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Historical themes, events and key individuals from Akhenaten to Xenophon.

Melvyn Bragg and guests discuss the life and work of Hans Holbein the Younger (1497-1543) during his two extended stays in England, when he worked at the Tudor Court and became the King's painter. Holbein created some of the most significant portraits of his age, including an image of Henry VIII, looking straight at the viewer, hands on hips, that has dominated perceptions of him since. The original at Whitehall Palace was said to make visitors tremble at its majesty. Holbein was later sent to Europe to paint the women who might be Henry's fourth wife; his depiction of Anne of Cleves was enough to encourage Henry to marry her, a decision Henry quickly regretted and for which Thomas Cromwell, her supporter, was executed. His paintings still shape the way we see those in and around the Tudor Court, including Cromwell, Thomas More, the infant Prince Edward (of which there is a detail, above), The Ambassadors and, of course, Henry the Eighth himself.WithSusan Foister Curator of Early Netherlandish, German and British Painting at the National GalleryJohn Guy A fellow of Clare College, University of CambridgeAndMaria Hayward Professor of Early Modern History at the University of SouthamptonProducer: Simon Tillotson.

Alexander the Great is one of the most celebrated military commanders in history. Born into the Macedonian royal family in 356 BC, he gained control of Greece and went on to conquer the Persian Empire, defeating its powerful king, Darius III. At its peak, Alexander's empire covered modern Turkey, Syria, Egypt, Iran, Iraq, Afghanistan, Pakistan and part of India. As a result, Greek culture and language was spread into regions it had not penetrated before, and he is also remembered for founding a number of cities. Over the last 2,000 years, the legend of Alexander has grown and he has influenced numerous generals and politicians.With:Paul Cartledge Emeritus Professor of Greek Culture and AG Leventis Senior Research Fellow at Clare College, University of CambridgeDiana Spencer Professor of Classics at the University of BirminghamRachel Mairs Lecturer in Classics at the University of ReadingProducer: Victoria Brignell.

Frederick the Great ruled Prussia from 1740 until his death in 1786. Born in 1712, he increased the power of the state, he made Prussia the leading military power in Europe and his bold campaigns had great implications for the European political landscape. An absolute monarch in the age of enlightenment, he was a prolific writer, attracted figures such as Voltaire to his court, fostered education and put Berlin firmly on the cultural map. He was much admired by Napoleon and was often romanticised by German historians, becoming a hero for many in united Germany in the 19th and 20th centuries. Others, however, vilified him for aspects such as his militarism and the partition of Poland. With Tim Blanning Emeritus Professor of Modern European History at the University of CambridgeKatrin Kohl Professor of German Literature at the University of Oxford and a Fellow of Jesus CollegeAnd Thomas Biskup Lecturer in Early Modern History at the University of HullProducer: Simon Tillotson.

In the Middle Ages, Prester John was seen as the great hope for Crusaders struggling to hold on to, then regain, Jerusalem. He was thought to rule a lost Christian kingdom somewhere in the East and was ready to attack Muslim opponents with his enormous armies. There was apparent proof of Prester John's existence, in letters purportedly from him and in stories from travelers who claimed they had met, if not him, then people who had news of him. Most pointed to a home in the earthly paradise in the Indies, outside Eden, with fantastical animals and unimaginable riches. Later, Portuguese explorers thought they had found him in Ethiopia, despite the mystified denials of people there. Melvyn Bragg asks why the legend was so strongly believed for so long, and what facts helped sustain the myths.WithMarianne O'Doherty Associate Professor in English at the University of SouthamptonMartin Palmer Director of the International Consultancy on Religion, Education, and CultureAndAmanda Power Senior Lecturer in Medieval History at the University of Sheffield.Producer: Simon Tillotson.

It is said that, in Britain from the 18th Century, copies of Josephus' works were as widespread and as well read as The Bible. Christians valued "The Antiquities of the Jews" in particular, for the retelling of parts of the Old Testament and apparently corroborating the historical existence of Jesus. Born Joseph son of Matthias, in Jerusalem, in 37AD, he fought the Romans in Galilee in the First Jewish-Roman War. He was captured by Vespasian's troops and became a Roman citizen, later describing the siege and fall of Jerusalem. His actions and writings made him a controversial figure, from his lifetime to the present day.WithTessa Rajak Professor Emeritus of Ancient History, University of ReadingPhilip Alexander Professor Emeritus of Jewish Studies, University of ManchesterAndMartin Goodman Professor of Jewish Studies, University of Oxford and President of the Oxford Centre for Hebrew and Jewish StudiesProducer: Simon Tillotson.

Melvyn Bragg and guests discuss the Cotton Famine in Lancashire from 1861-65. The Famine followed the blockade of Confederate Southern ports during the American Civil War which stopped the flow of cotton into mills in Britain and Europe. Reports at the time told of starvation, mass unemployment and migration. Abraham Lincoln wrote, "I know and deeply deplore the sufferings which the working-men of Manchester, and in all Europe, are called to endure in this crisis." While the full cause and extent of the Famine in Lancashire are disputed, the consequences of this and the cotton blockade were far reaching.WithLawrence Goldman Director of the Institute of Historical Research at the University of LondonEmma Griffin Professor of History at the University of East AngliaAndDavid Brown Senior Lecturer in American Studies at University of ManchesterProducer: Simon Tillotson.

Rabindranath Tagore was the first non-European to win a Nobel Prize for Literature. He has been called one of the outstanding thinkers of the 20th century and the greatest poet India has ever produced. His Nobel followed publication of Gitanjali, his English version of some of his Bengali poems. WB Yeats and Ezra Pound were great supporters. Tagore was born in Calcutta in 1861 and educated partly in Britain; King George V knighted him, but Tagore renounced this in 1919 following the Amritsar Massacre. A key figure in Indian nationalism, Tagore became a friend of Gandhi, offering criticism as well as support. A polymath and progressive, Tagore painted, wrote plays, novels, short stories and many songs. The national anthems of India and Bangladesh are based on his poems. WithChandrika Kaul Lecturer in Modern History at the University of St AndrewsBashabi Fraser Professor of English Literature and Creative Writing at Edinburgh Napier UniversityAndJohn Stevens Leverhulme Postdoctoral Fellow at SOAS, University of LondonProducer: Simon Tillotson.

Melvyn Bragg and his guests discuss the life of Matteo Ricci, a Jesuit priest who in the 16th century led a Christian mission to China. An accomplished scholar, Ricci travelled extensively and came into contact with senior officials of the Ming Dynasty administration. His story is one of the most important encounters between Renaissance Europe and a China which was still virtually closed to outsiders.With Mary Laven Reader in Early Modern History at the University of CambridgeCraig Clunas Professor of the History of Art at the University of OxfordandAnne Gerritsen Reader in History at the University of Warwick Producer: Simon Tillotson.

Melvyn Bragg and his guests discuss the California Gold Rush. In 1849 the recent discovery of gold at Coloma, near Sacramento in California, led to a massive influx of prospectors seeking to make their fortunes. Within a couple of years the tiny settlement of San Francisco had become a major city, with tens of thousands of immigrants, the so-called Forty-Niners, arriving by boat and over land. The gold rush transformed the west coast of America and its economy, but also uprooted local populations of Native Americans and made irreversible changes to natural habitats.With:Kathleen Burk Professor of Modern and Contemporary History at University College LondonJacqueline Fear-Segal Reader in American History and Culture at the University of East AngliaFrank Cogliano Professor of American History at the University of Edinburgh.

Melvyn Bragg and his guests discuss the scientific achievements of the Curie family. In 1903 Marie and Pierre Curie shared a Nobel Prize in Physics with Henri Becquerel for their work on radioactivity, a term which Marie coined. Marie went on to win a Nobel in Chemistry eight years later; remarkably, her daughter Irène Joliot-Curie would later share a Nobel with her husband Frédéric Joliot-Curie for their discovery that it was possible to create radioactive materials in the laboratory. The work of the Curies added immensely to our knowledge of fundamental physics and paved the way for modern treatments for cancer and other illnesses.With:Patricia Fara Senior Tutor of Clare College, University of CambridgeRobert Fox Emeritus Professor of the History of Science at the University of OxfordSteven T Bramwell Professor of Physics and former Professor of Chemistry at University College LondonProducer: Simon Tillotson.