What does it really mean to grieve — and when does grief become a danger to your life? In this weighty episode, host Gabe Howard sits down with Dr. Mary-Frances O’Connor, a leading authority in psychology and ADAA member expert, whose work on grief and loss has touched millions. Dr. O’Connor shares groundbreaking insights on the subtle yet critical differences between the stereotypical grief process and prolonged grief, revealing why your heart can literally stop functioning due to loss.

From staggering statistics showing a man’s heart attack risk skyrockets on the day his spouse dies, to the intimate science of how our bonds regulate our well-being, this conversation is as thought-provoking as it is moving. Discover practical strategies to navigate those raw, overwhelming moments of loss, and learn how to build a personal toolkit for healing. Whether you're coping with grief yourself or supporting someone who is, this episode promises a deep, human exploration into turning heartbreak into hope.

This episode has been sponsored by the Anxiety and Depression Association of America (ADAA).

“It's not just that you're having grief, which is normal. It's that we're unable to find a way to adapt given that we have grief. So people with prolonged grief feel like life holds no meaning anymore, or they feel so angry and bitter about what's happened that they have trouble connecting with their living loved ones.” ~ Mary-Frances O'Connor, PhD

Our guest, Mary-Frances O’Connor, PhD, is a professor of psychology at the University of Arizona, where she directs the Grief, Loss and Social Stress (GLASS) Lab, investigating the effects of grief on the brain and the body. Her book “The Grieving Brain” was included on Oprah’s list of Best Books to Comfort a Grieving Friend. O’Connor holds a PhD in clinical psychology from the University of Arizona and completed a postdoctoral fellowship in psychoneuroimmunology at the UCLA Semel Institute for Neuroscience and Human Behavior. Having grown up in Montana, she now lives in Tucson, Arizona.

Our host, Gabe Howard, is an award-winning writer and speaker who lives with bipolar disorder. He is the author of the popular book, "Mental Illness is an Asshole and other Observations," available from Amazon; signed copies are also available directly from the author. Gabe is also the host of the "Inside Bipolar" podcast with Dr. Nicole Washington.

Gabe makes his home in the suburbs of Columbus, Ohio. He lives with his supportive wife, Kendall, and a Miniature Schnauzer dog that he never wanted, but now can’t imagine life without. To book Gabe for your next event or learn more about him, please visit gabehoward.com.

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Is It Prolonged Grief or Depression? Understanding the Differences