Most men over 40 focus on lifting weights and dialing in their diet—but still overlook a major driver of long-term cardiovascular health.

In this episode, Ted speaks with Greg Mushen about why subsistence populations rarely develop heart disease, how walking influences glucose and lipid clearance, what genetics reveal about individual risk, and why daily movement may matter more than extreme workouts.

If the goal is to protect arteries, improve metabolic health, and age with resilience, this conversation offers a practical, research-driven framework worth listening to.

Today's Guest

Greg Mushen

Greg Mushen spent his career in tech but has maintained a lifelong interest in health, growing up in a medical family. He became deeply focused on longevity after becoming a father at 40, studying subsistence populations and examining how their lifestyle patterns map onto modern mechanisms of disease prevention.

Connect to Greg Mushen

X: @gregmushen

Substack: Dark Lab

You'll learn:

Why walking throughout the day may improve glucose and lipid clearance more effectively than a single workout

What subsistence populations like the Tsimane and Maasai reveal about heart disease and arterial health

How genetic differences influence lipid clearance and cardiovascular risk

The concept of "flux" and why matching intake with output is critical for metabolic health

And much more....

What Ted and Greg discuss:

(00:00) Introduction

(03:55) Meet Greg Mushen: From Zone 2 to 15K Steps (Why Walking?)

(07:28) Walking for Nutrient Partitioning, Glucose Control & Mitochondria

(15:25) The Amish "Natural Experiment" + Clearance Genes

(18:48) Genetics Meets Lifestyle: APOE4, Saturated Fat, and Personal Risk

(24:58) Diet vs Movement in Context: Maasai vs Tsimane and the 'Flux' Framework

(35:35) Athletes, High CAC Scores & Why Risk Can Still Be Low

(36:58) From Tech to Primary Research: How Greg Learned to Read Studies

(46:49) Calories, Appetite & Why Tracking Still Works (Even If You Hate It)

(57:23) Genetics, Methylation & Targeted Supplements (B12, Folate, Creatine, TMG)

(01:05:18) Final Thought