Have you tried magnesium but felt like it didn’t help—or even made things worse? Are you confused by all the different forms and dosages? In this episode, Ali and Becki break down how magnesium actually works in the body, why so many people think they “don’t tolerate” magnesium, and why form, dose, and context matter far more than most realize.

We also share the full story behind the reformulation of Relax & Regulate, our superstar magnesium product. You’ll learn why we chose magnesium bisglycinate paired with myo-inositol, how this combination supports nervous system regulation, sleep, anxiety, blood sugar, and hormone balance, and why it’s especially impactful for PCOS, perimenopause, and stress-driven symptoms.

Also in this episode:

Why is magnesium so important?
Signs of magnesium deficiency
Testing magnesium status
Cell Science Systems Micronutrient Panel
Episode 440 What does HTMA say about your health with guest Kaely McDevitt
Anxiety and Magnesium Deficiency
- Naturally Nourished Episode 470 SSRIs on the Rise
The magnesium GABA connection
- GabaCalm
How inositol supports serotonin
Why the combination of magnesium and inositol for blood sugar balance
Why magnesium deficiency is more pronounced in perimenopause
Forms of magnesium and absorption
Considerations of magnesium threonate
Why glycine matters and antiaging effects
Naturally Nourished Episode 331 Homocysteine and Methylation
Dosage considerations
- 1 scoop for maintenance
- 2+ scoops for PCOS, constipation, high cortisol, pregnancy
- Kids can start with ⅛-¼ scoop as early as age 2-3
- Teens ½-1 scoop to start for acne, anxiety, hormonal concerns

This episode is sponsored by Naturally Nourished Relax and Regulate

Relax & Regulate has always been a superstar for sleep, stress, and hormone support, and we’ve taken a good thing and made it even better! We’ve seen incredible results with 1000’s of clients using Relax and Regulate literally every day for 10+ years now.

We have increased magnesium bisglycinate from 200 mg to 250 mg to match clinical sleep research dosing, kept myo-inositol at the full 4-gram therapeutic dose, and improved the supporting ingredients so the entire formula is better absorbed, better tolerated, and more aligned with what we’re seeing clinically every day. Use code RELAX15 to save 15% on our reformulated Relax and Regulate!

Episode 481: Is Your Magnesium Working For You? Relax and Regulate Reformulation