Could a sleep supplement help reduce chronic pain?

While looking for ways to treat pain in those with musculoskeletal disorders, researchers examined studies in which sleep supplement melatonin had been used.  A study into the behaviour of immune cells in coeliac disease patients showed surprising results. Instead of being overactive, T cells in coeliac disease were subdued, and didn't survive as long as T cells from healthy people.  Spinal stimulators have been in use for many years, but the evidence for their benefit, or otherwise has been unclear until now. References Efficacy and effectiveness of melatonin for the management of musculoskeletal pain: a systematic review and meta-analysis of placebo and active controlled trials Functional immune profiling reveals CD4+ T cell dysregulation in coeliac disease (Immunology and Cell Biology, 2026) Transcutaneous spinal cord stimulation plus locomotor training versus sham-stimulation plus locomotor training in chronic spinal cord injury (eWALK): a multicentre, triple-blind, randomis...