Welcome to another energizing and empowering episode of The Hormone Prosperity Podcast with Dr. Kyrin! This week, we’re tackling a pressing question from our listener, Mavic, who’s confused about the various ways to dose Hormone Replacement Therapy (HRT).

Are you wondering if that HRT pill, patch, or cream is the best choice for your body? Curious about the hidden risks of oral estradiol or why your patch might be causing skin irritation? Dr. Kyrin breaks it all down with heartfelt clarity and solid science, as she explains why the method you use to dose hormones can spell the difference between prosperity or problems for your body.

What You’ll Learn in This Episode:

The First Pass Effect: Find out why oral estradiol and testosterone are problematic—hint, it’s harming more than helping by overloading your liver.
Better Dosing Methods: Discover why transdermal creams are the healthier alternative to patches, and how compounded bioidentical hormones can open up new possibilities for vitality.
Progesterone Done Right: Why oral progesterone is Dr. Kyrin’s go-to method for stress relief and sleep enhancement—but only when it’s crafted properly!
Myth-Busting Mainstream HRT: Are you still trusting the advice of a general physician or weekend-trained bioidentical hormone practitioner? Learn what to look for in a credentialed HRT expert.
The all-important balance of estradiol and estriol to protect your health and happiness.

Why This Episode Matters

Hormones hold the key to midlife joy, vitality, and a stronger, healthier you—yet too many women are left confused by mainstream advice or trapped in hormonal poverty. Dr. Kyrin’s insights will help you leave behind one-size-fits-all solutions and make confident, informed decisions about your HRT treatment.

Empower Your Journey

Dr. Kyrin invites every intelligent woman to stop settling for "good enough." This episode gives you the knowledge to question your current treatments, explore more effective options, and step into the hormonal prosperity you deserve!

Your Call to Action

Take the Free Hormonal Poverty Quiz

Could you be in hormonal poverty? Find out in just 90 seconds!

👉 CLICK HERE to take the quiz and assess where you stand.

Help Other Women Get Their Bliss Back

Enjoyed this episode? Please share it with a friend who’s also struggling with hormonal imbalance or midlife metabolic mayhem. Together, we can help more women reclaim their vitality and health. Don’t forget to leave us a review or rating—your support helps build this empowering community!

Podcast Episode Transcript:

Dr. Kyrin Dunston (00:00):

Coming up next, could your hormone dosing route be putting you at risk for greater problems? Find out next.

Dr. Kyrin Dunston (00:11):

Greetings friend. Welcome to the Hormone Prosperity Podcast with me, the hormone prosperity coach, Dr. Kyrin. Here's where intelligent women over 40 go to get credible guidance and inspiration on getting out of hormonal poverty and into hormonal prosperity and the joy and vitality that brings. Go from asking disempowering questions like, what's wrong with me? To asking empowering questions like, what would hormonal prosperity do? Hashtag WW HPD. Join me as we dive into today's episode and get started on your journey off the couch, into your genes and back into life because bliss is your birthright and a healthy body filled with hormonal prosperity is the vehicle that gets you there. Welcome. Let's get started.

Dr. Kyrin Dunston (01:01):

Welcome back to another episode of the Hormone Prosperity Coach. As we dive into talking about a question from Mavic, who wants to know about different dosing routes for HRT, which is a question that I see often, a lot of you are confused about. Should using a patch, should I be using a cream, a pill, a shot? Oh, like a pellet? What should I be doing? So let's dive into this question that Mavic proposed. She says, what's the latest on oral versus patches versus gels? For HRTI was initially prescribed patches, but that horribly irritated my skin. The adhesive question mark. So I'm on oral estradiol and progesterone, but are these oral pills less effective? I'm wondering about trying gels or spray that I've read a bit about in case the oral isn't as helpful pro slash protective. So thank you for this question, Mavic, I love it.

Dr. Kyrin Dunston (01:55):

There is so much to dive into here for all of you, hormone seekers, hormone finders, hormone users because oh, so much to dive into. So the first thing I'm gonna like circle with my red pen, the things that really catch my attention that are crucial alerts that need to be addressed. So number one is you say, I'm on oral estradiol and progesterone, oral progesterone, no problem. Cool. That's my favorite way, way to dose it for women, because it help can help with anxiety. When it goes through the gastrointestinal tract, it stimulates the nerves and neurotransmitters that go directly to your brain. Your gut is your second brain and it helps your GABA nerve neurotransmitter, which is your calm anti-anxiety, and it helps with sleep, love, progesterone, orally. Now estradiol or any estrogen orally or testosterone, no step away from the oral estradiol, the oral testosterone.

Dr. Kyrin Dunston (03:02):

Why? Because when you take estradiol or testosterone orally and it goes into your gastrointestinal tract, there's something that happens called the first pass effect. First pass effect, where these hormones go into the bloodstream that go right to your liver through the portal vein. They go from the gastrointestinal tract, collects the blood in the veins, and then it goes right up to your liver, the portal vein into your liver. Now your liver is the main sanitation department or detox central for almost everything in your body, most things, and especially your sex hormones. So you have a flood of sex hormones, estradiol and testosterone coming to the liver. And what that does is it overloads your detox profile and it causes biochemical changes that can actually increase your risk for well heart disease for one, but other health problems as well. And we call that the first pass effect you do.

Dr. Kyrin Dunston (04:10):

It doesn't happen with progesterone. So you do not want to take estrogen or testosterone in an oral capsule. Why? It's still on the market. I don't know. Now I say I don't know, but why? If you wanna ask anything about the pharmaceutical industry and why it's allowed, it's always a for-profit motive <laugh>, because a lot of women are not comfortable with the idea of using a patch. And that's really the only other route that we have right now for estrogen, for women that's commercially prepared by one of the big pharma companies. So that's an aside. You wanna step away from the oral estrogen and testosterone. It can contribute to all kinds of hepatic and systemic problems. So one ...