
Hosted by Dr. Joel Kahn · EN

Dr. Joel Kahn dives into a groundbreaking Phase 1 trial of Verve 102, a one-time intravenous gene-editing treatment that silences the PCSK9 gene to produce lasting LDL cholesterol reduction. Among 35 participants, the high-dose group saw LDL drop by 62% with mostly mild side effects — promising results, though Phase 2 and 3 trials and 15 years of follow-up still lie ahead. Also covered: updated colorectal cancer screening guidelines now starting at age 45, healthy lifestyle habits cutting mortality risk in cancer survivors by one-third, real-world weight regain data after stopping GLP-1 medications, why your B12 "normal" range may be too low, a blood test that may predict Alzheimer's years in advance, and a longevity preparedness tool from MIT AgeLab. Sponsored by Igennus — visit igennus.com/drkahn for 20% off.

In this episode of HeartDoc VIP, Dr. Joel Kahn breaks down the newly released — but not yet fully published — results from the highly anticipated Triumph-1 study on retatrutide, an investigational weight loss medication that's already generating major buzz in the cardiometabolic world. The reported weight loss results at 80 and 104 weeks are remarkable, with side effects appearing consistent with other medications in this class, including semaglutide and tirzepatide. Dr. Kahn discusses what's known so far, what questions still remain, and why the full peer-reviewed publication is so important before drawing final conclusions on risks and benefits. FDA approval may not be far away. Other topics in this packed episode include the troubling rise in fatal heart attacks among younger adults, a modified Mediterranean diet linked to lower diabetes risk, the connection between food preservatives and heart disease, atrial fibrillation in athletes, nitric oxide's role in brain health, fatty liver disease and cardiovascular risk, and how the American Heart Association's Life's Essential 8 score may predict diabetes risk in women. Thanks to Igennus for sponsoring this episode. Visit their site and use promo code DRKAHN to save on high-quality supplements.

This week, Dr. Kahn discusses Bryan Johnson's efforts to reverse his "biological age" and the 41 lessons he has shared along the way. These are valuable insights that Dr. Kahn largely endorses. Other topics include the sit-to-stand test; how PCOS can become PMOS; therapies for Peyronie's disease and PSA testing; plant-based diets and aging; plant-based diets during pregnancy; pregnancy complications; and the cardiac health of offspring. A big thanks to Igennus for supporting the podcast. Use discount code DrKahn to save on the BeKind line of plant-based nutritional products.

This week, Joel Kahn, MD, dives into fascinating new research on aged garlic extract and its potential role in healthy aging, muscle function, and cardiovascular wellness. He reviews a recent study showing how aged garlic extract improved muscle and aging markers in mice while also activating the NAMPT pathway in humans, which may help boost NAD+ production. Dr. Kahn also breaks down several newer studies highlighting the cardiovascular benefits of aged garlic extract, a supplement he's used at the Kahn Center for more than a decade. He discusses the specific Kyolic formula available here: Kyolic Aged Garlic Extract Additional topics include dietary nitrates from greens and nitric oxide production, the Mediterranean diet and longevity, high-intensity interval training and heart health, visual acuity and lifespan, plant-based diets and breast cancer outcomes, and the connection between poor sleep and survival rates. This episode is brought to you by VINIA and their line of heart-supporting products.

This week, Dr. Kahn discusses his long-standing interest in the amino acid glycine and its potential health benefits. Sleep is a key focus, highlighted by a new report on the widespread difficulty adults face in getting a full night's rest. Glycine may also offer favorable cardiovascular support. Additional topics include coffee and aging, methamphetamines and heart attacks, Lipoprotein(a) and cardiovascular risk, yoga and overall health, a tribute to Eugene Braunwald, MD, TMAO and atherosclerosis, and a new study on the benefits of adopting heart-healthy habits early in life. Thanks to the Fresh Pressed Olive Oil Club and the special discount offer at getfreshdrkahn.com

This week, Dr. Kahn reviews new data from the Global Burden of Disease study analyzing the relationship between diet and death from heart disease. In 2023, an estimated 5.9 million deaths worldwide were linked to poor dietary choices, led by excessive sodium intake and insufficient consumption of fruit and whole grains. It's a fascinating and important study with clear takeaways. Other topics include stents for angina, causes of sudden cardiac death, daytime napping and health outcomes, plastic-free diets, PCSK9 inhibitors vs. statins, calcium supplements, and the purity of fish oil samples. Thanks to the Fresh Pressed Olive Oil Club. Visit getfreshdrkahn.com for an incredible introductory offer.

This week, Dr. Kahn addresses a topic gaining attention in the media: whether taking the shingles vaccine (Shingrix in the USA) may reduce the risk of heart events and dementia. Multiple studies suggest this could be true, although no randomized trials have been performed to confirm it. Furthermore, most of these studies focus on a version of the vaccine that was discontinued in the U.S. in 2020 (Zostavax), making the assumption that Shingrix provides the same benefits somewhat speculative. This is a topic worth discussing with your primary care team. Other topics include controversies in nutrition, B vitamins and stroke risk, and the impact of medications for mild dementia. This episode is sponsored by the Fresh Pressed Olive Oil Club at getfreshdrkahn.com, featuring a limited $1 offer on high-quality olive oils.

This week, Dr. Kahn dives into heart disease in "masters athletes," highly active individuals over 35 who train and compete at a serious level. Despite their fitness, research shows they may face equal—or even higher—rates of cardiovascular issues like arrhythmias, coronary artery disease, and aortic dilation. A new consensus statement breaks down what to watch for and recommends advanced screening like EKGs, coronary calcium scans, and detailed blood work. Beyond that, Dr. Kahn shares insights from his own recent mitral valve surgery recovery and explores why common heart risk calculators often miss people who go on to have heart attacks. He highlights better testing options, including coronary calcium scoring, and discusses a study showing most heart attack patients would have been labeled "low risk" using standard tools. The episode also covers research on plant-based diets lowering dementia risk and reducing environmental impact, plus findings that avocados and mangos may improve vascular health. Sleep gets a spotlight too, with evidence that irregular sleep patterns can double heart attack risk, and that both too little and too much sleep may increase dementia risk. This episode is sponsored by the Fresh Pressed Olive Oil Club at getfreshdrkahn.com , featuring a limited $1 offer on high-quality olive oils.

This week, Dr. Kahn shares an update on his recovery following robotic mitral valve repair surgery at the Cleveland Clinic. Just 10–12 days post-op, he walks through his experience—from diagnosis and testing to surgery with Marc Gillinov, MD. He covers the procedure, time in the ICU, and early recovery milestones, along with what's next in his healing journey. Thanks to Igennus for sponsoring this episode—visit igennus.com and use code DrKahn.

This week, Dr. Kahn shares exciting updates from the American College of Cardiology meeting, highlighting several new trials focused on reducing heart events in patients with diabetes and those with established heart disease. The results are promising and could help prevent strokes, heart attacks, and even save lives. Additional topics include vegan diets and cancer risk, heart disease in police officers, the link between Alzheimer's disease and statins, concerns around erythritol sweeteners, Lp(a) levels in stent patients, niacin for fatty liver disease, and the role of beta blockers after heart attacks. This episode is brought to you by Igennus Healthcare Nutrition—formulators of high-quality, science-backed supplements designed for optimal absorption and effectiveness. Their products are rigorously tested and trusted by health professionals worldwide. Visit igennus.com and use code DrKahn to save on your order.