we found. Is that you got to fix your value metric. And so if you think about the denominator of enterprise value, which is market cap plus cash, a biotech company, the more cash they have on the balance sheet, the more Expensive. They looked to a traditional value metric. And so the first thing we do is, okay, we've got to exclude cash because cash is good, right? Like, biotechs need cash. That's their lifeblood. So you don't want to penalize them for having cash. So you just got to have only market cap as the denominator. And then let's think of the numerator. They're all unprofitable, and they're all basically spending money on science projects. And so what we then realized is that actually the level of spending, like, let's just take like a very crude assumption, which is that the level of spending correlates with the intangible value that's being created. Then you don't want to penalize a company that has no revenue for spending more in biotech, right? Like, actually, a company that spent $500 million last year on clinical trials is a lot more, is a lot more value than a company that spent 5 million on clinical trials. So if they're Both selling for 100 million of market cap, well, gee, you'd much prefer the one that spent $500 million last year because presumably someone gave them that money to do something promising. And, you know, presumably that $500 million of spending produced something promising. Right? Like there's got to, you know, you're sort of just taking the numbers on faith. But, like, if that's true, then like, yes, that should be a value stock and the one that's $5 million of spend last year and 100 million market cap is a very expensive stock and it should be penalized for that. There's just hopes and dreams. And so we actually found that that very simple framing of like, spend to market cap really nicely spread biotech returns. So that was sort of our first find. Like, okay, this is not totally impenetrable. You know, we haven't exited the land of any financial metrics working. There are some that work. And then the next challenge was thinking through the intangible value. What's the quality of these businesses? And Kai does a lot more sophisticated work around how to measure this, which is really cool. But we wanted a sort of cruder first pass that we could get through. And so what we again is, let's take biotech. One of the things we know about biotech is there are these biotech specialist hedge funds out there that have like 50 PhDs on staff that are going and researching, like, is this a promising oncology drug drug or not, who are going to read the clinical trial data. And so we said, well, what if we just say, well, let's take these specialists and we can define them as people. Anyone that owns a certain amount of biotech and for whom biotech is a certain percentage of their holdings. Let's define as a specialist and then let's look at what percent of each company is owned by specialists versus non specialists, right? Like if we have a $3 billion biotech and not a single biotech specialist fund owns it, that's telling you something pretty bad about that company, right? Like that anybody that has a scientist on staff has passed. And the only people that own it are like people that are like thinking it's going to cure cancer for sort of magic reasons that are illiterate when it comes to science. And then conversely, you could have a company that's like 70% owned by like 10 of the top biotech specialist funds and you're like, whoa, like I, you know, I don't know, they all, they all seem to agree that this is a good thing. So like maybe I should be in it too. And so we basically said, well that's actually a quality metric, right? Like the amount of sort of scientific rigor and vetting that's been done and that's been expressed through ABET is a really healthy metric of quality. And so then we can sort of take quality and value, which are sort of the classic two quant factors, or their third momentum, which we'll get to and sort of spread returns in that way and say, okay, gee, what we're focused is on the cheap, high quality businesses. And then third was momentum. You know, traditional momentum as measured by stock price doesn't seem to work particularly well in biotech. I think probably because it's mostly event driven. The trials come out and boom, something works or not. And whether it's been going up or going down prior to that doesn't make much of a difference. So what we looked is at peer momentum, which is a kind of cool, interesting newer field in quant thinking. And it's become very popular in the past decade or so of thinking through, you know, peer momentum effects and network effects and how does a company's suppliers or competitors, et cetera, impact their stock price? And people find that they co move. And so what we looked at is saying, well, let's use the clinical trial, the sort of subjects of the clinical trials, what each biotech company is researching, look how similar that is to, you know, other companies and then define a peer set of like these are the set of companies that are doing the most similar Science. And if those companies are doing really well, you should expect your company to do really well. And so there's sort of a peer momentum effect within biotech, which sort of makes intuitive sense. Right. If everybody's getting pumped about oncology, your oncology drug should work as well. And that should be sort of a powerful, you know, network effect. So those are sort of the three core factors that we identified that work in biotech and a little bit about what motivated us to get into it.