Christina Applegate + Jamie-Lynn Sigler: Get MeSsy!

Summary

Summary of "Let’s Talk Off Camera with Kelly Ripa"
Episode: Christina Applegate + Jamie-Lynn Sigler: Get MeSsy!
Release Date: July 30, 2025

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Introduction

In the July 30, 2025 episode of "Let’s Talk Off Camera with Kelly Ripa," host Kelly Ripa engages in an intimate and unfiltered conversation with two celebrated actresses, Christina Applegate and Jamie-Lynn Sigler. Both stars are not only renowned for their roles in popular television series like "Dead to Me" and "The Sopranos" but also for their courageous journeys navigating Multiple Sclerosis (MS). This episode delves deep into their personal experiences, the impact of MS on their careers and families, and their strategies for coping with the challenges posed by the disease.

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Introduction of Guests

Kelly Ripa warmly welcomes Christina Applegate and Jamie-Lynn Sigler, highlighting their shared experiences as child actors and their collaboration on the podcast "Messy," which focuses on the tumultuous aspects of life, particularly relating to MS.

• Kelly Ripa (00:00 - 03:15): "Today we have not one, but two amazing actresses joining us... Christina Applegate and Jamie Lynn Sigler."

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Personal Journeys with Multiple Sclerosis

Both Christina and Jamie candidly discuss their diagnoses with MS, emphasizing the sudden and life-altering nature of the disease. Christina shares the emotional turmoil of being diagnosed on camera during the filming of her show, which forced her to involve her audience in her personal struggle.

• Christina Applegate (01:11): "When I was diagnosed, I was on camera being diagnosed. I was getting sicker and sicker on film... I had no choice but to talk about it."

Jamie Lynn adds her perspective, highlighting the long-term impact of living with MS and the importance of emotional acceptance.

• Jamie Lynn Sigler (13:14): "I've lived with the disease for 24 years... sharing these deepest, darkest, scariest things... has been life-changing for me."

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Impact on Careers and Acting

The conversation shifts to how MS has affected their professional lives. Christina recounts the challenges of continuing her acting career while battling the disease, including physical limitations and the necessity to adapt her roles.

• Christina Applegate (17:48): "I had to finish this season of the show. It was important to me. We had to... I couldn't hide this."

Jamie Lynn discusses her advocacy in ensuring that her condition is acknowledged in her roles, striving to represent herself authentically without hiding her MS.

• Jamie Lynn Sigler (53:46): "Whenever I'm up for a role... I say, well, this is what I come with. I don't want to cover this up anymore."

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Family and Parenting Challenges

Both actresses open up about balancing their roles as mothers with the demands of managing MS. They share heartwarming yet poignant stories about their children's responses to their diagnoses and the ongoing efforts to maintain a supportive family environment.

• Christina Applegate (30:08): "I wanna watch New Girl alone... She's the reason I'm still here and trying."

• Jamie Lynn Sigler (30:00): "I have two sons... My older son... he's like my own personal Ted Lasso."

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Navigating Treatments and Medical Decisions

A significant portion of the discussion centers around the complexities of MS treatments. Christina reveals her struggles with medical decisions, particularly regarding infusions and the side effects that impact her daily life.

• Christina Applegate (34:38): "My neurologist has stopped my infusions for now because my B cells were still really low... I'm scared that if I wait too long, I might get worse."

Jamie Lynn emphasizes the importance of trusting medical professionals while also advocating for oneself in managing the disease.

• Jamie Lynn Sigler (35:18): "I have gotten really good at listening to my gut and my own intuition... it's a full-time job to live with a chronic illness."

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Coping Mechanisms and Support Systems

The guests discuss various strategies they employ to cope with MS, from seeking emotional support to finding ways to remain active and engaged despite their physical limitations. Christina speaks about the emotional toll and the need to set boundaries to preserve her well-being.

• Christina Applegate (27:36): "When I say I can't, I'm really saying I can't... I've always buckled up, buttercup."

Jamie Lynn shares her journey from isolating herself during tough days to seeking support from friends and family, recognizing the importance of not facing challenges alone.

• Jamie Lynn Sigler (40:00): "We are not meant as human beings to go through anything alone... Let us in on this with you. We want to be here for you."

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Public Perception and Advocacy

Christina and Jamie Lynn address how public perception has influenced their willingness to speak openly about MS. They acknowledge the pressure to maintain a certain image in the entertainment industry and the importance of authenticity in their advocacy efforts.

• Christina Applegate (32:15): "People still don't get it. They still assume... just because the girls are not gonna make a problem."

• Jamie Lynn Sigler (45:01): "I have a very full life... I don't want to deal with the stress of trying to pretend I'm something that I'm not anymore."

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Family Life and Emotional Struggles

The conversation delves into the personal toll MS takes on their relationships and family dynamics. Christina shares a poignant moment with her daughter Sadie, who expressed missing the person she was before her illness.

• Christina Applegate (30:13): "She says, I miss who you were before you got sick. And that just like, it's like knife to heart because I miss who I was before I got sick, too."

Jamie Lynn discusses her children's differing reactions to her condition, illustrating the diverse ways families cope with chronic illnesses.

• Jamie Lynn Sigler (31:01): "My older son... he's like my own personal Ted Lasso. My little one hates it... that's very healthy and I welcome it."

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Treatment Trials and Medical Challenges

Christina provides an in-depth look into the ongoing challenges with her treatment regimen, including the emotional and physical strain of managing infusions and the uncertainty surrounding her health.

• Christina Applegate (34:06): "It’s really such a bizarre condition... you go hours and... today I felt like I couldn't get to the bathroom. It's just that kind of thing. It's really so weird."

Jamie Lynn reflects on the experimental nature of some treatments and the constant hope interspersed with disappointment.

• Jamie Lynn Sigler (32:51): "How could we not be open to something that could potentially change our lives?... it's hard to think that you would go through your life until you die and never feel better."

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Support Systems and Community

The guests emphasize the importance of having a strong support system, whether through family, friends, or advocacy groups. Christina mentions the invaluable role of her close-knit circle of non-industry friends who provide unwavering support.

• Christina Applegate (38:29): "I have a very small bubble of friends... they are ride or die."

Jamie Lynn shares a transformative experience where her friends helped her realize the importance of not facing challenges alone.

• Jamie Lynn Sigler (40:00): "It was a really life-changing moment for me when they did that. Because we're not meant... to go through anything alone."

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Future Plans and Collaborations

As the episode wraps up, Kelly Ripa and the guests discuss future collaborations and projects. They express enthusiasm for furthering their advocacy through their podcast and potential new ventures that blend humor and heart to navigate life with MS.

• Seth Meyers (54:04): "I feel like Judd Apatow needs to write this buddy comedy for the two of you. I really do."

• Jamie Lynn Sigler (53:19): "We'll figure it out... teaching us to dance awkwardly could be hilarious."

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Closing Remarks

Kelly Ripa concludes the episode by expressing her gratitude to Christina and Jamie Lynn for their openness and resilience. She encourages listeners to support their podcast "Messy" and acknowledges the strength and inspiration drawn from their stories.

• Seth Meyers (55:00 - 55:34): "I honestly... I wish I could infuse you with good health right now... Thank you so much."

• Christina Applegate & Jamie Lynn Sigler (55:30 onwards): "Thank you, Kelly... We love being with you."

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Notable Quotes with Timestamps

• Christina Applegate (01:11): "When I was diagnosed, I was on camera being diagnosed. I was getting sicker and sicker on film."

• Jamie Lynn Sigler (13:14): "I've lived with the disease for 24 years... sharing these deepest, darkest, scariest things... has been life-changing for me."

• Christina Applegate (27:36): "When I say I can't, I'm really saying I can't... I've always buckled up, buttercup."

• Jamie Lynn Sigler (31:01): "My older son... he's like my own personal Ted Lasso... My little one hates it... that's very healthy and I welcome it."

• Christina Applegate (34:06): "It’s really such a bizarre condition... you go hours and... today I felt like I couldn't get to the bathroom."

• Jamie Lynn Sigler (32:51): "How could we not be open to something that could potentially change our lives?"

• Christina Applegate (38:29): "I have a very small bubble of friends... they are ride or die."

• Jamie Lynn Sigler (40:00): "It was a really life-changing moment for me when they did that."

• Seth Meyers (54:04): "I feel like Judd Apatow needs to write this buddy comedy for the two of you."

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Conclusion

This episode of "Let’s Talk Off Camera with Kelly Ripa" offers a profound and heartfelt exploration of living with Multiple Sclerosis, especially within the public eye of the entertainment industry. Christina Applegate and Jamie-Lynn Sigler provide invaluable insights into their personal struggles, resilience, and the unwavering support systems that help them navigate their journeys. Their transparency not only sheds light on the realities of chronic illness but also serves as an inspiration to listeners facing similar challenges.

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Additional Notes

• Podcast Promotion: The episode also features the promotion of Christina and Jamie Lynn’s podcast "Messy," encouraging listeners to engage with their continued advocacy and storytelling efforts.

• Future Collaborations: Discussions hint at potential future collaborations with notable figures like Judd Apatow, showcasing the blending of humor with serious life experiences.

Listen to the full episode on SiriusXM Podcasts+ for an unfiltered and engaging conversation with Christina Applegate and Jamie-Lynn Sigler.

Transcript

[Kelly Ripa]

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[Seth Meyers]

No such thing as camera off for dogs. Let's talk about next level dog care. That means treating them with next level protection from parasites with Nexguard Plus, Afoxylonir, moxidectin and parental chewable tablets. Nexguard plus Chews provide one and done monthly protection against fleas, ticks, heartworm disease, roundworms and hookworms. Plus they come in a tasty beef flavored soft chew that that's designed to be easy to give use with caution in dogs with a history of seizures or neurologic disorders. Dogs should be tested for existing heartworm infection prior to starting a preventive. So the next time you're at the vet, ask about Nexgard plus Chews.

[Christina Applegate]

When I was diagnosed, I was on camera being diagnosed. I was getting sicker and sicker on film. So I was having to take everyone on the journey with me because I had no choice. I had to finish this season of the show. It was important to me. It was important to our crew.

[Seth Meyers]

Somebody got to cue me or do I cue myself?

[Jan]

Cue yourself.

[Seth Meyers]

Ok, so season three, I am required to listen to myself. Is that what you're suggesting?

[Albert]

That's what the radio people say.

[Seth Meyers]

I feel as though I have been punished enough. Get ready everyone. We are back with circumstances. Season three of let's Talk off camera. So let's get talking.

[Christina Applegate]

Wow.

[Seth Meyers]

Never before has four applause sounded so mighty. Well, just when you think this show can't get any bigger. I don't know how else to segue. Think again because today we have not one, but two amazing actresses joining us. Christina Applegate and Jamie Lynn Sigler. They of course starred in two of our favorite shows, Dead to Me and the Sopranos. Do we see a theme here? Do we see a theme in my viewing? Do we see the kind of shows that I like? We're not the only ones. Jan with a podcast. I know you like to think we are, but we're not. They have a podcast called Messy where they get personal about messy curveballs life can throw you, which for them, as we know is ms, hence the title. Capital M E capital S S Y. I'm really looking forward to this Conversation. They're good girls. They're just great women. And Christina Applegate and I bonded many years ago over hating the same person. And I feel like it's true. Dear listeners, what they say. The enemy of your enemy is your friend. And that is how we met and fell in love with. But before we get to them, Albert, Jan, and even Seth, who now has his own mic. Because people find your voice very sexy. Seth.

[Jamie Lynn Sigler]

Hey, gang.

[Seth Meyers]

Or at least they did find your voice very sexy. What's going on with you guys? Have you recovered from Lola Consuelo's peppering you with requests to listen to her voice?

[Seth]

Oh, my God, it is so funny. She texts us, like, every morning. Every morning saying, can. Can I get. Can I listen to my podcast yet? We're like, lola, you gotta wait a minute. Michelle Obama's taking precedent.

[Albert]

Yeah. Hello.

[Seth Meyers]

What's so funny is Michael and Lola fighting at the dinner table over why Lola was the podcast guest? Because my kids. My kids, like, they're never home at the same time ever. You know, if Lola's home, Michael's out of town. If Michael's home, Lola, of course, is usually out of town, and. And Joaquin is never in town, and he'll never be on this podcast.

[Seth]

Well, I think you should tell Michael that he's gonna have his own episode.

[Albert]

Yeah.

[Jamie Lynn Sigler]

Oh, my gosh.

[Seth Meyers]

Yep.

[Albert]

Yeah.

[Seth Meyers]

He will be drunk with power.

[Christina Applegate]

Yeah.

[Seth Meyers]

Are you sure you will? Yeah.

[Seth]

And then it's gonna be a competition. Is whose episode rated better?

[Seth Meyers]

Oh, my gosh. Oh, my gosh. Oh. Oh, get your. Get your.

[Seth]

But Michael has to come with, like, some good dirt. I want some good. Bravo, dirt.

[Seth Meyers]

Bravo, dirt.

[Seth]

I want the dirt.

[Seth Meyers]

Yeah. He won't give you any.

[Seth]

Well, we'll torture him. We'll, like, will threaten to. To torture his figurines.

[Seth Meyers]

One of his figurines. One of his toys. One of his many toys.

[Seth]

Wait, what were you gonna say about Bob Iger? Is he coming back?

[Albert]

No, no, no.

[Seth]

So he's not coming back.

[Seth Meyers]

He wants to come in.

[Albert]

In the studio. Jason was there, and Jason and Jan. The. Bob Iger came up and.

[Seth]

Jason who?

[Seth Meyers]

Weinberg. Jason Weinberg the most. Talking to a whole. Weinberg is, dear listeners, probably the most powerful manager in Hollywood. He's been a friend of mine for, God, 35 years. I mean, we've been friends for a really long time. So what happened with so, no.

[Albert]

So Jan and Jason were there, and Bob Iger came up, and I said to Jason, you know, Bob is Jan's hall pass.

[Seth Meyers]

Oh, yeah, that's right.

[Albert]

But then I realized I don't have a hall pass because Jason said, who's your hall pass? And then I realized it. Is it weird that I don't have a hall pass? Like, I have no idea who that person would be. So I figured you.

[Christina Applegate]

No, no, no.

[Albert]

But this is why I figure you know me well enough to come up with a hall. You don't have to do it now, but there must be, like, who's the hall pass? Who's Kyle adjacent? As an actor, that would be. It's a tough one.

[Seth Meyers]

That's really Kyle adjacent.

[Seth]

It doesn't have to be anything about Kyle.

[Seth Meyers]

It's about, like, who's, like, his type? Who's Albert's type? Who's his type? Isn't that. Oh, God.

[Albert]

Seth, do you have a hall pass?

[Seth Meyers]

Not that I know of. Oh, please.

[Seth]

That's such.

[Seth Meyers]

It hasn't been discussed. Sydney and brother. Who's marked hall pass? Do we know?

[Seth]

Oh, yeah, he said it.

[Seth Meyers]

He did, didn't or. No, he said he had a childhood crush.

[Seth]

Sorry, it was a childhood crush.

[Seth Meyers]

Childhood crush was Alyssa Milano. Alyssa Milano. Text Mark right now and ask him, who is hall pass? Just text him and ask him. We. We need to know. I need to know what?

[Seth]

We need a hall pass, by the way. I can't. There's, like. I know you can't, like, sexually harass when you're more in power, but if I do the sexual harassing upwards, I'm not gonna get fired or anything.

[Seth Meyers]

No, he can't fire you for sexually harassing him. Up.

[Albert]

Jan, tell him who your husband's hall pass is.

[Seth Meyers]

Oh, who's your husband?

[Christina Applegate]

Liz Cho.

[Seth Meyers]

Oh, Liz Cho. That's right. I forgot. Liz Chao. Yeah, that could be Mark's hall pass too. I bet Liz Cho is.

[Albert]

Aw, he said I don't have one. She's my hall pass.

[Seth Meyers]

That's a dirty lie.

[Jamie Lynn Sigler]

Tell him.

[Seth Meyers]

That's a dirty lie. And I need him to come with a hall pass right now. Tell him there's a gun to his heads of his children and he has to pick a hall pass. Gun to the heads of his children.

[Albert]

Like, I find people hot. Like, I'll say, oh, that guy. But none of them are, like, should be a hall pass.

[Seth]

Okay, but we understand that a hall pass is on marrying that person. It's someone that you get a free excuse to go have sex with. But no, in Bob Iger's case, I'd marry him too.

[Seth Meyers]

You would make an exception to the hall.

[Seth]

If I get fire Telly.

[Seth Meyers]

You are Will quit in protest. I will quit taking care of me. I will terrify them and quit in protest.

[Albert]

He's your ballroom pass.

[Seth Meyers]

He's your. He's Jan. That's Jan's hall monitor. Jan becomes the hall monitor.

[Albert]

Oh, my God.

[Seth Meyers]

I love the lady of the hall.

[Seth]

Albert, your assignment is to come up with.

[Albert]

All right, I'll come up with one.

[Seth]

That's crazy. I have another hall pass.

[Seth Meyers]

Okay, give me jammed. It's crazy.

[Seth]

It's all in the Disney family.

[Seth Meyers]

Go, go. You're not David Muir. Oh, wow. Oh, David Muir is America's hall pass. I believe. You know when they're like. And David Muir, you know. World News Tonight, America's most watched news program. I think it should say world. David Muir, World News Tonight, America's hall pass. That's what I think. Like, you want to get new viewership. There's your tagline. America's hall pass. America. Back to Seth. Seth.

[Albert]

Who's your Seth?

[Seth Meyers]

I'm still thinking about Albert.

[Seth]

He's so deflecting.

[Albert]

He's totally spinning.

[Seth]

We should ask our guests. That's a good one, because they are ready.

[Seth Meyers]

All right. Are they ready?

[Seth]

Yeah, we should ask them.

[Seth Meyers]

Okay, let me tell you. I'm looking at Christina Applegate right now. Jamie Lynn Sigler is underneath us. The way. The way my. No, no, no. I'm telling a story. I'm just telling a story. Calm down, Albert. Don't panic. What I see is behind Christina Applegate is my headboard from my bed.

[Christina Applegate]

No.

[Seth Meyers]

Yes. Are you in my bedroom? Yeah. I knew it. I knew that you were Mark's hall pass. I knew it. I knew it. I. You know what? This is the weirdest way to discover the affair.

[Christina Applegate]

I'm so sorry. I mean, you guys had a good run.

[Seth Meyers]

We did really fine. I'm totally. Listen, if I lose Mark to you, that will make me happy. I will feel like. Cause I'll still feel like it's in the family.

[Christina Applegate]

I think we could all just do it together.

[Seth Meyers]

Yeah, it'll be fine.

[Christina Applegate]

I need a lot of help.

[Seth]

Who's their hall passes?

[Seth Meyers]

I want to know. Yeah, we want to. So we were. Before you two logged on, we were talking about our hall passes. Okay? Now Jan has very. Jan's very lofty. Bob Iger is her hall pass, followed by David Muir. So Jan basically wants to have sex with everyone at abc.

[Christina Applegate]

Okay.

[Seth Meyers]

She wants somebody rich and powerful. That's what she wants. Okay, Jamie, who is your hall pass?

[Jamie Lynn Sigler]

Well, you know, I'm in perimenopause, so I'M struggling even wanting to sleep with my own husband. I can't even imagine sleeping with anybody else. But I really, I love Steve Carell in the way that I just would love to be with him all the time. I don't think I want to sleep with him, but I just want to be with him. Is that count as a hall pass?

[Seth Meyers]

Yes. A perimenopause for sure.

[Christina Applegate]

Yeah.

[Seth Meyers]

Wait till you go through menopause and then you essentially only want to have sex with yourself. It's fine, Jan. It's all ahead of you. It's coming to you too. Besides Mark, Christina, who is your hall besides Mark?

[Christina Applegate]

I have, I have so many that I just want. It's like the same thing with Jamie. Like I don't really want to be touched at all, but to like hang out.

[Seth Meyers]

Yeah, to hang out someone.

[Christina Applegate]

Like, I adore my anchorman boys. Like I. When she said Steve Carell, like Paul and Will, like I could sit and hang out with them all day long. But the one person that I have hung out like a four hour dinner who's like my favorite person is Martin Short, like giggling.

[Seth Meyers]

He's like hysterically for four hours. He's the sweetest. He's the sweetest man. He's a kind person.

[Christina Applegate]

Yep.

[Seth Meyers]

I mean, I think he, I think he's a kind person. Please don't tell me he's sinister behind the scenes.

[Christina Applegate]

No, I can't sit with someone for four hours at dinner if, if, if they're on the whole time. Right. Like it really was his big heart and his big everything and he's also hilarious. So you're entertained.

[Seth Meyers]

Yeah, exactly. I, I've got to tell you, I've got to congratulate you on the undertaking of Messi, the podcast. It's really broken through. It's helped a lot of people. But I, I would think, Jan, you'd agree, like sometimes the things we do, you know, to put, to put a message out there into the universe really also inadvertently helps ourselves. Do you feel that it has been a cathartic experience for the two of you? You are in this hideous fucked up club that nobody wants to be a member to. It's like a membership nobody wants. And yet I would think that the sisterhood between the two of you and the way you present the hard stuff, you don't sugarcoat anything. But there's like somehow, like it's a very, it's very funny the way you talk about hard shit and I'm laughing. So how do you do that? How does that happen before we even.

[Christina Applegate]

Jamie, I'm going to have you go. But. But I have to acknowledge something with you, Kelly, is that when I went public with my Ms. Diagnosis, I received from you the. The biggest thing of flowers. You can't say it's a bouquet. It was like its own island of flowers. And the card just said, fuck. And I still have that card.

[Seth Meyers]

I had a feeling you might receive it in the right way or that we would. Or that we would never speak again.

[Christina Applegate]

And I was like, I laughed and cried and kept it. It was the only thing I've ever kept that has been sent here. So, anyway, so sorry. Your question, Jamie, how do, how do.

[Seth Meyers]

You navigate all of this stuff and make it so funny and humorous?

[Jamie Lynn Sigler]

Well, I owe a lot of that to my sister Christina for that. You know, I think that I have lived with the disease for 24 years, have talked about the disease for eight, but the way in which I am able to share and the way in which I've actually been able to sit with myself more through this podcast of how I really feel about this, I think has been life changing for me. And I've in turn, like, Ms. Aside, I really feel like I have gotten to know myself more authentically and like, sat back into my more authentic self because of it. Because when you share these deepest, darkest, scariest things that your fear would be judged or taken the wrong way with such abandon, I mean, what else have you got to lose? And that's just kind of how it's made me feel about my life in.

[Seth Meyers]

General now and when you are diagnosed 24 years ago. So I'm not being too personal, but you're a very young girl.

[Jamie Lynn Sigler]

Yeah.

[Seth Meyers]

24 years ago, you are a very young girl. Did you even understand what that was, what they were saying to you, what anybody was talking about?

[Jamie Lynn Sigler]

No. And I didn't ask and I didn't want to know. It was very easy for me to live in a state of denial. I was not symptomatic at the time. So keeping it a secret, living a lie, felt like the responsible thing to do. I don't know if the business was in a place at the time that they would be as accepting as maybe they are now with those types of things. But it just feels like the right. It felt like the right thing. And I was able to not really be the responsible patient I wish I had been at the time. But I give myself a lot of grace about that because I was a kid, like you said. And, you know, it's been a real journey for me, in all the ways, physically, emotionally, spiritually, with this. But I think we're all given a great thing in our lives that can be a catalyst for a lot of things. And so this coming at that time in my life was mine.

[Seth Meyers]

You both were child actors. You both grew up in front of our eyes, in front of the camera. Television viewing audiences feel they have a certain ownership, and they want to keep you in the place that you were and how you were when they met you. Do you feel that you received any. I don't know if this is the right word, not pushback, but do you feel that the audience felt like it's something you shouldn't discuss because they want to think about the two of you as being young, carefree little girls for the rest of their lives?

[Christina Applegate]

Well, for me, when I was diagnosed, I was on camera being diagnosed. I was getting sicker and sicker on film. So I was having to take everyone on the journey with me because I had no choice. I had to finish this season of the show. It was important to me. It was important to our crew. It was important to, you know, Linda and myself and Liz. Like, we had to. Like, we were gonna stop, actually, because it was getting so hard for me to do anything. So anyway, for me, it was kind of like, fuck everyone. Like, this is. This is it right now. Like, you're watching this in real time. I mean, I was taken down in four months. Like, all I had was tingling in my toes. And four months later, I'm not able to walk to set anymore. So I had no choice but to talk about it, to be honest about it. And also, I was embarrassed. Like, there I was. I'd gained 50 pounds from the medications, and I'm sitting in all the scenes, and you can tell that I'm, like, not walking well. Like, I had to be really honest and say, this is the deal, guys. I can't hide this.

[Seth Meyers]

And so you didn't have that sort of window of time that Jamie had where you sort of came out on your own, on your own volition because you had matured, grown, felt like it was. Would be important to share with people. It just sort of happened to you, like, hit you like a ton of bricks.

[Christina Applegate]

Yeah, I had to. From day one of filming that year, I was already sick and didn't know it. They were saying that I had peripheral neuropathy for a long time. And then finally my neuro was like, we got to do an MRI on your brain. And he called me and said, I need to talk to you. Today it was a Monday at 7pm and they wanted me to do another scene that night. And I said, I can't, because I have a feeling this is not going to be good news. And I went home from work and got on, and the first thing he said was, I'm so sorry. And that was it. I had to call and go, guys, this is Ms. This is way bigger than we understood. And this is for my life. So it was like scrambling to try to come up with ways to get me to set that it didn't have to be in a wheelchair, but if I was in a wheelchair, so people didn't see it, like, and, you know, not telling the crew right away so that I could process. It was a lot of stuff going on.

[Seth Meyers]

Okay. So I live in New York City, where everything is a competition, even illness. Like, if. If a person cannot have cancer, because everybody in class is going to tell you how they had cancer worse and how what they went through is worse. And you literally. And I'm not saying I have cancer. That's not what I'm announcing here.

[Christina Applegate]

Let's knock on our head.

[Seth Meyers]

Yes. I'm just. I'm just. Yeah, let's knock on everything. Knock on my headboard.

[Christina Applegate]

How tall is yours? Because mine's six feet tall, so I don't know.

[Seth Meyers]

Is yours, too? I'm telling you, I'm Albert.

[Christina Applegate]

You've been in the bed.

[Seth Meyers]

It looks like you're in my bedroom.

[Christina Applegate]

That's really funny. Okay.

[Seth Meyers]

From my vantage point, you could be in my bedroom.

[Christina Applegate]

Okay.

[Seth Meyers]

But do you feel like people will come up to you and instead of just, you know, saying thank you for sharing the story, they then feel the urge to regurgitate their story onto you?

[Christina Applegate]

I get a lot of, like, I know a friend of a friend who cured Ms. Through this, right? And I'm like, that's amazing.

[Seth Meyers]

Right?

[Christina Applegate]

Because there's, like, millions of us that still have it, right? And. But congratulations to your friend of your friend's cousins, right?

[Seth Meyers]

Dogs who ate a grapefruit, and now.

[Christina Applegate]

It'S gone and they're cured.

[Seth Meyers]

Yeah.

[Christina Applegate]

You're like, yeah, that's amazing.

[Seth Meyers]

Yeah, got it.

[Christina Applegate]

If that's the case, we'd all be doing a jig, but we can't really dance anymore. Jamie.

[Seth Meyers]

It'S a good thing Ms. Doesn't affect comic timing.

[Jamie Lynn Sigler]

That's right. That's right. If anything, it makes it better and darker. I don't know if I get that per se, but I do. You know what I do get, which was a lot of what I didn't want, when I didn't want to come out about it was for this reason. I just didn't want the stares. I didn't want the long looks of sympathy. I don't like that type of attention. I don't do well with that type of attention. It makes me very self conscious, it makes me feel judged, it makes me feel limited. Fortunately, I am surrounded by incredible group of family and friends that do the opposite and like push me to do things that even I think I can't. But I don't like. I don't like the looks of sympathy. Those are the things that bother me the most.

[Seth Meyers]

Right.

[Christina Applegate]

And the, and the. How are you? Yeah, are you. And you're like fuck you. Don't even ask me how I am. How do you think I'm doing? You know, it's bubblegum and posies. No, it's not.

[Seth Meyers]

But in show business it is like a very, it's a shallow business and it's not known for its like circle of like fortitude. Did you feel that people like rallied around you or sort of abandoned you? How annoying is it when you come back from this store, aa batteries in hand, ready to sit down and watch your favorite show just to realize your TV remote control only takes AAA batteries and you're all out? Of course you are. Who buys those? Well, did you know Walmart has Express Delivery? It's a total game changer for those need it now moments. And let's be honest, those want it now moments too. Walmart Express Delivery gets your order to you in as fast as an hour. And it's not just groceries. We're talking everyday essentials when you need them the most. Baby wipes. Check. Pet food. Got it. Cereal for the kids. Breakfast? Yep. Birthday candles you forgot to grab at the store. Covered. Oh, and one of the best parts about Walmart Express Delivery is it's so convenient. You can handle everything straight from the app. It's quick, easy and saves you time for, well, everything else going on in your busy life. Try Express Delivery today and get free delivery with promo code Express. That's code. Express promotion. Valid for first Express Delivery Order $50.00 Minimum Sub to availability restrictions apply. If you know anything about me, it's that I love to do laundry. It just gives me such satisfaction. But did you also know that skincare can start in the laundry room? The first step of a sensitive skincare routine is choosing the right laundry detergent. All free Clear is the number one detergent brand recommended by dermatologists for sensitive skin. All free clear is 100% free of dyes and fragrance allergens. It provides an effective clean that's gentle on the skin while removing impurities like dirt and body oil that can irritate your skin. It's made with eight carefully selected ingredients to fight stains and be gentle on skin. How great is that? All Free Clear has been a game changer for me. It leaves my clothes feeling fresh and my skin feeling happy. I especially love that it doesn't give my laundry a strong artificial odor like some other brands. You know what I mean? For an effective skin friendly clean wash with All Free Clear, Thrive Cosmetics makes vegan and cruelty free products you can depend on for everything from daily wear to show stopping self expression like their liquid Eyelash extension mascara and their brilliant eye brightener which I'm loving. But here's the greatest part. This company is bigger than beauty. Thrive Cosmetics have donated over $150 million worth of products and cash funds over to 600 giving partners the U.S. their donations support eight major causes including those affected by cancer, homelessness, domestic abuse and more. So while I really like their products, it also really feels good to know that my purchases are supporting others. Try your new trusty favorites with an exclusive set for our listeners. New customers can get the Liquid Eyelash Extensions mascara and a mini size Brilliant eye brightener at a special set price with free shipping@thrive cosmetics.com off camera that's Thrive Cosmetics. C A U S E M E t I c s.com off camera did you feel that people like rallied around you or sort of abandoned you? This is to both of you and simultaneously, one at a time, whatever I felt rallied around.

[Christina Applegate]

But I also didn't want to be around anyone too.

[Seth Meyers]

Right.

[Christina Applegate]

You know, there's this whole part of me for the last like almost three and a half years or however long it's been that I just want to be alone. I, I, it's too hard to do things or go places. Like we've talked, you know, Jamie and I have spoken ad nauseam about this. Like the build up to have to do something starts a week before you have to go somewhere. Yeah. It's like this panic that you go through of like okay, are there a lot of stairs? Is you know, what's the weather going to be like what shoes am I going like all that stuff? Right, James?

[Seth Meyers]

Yeah.

[Jamie Lynn Sigler]

And you just, you know, I think that we have a very unique perspective of living a life for a very long time as an able bodied person and now living as a disabled person. And there are Times where you, like, go up and out about your day. And then especially on a film set where I, like, you were saying, like, we were kid actors, like, you're bred to be good girls. You're bred to just show up, not be a problem, not stand out in a bad way. You know, be really easy to work with, be very likable. So then you give me something like Ms. When I have to show up. And I feel. I mean, I would apologize. I'm so sorry. Like, I don't think I can really, like, walk this long for this scene. And you find yourself just feeling like everything you didn't want to be. But I think that I had to learn over time that me advocating for myself and Christine and I talk all the time about setting boundaries for what we can and can't do is the only way that we can do our jobs. And it takes. For me, it took a very long time to be able to do that without feeling like I needed to apologize constantly for it.

[Christina Applegate]

Jamie was, like, integral for me because when I was at work, she said, okay, now this is what you have to do. Now. Maybe it took her a longer time because of fear of, you know, saying, hey, you know what? This is the way it is. I can't do all of this stuff.

[Jamie Lynn Sigler]

Yeah.

[Christina Applegate]

And it took them a while to stop asking me if I had another take in me. And when I'm like, at that some point, you have to just be like, guys, let's have a meeting.

[Seth Meyers]

Right?

[Christina Applegate]

When I say I can't, I'm really saying I can't. Because you know that I would push. I've been pushing my whole life. Whether it was when I had cancer and working at the same time or breakups and bad things happening in my life, I've always, like, you know, buckle up, buttercup.

[Seth Meyers]

You bite down on the rag and you go and do it. And like, it's that simple. And what's astounding to me is that flash forward 20 years later, you're in a position where Jamie has to help you navigate how to be on set. Because people still don't get it. They still assume, especially the girls, are gonna not be difficult, not make a problem and give them a thousand takes if they ask for it. Just because. Just because. And so I'm curious, did anybody ever nodding your own head, but did anybody make you feel bad, like, well, we're working with you. What else do you want us to do? We let you do one less take. Did you ever get any of that?

[Christina Applegate]

I was in a female Run show.

[Seth Meyers]

Yeah.

[Christina Applegate]

I think that's all I need to say, you know, like one dude, and he's awesome, Right. His name's Joe and he was amazing. And all they wanted to do was make sure I was okay. Now, when they didn't understand, it would actually get my co star very frustrated. And I remember her, like, saying, hey. She said, no, right? Like, we're done here and I support her in this. And it took that, but it wasn't like someone. They were like, they were upset about it. We were all confused. I mean, I didn't know anything about ms, knowing people that had had it. I didn't know it was going to take me down this way. And so I was so confused and scared and all of that. So it was nice having advocates, to be honest with you. I had advocates, and that felt really, really nice.

[Seth Meyers]

Yeah. Thank God. I'm just curious about, you know, you're not just working actors, you're also parents, and children are draining, so I'm so curious. On the best day, you feel like you've been hit by a truck. So tell me about navigating Ms. While raising kids. So, Jamie, you have two sons, right?

[Jamie Lynn Sigler]

Yes.

[Seth Meyers]

And you have Sadie Christina. Right.

[Christina Applegate]

And she's 13, 14 now.

[Jamie Lynn Sigler]

14.

[Seth Meyers]

Oh, God, it's the worst age.

[Christina Applegate]

I know.

[Jamie Lynn Sigler]

It's the worst age.

[Christina Applegate]

See, beach, we're going through some stuff right now.

[Seth Meyers]

Do you want to send her to live with me for like, six years and then I'll return her when she's.

[Christina Applegate]

Like, no, I don't get up in the morning with that because, I mean, I get up because of her. That's like, yeah, she's the reason I'm still here and trying. Yeah. But she did say to me, and we got in a big thing the other day, and sorry, Sadie, but it has to be said. She says, I miss who you were before you got sick.

[Seth Meyers]

Yeah.

[Christina Applegate]

And that just like, it's like knife to heart because I miss who I was before I got sick, too. Very much so. Every day of my life at such a loss. Anyway, see, now I'm gonna cry. See, this is my problem. I'm either like extremely traumatic and crying, or I'm cracking myself up so I'm never in between. Jamie.

[Jamie Lynn Sigler]

That'S. That's the truth. It's. It's how it is. And I, I. Those words, I mean, I've have gone through my own head. I think I judge myself the most as a mother through this journey. I think that's been the hardest part for me. I have two Children who react to it in two very different ways. My older son, he looks at me all, you're gonna beat this thing one day, Mom. Like, he's like my own personal Ted Lasso. Like, he thinks. Like, he congratulates me all the time for how hard I work. He tells me I'm doing amazing. He's my cheerleader. My little one hates it. He's mad that I can't run like all the other moms. He points out all the time why he. I walk like an old lady. That's what he says. Or, like, why I can do this and I can't do that. And I think that's very healthy and I welcome it. And I want him to be able to express himself with me. I don't want him to feel. Feel bad because of how he feels about this, because this affects our entire family. My husband has to make sacrifices every day. So do my kids. For me, so do I. But this is just. I'm the mom they chose, and that's what I have to kind of remind myself all the time.

[Seth Meyers]

Can you tell me about your. I know, like, each treatment is, like, individualized. It's, like, patient specific. And. And. But do they give you. Is it. Are you constantly in a space where you are experimenting? This didn't work, so we're going to try this. That stopped working. Now we try this. And so when that happens, do you have, like, these great, like, spans of hope and things are getting better and then it's crushed. Walk me through that roller coaster.

[Jamie Lynn Sigler]

That's.

[Seth Meyers]

That's like.

[Jamie Lynn Sigler]

I mean, I think that's where this can sort of be universal for people. Do you know what I mean? When it comes to healing and whatever they're looking for in their lives. But yes. Look, when you're living with something like Ms. And something comes across your algorithm or your feed of, like, it's parasites, or it's, you got to do this or you got to do that. Like, I would be lying if I didn't say that I don't scroll through and do all my. Like, should we try this? Should we try this? Or days that. I have a couple of bad days. Next thing you know, my husband's up all night, like, researching, like, well, I heard of this stem cell in this country, and. Yes. And have I tried a lot of things? Yes. Have been. Have I been heartbroken hundreds of times? Yes. I would say the one thing that I'm consistent with is my Ms. Medication. But as far as anything experimental on top of that, I mean, how could we not be open to it. How could we not be open to something that could potentially change our lives? And I do have a lot of hope. And sometimes I get mad at myself for the hope and I get down at myself for having it. But we're still young in so many ways. So it's just. It's just hard to think that you would go through your life until you die and never feel better.

[Christina Applegate]

I was going to say, because I want to ask you this, Jamie, is that my neurologist has stopped my infusions for now because my B cells were still really low. So this is like what we deal with is like they want to kill your B cells. It's like almost like a chemo, but not. But it is because it's doing something really gnarly. But she's stopped me and now I'm flipping out. Not stopped completely, but like, it's been almost a year now since I've had one. And I'm scared, to be honest with you, that if I wait too long, am I. Is my getting worse because I'm not doing it, I guess. I don't know. These are my questions that I think about this every day.

[Jamie Lynn Sigler]

I think you have to put your. Your trust in your doctor. But also I think what I have gotten really good at is listening to my gut and my own intuition, because at the end of the day, it's your body and nobody knows it more than you. And I've had to speak up for myself many times about changes that need to be made or things that I felt were right or not right. But it's a full time job. It's a full time job to live with a chronic illness. There's never a day that you can just take a day off from not thinking about it, you know?

[Christina Applegate]

Yeah, it's a lot of management. Like today, I was gonna say, like a couple days ago, I had to go out and I had to do a lot of walking. And like, I pushed, I pushed, I pushed because I didn't want to, like, take focus away from where we were. And like today I like fell going to the bathroom. Like, you know, you never know what's gonna happen. It's really such a bizarre condition disease that you can be like, oh, okay, I did that. I went hours and, you know, stuff. And then I got up today and I was like, oh, this is great. I'm gonna end up soiling myself because I can't get to the bathroom. Like, it's just that kind of thing. It's really so fucking Weird.

[Seth Meyers]

How often do you talk to your doctor and do you have the kind of relationship with her where you can say, I feel that at this stage, I really need an infusion right now.

[Christina Applegate]

I. I've been on it, like, constantly. And they're like, let's wait till May to do your next blood test. And if my cells have gone up, then I'm doing a disservice to myself, too. So I, like, want to do. I call her all the time, like, can I just do the. The blood work? And she's like, no, because you don't need it right now. But so then we get into, like, a thing, you know, where it's, like, back and forth where I'm, like, begging, like, please. Like, please. And she's like, it's too hard on your body. And I don't want you taking it too much because it is. It's the.

[Seth Meyers]

It wipes you.

[Christina Applegate]

It's. It knocks you down. Your immune system goes to, like, for a little while.

[Seth Meyers]

Yeah.

[Christina Applegate]

So it's. Yeah, it's gnarly, but I don't know. I don't even know what I'm talking.

[Seth Meyers]

Well, when your immune system goes to sweating.

[Christina Applegate]

Because now I'm mad at my doctor. Now I'm, like, really mad. Like, look at my glasses. They're fogging up.

[Seth Meyers]

No, it's okay. I am pissed off.

[Christina Applegate]

Listen, I'm about to make phone calls in a minute.

[Seth Meyers]

There's a reason our podcast is off camera so that nobody ever is also off camera. I don't understand these people that want to do a podcast and be seen. My goal is to get my talk show off camera. Like, I just want to do the talk show.

[Jamie Lynn Sigler]

You're too pretty.

[Seth Meyers]

No, but I feel like we could do it, like, behind a scrim or a screen and just. You know what I mean? Like, Jan and I talk about this a lot. When the shit hits the fan, you really find out who your friends are. You really find out who's, like, a true blue and who is See you later. And have you. Have you experienced that? Has it been mostly a pleasant surprise, or have you been like, has there been a person that has shocked you with their lack of support for me?

[Christina Applegate]

No. I've had a very small. I have live in a very small bubble of friends. They're not in the industry. They're not actors, they're bartenders. They're, you know, hairstylists. Like, very small. That I've known for 30 plus years. That's my crew, and they are Ride or Die. So for Me, if anything, I have to turn them away, right? From wanting to come see me because I'm like, I'm re watching New Girl again, so I don't want you here. I. I wanna. I wanna watch New Girl alone.

[Seth Meyers]

Yeah.

[Christina Applegate]

And giggle. It's such a good show. We should all revisit it.

[Seth Meyers]

Sorry.

[Christina Applegate]

So I had that, but I did. When I had cancer, I. I was friends with some people in this industry and I got an email from one of them that says, I can't be friends with you anymore because you have cancer. That's all? Yeah, that's all. We're not going to mention who it was. We're not going to mention under the circumstances, but that was an email I got and I was like, you're fucking kidding me. What? That was it never talked to this person again.

[Seth Meyers]

You have to tell me off camera.

[Christina Applegate]

Off camera, you're gonna be shocked.

[Seth Meyers]

And then I will kill them. Because I'm from New Jersey. Jamie, with respect to your show that I watched, and I was like, what's the problem? This is just New Jersey. This isn't even. This is not a mob show. This is just a Life in New Jersey show.

[Jamie Lynn Sigler]

Oh, man.

[Christina Applegate]

Yeah, that one. That one still gets me sweaty. And that was in 2008. And I still get sweaty. Look at him fogging up again.

[Seth Meyers]

So, like, what gets you through the hard days? Like, is there a thing that either one of you, both of you do, that gets you through, like, a shit day?

[Jamie Lynn Sigler]

So I used to, for a long time, only ever go through my shit days alone. I didn't think that anyone could ever have the space to hold for it. I didn't feel like it was the right thing for me to do to put it on anyone. And that took its toll. So I have gotten better thanks to some urging by my friends to reach out. In fact, it got so bad at one point where I think I was struggling so much in. My friends knew and I wasn't saying anything, that we all got together for like, a little brunch. And I thought, you know, it's just a normal thing. And they all looked at me and they were like, jamie, we will not let you leave this table until you scream. And I was like, what are you talking about? They're like, we can't watch you muscle through this anymore without telling us. It's hard. Like, it's getting awkward for us. Sometimes when you're just like, I'm fine. I'm like, they always say on my tombstone, it'll say I'm fine. Like, please just let us in on this with you. We want to be here for you. And it was a really life changing moment for me when they did that. Because we're not, we're not meant as human beings to go through anything alone, you know, And I didn't do anything to deserve this. I've done a lot of work around all of the terrible and wrong beliefs that I've had around why this is in my life. And in the end of the day I just have to accept it, but that doesn't mean that I have to go through the shitty days alone. Yeah, and then there's Bravo.

[Seth Meyers]

Yeah, and then I was gonna say Bravo.

[Christina Applegate]

That's it, Bravo. We had Andy on us just recently and I know you two are, yeah, close. Andy, that was like our most exciting guest, like, I think probably ever for us in that sense of like, we're such, we are such Bravo obsessed geek fans.

[Seth Meyers]

Well, here's the thing. He, like, he's not just like a vanity produce, he is in it. You know what I mean? Like, he, you're so lucky he's.

[Jamie Lynn Sigler]

That you have him on your speed dial.

[Seth Meyers]

Well, listen to this. So I'm going to tell us more, please. My, my. So my son graduated film school in 2020, the pandemic of 2020. And, and he had a couple of jobs lined up out in la. They quickly vanished and Jan found. What was, what was that? Was it. What's the resume place that you told him to check, to put, put his resume on.

[Seth]

Oh, staff me up.

[Seth Meyers]

Staff me up. So she, Jan is like, listen, nothing is shooting. The industry is closed down. You should go on staff me up and see if you can get a job like as a day producer on anything. Just like, just work is work, right? So he's like, you know, he's this young kid and so he starts getting, you know, day hires on a cooking show, on this kind of show, that kind of show. Slowly but surely he starts, he starts getting work regularly and we're happy because he's finally off the tit. And I'm like, okay, great, we got one out of the house and he's got jobs and now he can pay his own rent. And this is great. And so he tells Mark and me at dinner, oh, I've got this new job. It's, it's pretty cool. And I was like, oh, what is it? And he's like, well, I can't tell you. I had to sign an NDA. And I was like, you had to sign an NDA? We paid for your fucking film school.

[Christina Applegate]

You were telling us.

[Seth Meyers]

Now you were telling you will tell us. And he's like, no, I can't. I signed an NDA. And it's like, if I tell you, then I'm not a trustworthy person. And I was like, okay, fine. So all of a sudden I'm at work and he goes, hey, mom. He sends me a picture of a Cookie monster cupcake. And he goes. He goes, check this out. Is this the bakery where you used to get my cupcakes when I was a little kid? He sends me this text and I go, are you filming Teresa Giudice's wedding for the Real Housewives of New Jersey? And he was like, what? And I go, is that where you are right now? Cause it was summer. It was summer. He's at a bakery that I know very well. It's a wedding bakery, but they also sell other shit, like kids cupcakes. And that is where I used to get his cupcakes. And I was like, you are in Franklin Lakes, New Jersey, and you are filming the Real Housewives of New Jersey Teresa's wedding. And I know it. I know. I don't even get.

[Christina Applegate]

I don't.

[Seth Meyers]

I don't care. I know that's what you're doing. And that was like his first, like, big time job. Big time.

[Jamie Lynn Sigler]

What a moment.

[Seth Meyers]

But now he's.

[Seth]

Now he's a producer on New York.

[Seth Meyers]

He does all the Real Housewives New Jersey summer house. Summer house. Are you so proud? Oh, my God. Do you know what I do every time I see a picture of his name on Jenna Lyons tit? I freeze frame the TV and I take a picture and I send it to him. I'm like, jenna line's tit. Or like, then I'm like, I like, I just like whoever's tit he's on, I'm like, melissa Gorgas tit. And I just send it to him. I'm like, you're on Melissa Gorgas Tit. Like, I love seeing his name in the credits.

[Christina Applegate]

That is so exciting for us.

[Seth Meyers]

So cool.

[Jamie Lynn Sigler]

So cool.

[Seth Meyers]

I would say, I would say have him on the podcast, but he won't tell you anything.

[Jamie Lynn Sigler]

He won't tell me anything.

[Christina Applegate]

I was going to say, we really want you on, but I think now we're to going. I think we're gonna bump you.

[Jamie Lynn Sigler]

Can you just at least send us photos? We just would love the photos. Just send us like little photos and we'll try to, you know, investigate or guess where. Where he's at.

[Seth]

We got mentioned on Real Housewives of Beverly Hills this season because of Kyle.

[Seth Meyers]

Yes.

[Seth]

And Dorit because Dorit was mad that Kyle went on our podcast.

[Seth Meyers]

Kyle went and they mentioned it on the.

[Seth]

On the show.

[Christina Applegate]

And we're like, we made it.

[Seth Meyers]

We're finally made it.

[Jamie Lynn Sigler]

I get it.

[Seth Meyers]

We're like, like our little podcast is on Beverly Hills Housewives. We are now housewives famous.

[Christina Applegate]

You made the big time, Kelly. You finally made it.

[Seth Meyers]

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[Christina Applegate]

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[Jan]

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[Christina Applegate]

Talk about sexual health. That makes sense. No shame, just facts.

[Jan]

This visit bedsider.org today.

[Seth Meyers]

Have you interviewed a housewife yet, besides Andy?

[Christina Applegate]

No, no, we're reaching out to a couple right now.

[Jamie Lynn Sigler]

Yeah, we're a little. We have Jesse from summer house.

[Christina Applegate]

Yeah, we have Jesse Solomon.

[Seth Meyers]

Okay, that's. That counts.

[Christina Applegate]

I was actually asked many years ago, before Sadie was born actually, to be a Beverly Hills housewife and. Okay, so this is the funniest thing about it. I was like, hell, no. First of all, no. And second of all, I sit here, right? Like, what? I don't like going anywhere. So I don't like eating big meals. I don't like hair and makeup. Like, all the things that it was like. It's like, my nightmare. And so my daughter starts elementary school, and we meet this beautiful couple, and one of them is the executive producer here for Beverly Hills. And I said, oh, yeah, that's so weird. I was asked. He goes, yeah, I'm the one who asked. It was before I had met him.

[Jamie Lynn Sigler]

Wow.

[Christina Applegate]

And I said, do you regret that I didn't do it? He goes, oh, my God. You'd be the most boring fucking housewife on the planet. Like, well, because the worst.

[Seth Meyers]

You're not. Here's the thing. And I say this with love and respect, right? I say this with love and respect. You're a very pragmatic, not unhinged person. And I think there has to be a certain level of really wild thinking and wild behavior. And I feel like, you know, I can say this to you because we are so similar. I never leave my house. I don't go anywhere. I don't do anything. And I. Besides my job, like, besides going to my job, I just immediately come home, and then I'm back in my sweats, and I'm back in bed, and I'm watching reality tv. So that's like. Like, unless, like, I would be the kind of housewife where they'd be like, I guess we're gonna go shoot Kelly watching other housewife franchises. It's gonna be the weirdest episode ever, right? Like, that would be your episode.

[Christina Applegate]

Yeah. He was giggling so hard when we were talking about it because he was like, knowing you now, he's like, I would have never asked. Like, honestly. Cause he knows that, like, I'm dirty. I rarely take a shower. I don't like to leave the house. I'm a little curmudgeony. I roll my eyes a fuck ton at people.

[Seth Meyers]

Well, that would be good to watch, though. That would be good.

[Christina Applegate]

That'd be like, ugh. Like, one time I did that somewhere, and my assistant, like, hit me. She's like, your face. You're literally listening to someone and you're making faces at them as if you want to kill them. I was like, now it goes, yeah.

[Seth Meyers]

When they tell you, smile, Kelly, smile. Do they ever say smile? And I'm like, I am smiling. And I'm like, in my head, I think I'm smiling. Why does it not look that way.

[Christina Applegate]

No. My daughter was saying when, you know, she misses who I was, she's like, you just always look mad. I was like, I never looked mad before because I was mad.

[Seth Meyers]

Yeah, I was pissed off a lot.

[Christina Applegate]

Of people all the time, but I guess I just look super duper mad all the time, except for when I'm cracking myself up.

[Seth Meyers]

You said you're taking a break from acting. Do you see a. A world in which it's just a temporary break? You go back once you're. Once your health is like.

[Christina Applegate]

We had Judd Apatow on. Well, he's coming up. I don't know when at some point, but we interviewed him last week, and both of us were like, we will do whatever to be in one of your movies, and you can write a whole scene with us just sitting, and we're gonna be really good. Waist up. We're gonna be really good.

[Seth Meyers]

That would be like, a really funny scene.

[Jamie Lynn Sigler]

Well, you know, it's just because there is so much humor and heart when it comes to this type of storytelling. But for me, I think that, like, I have done so much acting where we worked around this, and I've been very grateful to the employers and the crew and the teams of people that have made me feel comfortable and have made that possible. But I am now at this point where, like, whenever I'm up for a role or I'm talking about a project, I'm like, well, this. This is what I come with. So as long as you're okay with me walking this way, like, I don't want to cover this up anymore. I'm doing myself a disservice. I'm doing Ms. Community disservice. Like, this doesn't define my life. I have many roles in my life. I have a very full life. And I think it's, at least for me, a tricky thing to find exactly what that right thing will be. And if I don't find it, I don't find it. But I don't want to deal with the stress of trying to pretend I'm something that I'm not anymore.

[Christina Applegate]

I think Jamie has it. She's so much stronger than I am. Like, I don't know if you follow her on Instagram. Hold on a second. You were at a festival, dude, for what, a couple of days?

[Jamie Lynn Sigler]

But did you see how I look? So I go, my husband helps put on a country music festival here in Texas every year. It's called Cattle Country. It's so fun. But I walk around, I hold on to My girlfriends, when we have to go across the thing, my husband literally throws me in a rag wagon with my cowboy boots hanging off the side and pushes me across. We figure it out. They set me up in a corner near a pole and I dance to all the people. You know, I figure you figure out ways to still participate in your life, and that's what time has given me.

[Christina Applegate]

And in hot.

[Jamie Lynn Sigler]

We'll get there.

[Christina Applegate]

Jean shorts. Hot jean shorts with gorgeous olive colored, beautiful legs. She's the most.

[Jamie Lynn Sigler]

You love my legs.

[Seth Meyers]

Jamie's. Jamie's sexy.

[Christina Applegate]

I'm a sexy with Jamie's legs. Like, I can't.

[Jamie Lynn Sigler]

I don't.

[Christina Applegate]

But I was just. As you were talking, Jamie, I was like, why can't we play characters that like. Because our walking is a little compromised. That they just dance when they walk? Like, they kind of do like a. Like everything's like a little weird, a little awkward.

[Jamie Lynn Sigler]

You could teach us that. You're the perfect gal for that. Let's do it.

[Seth Meyers]

I feel, I feel like Judd Apatow needs to write this buddy comedy for the two of you. I really do. Listen, I think it would be. I'd love it. I love his writing anyway. I think he understands women. I really do. Like, I think he gets it.

[Jamie Lynn Sigler]

Well, he was saying that Leslie really does that for him. He was. It was cool. He was saying in the interview that she really helps him get the perspective of the woman when he's writing.

[Seth Meyers]

Yeah.

[Jamie Lynn Sigler]

We were talking about how great she is. Because my friends and I all say that Leslie man is a verb because, you know, when kids fuck with your kids, it unleashes apart a rage inside of you. Like the thing, things I've wanted to say to other 10 year old children, I'm not proud of, but like I said, I'm like, I want to go full Leslie Mann on those children.

[Seth Meyers]

Out of that person.

[Jamie Lynn Sigler]

Yeah, that's right.

[Seth Meyers]

I got it.

[Jamie Lynn Sigler]

That's right.

[Seth Meyers]

But those kids always have moms, just so you know.

[Christina Applegate]

Of course they do.

[Seth Meyers]

They always. It's like, for sure. Well, I gotta tell you, I loved having you both on the podcast. Thank you so much for being here.

[Christina Applegate]

We love being with you. We could talk to you for hours. You need to come on ours and then we need to come to New York and we want to come see you.

[Seth Meyers]

Please.

[Christina Applegate]

I know it's been too long.

[Seth Meyers]

Listen, I love seeing both of you and I wish you all good health. I, I honestly, it's like, I wish I could. I wish I could infuse you with good Health right now. You know, I have nothing but love and well wishes for you. And I want to remind our listeners, don't forget to check out Jamie and Christina's podcast. You're not the only one with a podcast, Albert. It's called Messy. It's incredible. It will make you feel things and you will be utterly entertained and moved. And thank you so much.

[Christina Applegate]

Thanks, Kelly.

[Jamie Lynn Sigler]

Thank you so much.

[Christina Applegate]

I love you, girl.

[Seth Meyers]

Love you so much.

[Christina Applegate]

Always have. We've always said we're gonna be best friends.

[Seth Meyers]

It's happening. It's happening one way or the other.

[Christina Applegate]

Yep.

[Seth Meyers]

Bye, babe.

[Christina Applegate]

Bye, guys. Bye.

[Seth Meyers]

Well, that was that, Albert.

[Albert]

That's it.

[Seth Meyers]

Did you learn anything today?

[Albert]

I love them.

[Seth Meyers]

Yeah, yeah.

[Albert]

They need to come here, the three of them. Get in your bed, watch tv.

[Seth Meyers]

Well, Christine is in my bed right now. It's the craziest thing I ever saw. That was wild. That's it, everybody. We can't wait to talk off camera next week. So check our socials. We have socials.

[Seth]

We do have socials.

[Seth Meyers]

What do we have?

[Albert]

Very social.

[Christina Applegate]

We have.

[Seth]

Let's talk off camera.

[Seth Meyers]

Oh, but is it like Instagram?

[Seth]

Yeah, okay, Instagram.

[Seth Meyers]

Check our socials, which means Instagram. For the next live series, XM call in show on radio Andy. That's right. We're doing live call ins on radio Andy. The number to call is 844-305-2639. That's 844305, Andy.

[Christina Applegate]

Oh, cute.

[Seth Meyers]

Andy. A N D. We're gonna post when.

[Seth]

We'Re doing it for people to call in. We'll be like, call in now. We'll do like an Instagram live and have people call in and it's a.

[Albert]

Five o' clock drive.

[Seth Meyers]

Oh, five o' clock drive. That's right. We're doing all sex.

[Seth]

We're not doing all sex.

[Seth Meyers]

We're doing all sex. Because five o' clock is the horn dog hour.

[Albert]

That's right.

[Seth Meyers]

So get your horn dogs ready because we're discussing.

[Seth]

We might talk about a few other things in sex. But yes, there will be sex.

[Seth Meyers]

There will be sex, but mostly sex. Jan will. Albert will tell you where to get a cheesesteak on the turnpike.

[Albert]

That's right.

[Seth Meyers]

And then Jan is going to talk about the turnpike. Jan is going to talk about her fantasy one night stand with Bob Iger and David Muir.

[Albert]

That's right.

[Seth]

Together.

[Seth Meyers]

Well, see you next time, everybody. Bye. Let's talk off camera with Kelly Ripa is a production of Malojo Productions. From Malojo, our team is Kelly Ripa Mark Consuelos, Albert Bianquini, Janchelade Sarah Seth Bronquist, Roz Therian, Devin Schneider, Michael Halperin, Julia Desch and Team Radio Andy Lisa Mantineo, Scott Marlowe, Jake Getz.

[Christina Applegate]

If you're.

[Jan]

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[Kelly Ripa]

Don't take Zepbound if allergic to it or if you or someone in your family had medullary thyroid cancer or multiple endocrine neoplasia syndrome type 2. Tell your doctor if you get a lump or swelling in your neck. Stop Zepbound and call your doctor if you have severe stomach pain or a serious allergic reaction. Severe side effects may include inflamed pancreas or gallbladder problems. Tell your doctor if you experience vision changes, depression or suicidal thoughts before scheduled procedures with any anesthesia. If you're nursing pregnant, plan to be or taking birth control pills. Taking Zeppan with a sulfonylurea or insulin may cause low blood sugar. Side effects include nausea, diarrhea and vomiting, which can cause dehydration and worsen kidney problems.

[Jan]

Discover the weight loss you could be bound for. Ask your healthcare provider about Zepbound or call 1-800-545-5979. Explore Savings Options regardless of insurance status at Save on zeppbound.com Terms and conditions apply.

[Unknown]

Are you on the right track? What do you want to be remembered for? Is this really all there is? Asking big questions about your life can feel overwhelming, but the Hidden Brain Podcast, hosted by me, Shankar Vedantam, is here to help you get started. All through the month of July, Hidden Brain will bring you our your 2.0 series with a special focus on purpose, passion and meaning. If you're feeling adrift, alone or burned out this series is for you. Join us.