Imagine throwing away your antidepressants and never needing them again. For about 85% of the people who sit with Dr. Jeff McNairy, that is exactly what happens.

He is the Chief Medical Officer of Rythmia, the world's only medically licensed ayahuasca retreat, and he looks at the most stigmatized corner of mental health through a clinical lens: the chemistry, the screening, the data, and the integration work that decides whether change lasts.

Meet our guest

Dr. Jeff McNairy holds a doctorate in psychology and a master's in public health from UCLA. He ran locked psychiatric units in Pasadena and was administrative director of Passages Malibu before trying plant medicine himself in 2014. For 25+ years he has worked at the intersection of Western psychology and indigenous medicine, and today he runs the medical operation and Costa Rican licensing for Rythmia.

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Key takeaways

Ayahuasca pairs DMT with an MAOI vine so the compound survives digestion and reaches the brain
It activates a gene that links the amygdala to the prefrontal cortex, letting stored trauma surface and release
About 85% of guests who came off antidepressants to attend never go back on them
Rythmia turns away ~22 people a day for SSRIs, benzodiazepines, heart conditions, bipolar 1, schizophrenia, or type 1 diabetes
The ceremony is the start, not the finish: every guest gets a free 13-week integration program
A "psychosomatic" purge (vomiting, yawning, sweating) is how the body lets go of held emotion
Intention plus meditation may drive a real epigenetic effect, per emerging UK research
The biggest red flag in plant medicine is a retreat without firm staff-guest boundaries

Episode highlights

00:00 Intro

02:25 What ayahuasca actually is (DMT + MAOI)

05:22 What a week at Rythmia looks like

10:22 How emotions get stored in the body

12:31 85% come off antidepressants and don't go back

17:19 The free 13-week aftercare program

38:41 Foods that pull you out of the medicine

48:51 Testing biological age before and after

51:31 How Rythmia measures success (98%)

53:42 Breaking the hippie stereotype 57:59 When NOT to do ayahuasca

1:05:57 What he's building next

Links

Watch it on YouTube: https://youtu.be/N6SdiFFKFTY
Full episode show notes: https://outliyr.com/263

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