Gene Therapy and Genetic Cardiomyopathies

Guest: John Giudicessi, M.D., Ph.D.

Host: Malcolm Bell, M.D.

In this podcast, listeners will learn what gene therapy is and the types of genes therapies under development for an array of genetically mediated cardiovascular disorders. In addition, active and upcoming gene therapy clinical trials for the treatment of specific arrhythmogenic, dilated, hypertrophic and restrictive cardiomyopathy genotypes will be discussed.

Topics Discussed:

What is gene therapy?
How do gene therapies differ from conventional management of genetic arrhythmogenic, dilated, hypertrophic and restrictive cardiomyopathies?
Are there different types of gene therapies?
What gene therapy trials are currently active or upcoming at Mayo Clinic and other institutions?

Connect with Mayo Clinic's Cardiovascular Continuing Medical Education online at https://cveducation.mayo.edu or on Twitter @MayoClinicCV and @MayoCVservices.

LinkedIn: Mayo Clinic Cardiovascular Services

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No CME credit offered for this episode.

Podcast episode transcript found here.

Recorded 21-October-2025