Folinic acid has been showing up everywhere in conversations about autism—but what does the research actually tell us, and why should occupational therapists pay attention? In this episode of Ideas at Play, we break down a high-quality randomized controlled trial on folinic acid and translate the findings into practical, OT-relevant insights. We unpack the brain-based “why,” highlight what the study found (including changes related to autism characteristics and language), and talk about how this information fits into real-world practice. As always, we center participation, functional outcomes, and collaboration with families and medical teams. This episode is for informational purposes only and is not medical advice. Families should always consult their physician before starting or changing supplements or medications.

We share our own thoughts in the Research Review and encourage you to read the original article too.

Panda, P. K., Sharawat, I. K., Saha, S., Gupta, D., Palayullakandi, A., & Meena, K. (2024). Efficacy of oral folinic acid supplementation in children with autism spectrum disorder: A randomized double-blind, placebo-controlled trial. European Journal of Pediatrics, 183(11), 4827–4835. https://doi.org/10.1007/s00431-024-05762-6

Update 2/4/26: The article we featured by Panda et al. (2024) was retracted on 1/29/26. It was discovered that the authors handled the data inappropriately and the journal lost confidence in the findings. Despite this, there is still solid evidence supporting the use of folinic acid with autistic children. Here are a few additional articles that support the information provided in this episode.

Additional Citations:

Hoxha, B., Hoxha, M., Domi, E., Gervasoni, J., Persichilli, S., Malaj, V., & Zappacosta, B. (2021). Folic Acid and Autism: A Systematic Review of the Current State of Knowledge. Cells, 10(8), 1976. https://doi.org/10.3390/cells10081976

Rossignol, D. A., & Frye, R. E. (2021). Cerebral Folate Deficiency, Folate Receptor Alpha Autoantibodies and Leucovorin (Folinic Acid) Treatment in Autism Spectrum Disorders: A Systematic Review and Meta-Analysis. Journal of Personalized Medicine, 11(11), 1141. https://doi.org/10.3390/jpm11111141

Sener, E. F., Oztop, D. B., & Ozkul, Y. (2014). MTHFR gene C677T polymorphism in autism spectrum disorders. Genetics Research International, 2014, Article 698574. https://doi.org/10.1155/2014/698574

Bobrowski-Khoury, N., Ramaekers, V. T., Sequeira, J. M., & Quadros, E. V. (2021). Folate receptor alpha autoantibodies in autism spectrum disorders: Diagnosis, treatment and prevention. Journal of Personalized Medicine, 11(8), Article 710. https://doi.org/10.3390/jpm11080710

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