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Show Notes

How do you actually measure muscle growth?

In this episode of Muscle Intelligence, Ben Pakulski sits down with Dr. Eduardo De Souza, one of the top hypertrophy researchers in the world, to break down the real science behind building muscle.

They unpack why most studies don’t use the gold standard (MRI), how ultrasound stacks up, and whether training volume, exercise selection, or rep schemes truly matter. They explore the myths around sarcoplasmic hypertrophy, how aging affects muscle quality, and what actually determines growth after 40.

Whether you’re a coach, athlete, or lifelong lifter, this is essential knowledge for training smarter, not just harder. Get ready for a deep, clear, and evidence-backed conversation on hypertrophy like you’ve never heard before.

Points To Watch Out For

MRI is still the gold standard for hypertrophy
Ultrasound can be a valid, cheaper alternative
Aging muscle shows more fibrous, non-contractile tissue
High volume ≠ always better gains, individual response matters
Effective Reps Model lacks peer-reviewed validation

About Ben

Ben Pakulski is the Chief Performance Officer to elite executives, successful entrepreneurs, and top athletes. With over 25 years of experience, he coaches high achievers to build the physical, psychological, and metabolic resilience required to lead at the highest level.

As the creator of the Muscle Intelligence framework, Ben specializes in aligning biology and behavior to drive sustained peak performance. His mission is to redefine what’s possible for people in their prime and push the boundaries of human potential.