
Hosted by Nick Urban | Longevity, Biohacking, & Performance · EN

Ever wonder which health trends are actually worth your time in 2026? Nick Urban breaks down what truly moves the needle… active wearables, multi-sensor monitoring, recovery systems, & environment-first strategies that deliver measurable ROI. Meet our host Nick Urban is a BioHarmonizer, athlete, and founder of Outliyr.com, as well as the host of theHigh Performance Longevity podcast. A certified Chek Practitioner, Personal Trainer, and Performance Health Coach, he bridges the gap between ancient medical systems like Ayurveda & Traditional Chinese Medicine and cutting-edge modern science. Nick is dedicated to distilling the wisdom of the world’s top performers into practical strategies, helping others transition from merely surviving to truly thriving. Thank you to our partners Outliyr Biohacker’s Peak Performance Shop: get exclusive discounts on cutting-edge health, wellness, & performance gear Ultimate Health Optimization Deals: a roundup article of all the best current deals on technology, supplements, systems and more Gain mental clarity, energy, motivation, and focus with the FREE Outliyr Nootropics Mini-Course The simple, guided, and actionable Outliyr Longevity Challenge helps you unlock your longevity potential, slow biological aging, and maximize your healthspan Key takeaways Devices now regulate your biology instead of only tracking it, saving time & guesswork Clean water & clean air outperform fancy diets, boosting recovery, sleep, & energy Digital twins let you test health changes virtually, predicting long term results with real data Multi sensor wearables track more than glucose, showing hormones & biomarkers together for better decisions Mental training matters as much as physical training, with practices like meditation becoming mainstream for resilience & focus Next generation light panels mimic sunlight using multiple wavelengths, delivering broader benefits than narrow spectrum devices Peptides now come as sprays, strips, & capsules instead of only injections, improving ease of use & safety Regulations increasingly target ultra processed addictive foods, pushing better metabolic health & clearer labels Recovery practices like hot cold therapy, breathwork, & saunas are becoming social rituals that blend health & community Women’s health research & technology are expanding, delivering more tailored & effective solutions Episode highlights 0:00 Introduction 01:23Track health trends with systems thinking 02:29 Move from passive wearables to active regulation 05:39 Optimize foundational inputs like water & air 09:17 Personalize health with multi sensor intelligence 12:32 Train mental fitness & nervous system resilience 21:02 Redefine recovery longevity & future health Links Watch it on YouTube: https://youtu.be/S4QSzlMJmI4 Full episode show notes: outliyr.com/245 Connect with Nick on social media Instagram Twitter YouTube LinkedIn Easy ways to support Subscribe Leave an Apple Podcast review Suggest a guest Do you have questions, thoughts, or feedback for us? Let me know in the show notes above and one of us will get back to you! Be an Outliyr, Nick

Could reaction speed be the missing metric for brain health? Dexter Ang shares how wrist-based neurotechnology quantifies cognition, personalizes interventions, & supports long-term mental performance for executives & elite performers. Meet our guest Dexter Ang is the co-founder & CEO of Pison Technology, developing wearable neuromuscular sensing & nervous system interfaces. Inspired by caring for his mother after her ALS diagnosis, he returned to MIT to build sensors that translate wrist biopotentials into digital commands. His work bridges human biology & digital systems across assistive technology, robotics, IoT & defense. Thank you to our partners Outliyr Biohacker’s Peak Performance Shop: get exclusive discounts on cutting-edge health, wellness, & performance gear Ultimate Health Optimization Deals: a database of of all the current best biohacking deals on technology, supplements, systems and more Latest Summits, Conferences, Masterclasses, and Health Optimization Events: join me at the top events around the world FREE Outliyr Nootropics Mini-Course: gain mental clarity, energy, motivation, and focus Key takeaways Almost everyone operates at only 60–70% of their brain’s true potential due to low awareness Wrist sensors accurately measure cognitive state & nervous system signals without head worn devices NASA & clinical science use reaction time as the gold standard for measuring cognitive function, readiness, & risk Processing speed, inhibition, & agility are distinct cognitive dimensions, each revealing different aspects of brain health & decision making Reaction time biofeedback training produces measurable gains in attention, discipline, & mood regulation Individual responses vary widely, making personalized protocols far more effective than general advice Strong cognitive performance depends on quality sleep, consistent routines, & circadian rhythm discipline Caffeine improves alertness but often worsens decision inhibition, with effects varying by person & task Knowing personal cognitive highs & lows helps time important work & decisions for peak performance Processing speed training lowers dementia risk & strengthens long term brain resilience more than memory games Episode highlights 00:00 Measure Brain Performance with Real World Signals 01:20 Turn Personal Adversity into Cognitive Innovation 03:05 Use Reaction Time as a Core Brain Health Biomarker 07:54Train Cognition Through Feedback not Guesswork 14:02 Apply Cognitive Data to Performance & Resilience 33:58 Integrate Neural Data into Personalized Experimentation Links Watch it on YouTube: https://youtu.be/OAvyoLfz5uk Full episode show notes: outliyr.com/244 Connect with Nick on social media Instagram Twitter (X) YouTube LinkedIn Easy ways to support Subscribe Leave an Apple Podcast review Suggest a guest Do you have questions, thoughts, or feedback for us? Let me know in the show notes above and one of us will get back to you! Be an Outliyr, Nick

What makes methylene blue so different from most nootropics is how little it takes to have an effect. In this clip, Mark Sloan explains why ultra-low doses of methylene blue can support mental clarity, calm energy, and mitochondrial performance without overstimulation. You’ll hear why: Just a few milligrams can support steady, all-day focus Low doses reduce risk while increasing safety and accessibility Methylene blue supports mitochondrial energy production at the cellular level It plays a role in the NAD to NADH ratio, a key marker of metabolic health The brain benefits disproportionately due to high energy demand Tune in to Episode 68, where we go deeper into methylene blue, mitochondria, metabolic health, and why low-dose strategies often outperform aggressive protocols. Links Watch it on YouTube: https://youtu.be/q5PBJJAypDQ Full episode : https://outliyr.com/68 Connect with Nick on social media Instagram Twitter (X) YouTube LinkedIn Easy ways to support Subscribe Leave an Apple Podcast review Suggest a guest Do you have questions, thoughts, or feedback for us? Let me know in the show notes above and one of us will get back to you! Be an Outliyr, Nick

Why does gut health affect your brain and metabolism so deeply? Martha Carlin explains how the microbiome, endotoxin, & the glycocalyx influence energy, cognition, and long-term resilience & why gut repair is central to protecting longevity. Meet our guest Martha Carlin is a pioneering citizen scientist & systems researcher who investigates the links between the microbiome, chronic disease & environmental toxins after her husband’s Parkinson’s diagnosis. She is the founder & CEO of The BioCollective, collaborating with leading institutions while developing BioFlux™ metabolic modeling & Sugar Shift®, a patented probiotic shown to improve metabolic health. Martha’s work bridges science & real-world application, empowering people to restore gut balance & transform whole-body health. Thank you to our partners Outliyr Biohacker’s Peak Performance Shop: get exclusive discounts on cutting-edge health, wellness, & performance gear Ultimate Health Optimization Deals: a database of of all the current best biohacking deals on technology, supplements, systems and more Latest Summits, Conferences, Masterclasses, and Health Optimization Events: join me at the top events around the world FREE Outliyr Nootropics Mini-Course: gain mental clarity, energy, motivation, and focus Key takeaways Be mindful of everything you eat & drink Your body reflects daily choices The modern food supply including chemicals & engineering drives or disrupts long-term wellness Your gut microbiome influences nearly every aspect of health, not just digestion Gut bacteria differences correlate with neurological disease profiles such as Parkinson’s Stool analysis reveals more health data than most expect Investigate output for internal clues Genetic material from food & microbes transfers into the body, influencing health in unexpected ways Single-strain probiotics fall short Full microbial teams support stronger gut ecosystems & outcomes Household chemicals damage the gut lining Auditing cleaning products protects barrier health Gut health depends on balance & relationships, not just which organisms exist Quality water & whole foods are the strongest foundational longevity levers so start there Episode highlights 04:12 Recognize the microbiome as a driver of chronic disease 05:51 Address the gaps in modern gut health care 17:25 How microbes adapt, share genes & influence biology 21:07 Build resilient microbial ecosystems instead of single strain fixes 41:05 Protect the gut lining to reduce inflammation system wide Links Watch it on YouTube: https://youtu.be/4Z1f2pr6QjY Full episode show notes: outliyr.com/243 Connect with Nick on social media Instagram Twitter (X) YouTube LinkedIn Easy ways to support Subscribe Leave an Apple Podcast review Suggest a guest Do you have questions, thoughts, or feedback for us? Let me know in the show notes above and one of us will get back to you! Be an Outliyr, Nick

Could saying no actually be your best longevity strategy? Blair LaCorte reveals why avoiding over-optimization and focusing on system biology, compassion, and purpose instead leads to authentic biosynergy and lasting vitality. Meet our guest Blair LaCorte is a dynamic business executive whose career spans entertainment, aviation, AI, technology, aerospace, consulting, investing & military logistics. He has held CEO & C-level roles at leading companies like PRG, XOJET/Vista, TPG, Autodesk & Oracle, while also taking startups such as AEye Technologies & VerticalNet to IPO. Currently an astronaut-in-training with Virgin Galactic & Vice Chairman of the Buck Institute, Blair continues to drive innovation, growth & global impact. Thank you to our partners Outliyr Biohacker’s Peak Performance Shop: get exclusive discounts on cutting-edge health, wellness, & performance gear Ultimate Health Optimization Deals: a database of of all the current best biohacking deals on technology, supplements, systems and more Latest Summits, Conferences, Masterclasses, and Health Optimization Events: join me at the top events around the world FREE Outliyr Nootropics Mini-Course: gain mental clarity, energy, motivation, and focus Key takeaways Tech is for control, not a cure all Forgetting biology leads to problems, not progress Over optimizing health with gadgets causes new problems Step back & look at the whole picture Scientific knowledge & personal belief both affect your biology & well being more than most realize Staying healthy is better than only reacting to sickness Small daily choices matter more than silver bullets Focus on what works for you Test, observe, & stick with what fits your life & makes you feel good Relationships lower stress & boost your immune system Loneliness is a major health risk at any age Some stress helps growth Chronic unbroken stress harms your body Find ways to activate & calm yourself Knowing health tips isn’t enough Build habits you enjoy, ideally with friends or community support, for lasting results No two people are alike Track your own changes & work out routines & diets that fit you specifically Modern testing makes it easier to spot issues early Keep personal health records to track your biomarkers over time Episode highlights 04:19 Why Technology Alone Won’t Save Your Health 21:17 The Real Framework for Habit Change That Works 28:50 What Truly Multiplies Healthspan Results 36:44 Practical Ways to Strengthen Connection & Reduce Stress 46:28 How to Personalize Health in a Complex World Links Watch it on YouTube: https://youtu.be/U2QuhPEugq4 Full episode show notes: outliyr.com/223 Connect with Nick on social media Instagram Twitter (X) YouTube LinkedIn Easy ways to support Subscribe Leave an Apple Podcast review Suggest a guest Do you have questions, thoughts, or feedback for us? Let me know in the show notes above and one of us will get back to you! Be an Outliyr, Nick

Still trusting labels like “heart-healthy” or “cold-pressed”? Seed oils quietly erode gut health, brain function, & energy regulation. Dr. Cate Shanahan unpacks why they’re worse than sugar, what your mitochondria actually need, & which ancestral fats support real biosynergy. This episode brings clarity on the biggest dietary villain hiding in plain sight and how to kick it for good. Meet our guest Dr. Cate Shanahan is a widely respected physician & author whose work has sparked major movements around ancestral nutrition, seed oil elimination, & traditional eating. Her book Deep Nutrition and nutrition strategies have influenced top health leaders, professional athletes like Kobe Bryant & Aaron Judge, and millions worldwide. Known for exposing the metabolic damage caused by seed oils, she’s helped shift public discourse on nutrition from obscurity to mainstream awareness. Dr. Cate’s mission is to empower people of all backgrounds to reclaim their health through food not pharmaceuticals. Thank you to our partners Outliyr Biohacker’s Peak Performance Shop: get exclusive discounts on cutting-edge health, wellness, & performance gear Ultimate Health Optimization Deals: a database of of all the current best biohacking deals on technology, supplements, systems and more Latest Summits, Conferences, Masterclasses, and Health Optimization Events: join me at the top events around the world FREE Outliyr Nootropics Mini-Course: gain mental clarity, energy, motivation, and focus Key takeaways Eating a large serving of fries from a restaurant is said to deliver the equivalent toxicity of smoking an entire pack of cigarettes Oils can take up to six years to fully remove from the body The “Hateful Eight” seed oils Dr. Shanahan warns against include common household staples linked to chronic health issues Most seed oils were originally industrial lubricants; factory processing introduces toxins harmful to human health Labeling seed oils as “plant-based” misleads consumers into thinking they're safe, despite harmful effects Factory refining & heating oxidize fats, creates toxic byproducts that damage cells & contribute to disease Neutral or flavorless oils lack nutrients; strong-flavored oils often contain more beneficial compounds Seed oils trigger gut inflammation, leading to symptoms like bloating, heartburn, & IBS Oxidative stress from damaged fats accelerates aging, damages mitochondria, & drives chronic illness Detoxing seed oils supports taste reset, reduces sugar cravings, & rebuilds metabolic health Soy oil makes up 80% to 90% of all the seed oils being sold Episode Highlights 00:00 The Dangers of Seed Oils 05:10 What Are the Hateful Eight & Why They’re Toxic 09:10 The Seed Oil Takeover: Industry & Influence 12:55 How “Healthier” Labels Mislead People 23:25 The Fish Oil & Cholesterol Myths 28:37 Practical Fixes for Everyday Health Links Watch it on YouTube: https://youtu.be/JhPT5utza9E Full episode show notes: outliyr.com/217 Connect with Nick on social media Instagram Twitter (X) YouTube LinkedIn Easy ways to support Subscribe Leave an Apple Podcast review Suggest a guest Do you have questions, thoughts, or feedback for us? Let me know in the show notes above and one of us will get back to you! Be an Outliyr, Nick

Can pressure actually fuel your success? Dr. Haley Perlus reveals how Olympic-level habits turn stress into strength. From 5-minute rituals to mindset reframes, Dr. Haley Perlus shares how to bioharmonize your habits, rewire your mindset & use emotional regulation for lasting results. Perfect for athletes & high performers chasing clarity, confidence & consistency. Meet our guest Dr. Haley Perlus is a Performance Psychology expert who helps business leaders & high achievers apply elite athletic mental strategies to reach peak performance. With a Ph.D. in Sport Psychology & certifications in coaching, fitness, & nutrition, she turns high-pressure environments into platforms for success. Her clients include Fortune 500 companies & top executives seeking to master resilience, focus, & decision-making. Haley delivers science-backed tools that go beyond motivation to drive lasting productivity & leadership excellence. Thank you to our partners Outliyr Biohacker’s Peak Performance Shop: get exclusive discounts on cutting-edge health, wellness, & performance gear Ultimate Health Optimization Deals: a database of of all the current best biohacking deals on technology, supplements, systems and more Latest Summits, Conferences, Masterclasses, and Health Optimization Events: join me at the top events around the world FREE Outliyr Nootropics Mini-Course: gain mental clarity, energy, motivation, and focus Key takeaways Start your day with simple, consistent habits to set a positive tone & build success momentum Move daily & get outside to boost mood & bring out your best self Embrace pressure & stress as tools for growth & fulfillment Focus on strengths to handle stress & build control & confidence Recognize & accept uncomfortable feelings, then channel the energy into action Shift how you interpret stress and reframe stories to turn stress into a helpful force Tweak your environment to break mental blocks & improve motivation & focus Build micro habits daily then small consistent actions will grow into non-negotiables Build identity around inner strengths & values not just roles or achievements Bounce back quickly because success comes from fast recovery & energy shifts, not perfection Episode Highlights 3:41 Goal Setting & Pre-Performance Routines 9:21 Redefining Pressure as a Performance Enhancer 16:32 Implementing Pressure & Stress Management Tactics 29:03 Role of Training, Habits, & Recovery 57:11 Tools for Optimal Focus & Concentration Links Watch it on YouTube: https://youtu.be/UeKPJtkGLpw Full episode show notes: outliyr.com/216 Connect with Nick on social media Instagram Twitter (X) YouTube LinkedIn Easy ways to support Subscribe Leave an Apple Podcast review Suggest a guest Do you have questions, thoughts, or feedback for us? Let me know in the show notes above and one of us will get back to you! Be an Outliyr, Nick

How are 500,000 people using neurofeedback to hack their sleep, stress & focus without relying on stimulants or wearables? Ariel Garten, neuroscientist & Muse co-founder, breaks down how EEG & FNIRS technology tracks brainwaves in real time to guide meditation, sharpen focus, & deepen sleep. This episode reveals how brain training stacks up against smart rings, & why heart rate variability, digital sleeping pills, & prefrontal cortex tuning matter more than ever. Meet our guest Ariel Garten is a neuroscientist & former psychotherapist who co-founded Muse, the brain-sensing EEG headband that’s helped over 500,000 users reduce stress, sleep better & improve meditation. She’s passionate about making brain health accessible through innovative tech that empowers people to take control of their mental well-being. Ariel is also a sought-after speaker, known for bridging science, technology & human potential. Thank you to our partners Outliyr Biohacker’s Peak Performance Shop: get exclusive discounts on cutting-edge health, wellness, & performance gear Ultimate Health Optimization Deals: a database of of all the current best biohacking deals on technology, supplements, systems and more Latest Summits, Conferences, Masterclasses, and Health Optimization Events: join me at the top events around the world FREE Outliyr Nootropics Mini-Course: gain mental clarity, energy, motivation, and focus Key takeaways Learn how different brainwave types (delta, theta, alpha, beta, gamma) relate to your state of mind & focus Prioritize quality sleep, sunlight, food & loving connections as non-negotiables for long-term brain health Use clinical-grade EEG for real-time insight into brain activity as it’s more accurate than wrist or ring wearables Speed up meditation progress with tech that provides real-time feedback on attention & focus Train sleep quality with biofeedback tools like the digital sleeping pill that guide the brain into deeper sleep & track stages Support relaxation & boost brainwave coherence for calm focus through heart rate variability & controlled breathing Build cognitive flexibility through regular brain training & meditation to improve adaptability & focus recovery Boost brain oxygenation, endurance & prefrontal cortex performance through physical exercise Prioritize recovery especially sleep & relaxation, for brain growth & post-training performance Stay flexible by adapting meditation, exercise & brain training schedules to life’s changing demands Episode Highlights 5:30 How Muse Made Clinical-Grade Neurofeedback Accessible at Home 9:25 Use Cases for Neurofeedback & Brain Training 27:07 Connection Between HRV, Vagus Nerve, & Brainwave Activity 37:58 Designing a Minimalist Muse Protocol for Daily Use 1:02:26 Addressing Myths & Misconceptions in Cognitive Training Links Watch it on YouTube: https://youtu.be/Y1OuaYFXXdo Full episode show notes: outliyr.com/215 Connect with Nick on social media Instagram Twitter (X) YouTube LinkedIn Easy ways to support Subscribe Leave an Apple Podcast review Suggest a guest Do you have questions, thoughts, or feedback for us? Let me know in the show notes above and one of us will get back to you! Be an Outliyr, Nick

What if your body had built-in tools to regenerate itself but you’ve been looking in the wrong places? Dr. Khoshal Latifzai reveals overlooked therapies like peptides, shockwave, stem cells, & ketamine that go beyond symptom masking. He explains how athletes & longevity seekers use diagnostics, fasting, & advanced biologics to stay ahead of aging & feel better, faster. Meet our guest Dr. Khoshal Latifzai is a Yale-trained, board-certified emergency physician who founded Rocky Mountain Regenerative Medicine to focus on prevention, longevity & performance. Inspired by his humanitarian work & experience in critical care, he blends advanced biologics, hormone optimization & regenerative therapies to treat pain, enhance vitality & extend healthspan. His personalized approach serves athletes, executives & anyone seeking to thrive at every stage of life. Thank you to our partners Outliyr Biohacker’s Peak Performance Shop: get exclusive discounts on cutting-edge health, wellness, & performance gear Ultimate Health Optimization Deals: a database of of all the current best biohacking deals on technology, supplements, systems and more Latest Summits, Conferences, Masterclasses, and Health Optimization Events: join me at the top events around the world FREE Outliyr Nootropics Mini-Course: gain mental clarity, energy, motivation, and focus Key takeaways Track biomarkers regularly through frequent, detailed bloodwork to personalize health strategies & catch negative effects early Cycle medications & supplements like peptides & metformin to prevent tolerance & maintain effectiveness Personalize metformin use since benefits, dosing & side effects vary Use low-dose rapamycin for potential longevity benefits, monitoring closely with regular biomarker testing Go beyond standard panels by checking ApoB, Lp(a) & homocysteine for better insight into cardiovascular risk Question outlier biomarkers like A1C by considering factors such as red blood cell lifespan before making assumptions Use ketamine therapy under supervision to address depression & anxiety when conventional treatments fall short Trigger targeted repair in joints or tissues using shockwave therapy to activate local stem cell healing Bank stem cells early while they’re younger & more effective to improve outcomes for future injuries or illnesses Support stem cell health with regular fasting, exercise & optimized metabolic function to maintain potency with age Episode Highlights 09:39 Metformin & Rapamycin for Longevity 16:53 Underrated Biomarkers & Diagnostics 24:23 Ketamine Therapy for Brain Remodelling 45:30 Shockwave & Stem Cell Therapy Deep Dive Links Watch it on YouTube: https://youtu.be/UbA4DzzNqN0 Full episode show notes: outliyr.com/214 Connect with Nick on social media Instagram Twitter (X) YouTube LinkedIn Easy ways to support Subscribe Leave an Apple Podcast review Suggest a guest Do you have questions, thoughts, or feedback for us? Let me know in the show notes above and one of us will get back to you! Be an Outliyr, Nick

Why do so many people still suffer from weak bones, heart issues, & brain fog despite taking supplements daily? Dr. Carolyn Dean reveals the hidden imbalances behind common supplement routines especially the dangerous overuse of calcium & poorly absorbed magnesium. This episode breaks down why forms like magnesium L-threonate matter, how omega-3s may not be the hero you think, & what your body actually needs to function better at the cellular level. Meet our guest Dr. Carolyn Dean is a medical doctor & naturopath with over 40 years of experience. She’s the author of 35+ books, including The Magnesium Miracle, Total Body ReSet for Women’s & Men’s Health, IBS for Dummies, Hormone Balance, Death by Modern Medicine (2025 edition) & more. In 2015, she founded RnA ReSet to deliver proprietary formulations that support lasting health, vitality & well-being for individuals at any stage of wellness or illness. Thank you to our partners Outliyr Biohacker’s Peak Performance Shop: get exclusive discounts on cutting-edge health, wellness, & performance gear Ultimate Health Optimization Deals: a database of of all the current best biohacking deals on technology, supplements, systems and more Latest Summits, Conferences, Masterclasses, and Health Optimization Events: join me at the top events around the world FREE Outliyr Nootropics Mini-Course: gain mental clarity, energy, motivation, and focus Key takeaways Synthetic nootropics often trigger short-term reactions & deplete vital nutrients like magnesium over time Magnesium & other minerals play a critical role in brain energy & function, yet most people remain deficient Extreme therapies like saunas or cold plunges drain essential minerals, leading to hidden side effects Each brain cell holds up to 2 million mitochondria, making proper nutrition essential for brain energy Regular blood tests fail to show true magnesium status, since most magnesium resides in cells & bones Too much calcium with too little magnesium makes bones brittle rather than stronger Most fish oil supplements undergo heavy processing, oxidize easily & often cause harm while algae-based omega-3 offers a safer option High doses of vitamin C support collagen, bone & artery strength far beyond the minimal RDA Mega-dosing one nutrient (like iodine or zinc) throws off balance & depletes others your body needs Food-based, methylated B vitamins support mental health & epigenetics better than high-dose synthetics Episode Highlights 01:48 The Science & Impact of Magnesium 16:03 Other Essential Nutrients for Brain & Cellular Health 33:12 Rethinking Nutrient Supplementation & Testing 01:04:08 Misconceptions About Magnesium L-threonate for Brain Health Links Watch it on YouTube: https://youtu.be/3Js0dOha6JE Full episode show notes: outliyr.com/213 Connect with Nick on social media Instagram Twitter (X) YouTube LinkedIn Easy ways to support Subscribe Leave an Apple Podcast review Suggest a guest Do you have questions, thoughts, or feedback for us? Let me know in the show notes above and one of us will get back to you! Be an Outliyr, Nick