Howie and Harlan are joined by Mark Siegel, director of Yale's internal medicine residency program, to discuss his approach to mentoring young physicians and building a medical community grounded in purpose and compassion. Harlan examines a breakthrough targeted therapy that could reshape the treatment of pancreatic cancer and other hard-to-treat cancers; Howie tracks the Ebola outbreak in the Democratic Republic of the Congo and argues that policy decisions are hampering the global response.

Show notes:

A Cancer Breakthrough

"Daraxonrasib or Chemotherapy in Previously Treated Metastatic Pancreatic Cancer"

"Multi-Selective RAS(ON) Inhibitor Nearly Doubles Survival Time in People With Metastatic Pancreatic Cancer"

"KRAS mutation: from undruggable to druggable in cancer"

Mark Siegel

Mark Siegel: Program Director Notes

Mark Siegel on Substack

Academic medicine

Signaling system

Mark Siegel: "What I've Learned in 63 Years"

Yale School of Medicine: Residency & Fellowship Programs

Mark Siegel: "A Sudden Loss Of Vision"

Health & Veritas Episode 224: Nicholas Christakis: The Science of Human Connection

Ebola

WHO: Bundibugyo virus disease outbreak, Democratic Republic of the Congo

WHO: Ebola, The Democratic Republic of the Congo, 2026

WHO: Alert and Response

"'We are catching up'—WHO chief on DR Congo's Ebola fight"

"Uganda Closes Border With Congo as Ebola Fears Rise"

"Kenyan Court Deals New Blow to Plans for U.S. Ebola Unit"

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