Podcast
Histamine Well Podcast: Exploring Histamine, Methylation & Holistic Health
Hosted by Joanne Kennedy · EN
The Histamine Well is a podcast for health practitioners and patients alike, bridging the gap between complex science and practical understanding. With a focus on histamine, methylation, and related health topics, the show translates advanced concepts into actionable insights for practitioners while empowering patients with accessible, evidence-based knowledge.
Your host, Joanne Kennedy, is a naturopath and expert in histamine intolerance, MTHFR, and methylation. She is also an author and runs an online group coaching program for practitioners and students on histamine and methylation. Jo loves breaking down complex science into clear, easy-to-understand language, offering practical tips and the latest insights to empower you to take charge of your health.
39episodes
Episodes
Newest firstAll episodes
47. The Bile-Histamine Connection: SIBO, Estrogen, Mold & Oxalates Explained
Yesterday00:10:31Tap to summarizeWhat if your histamine symptoms aren’t just about food? In this episode of the The Histamine Well Podcast, Joanne explores the overlooked connection between bile flow, histamine intolerance, SIBO, estrogen dominance, mold exposure, oxalates, methylation, and chronic inflammation.Bile plays a critical role in digestion, detoxification, hormone clearance, and microbial balance in the gut. When bile flow becomes sluggish, it can contribute to bacterial overgrowth, poor fat digestion, impaired estrogen detoxification, oxalate accumulation, and worsening histamine symptoms.In this episode, Joanne explains:How poor bile flow contributes to histamine intoleranceWhy mold toxicity and mycotoxins affect the liver and gallbladderThe vicious cycle between SIBO and bile dysfunctionHow estrogen dominance impacts bile flow and histamineWhy oxalates can worsen inflammation and histamine symptomsThe role of methylation and phosphatidylcholine in healthy bile productionHow vagus nerve dysfunction affects digestion and bile releaseCommon signs and symptoms of poor bile flowThis episode is essential listening for anyone struggling with histamine intolerance, MCAS, gut health issues, bloating, hormone imbalances, mold illness, chronic inflammation, food sensitivities, or unexplained digestive symptoms.🎧 Subscribe to The Histamine Well Podcast for evidence-based conversations on histamine intolerance, methylation, SIBO, mold illness, women’s hormones, and functional medicine.#HistamineIntolerance #SIBO #GutHealth #MoldIllness #EstrogenDominance #Oxalates #Methylation #FunctionalMedicine #BileFlow✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively. 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!📆 Work with us 1:1! Book a consultation and take your first step to real healing.🎤 Have a topic suggestion? Submit it here!
Transcribe →46. High Homocysteine: Histamine, Methylation & Why You Might Not Tolerate Methylated B Vitamins
3w ago00:12:29Tap to summarizeCan methylated B vitamins make your symptoms worse instead of better? In this episode of The Histamine Well Podcast, Joanne explains the connection between high homocysteine, histamine intolerance, methylation, and why some people react poorly to methylated nutrients.High homocysteine is associated with cardiovascular disease, cognitive decline, inflammation, and neurological health concerns — yet lowering it isn’t always simple. Many people experience headaches, anxiety, insomnia, digestive issues, skin flare-ups, or worsening histamine symptoms when taking methylfolate or methyl B12.Joanne breaks down the methylation cycle in simple terms, explains the role of histamine in nutrient tolerance, and explores how genetics such as the MTHFR gene mutation and COMT enzyme activity may influence how your body responds to methylated supplements.In this episode, you’ll learn: • What high homocysteine means and why it matters • The connection between homocysteine and methylation • Why methylated B vitamins can trigger symptoms • Histamine intolerance and supplement sensitivity • The role of MTHFR, COMT, and methylation pathways • Overmethylation vs undermethylation explained • Practical clinical insights for improving tolerance to methyl nutrientsWhether you're a practitioner, student, or navigating your own health journey, this episode offers practical education on histamine, methylation, gut health, and root-cause healing.Subscribe to The Histamine Well Podcast for expert discussions on histamine intolerance, women’s hormones, functional medicine, gut health, methylation, and integrative wellness.✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively. 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!📆 Work with us 1:1! Book a consultation and take your first step to real healing.🎤 Have a topic suggestion? Submit it here!
Transcribe →Q&A. Should I Take Calcium-D-Glucarate Whilst On HRT Oestrogen?
4w ago00:04:31Tap to summarizeCan you take Calcium-D-Glucarate while on HRT estrogen during menopause? In this short Q&A episode of The Histamine Well Podcast, Joanne explores the relationship between estrogen detoxification, hormone replacement therapy (HRT), menopause, gut health, and histamine-related symptoms.Many women are advised to take supplements that support estrogen detox, but is this always the right approach when using bioidentical hormones or estrogen therapy? Joanne explains why Calcium-D-Glucarate may not be beneficial for menopausal women on HRT, how estrogen balance works during menopause, and why understanding your hormone dose matters for symptom relief and long-term wellbeing.This episode also covers: The role of estrogen during menopause and HRT Why over-detoxifying estrogen may worsen symptoms The connection between beta-glucuronidase, the estrobolome, and gut microbiome health Histamine intolerance, hormone imbalance, and menopause symptoms Natural considerations for estrogen metabolism and hormone support Why gut health may be more important than estrogen detox supplements If you're navigating menopause, hormone replacement therapy, estrogen dominance symptoms, histamine intolerance, or gut-related hormone imbalance, this episode offers practical clarity backed by clinical naturopathic insight. Subscribe to The Histamine Well Podcast for expert conversations on histamine intolerance, methylation, gut health, hormones, mold illness, MCAS, menopause, and functional medicine approaches to healing.✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively. 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!📆 Work with us 1:1! Book a consultation and take your first step to real healing.🎤 Have a topic suggestion? Submit it here!
Transcribe →45. Case Study: SIBO, Histamine Intolerance & Hormonal Imbalance
4w ago00:16:54Tap to summarizeIn this episode of The Histamine Well, Joanne shares a powerful clinical case study exploring the connection between SIBO (Small Intestinal Bacterial Overgrowth), histamine intolerance, hormonal imbalance, estrogen dominance, gut health, bloating, acne, fatigue, and PMS symptoms.This episode follows the journey of a 37-year-old woman who experienced rapid body changes over two years — including unexplained weight gain, chronic bloating, severe PMS, hormonal acne, headaches, fluid retention, breast tenderness, digestive discomfort, and low energy. Through functional testing and a naturopathic treatment approach, Joanne uncovers how gut dysfunction, histamine overload, and hormone imbalance can work together to drive chronic symptoms.You’ll discover how SIBO contributes to nutrient malabsorption, inflammation, estrogen dominance, histamine intolerance, and digestive dysfunction, along with why symptoms such as bloating, fatigue, skin issues, and menstrual changes are often connected.In this episode, Joanne discusses:The link between SIBO, histamine intolerance, and hormonal imbalanceWhy bloating, PMS, headaches, and acne may stem from gut dysfunctionThe difference between hydrogen and methane SIBOHow nutrient deficiencies affect hormones, mood, and energyWhy is bowel motility essential for successful SIBO treatmentThe role of biofilms in persistent gut symptomsFunctional medicine strategies for improving gut and hormone healthWhether you are a practitioner, student, or someone navigating digestive and hormone-related symptoms, this episode offers practical insight into the deep connection between gut health, histamine, hormones, and systemic inflammation.✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively. 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!📆 Work with us 1:1! Book a consultation and take your first step to real healing.🎤 Have a topic suggestion? Submit it here!
Transcribe →Q&A. How Do Epsom Salt Baths Work & Why Are They Good For Me?
Apr 2200:04:35Tap to summarizeCan something as simple as an Epsom salt bath support detoxification, gut health, and nervous system regulation?In this Q&A episode of The Histamine Well Podcast, Joanne breaks down the clinical benefits behind Epsom salt baths (magnesium sulfate)—and why they’re often recommended for patients dealing with histamine intolerance, sulfur issues, chronic fatigue, and food sensitivities.You’ll learn how magnesium and sulfate work together in the body, how they’re absorbed through the skin, and why this gentle therapy can support everything from sleep and muscle relaxation to liver detox pathways and gut lining integrity.🎧 In this episode, you’ll learn: What Epsom salt (magnesium sulfate) actually is How transdermal absorption supports magnesium levels The role of sulfate in liver detoxification (sulfation pathway) Why sulfate is essential for gut lining, skin, and connective tissue health How Epsom salt baths support the nervous system and stress response Why they’re helpful for people with histamine intolerance, sulfur sensitivity, mold illness, and oxalate issues How to safely start Epsom salt baths (especially if sensitive) Epsom salt baths aren’t just about relaxation—they’re a powerful, low-cost tool to support detox pathways, reduce stress, and restore key nutrient levels without burdening the digestive system.This makes them especially beneficial for those who struggle to tolerate supplements or are dealing with complex chronic symptoms.If you’ve ever wondered whether Epsom salt baths actually “do anything”—this episode will give you a clear, science-backed answer and practical guidance.Tune in to learn how to use this simple therapy effectively and safely.✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively. 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!📆 Work with us 1:1! Book a consultation and take your first step to real healing.🎤 Have a topic suggestion? Submit it here!
Transcribe →44. Sulfur Intolerace Explained: What Is It? Why Does It Happen? How Does It Increase Histamine?
Apr 2000:24:01Tap to summarizeAre “healthy” foods like broccoli, garlic, eggs, or red meat making you feel worse instead of better?In this episode of The Histamine Well Podcast, Joanne breaks down one of the most overlooked root causes of food sensitivity, gut symptoms, and chronic fatigue: sulfur metabolism dysfunction.If you’ve been struggling with histamine intolerance, unexplained food reactions, bloating, brain fog, or fatigue, this episode will help you understand what may really be going on beneath the surface.🎧 In this episode, you’ll learn:What “sulfur intolerance” actually is (and why that term is misleading)The difference between sulfide, sulfite, and sulfateHow disrupted sulfur metabolism impacts your gut, energy, skin, and brainThe connection between hydrogen sulfide gas and mitochondrial dysfunctionWhy sulfur issues can trigger or worsen histamine intoleranceHidden sources of sulfur in foods, supplements, and waterThe role of methylation, molybdenum, and gut bacteriaKey symptoms of sulfur imbalance (including bloating, fatigue, headaches, and food sensitivities)Many people are told to simply eliminate more and more foods—but what if the real issue isn’t the food itself?This episode offers a functional medicine perspective to help you understand the deeper biochemical pathways behind your symptoms and why your body may be reacting the way it is.Understanding sulfur metabolism can completely shift how you approach healing—and may explain why nothing else has worked.✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively. 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!📆 Work with us 1:1! Book a consultation and take your first step to real healing.🎤 Have a topic suggestion? Submit it here!
Transcribe →Q&A. Why Does My Anxiety Get Worse at Night or Wake Me Up at 3am?
Apr 1500:03:12Tap to summarizeDo you find your anxiety worsening at night—or waking you suddenly between 2AM and 4AM with a racing heart and intrusive thoughts?In this Clarity Session Q&A, Joanne explores one of the most common patterns seen in clinic: night-time anxiety and early morning wake-ups—and why this is often more than just a psychological issue.This episode explains the physiological root causes of anxiety at night, including the critical role of blood sugar regulation, liver glycogen stores, and stress hormones like cortisol and adrenaline. When blood sugar drops overnight, your body triggers a stress response—leading to symptoms that can feel like panic attacks. You’ll learn: Why anxiety often spikes between 2AM–4AM The connection between low blood sugar and night-time panic How cortisol and adrenaline disrupt sleep Common triggers like skipping meals, low protein intake, and caffeine use Why this pattern is especially common in perimenopause Simple strategies to stabilize blood sugar and improve sleep qualityJoanne also shares practical tips, including how a protein-based evening snack may help prevent early morning wake-ups and reduce overnight anxiety.If you’ve been struggling with disrupted sleep, anxious thoughts at night, or waking at 3AM feeling wired, this episode offers a new perspective—and actionable steps to support your body.✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively. 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!📆 Work with us 1:1! Book a consultation and take your first step to real healing.🎤 Have a topic suggestion? Submit it here!
Transcribe →43. Blood Sugar & Anxiety in Women: The Hidden Cause of Chronic Anxiety
Apr 1300:15:39Tap to summarizeAre you struggling with anxiety, overwhelm, or constant nervous system dysregulation—despite normal lab results?In this episode of The Histamine Well Podcast, Joanne uncovers one of the most overlooked root causes of anxiety in women: blood sugar instability.Learn how blood sugar spikes and crashes can trigger cortisol and adrenaline, creating symptoms that feel exactly like anxiety disorders. Joanne breaks down why this often goes undiagnosed, even when glucose, insulin, and HbA1c levels appear normal.This episode explores the connection between blood sugar, hormones, histamine, gut health, and neurotransmitter production—and why women are particularly vulnerable, especially during high stress or perimenopause.You’ll also discover real-life patterns seen in clinical practice, including: High-achieving women relying on coffee and insufficient protein intake, contributing to blood sugar instability Busy mothers under-eating and overwhelmedWomen using intermittent fasting in ways that disrupt hormonesHidden links between histamine intolerance and blood sugar imbalanceIf you’ve ever felt like your anxiety “doesn’t make sense,” this episode will help you understand what’s really happening in your body—and what to do about it.✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively. 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!📆 Work with us 1:1! Book a consultation and take your first step to real healing.🎤 Have a topic suggestion? Submit it here!
Transcribe →Q&A. Why Do I Still Have Inflammation When My CRP & ESR Are Normal?
Apr 800:03:23Tap to summarizeIf your blood tests are “normal”… why do you still feel inflamed?In this Q&A Clarity Session of The Histamine Well Podcast, Joanne answers a deeply important and often overlooked question: why symptoms of inflammation can persist even when CRP and ESR markers come back normal.Many people are told everything is “fine” based on standard blood work—yet continue to experience fatigue, brain fog, skin issues, gut dysfunction, and hormonal imbalances. This episode explains why that disconnect happens and what may actually be driving your symptoms.CRP (C-reactive protein) and ESR (erythrocyte sedimentation rate) are commonly used markers for inflammation—but they primarily detect acute, systemic inflammation, not the chronic low-grade inflammation seen in many complex health conditions. In this episode, you’ll learn: Why CRP and ESR can be normal despite ongoing symptoms The difference between acute vs chronic low-grade inflammation Common drivers of hidden inflammation (gut issues, histamine, mold, blood sugar imbalance, stress) How inflammation can show up as skin, neurological, hormonal, and digestive symptoms Why patients are often dismissed despite real underlying issues If you’ve ever been told “your labs are normal” but still don’t feel well, this episode will give you the clarity and validation you’ve been looking for.This is essential listening for anyone dealing with: Histamine intolerance Chronic inflammation Gut health issues (SIBO, candida, dysbiosis) Hormonal imbalances Unexplained symptoms despite normal blood tests 🎧 Subscribe to The Histamine Well Podcast for more expert insights on root-cause healing, inflammation, and complex chronic conditions.✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively. 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!📆 Work with us 1:1! Book a consultation and take your first step to real healing.🎤 Have a topic suggestion? Submit it here!
Transcribe →42. Why Your Hormones Haven't Improved Despite Treatment - The Role of Inflammation, Histamine & Methylation
Apr 600:13:49Tap to summarizeIn this in-depth episode of The Histamine Well Podcast, Joanne explores why hormone symptoms often persist despite treatment, and what may be driving this beneath the surface.Drawing on clinical observation and biochemistry, Joanne explains how chronic inflammation, histamine dysregulation, and methylation imbalances interact to disrupt hormonal signaling, ovulation, and recovery.If you’ve tried supplements, improved your diet, and still experience symptoms like PMS, PMDD, anxiety, insomnia, migraines, or hormonal acne, this episode provides a deeper framework for understanding why.What You’ll LearnWhy hormones may not improve despite treatmentHow inflammation disrupts ovulation and lowers progesteroneThe connection between histamine intolerance and estrogen dominanceWhy symptoms worsen around ovulation and before your periodThe role of methylation in estrogen detoxificationDifferences between overmethylation and undermethylationWhy some supplements may worsen symptomsKey drivers behind PMS, anxiety, sleep issues, and hormonal imbalance✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively. 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!📆 Work with us 1:1! Book a consultation and take your first step to real healing.🎤 Have a topic suggestion? Submit it here!
Transcribe →