In Part 2, Dr. Jess Pelletier speaks with Dr. Moses Kitakule about tuberculosis (TB) complications, including pulmonary and extrapulmonary emergencies and serious side effects of anti-TB medications.

Take-Home Points:

There are a number of life-threatening pulmonary emergencies that can occur in active or latent TB patients due to structural lung changes, and we need to be ready to manage them
Extrapulmonary TB can impact any organ system, but some of the most dangerous emergencies to be aware of include:
- Cardiac
  - Cardiac tamponade 2/2 pericarditis with effusion
  - Myocarditis/sudden cardiac death
  - Increased risk of coronary artery disease/acute coronary syndrome
  - Aortitis
- Neurologic
  - Meningitis
  - Tuberculomas
  - Spinal tuberculous arachnoiditis
  - Increased risk of ischemic stroke
- Hematologic
  - Decreased cell lines, TTP, coagulopathy
- GI
  - Bowel obstruction/perforation
  - Peritonitis
  - Tuberculous appendicitis
- Osteoarticular
  - Osteomyelitis
  - Septic arthritis
First-line anti-TB drugs can be quite toxic, with the most concerning emergencies including seizures, hepatoxicity, hematologic emergencies, life-threatening rashes, optic neuritis, and pneumonitis

You can view the full show notes and references here: https://docs.google.com/document/d/1ubGVR3i9lab1MM7NgXMjeORhQ-jFQt6C51R-9xI1VW4/edit?usp=sharing

ID4U Episode 3 Tuberculosis Part 2

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