Podcast
FoundMyFitness
Hosted by Rhonda Patrick, Ph.D. · EN
Promoting strategies to increase healthspan, well-being, cognitive and physical performance through deeper understandings of biology.
10episodes
Episodes
Newest firstAll episodes
Aliquot #1: Q&A Mashup - Pregnancy and child development
Aug 25, 202000:24:05Tap to summarizeGet a sample of our new premium member's content, known as Aliquots, by listening to this in-depth Q&A mashup on pregnancy and child development. What's an aliquot, you may ask? Aliquots are special, curated segments prepared and distributed to premium members via the premium members podcast feed. This particular collection of segments covers every single major discussion of pregnancy and child development spanning years of members-only Q&As. Just for a few examples, it covers... My pre-pregnancy regimen, including diet, exercise, vitamins and sleep Nutrition for babies and toddlers to maximize brain development and growth Extra precautions that I took during my pregnancy And much, much more! Learn more about our premium podcast feed The Aliquot by clicking here. Learn more about premium membership benefits by clicking here.
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The Biology of Breast Milk
Aug 25, 202000:38:20Tap to summarizeThis episode aims to be the most comprehensive compendium on the biology of breast milk ever recorded. Looking at the converging clinical and animal evidence of the impact of breast milk paints a complex and beautiful mosaic of developmentally supportive effects that range from allowing the mother to act as a “compensatory” immune system to possibly supporting the development of entire organ systems through the integration of maternal stem cells found in breast milk. Episode Highlights 00:07:11 - Breast milk composition and production 00:09:59 - Human milk oligosaccharides in breast milk establish the infant gut microbiome 00:15:48 - Omega-3 fatty acids and other components in breast milk boost brain development 00:18:14 - Vitamins and minerals in breast milk 00:22:05 - Breast milk stem cells and multi-organ microchimerism 00:22:54 - Harmful substances transferred to infant via breast milk 00:28:03 - The effects of breastfeeding on the infant's immune system 00:31:17 - Effects on intelligence 00:34:36 - Breastfeeding as a benefit to maternal health Get our detailed summary, timeline, references and more on the FoundMyFitness episode page. Breastmilk and breast feeding is now a dedicated Topic section on the website. View that article by clicking here. Did you enjoy this episode? If you’re interested in learning more about this topic, check out a preview of our very first Aliquot episode: Aliquot #001: Pregnancy & Child Development. It features a compilation of pregnancy and child development-related topics taken from several Q&A episodes over the last couple of years. Click here to hear this preview of our premium podcast The Aliquot by clicking here now.
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COVID-19 Q&A #2 - Antibody-Dependent Enhancement, Cross-Immunity, Immunity Duration & More
Jun 10, 202000:55:24Tap to summarizeThis is a continuation of the last episode where Dr. Patrick took questions from newsletter subscribers around the on-going pandemic and tried to add value by talking about some of the recent research, among other things. Some of the topics that came up as a result of the questions submitted include: 00:04:03 - Data surrounding SARS-CoV-2 duration 00:06:37 - SARS-CoV-2 and potential immunity 00:11:35 - Some of the main factors known to play a role in immune variation 00:12:05 - What role genetics may play in immune function 00:14:27 - How previous viral exposure regulates immunity 00:15:05 - What cross immunity is and how it may be relevant for SARS-CoV-2 00:19:46 - Antibody-dependent enhancement and SARS-CoV-2 relevance 00:21:50 - How sleep is a key regulator of immune function 00:23:44 - Microbiome composition and immune function 00:28:31 - The differential effects of exercise intensity and duration on immune regulation 00:35:00 - How specific micronutrient inadequacies may promote immune dysregulation 00:47:20 - The effect of sex hormones on immune function 00:48:55 - How biological age age may play a role in immune regulation 00:49:46 - Controversy surrounding hypertension drugs such as ACE inhibitors and COVID-19 00:53:15 - ARDS and long-term lung damage Get our detailed summary, timeline, references and more on the FoundMyFitness episode page.<...
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Vitamin C: Oral vs. Intravenous, Immune Effects, Cancer, Exercise Adaptation & More
May 13, 202001:19:11Tap to summarizeIn this episode, Dr. Rhonda Patrick discuss all things vitamin C. This episode covers oral bioavailability, intravenous vitamin C bioavailability, immune cell function, common cold and other viral infections, lung function, sepsis, pneumonia, inflammation, intravenous vitamin C and cancer, role in exercise, safety concerns, and so, so much more! Episode Timeline (abridged) 00:07:33 - Background on vitamin C 00:17:09 - Bioavailability of vitamin C [including dosing frequency] 00:22:53 - Vitamin C in the context of the common cold 00:28:09 - Vitamin C and lung function 00:35:54 - Vitamin C in the context of exercise [includes discussion of blunting of exercise adaptation] 00:45:51 - Vitamin C and fatty acid oxidation, including relevance in obesity 00:48:44 - Vitamin C and the brain 00:51:15 - Intravenous Vitamin C and its use for the treatment of certain kinds of infection 00:55:33 - Intravenous Vitamin C and cancer 00:57:40 - Effect of Vitamin C on fertility and reproduction 00:58:36 - Intravenous vitamin C and cardiovascular health 01:00:42 - Vitamin C and inflammation 01:02:38 - Vitamin C’s mechanisms of action 01:08:34 - Intravenous and Oral vitamin C safety 01:10:20 - Vitamin C intake and kidney stone risk 01:13:57 - Conclusions Get the full timeline, show summary, and all references for this episode by clicking here. View our new 28-page vitamin C overview article with over 190 references by clicking here. Premium membership: Members enjoy extra science emails twice per month, my monthly Question & Answer sessions, and a whole lot more. Support t...
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COVID-19 Q&A #1 with Rhonda Patrick, Ph.D.
Apr 14, 202001:14:26Tap to summarizeThis episode features Dr. Rhonda Patrick answering some of the most popular questions related to COVID-19. Look for another COVID-19-focused Q&A, coming soon. Some of the questions we selected from the batch to cover in this episode include: 00:02:36 - Are children and infants susceptible to COVID-19? Are some more susceptible to a more severe form of the disease? Are they carriers of it and possibly spreading transmission? 00:11:00 - Can you explain a little about hydroxychloroquine as possibly treating COVID-19? How does it work? Does it have to do with it being a zinc ionophore? 00:17:58 - Can you talk about quercetin's role as a zinc ionophore? 00:20:51 - Is there any indication blood type influences COVID-19 risk? 00:24:52 - Would you shed light on the conversation regarding vitamin D upregulating ACE2 receptors and vitamin D's influence on susceptibility to COVID19 infection? 00:43:45 - Can you discuss whether sauna use might help prevent COVID19? 00:52:55 - Is it true that high dose intravenous vitamin C might help treat COVID-19? 01:04:35 - What are your thoughts on melatonin being a potential factor for impacting the severity of the virus via its effects on inflammation and oxidative stress? To supplement this podcast Q&A, we’ve also made a video, summary, timeline, and references. You can view all of these on the episodes page on my website at foundmyfitness.com/episodes/covid-19-qa-1. If you enjoy this question & answer format, consider joining my premium membership community! Non-COVID-19 related Q&As happen monthly, you get access to an an exclusive bi-weekly science digest email, and much more more! Click here to learn about premium.
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New Omega-3, sulforaphane research, and more! [Kevin Rose Show]
Jan 6, 202001:36:34Tap to summarizeThis episode was originally recorded for The Kevin Rose Show. Given some of the unique discussions we had, I had no choice but to ask the great Kevin Rose if he would let me re-post it over here on the FoundMyFitness podcast feed. A request which he graciously obliged. In this episode, we discuss... 00:08:00 - Omega-3 00:27:23 - Metformin 00:50:05 - Sulforaphane 01:06:57 - Magnesium L-Threonate 01:13:44 - Sauna 01:23:48 - New FMF Membership Learn more about the new premium membership. Learn more about sauna on our overview page. Learn more about metformin on our overview page. Learn more about Kevin Rose at his website or on his Twitter @kevinrose. You can also subscribe to either of his two podcasts: Kevin Rose Show Foundation by True Ventures
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Is Resveratrol a Longevity Compound?
Dec 30, 201900:28:57Tap to summarizeIn this episode, Rhonda gives a summary of the science of resveratrol including its effects in animals and humans, mechanisms, and the bottom line on resveratrol supplementation and safety. Learn more about resveratrol at our comprehensive overview Relevant timepoints... 00:03:39 - Clinical effects of resveratrol in humans 00:04:10 - Effects on cardiovascular health biomarkers in humans 00:06:54 - Reduction of inflammatory biomarkers in humans 00:08:11 - Improved cognition and memory in clinical studies 00:11:23 - Healthspan improvements in animals 00:12:28 - Induction of longevity genes via xenohormesis 00:16:19 - Contradictory effects on exercise-associated benefits 00:20:34 - Various factors that affect resveratrol bioavailability 00:23:09 - Unintentional effects on drug metabolism Get earlier access with the premium members early access podcast feed, monthly Q&A sessions, an exclusive bi-weekly science digest email, and more! Click here to learn about premium. Click here to sign-up for a three issue trial of the bi-monthly science digest.
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NAD+, Nicotinamide Riboside, and Nicotinamide Mononucleotide with Rhonda Patrick
Nov 13, 201900:35:41Tap to summarizeIn this episode, Rhonda describes NAD+ (perhaps one of the most important molecules in the human body), why it is so important for aging, and why it declines with age. She discusses some of the popular NAD+ boosters like nicotinamide riboside and nicotinamide mononucleotide, explains what the animal and human data say, discusses some of the concerns associated with using these boosters, and provides some concluding thoughts. Learn more about NAD+ Learn more about nicotinamide riboside Learn more about nicotinamide mononucleotide Learn more about sirtuins Get earlier access with the premium members early access podcast feed, monthly Q&A sessions, an exclusive bi-weekly science digest email, and more! Click here to get started.
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Dr. David Sinclair on Informational Theory of Aging, Nicotinamide Mononucleotide, Resveratrol & More
Nov 6, 201901:22:01Tap to summarizeDavid A. Sinclair, PhD, is a professor in the Department of Genetics at Harvard Medical School and co-director of the Paul F. Glenn Center for the Biological Mechanisms of Aging. He is the co-founder of the journal Aging, where he serves as co-chief editor. Dr. Sinclair's work focuses on understanding the mechanisms that drive human aging and identifying ways to slow or reverse aging's effects. In particular, he has examined the role of sirtuins in disease and aging, with special emphasis on how sirtuin activity is modulated by compounds produced by the body as well as those consumed in the diet, such as resveratrol. His work has implications for human metabolism, mitochondrial and neurological health, and cancer. In this episode, we discuss... 00:17:59 - How caloric restriction, fasting, and exercise increase levels of a molecule called NAD+ and how this activates sirtuins, a family of genes involved in longevity. 00:21:47 - How NAD+ levels and sirtuin activities decrease with age, and how animal studies suggest that raising cellular NAD+ levels can trick the body into thinking it is younger. 00:23:03 - How resveratrol enhances the binding of sirtuins to NAD+ thus making sirtuins more easily activated for a longer period. 00:27:36 - We also discuss Steve Horvath's epigenetic aging clock, which measures DNA methylation groups, and how they may play a role in widespread gene regulation, including sirtuin genes, and how NAD+ may participate in resetting the clock. 00:31:54 - How the signal that resets the epigenetic clock in mice involves the Yamanaka factors -- a group of four transcription factors that can reprogram an adult cell to become a pluripotent stem cell that can form any cell type. 00:46:48 - How resveratrol is a xenohormetic compound and is produced when grape plants are stressed either in response to fungus or lack of water. 00:55:35 - How a phase 2 clinical trial involving people with Alzheimer's disease showed resveratrol improved cognitive function, improved cerebrospinal fluid amyloid beta levels, lowered markers of activated microglia, and more. 00:58:03 - How both nicotinamide riboside and nicotinamide mononucleotide have been shown to improve cognitive function and brain pathology in mice that have been engineered to get a disease similar to Alzheimer's disease. 01:06:19 - How older ...
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Sauna Use as an Exercise Mimetic for Heart and Healthspan
Sep 16, 201900:46:37Tap to summarizeThis podcast is the audio from a presentation Dr. Rhonda Patrick gave on how the sauna may be an exercise mimetic for heat health and healthspan. Sauna use has emerged as a means to increase lifespan and improve overall health, based on compelling data from observational, interventional, and mechanistic studies. Listen in to find out more. Click here to get the episode show notes and video. Watch the episode with cardiologist and sauna scientist Dr. Jari Laukkanen. Did you enjoy this podcast? It was brought to you by people like you! Click here to visit our crowdsponsor page where you can learn more about how to support the podcast.
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