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Host: Darryl S. Chutka, M.D. Guest: Benjamin Lai, M.D. Substance use disorders are chronic and often relapsing conditions associated with compulsive substance use. They result from a complex interaction of chemistry within the brain, often combined with genetic and environmental issues. Common substances involve alcohol, stimulants, sedatives and opioids; opioids commonly prescribed by health care clinicians. Early identification of patients and care coordinated with behavioral health specialists is the best approach to improved patient outcomes. The topic for this podcast is “Addiction Care and Empowering Non-Specialists”, and my guest is Dr. Benjamin Lai, A Family Medicine physician from the Department of Family Medicine at the Mayo Clinic. Connect with us! Mayo Clinic Talks Podcast Season 6 | Mayo Clinic School of Continuous Professional Development

Host: Darryl S. Chutka, M.D. Guest: Michael Mueller, M.D. Fibromyalgia is a chronic health problem commonly seen in a primary care setting. It can be challenging to diagnose and even more so to manage. It can have a devastating effect on a patient’s lifestyle, and patients will commonly go from provider to provider seeking relief for their chronic symptoms. We now have a better understanding of the pathophysiology of fibromyalgia; unfortunately, the treatment remains less than optimal. What do we know regarding the cause of the symptoms in fibromyalgia? How can we efficiently establish a diagnosis in patients with the condition without excessive testing? How do we explain the disorder to patients and what’s the long-term outlook for patients? These are some of the questions I’ll be asking my guest, Dr. Michael Mueller, an internist in the Division of General Internal Medicine at the Mayo Clinic as we discuss “Fibromyalgia”. Connect with us! Mayo Clinic Talks Podcast Season 6 | Mayo Clinic School of Continuous Professional Development

Host: Darryl S. Chutka, M.D Guest: Mark D. Tyson, III, M.D., M.P.H. Bladder cancer is one of the most common malignancies worldwide, and primary care clinicians are often the first to evaluate patients with bladder cancer. The symptoms are usually subtle and may include either gross or microscopic hematuria. The decision in whether to investigate these presenting symptoms can often impact early diagnosis and the patient’s outcome. When should we investigate hematuria? What should an evaluation of hematuria consist of? What is the treatment for bladder cancer? How should patients with recurrent bladder cancer be managed? What role does the primary care clinician play in the long-term management of patients? I’ll be asking these questions and more of my guest, Dr. Mark Tyson, a urologist at the Mayo Clinic as we discuss “Bladder Cancer”. Connect with us! Mayo Clinic Talks Podcast Season 6 | Mayo Clinic School of Continuous Professional Development

Host: Darryl S. Chutka, M.D. Guest: Stacey Rizza, M.D. Hantavirus has been in the news lately. Although it’s rare, it can cause serious disease which can be life-threatening. Early symptoms are similar to other common viral infections including fever, myalgias, headache, and fatigue. As a result, the ability to establish an early diagnosis is challenging. Who’s at risk of acquiring Hantavirus? Does it have the potential to become our next pandemic? How likely is human-to-human transmission? Is there any effective treatment and what preventive measures should one take to minimize the acquisition of the disease? I’ll get answers to these questions in this podcast as we discuss Hantavirus. My guest is an infectious disease specialist, Dr. Stacey Rizza from the Mayo Clinic. Connect with us! Mayo Clinic Talks Podcast Season 6 | Mayo Clinic School of Continuous Professional Development

Host: Darryl S. Chutka, M.D. Guest: Joseph Murray, M.D. Celiac Disease affects approximately 1% of the population worldwide and can present at any age, frequently with very subtle, atypical or at times entirely non-GI symptoms. The presentation can be extremely diverse and may involve a variety of organ systems. If not recognized and effectively treated, multiple potentially serious complications can develop. Primary care clinicians are often the initial point of contact, and we need to know the common presenting symptoms, which tests should be ordered when we suspect the disease and when a referral is necessary. We also play a role in long-term management by monitoring for nutritional deficiencies, bone integrity, and the patient’s adherence to a gluten-free diet. In this podcast, we’ll explore Celiac Disease with my guest, Dr. Joseph Murray, a gastroenterologist from the Mayo Clinic, and a nationally recognized specialist in Celiac Disease. We’ll focus on practical information you can apply to your practice. Connect with us! Mayo Clinic Talks Podcast Season 6 | Mayo Clinic School of Continuous Professional Development

Host: Darryl S. Chutka, M.D. Guest: Uma Thanarajasingham, M.D., Ph.D. Systemic lupus is a chronic autoimmune disease with a variety of immunologic and laboratory abnormalities. It has numerous clinical manifestations potentially involving multiple organs. It’s known as the great imitator because it can mimic a variety of other diseases, and it’s not uncommon for patients to have symptoms for a number of years prior to a diagnosis being established. What symptoms should alert us to the possibility of lupus? What do we do with a low titer, positive ANA? How is a firm diagnosis established and what role does the primary care clinician play in the management of those with lupus? I’ll be asking these questions and more of my guest, Dr. Uma Thanarajasingam from the Division of Rheumatology at the Mayo Clinic as we discuss “Lupus Today: Advances in Diagnosis and Treatment”. Connect with us! Mayo Clinic Talks Podcast Season 6 | Mayo Clinic School of Continuous Professional Development

Host: Darryl S. Chutka, M.D. Guest: Carl H. Cramer, III, M.D. Kidney transplantation has significantly improved the outlook for children with end-stage renal failure. The journey these children follow to transplantation starts in primary care with the recognition of chronic kidney disease, timely referral to nephrology, and long-term coordination of care with the transplant team. What are the most common health conditions which result in chronic kidney disease in children? What are some of the challenges faced in pediatric kidney transplantation and what do primary care clinicians need to know in caring for these children following kidney transplant? These are some of the questions I’ll be asking my guest Dr. Carl Cramer, a pediatric nephrologist and specialist in pediatric renal transplantation at the Mayo Clinic as we discuss “Pediatric Kidney Transplant”. Mayo Clinic Talks: Transplantation Series Connect with us! Mayo Clinic Talks Podcast Season 6 | Mayo Clinic School of Continuous Professional Development

Host: Darryl S. Chutka, M.D. Guest: Rebecca Ameduri, M.D. Most primary care clinicians see very few children with advanced heart failure or complicated congenital heart disease. However, when they are a part of our practice, they require timely referral and coordination with other medical specialties, as well as ongoing longitudinal and supportive care not only for the patient but also for their family. A heart transplant is a lifesaving and life-changing procedure for these patients. As the survival of these children improves, more transplant recipients are living into adulthood. For primary care clinicians, what are some early “red flag” symptoms that should raise our suspicion for cardiac failure? What tests should we order and when is the best time for a child to be referred for consideration for a heart transplant? The topic for this podcast is “Pediatric Heart Transplant” and we’ll tackle these issues and more. My guest is Dr. Rebecca Ameduri, a pediatric cardiologist with special expertise in pediatric heart transplantation. Mayo Clinic Talks: Transplantation Series Connect with us! Mayo Clinic Talks Podcast Season 6 | Mayo Clinic School of Continuous Professional Development

Host: Darryl S. Chutka, M.D. Guest: Lauren Jackson, M.D. Deep brain stimulation is an established management option for Parkinson’s Disease. It’s a neurosurgical procedure in which thin electrodes are implanted into various areas of the brain and then connected to a pulse generator that produces electrical stimulation which modulates abnormal brain activity. The procedure has the potential to improve the quality of life in those with Parkinson’s by reducing motor symptoms including tremor, rigidity and bradykinesia. It also enables a reduction in doses of dopaminergic medications. Who’s a candidate for this procedure? Is there an optimal time in the course of the disease to perform it? What can patients expect in terms of symptom improvement? How long do patients see benefits? These are some of the questions I’ll be asking my guest, Dr. Lauren Jackson, a neurologist from the Department of Neurology at the Mayo Clinic. The topic for this podcast is “Deep Brain Stimulation for Parkinson’s Disease”. Connect with us! Mayo Clinic Talks Podcast Season 6 | Mayo Clinic School of Continuous Professional Development

Host: Darryl S. Chutka, M.D. Guest: Forrest Sturgill, M.D. Parkinson’s Disease is a relatively common neurodegenerative disorder characterized by motor symptoms such as bradykinesia, rigidity and resting tremor, as well as non-motor symptoms such as autonomic dysfunction, mood disorders and cognitive changes. The diagnosis is established with a medical history and physical exam. Parkinson’s is truly a disorder where the neurologist needs to work with the primary care clinician to provide optimal care of the patient. What are the typical presenting symptoms of Parkinson’s? Is an urgent referral to a neurologist necessary? When should pharmacologic treatment be started? The topic for this podcast is “Advancements in the Diagnosis and Treatment of Parkinson’s Disease” and these are some of the questions I’ll be asking my guest, Dr. Forrest Sturgill, a neurologist in the Department of Neurology at the Mayo Clinic. Connect with us! Mayo Clinic Talks Podcast Season 6 | Mayo Clinic School of Continuous Professional Development