
Hosted by Angela Foster · EN

Vertical jump improved by over three centimetres in elite soccer players after just six weeks, simply by targeting one overlooked part of cellular biology: the mitochondria. Angela Foster talks with Dr Anurag Singh, Chief Medical Officer at Timeline, about the science of mitophagy, the process that clears out dysfunctional mitochondria, and how the clinically studied compound urolithin A supports it. They walk through real clinical trial data spanning soccer players, elite weightlifters and Olympic-level runners, with a particular focus on findings in women, exploring measurable gains in strength, power and recovery markers like reduced muscle damage and perceived effort. Listeners will learn why mitochondrial renewal takes weeks rather than days to show up, what it actually means when energy dips after stopping supplementation and rebounds on restarting, and why this matters especially for women navigating perimenopause, when recovery and inflammation can shift noticeably. Tune in to understand what's really happening at the cellular level behind your energy and recovery. KEY TAKEAWAYS Understand mitochondrial health as a three-stage cycle: biogenesis (creating new mitochondria), fission and fusion (making existing ones more efficient), and mitophagy (clearing out dysfunctional ones). Neglecting that final clearance step is, as Dr Singh puts it, like never taking the garbage out of a cluttered house. Expect mitochondrial and performance benefits to build gradually rather than instantly. Clinical studies show improved mitochondrial health in muscle tissue after one month, with measurable strength and power gains showing up after two to four months, so don't judge a mitochondria-targeted intervention by how you feel after a week. Pay attention to recovery markers, not just strength numbers, when evaluating training interventions. In a four-week study with elite runners, those taking mitopure showed lower rate of perceived exertion and lower creatine kinase, a muscle damage marker, suggesting easier recovery rather than just raw performance gains. Try a deliberate break from a supplement or intervention to gauge whether it's actually working for you. Both Angela and Dr Singh independently noticed an energy dip after stopping urolithin A supplementation, which is a practical way to separate real effect from placebo. Look for research that specifically includes women, since women are historically underrepresented in supplement and performance studies. Timeline's trials run roughly two-thirds female participants, which matters for understanding how recovery and inflammation patterns shift during phases like perimenopause. STANDOUT QUOTES "If we have a super cluttered house, there's only so much we can do to improve it. At one point, we've got to take out the garbage." — Dr Anurag Singh "Rome wasn't built in a day." — Dr Anurag Singh "It's the only thing we know outside of exercise and fasting that hits that mitochondria specific autophagy." — Dr Anurag Singh "I feel like I can do everything and have fun with my kids." — Angela Foster "That's the reason we're doing all this, right? It's our life. We want to live it healthily, fully." — Dr Anurag Singh VALUABLE RESOURCES • Take the BioSyncing Quiz to help you understand what’s actually happening in your body and how to fix it. 👉 https://biosyncing.scoreapp.com/

Most women think poor sleep is inevitable as they get older. It isn't. It is your stress hormones, your cortisol cycle, and a specific stage of deep sleep called N4, and all three can be addressed. I sit down with Dr. Juliane Hellhammer, a psycho-neuro-endocrinologist specialising in stress and sleep, and what he shares will make you rethink everything you thought you knew about rest and recovery. If you have ever woken at 2am with your mind racing, struggled to feel recovered no matter how much sleep you get, or wondered whether your wearable is actually telling you the truth about your sleep quality, this episode gives you the science and the solutions. Because what if the sleep stage that matters most is the one no one is talking about? WHAT YOU’LL LEARN • Why perimenopausal women wake up at 2am and what is actually driving it • What N4 deep sleep is and why it matters after 40 • What destroys deep sleep quality in perimenopausal women and how to fix it • Can wearables accurately measure deep sleep stages • What poor sleep does to brain fog and fatigue in perimenopause • Why trying too hard to sleep is keeping you awake • What genuinely high quality sleep looks like TIMESTAMPS 00:00 Why Deep Sleep, Stress & Sleep Duration Matter in Perimenopause 07:48 Why Trying Too Hard to Sleep Is Destroying Your Deep Sleep 13:26 What High Quality Sleep Really Looks Like and The Ancient Ingredient That Improves It 23:20 Why You Wake Up at 2–4am in Perimenopause and How to Fix It 27:34 Top 3 Evidence-Based Upgrades for Sleep and Recovery 30:25 How to Use the Sleep Well Supplement for Best Results VALUABLE RESOURCES • Take the BioSyncing Quiz to help you understand what’s actually happening in your body and how to fix it. 👉 https://biosyncing.scoreapp.com/ ABOUT THE GUEST Dr. Juliane Hellhammer is a psychoneuroendocrinologist, PhD researcher, and Founder and CEO of daacro, a specialist clinical research organisation based in Trier, Germany, focused on stress, sleep, and psychobiology. With decades of experience running clinical trials on how chronic stress and cortisol impact health, she is one of Europe's leading experts on the physiological relationship between stress and sleep disorders. Try Sleep Well Dissolvable Granules: https://www.avogel.co.uk/herbal-remedies/sleep-well/ Website: http://www.daacro.com LinkedIn: https://www.linkedin.com/in/juliane-hellhammer-phd-38865232/

Why Wearing Sunscreen All Day May Be Doing More Harm Than Good for Women Over 40 In this thought-provoking episode, Angela Foster sits down with renowned beauty expert and author Liz Earle MBE to challenge conventional wisdom about sunscreen and sun exposure. Liz discusses why current public health messaging around universal, all-day SPF use might be too extreme, potentially robbing us of vital Vitamin D and other essential benefits of natural daylight. KEY TAKEAWAYS Many people assume they still get Vitamin D while wearing sunscreen. However, Liz points out that this only happens because most people apply it too thinly or miss spots. Applying high SPF when it is completely unnecessary, like on a dark winter morning during an underground commute, is a sign that public health messaging has become too broad. Our skin isn't just a physical barrier; it actively receives light and communicates with the body's immune system. Exposing your skin to gentle, early-morning sunlight (when the UV index is low) acclimatizes it. Medical professionals and researchers are beginning to speak out against extreme sun avoidance. BEST MOMENTS "When people say, 'Yes, you get Vitamin D from the sun when you're using sunscreen,' yeah, because you're not using your sunscreen properly. You're actually allowing some of that UVB to come through the skin." "The worst thing that we can do is stay indoors all year and then rush out for our two-week summer beach holiday and fry ourselves on the beach... That's because our skin has not got used to the sunlight." "The skin is actually an organ of light reception. This is what we're just beginning to understand, that the skin has light receptors on it for reasons—they're signaling, it's not just blocking and keeping our insides intact." "I don't know if you take collagen supplements, I do, but actually by going out in early morning light, I'm telling my body to make more collagen. So it's preparing the skin." "He says that he thinks that we will look back at this time and our lack of sun exposure as being as damaging to our health as smoking." VALUABLE RESOURCES • Take the BioSyncing Quiz to help you understand what’s actually happening in your body — and how to fix it. 👉 https://biosyncing.scoreapp.com/ A BIG thank you to our sponsors who make the show possible: • Timeline - Support your mitochondrial health: Timeline Mitopure delivers Urolithin A at the clinically studied dose to support cellular renewal and energy production, helping counter the natural decline in mitochondrial function that comes with age. 👉 Get 20% off Mitopure when you visit http://timeline.com/ANGELA and use code ANGELA. * These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Most women in perimenopause are training hard, eating well, and still dealing with joint pain, stiffness, and injuries that never fully heal. Juliet Starrett, New York Times bestselling author and co-founder of The Ready State, joins me to reveal why the joint pain and stiffness so many women write off as ageing is actually a specific syndrome nobody warned you about. We get into what 30 minutes of floor sitting a day can do for your hips and low back, why most exercise routines are silently narrowing your range of motion, and the five weekly movement non-negotiables Juliet recommends for every woman over 40. WHAT YOU'LL LEARN • Why perimenopause triggers joint pain, frozen shoulder, and mobility loss • How 30 minutes of floor sitting a day rewires your hips and reduces pain• Best movement habits for women over 40 • How strength training may be stealing your flexibility over time • How to train through injury without making it worse • The HRV myth debunked and what to track instead VALUABLE RESOURCES • Take the BioSyncing Quiz to help you understand what's actually happening in your body and how to fix it. 👉 https://biosyncing.scoreapp.com/ A BIG thank you to our sponsors who make the show possible: • Timeline - Support your mitochondrial health with Urolithin A at the clinically studied dose to support cellular renewal and energy production, helping counter the natural decline in mitochondrial function that comes with age. 👉 Get 20% off Mitopure when you visit http://timeline.com/ANGELA and use code ANGELA. * These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. ABOUT THE GUEST Juliet Starrett is a New York Times bestselling author and co-founder of The Ready State, where she and her husband Dr. Kelly Starrett have spent decades helping people move better, hurt less, and stay physically capable as they age. Their work focuses on making mobility and strength training practical and accessible for anyone dealing with pain, stiffness, or the feeling that their body is working against them.Website: https://thereadystate.com/Instagram: https://www.instagram.com/julietstarrett/YouTube: https://www.youtube.com/@TheReadyState

Whittling your diet down to five "safe" foods isn't healing your gut — it's masking a deeper imbalance that declining estrogen may be driving. Nutrition expert Cynthia Thurlow joins Angela Foster to unpack why so many women suddenly can't tolerate foods they once ate freely, and what's really happening behind the bloating, palpitations and brain fog. The conversation explores the link between estrogen loss and a leaky small intestine, the histamine-hormone "perfect storm" that can trigger hives and cramping, and why bloating during perimenopause is so often multifactorial. Cynthia also explains when bloating becomes a red flag worth investigating. You'll learn how to identify your personal food triggers without cutting entire food groups, why eating in a parasympathetic state matters, and which gut supports — from fibre and hydration to TUDCA — can help as progesterone and estrogen decline. If you've ever felt like your body suddenly turned against your favourite foods, this episode will help you understand why. KEY TAKEAWAYS Stop eliminating food groups as your default fix. Whittling your diet down to a handful of "safe" foods signals an underlying gut imbalance that needs support — not an ever-expanding exclusion list. Recognise food sensitivities as a likely leaky gut symptom. As estrogen declines it acts like failing "mortar" in the small intestinal lining, letting food particles leak into the bloodstream and provoke an immune response. Watch the histamine-estrogen "perfect storm." During high-estrogen days, loading up on high-histamine foods (leftovers, kombucha, fermented items) can trigger hives, congestion, cramping and diarrhoea — so keep histamine foods low or infrequent during those windows. Eat in a parasympathetic state. Sit at a table, remove distractions, and take four to five deep breaths before meals rather than eating standing, in the car, or on the move. Always get persistent bloating evaluated. Bloating from morning to night is different from bloating that appears after meals, and persistent symptoms should be checked because, in rare cases, they can signal something serious like ovarian cancer. QUOTES "The goal is to never get to a point where you're excluding entire classes of foods." "If we look at the small intestinal lining as like a brick and mortar system, the mortar is the estrogen." "I literally was talking to a podcast host and I broke out in hives head to toe because I was high estrogen, high histamine stress. And it was like the perfect storm." "It's not really that you need to cut out all these food groups. We just have a nuanced conversation. Don't go overboard with any one food." "I've just seen too many people blow off symptoms for a year or two that end up being bigger issues than they would have been had they been addressed up front." VALUABLE RESOURCES • Take the BioSyncing Quiz to help you understand what’s actually happening in your body — and how to fix it. 👉 https://biosyncing.scoreapp.com/ A BIG thank you to our sponsors who make the show possible: • Timeline - Support your mitochondrial health: Timeline Mitopure delivers Urolithin A at the clinically studied dose to support cellular renewal and energy production, helping counter the natural decline in mitochondrial function that comes with age. 👉 Get 20% off Mitopure when you visit http://timeline.com/ANGELA and use code ANGELA. * These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

You're training consistently, eating well, sleeping as best you can and yet the energy isn't there, recovery is taking longer, and something just feels off. Brad Currier, one of the leading researchers in mitochondrial science, gets into why mitochondrial decline is the hidden driver behind low energy, slower recovery, and reduced muscle performance in women over 40 and what the latest clinical research shows you can actually do about it. If you want to train hard, recover well, and feel genuinely energetic into your 40s and beyond, this one is worth your full attention. WHAT YOU’LL LEARN • Why mitochondria decline with age and what it means for energy and recovery after 40 • What mitophagy is and why most active women in their 40s should know this • How urolithin A triggers mitophagy and what the clinical data actually shows • What rep range builds strength and longevity for women in their 40s • How exercise improves skin health and collagen from the inside out VALUABLE RESOURCES • Take the BioSyncing Quiz to help you understand what’s actually happening in your body — and how to fix it. 👉 https://biosyncing.scoreapp.com/ A BIG thank you to our sponsors who make the show possible: • Timeline - Support your mitochondrial health: Timeline Mitopure delivers Urolithin A at the clinically studied dose to support cellular renewal and energy production, helping counter the natural decline in mitochondrial function that comes with age. 👉 Get 20% off Mitopure when you visit http://timeline.com/ANGELA and use code ANGELA. * These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. ABOUT THE GUEST Brad Currier, PhD, is a Senior Clinical Scientist at Timeline and completed his PhD at McMaster University, where his background as an elite athlete led him into muscle physiology and performance nutrition research. He co-authored the new ACSM resistance training guidelines and leads clinical trials on urolithin A and mitochondrial health. His work sits at the intersection of cellular science and real-world performance, helping active women understand why energy, recovery, and muscle function change after 40 and what the clinical evidence says they can do about it. Instagram: https://www.instagram.com/brad_currier/ LinkedIn: https://ch.linkedin.com/in/brad-currier

Navigating midlife body changes can feel like waking up in a completely different body, even when your routine hasn't changed. Around 15% of active women transition through menopause without experiencing significant weight gain, finding that standard calorie deficits and exercise still work. However, the vast majority notice that previously effective fitness and nutrition habits suddenly stop yielding results. This shift is highly associated with a changing hormonal environment—specifically decreasing estradiol and declining progesterone levels—rather than just the natural ageing process. While it seems logical that hormone replacement therapy (HRT) would be the perfect fix, the reality is much more complex. HRT yields highly variable results for body composition; it helps some lose fat, has no impact on others, and can even cause weight gain. WHAT YOU’LL LEARN Approximately 15% of active women navigate menopause without significant weight gain and can still successfully lose weight using standard calorie deficits. For many women, the fitness and nutrition strategies that worked five or ten years ago become noticeably less effective during midlife. Accelerated fat gain during menopause is heavily associated with decreasing estradiol and progesterone levels, alongside rising follicle-stimulating hormone (FSH). Distinguishing between weight gain caused by natural ageing and weight gain caused specifically by menopause remains a complex challenge for researchers. Hormone therapy does not offer a universal solution for weight management, with individual results varying wildly from fat loss to unexpected fat gain. VALUABLE RESOURCES • Take the BioSyncing Quiz to help you understand what’s actually happening in your body — and how to fix it. 👉 https://biosyncing.scoreapp.com/ A BIG thank you to our partner who makes the show possible: • Timeline – Support your mitochondrial health and muscle strength with Mitopure®, the only clinically validated Urolithin A supplement backed by 15+ years of research. Use code ANGELA for 20% off 👉 https://www.timeline.com/promotions/exclusive-offer-for-angela-foster-s-community

Brain fog in perimenopause isn't inevitable decline.Brain fog in perimenopause isn't inevitable decline. It's a systems puzzle, and once you understand what's actually driving it, you can do something about it. In this episode I'm joined by Dr. Sarah McKay, neuroscientist and author of The Women's Brain Book, and we break down the real neuroscience behind why your brain feels different in midlife, what the research actually says about HRT and brain health, and the evidence-based strategies to protect and optimise your cognitive performance. WHAT YOU’LL LEARN • What actually causes perimenopause brain fog (it's not just your hormones) • How night sweats disrupt sleep architecture even when you don't fully wake up • Why anxiety and waking at 3am are early signs of the perimenopause transition • What the research really says about estrogen, progesterone, and testosterone on brain health • Why the progesterone and GABA sleep claim is not what it seems • How your career and daily habits are already shaping your long-term dementia risk • Why your mindset about aging may be affecting your cognitive performance • The daily framework for protecting your brain: sleep, nutrition, strength training, and stress TIMESTAMPS: VALUABLE RESOURCES • Take the BioSyncing Quiz to help you understand what’s actually happening in your body — and how to fix it. 👉 https://biosyncing.scoreapp.com/ A BIG thank you to our sponsor who make the show possible: - MitoQ - Support your cells at the source with MitoQ NAD+ Dual Action, designed to boost NAD levels and help your cells actually use them for steady energy and sharper focus 👉 https://www.mitoq.com and use code ANGELA for 10% off your first order. ABOUT THE GUEST Dr. Sarah McKay is a neuroscientist and author of The Women's Brain Book, a fully updated guide to the female brain across perimenopause, menopause, and midlife ageing. She has dedicated her career to helping women understand the brain science behind hormones, cognition, and brain health, cutting through the noise to give women evidence-based answers about what is actually happening in their brains and bodies at midlife. Website: https://drsarahmckay.com/ Instagram: https://www.instagram.com/drsarahmckay/

Health expert and Parsley Health founder Dr. Robin Berzin joins host Angela Foster to discuss a proactive approach to managing perimenopause and menopause. Dr. Berzin emphasises the importance of listening to our bodies, tracking whole-body symptoms over time using tools like the Parsley Symptom Index, and utilising continuous blood work to catch early hormonal shifts before standard symptoms like hot flashes begin. WHAT YOU’LL LEARN How to actively listen to your body and identify early, subtle signs of perimenopause before major symptoms like hot flashes even begin. How tracking whole-body symptoms and blood work over time reveals personalised hormonal trends that one-off lab tests completely miss. How optimising sleep consistency and monitoring heart rate variability (HRV) with wearables can lower your biological age and improve stress resilience. How a personalised combination of proactive lifestyle tracking, lab data, and tailored hormone therapies can naturally regulate your metabolism, mood, and energy levels. VALUABLE RESOURCES • Take the BioSyncing Quiz to help you understand what’s actually happening in your body — and how to fix it. 👉 https://biosyncing.scoreapp.com/ A BIG thank you to our partner who makes the show possible: • Timeline – Support your mitochondrial health and muscle strength with Mitopure®, the only clinically validated Urolithin A supplement backed by 15+ years of research. Use code ANGELA for 20% off 👉 https://www.timeline.com/promotions/exclusive-offer-for-angela-foster-s-community

What if the key to looking and feeling 20 years younger wasn't another supplement stack, but something you could get for free, starting tomorrow morning? Liz Earle's biological age is over 20 years younger than her chronological age, and in this episode she breaks down exactly why. It comes down to three things most women in their 40s and 50s have never considered: circadian rhythm and the light you are exposed to, the water you are drinking, and the energy your cells are actually running on. If you are feeling tired, foggy, or like your body is aging faster than it should, this episode will change how you see your daily environment. WHAT YOU’LL LEARN • Why morning light fixes low energy, poor sleep, and hormone imbalance after 40 How indoor LED lighting damages your mitochondria and the simple swap that reverses it • Why sunscreen may be blocking the vitamin D and nitric oxide you need after menopause • How tap water disrupts hormones and energy and what to drink instead • What EZ water is and why it matters for mitochondrial energy and aging after 40 • Why mineral deficiency causes fatigue and brain fog in perimenopause • How grounding and circadian light slow visible aging from the inside out TIMESTAMPS: VALUABLE RESOURCES • Take the BioSyncing Quiz to help you understand what’s actually happening in your body — and how to fix it. 👉 https://biosyncing.scoreapp.com/ A BIG thank you to our sponsors who make the show possible: • Stride - Find out your biological age and how your daily habits are influencing it with DNA, bloodwork and microbiome testing with a Stride One membership 👉 https://www.getstride.com/angela/ for 10% off • Timeline - Support your mitochondrial health: Timeline Mitopure delivers Urolithin A at the clinically studied dose to support cellular renewal and energy production, helping counter the natural decline in mitochondrial function that comes with age. 👉 Get 20% off Mitopure when you visit http://timeline.com/ANGELA and use code ANGELA. * These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. 👉 Liz Earle’s new book, How to Age: Supercharge Your Health and Feel Better Than Ever If not please use this https://amzn.to/4wCbux2 ABOUT THE GUEST Liz Earle, MBE, is a bestselling author, wellness pioneer, and one of the UK's most trusted voices on healthy aging for women. With nearly 40 years in the wellness space, she specialises in the science of longevity, circadian biology, skin health, and mitochondrial nutrition. Her latest book How to Age explores how light, water, and cellular energy determine how well women age after 40 and beyond. Website: https://www.lizearle.com Instagram: https://www.instagram.com/lizearleme/?hl=en YouTube: https://www.youtube.com/c/lizearlewellbeing