Podcast
Nice Genes!
Hosted by Genome BC · EN
From healthcare and biotechnology to forests and fisheries, the evolving study of genomics is leading to some of the most exciting and world-changing discoveries in science and medicine. Like – did you know that your individual genomic signature can help determine the healthcare treatment you receive? Or that mapping the genomes of trees can inform forest management?
But while the study of genomics holds great promise for the health of people, animals, and the environment, it also confronts us with big questions: How do we study genetic patterns in a way that respects sensitive genetic information, history, and equity? How do we use the power of genomic research to fight climate change? Save the salmon?
Join Dr. Kaylee Byers – a self-described “rat detective” and science communicator as she guides you through fascinating conversations about the what, the why, and the how of genomics.
26episodes
Episodes
Newest firstAll episodes
Menopause Mysteries
Dec 200:30:49Tap to summarizeTurning up the heat on a life stage science is still catching up to.Ok, most of us may have gotten “the period talk.” But the “menopause talk?” Not so much. For something that half the world will experience, menopause and perimenopause are still wildly misunderstood. Luckily, the DNA detectives are finally reopening a mystery that’s been overlooked for too long.In this episode, Dr. Kaylee Byers unpacks the science behind menopause. She calls on educator Shirley Weir to understand what menopause and perimenopause actually are– and why so many people feel dismissed when they try to get answers. Plus, reproductive genomics researcher Dr. Aspasia Destouni reveals what our genes (and a few unlikely informants– from orcas to naked mole rats) can teach us about the rebellious internal clock that drives ovarian aging.Special thanks to Andrea Rathborne- creator, host and producer of the Half Betty podcast.A note on language: This episode often uses the terms “women” and “female” interchangeably, but we want to acknowledge that menopause is not experienced exclusively by women. People of various gender identities can go through perimenopause and menopause, and it's important to be inclusive in how we talk about this life stage.Resources: Menopause and perimenopause can feel isolating, and support isn’t always easy to find. Check out resources below for guidance and trusted support networks.- Resources to help you on your menopause health journey- Menopause Foundation of Canada- Menopause & Midlife Health- BC Women’s Hospital + Health Centre- Older Adults - Trans Care BC- Balancing Your Health and Wellness During Menopause- First Nations Health Authority–Highlights(5:05) What are menopause and peri-menopause(14:09) Why menopause ages on a different timeline than the rest of the body(20:24) What genomics (and naked mole rats!) reveal about ovarian aging(24:29) Which animals experience menopause and the evolutionary reasons why–Show Notes/Resources:1. Menopause and Perimenopause- Health Link BC2. ‘Unprepared and Disoriented.’ New Findings on Menopause Impacts- The Tyee3. IN HER WORDS Women’s Experience with the Healthcare System in British Columbia- BC Women’s Health Foundation, Pacific Blue Cross4. Health and Economics Research on Midlife Women in British Columbia- Women’s Health Research Institute at BC Women’s5. Menopause and Work in Canada- Menopause Foundation of Canada6. Postreproductive killer whale grandmothers improve the survival of their grandoffspring- PNAS7. Demographic and hormonal evidence for menopause in wild chimpanzees- Science8. Naked mole rats defy the biological law of aging- Science
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Gut Check
Nov 1800:31:42Tap to summarizeWhat genomics can tell us about food safety, the microbiome, and the mind.You’ve heard the saying, “you are what you eat”... Well, our gut microbes take that very literally. If you’ve ever gone on vacation, eaten something tasty, and next thing you find yourself bonding with a bathroom floor, you’re not alone. Food poisoning might occasionally make for a good story later, but it’s a serious issue that lands millions of people in hospitals every year– and tracing the culprit isn’t always as simple as pointing at last night’s tacos.In this episode, Dr. Kaylee Byers chats with microbiologist Dr. Lawrence Goodridge, who explains how genomics helps track foodborne outbreaks – from the harmful bacteria in our food to the microbes living inside us. Then, Dr. Mary Sco. dives into the science of the gut-brain connection, revealing how your gut and brain are constantly in conversation.So grab a snack, and get ready to stomach the science.Highlights(4:00) The bacteria behind food poisoning(10:13) How genomics helps track foodborne outbreaks(16:35) The microbiome in all its glory, and the gut-brain connection(23:59) Some poo-ticular scientific treatments–Resources1. Yearly food-borne illness estimates for Canada- Government of Canada2. Salmonella Syst-OMICS – Salmonella Syst-OMICS Consortium3. Hack Your Health- The Secrets of Your Gut Health- Netflix4. Probiotics: 100 years (1907-2007) after Elie Metchnikoff's Observation- Research Gate5. Revisiting Metchnikoff: Age-related alterations in microbiota-gut-brain axis in the mouse- Brain, Behavior, and Immunity6. Intragastric infection of germfree and conventional mice with Salmonella typhimurium- NIH7. A randomised controlled trial of dietary improvement for adults with major depression (the ‘SMILES’ trial)- BMC Medicine8. Pick fecal microbiota transplantation to enhance therapy for major depressive disorder- Progress in Neuro-Psychopharmacology and Biological Psychiatry
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Bite Club
Nov 400:32:57Tap to summarizeHow vector-borne diseases spread– and the critters that carry themMalaria, Lyme disease, dengue, Zika… what do they all have in common? They’re what we call vector-borne diseases– spread to us by tiny, bite-happy arthropods. These little troublemakers are responsible for 17% of all infectious diseases worldwide, and with climate change and urbanization on the rise, they’re becoming an even bigger threat.In this episode, Dr. Kaylee Byers sits down with insect investigator Dr. Gonzalo Vazquez-Prokopec to untangle the intricate web of vector-borne disease dynamics, and explain what makes these insects such masterful disease spreaders. Then, Dr. Pooja Swali shares how ancient DNA from thousands of years ago revealed a pathogen’s curious evolutionary switch from one creepy crawly to another.From mosquitoes to ticks to the not-so-affectionate kissing bug, every insect in this lineup is guilty of something– and genomics is helping us figure out what.Highlights(5:51) Vector disease dynamics: The pathogen, the vector, and the host– a love triangle.(13:10) A neglected disease you may have never heard of.(17:20) Ancient DNA uncovers the tale of an opportunistic pathogen and a surprising partner in crime.(26:20) What changes to our environments does to our disease landscape–Resources1. Vector-borne diseases- The World Health Organization2. Ancient DNA used to map evolution of fever-causing bacteria- Science Daily3. Mapping the distribution of Amblyomma americanum in Georgia, USA- Parasites & Vectors4. Focal persistence and phylodynamics of Heartland virus in Georgia- Virus Evolution
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Why Athletes Collapse
Oct 2100:34:18Tap to summarizeThe genetic clues behind sudden cardiac arrest in young individualsEvery so often, we see headlines about an elite athlete collapsing mid-game. The crowd goes silent, emergency crews rush to the field, and everyone’s left wondering: how could this happen? The truth is, sometimes a hidden heart condition written deep in our DNA will unmask itself on the field.In this episode, Dr. Kaylee Byers sits down with sports cardiologist and cardiogeneticist Dr. Prashant Rao to explore the genetic roots of sudden cardiac events in young athletes. Together, they unpack the most common underlying genetic conditions responsible, what genomics is revealing about the specific genes involved, and the ongoing debate around genetic screening. Plus, the remarkable story of JJ: a young wrestler who survived cardiac arrest thanks to his early genetic diagnosis and fast-acting friends.Listen in to learn why these devastating events happen, and how genomics is helping keep athletes safely in the game.Highlights(7:23) The most common underlying genetic heart conditions(11:40) Meet the 18 year old wrestler who survived cardiac arrest(21:32) A hot debate in sports cardiology(24:51) Tailoring training through genotype–Resources1. 78 minutes in the life (and near death) of Fabrice Muamba- The Guardian2. Reggie Lewis death, explained: Revisiting the tragic passing of Celtics star in 1993- The Sporting News3. Marc-Vivien Foe death: His legacy 10 years after collapsing on pitch- BBC Sport4. The day Denmark stood still: Christian Eriksen’s collapse and the heroes who saved him- The Guardian5. Soccer star speaks out 2 months after collapsing on field mid-game- ABC News6. Sudden Cardiac Death in National Collegiate Athletic Association Athletes: A 20-Year Study- AHA Journals7. Sudden cardiac death in the young: the molecular autopsy and a practical approach to surviving relatives- European Heart Journal8. An 18-Year-Old Athlete Almost Dropped Dead, but Friends Saved His Life: 'It's Really a Miracle'- People Magazine
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Genetics and the Silver Screen
Oct 700:31:07Tap to summarizeHow medical dramas shape the way we think about genomicsMedical dramas have been a staple of television for decades, from iconic primetime hits like Grey’s Anatomy and HOUSE, to newer favorites like The Pitt. It’s easy to get swept up in the high-stakes surgeries, love triangles, and melodramatoc monologues– but when it comes to the science, a second opinion might be in order.In this episode, host Dr. Kaylee Byers sets out to investigate how these kinds of TV shows shape our perceptions of science. First up, Watson script consultant Dr. Krysta Coyle breaks down some of the biggest genomic missteps medical dramas make, and dishes on what it’s like to be the science voice on set. Then, Ayden Eilmus, a bioethicist and medical drama scholar, explores the evolution of genetics on TV, from problematic eugenics-era storylines to the more complex and ethically rich portrayals we see today.Hit "play" to uncover how our guilty-pleasure binge watches can have a bigger impact than just entertainment.Highlights(3:54) Common genomic missteps on TV(9:34) What it’s like consulting on a medical TV show(14:42) Genetics on TV: then and now(25:57) Why representation matters–Resources1. Eugenics and genetic screening in television medical dramas- BMJ Journals2. Genetics in Television Medical Dramas- J Lit Sci3. How Accurate Are Medical TV Shows?- Cleveland Clinic4. Eugenics: Its Origin and Development (1883 - Present)- National Human Genome Research Institute 5. Watson Episode 12 recap: Bioengineered chaos, betrayal, and Moriarty’s return- Soap Central6. Private Practice (2007, S1E6)7. Chicago Hope S5E128. Grey's Anatomy, (2015, S11E10)
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Babies and Breakthroughs
Sep 2300:30:12Tap to summarizeHow new genomic approaches are helping diagnose and treat our tiniest patientsWelcoming a new baby brings boundless love, joy, and the usual sleepless nights of early parenthood. But in the NICU, when a newborn is unexpectedly sick, it’s the uncertainty that keep parents awake.In this episode, our investigation takes us inside the neonatal intensive care unit, where genomic tools are mapping medical mysteries in record time. You’ll hear the remarkable story of “Baby KJ,” the first newborn to receive a personalized CRISPR treatment; insights from pediatric geneticist Dr. Tara Wenger on how new approaches to testing are changing care; and the story of Meredith Thomas– a mother whose fight for answers helped uncover a diagnosis that saved her daughter’s life.From faster diagnoses to fairer care, join Dr. Kaylee Byers to learn how these genomic breakthroughs are redefining what’s possible for newborns and their families.Highlights(3:50) A study that changes the way we test ill newborns(9:00) Meet a mother who advocated for her sick daughter(13:56) A visit from the genetics team and a life saving diagnosis(19:12) Making healthcare more equitable–Resources1. World's First Patient Treated with Personalized CRISPR Gene Editing Therapy at Children’s Hospital of Philadelphia- Children’s Hospital of Philadelphia2. SeqFirst: Building equity access to a precise genetic diagnosis in critically ill newborns- The American Journal of Human Genetics3. Implementation of First-Line Rapid Genome Sequencing in Non–Critical Care Pediatric Wards- The Journal of Pediatrics4. Genetic Non-Discrimination Act- The Government of Canada
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Life in the Fast Lane
Dec 17, 202400:30:44Tap to summarizeRapid Evolution in the Modern AgeEvolution is like the ultimate slowburn, unfolding over millennia. And in our modern society, where things move so fast, it’s easy to miss this incremental but constant transformation. Not only is evolution happening all around us, in some cases it’s even picking up the pace.In our season finale, our resident superhero, Ratwoman, returns with a new sidekick: The Bat Whisperer. Join Dr. Kaylee Byers and Dr. Cecelia Sánchez as they team up to explore the marvels of rapid evolution– from bats in the Solomon Islands, to modern dating. We’ll meet cave explorer and mammal detective Dr. Tyrone Lavery along with paleontologist and evolutionary biologist Dr. Nick Longrich to unlock predictions for the future, by looking into the past.With unprecedented access to genomic information, we can now remix evolution like never before. But just because we can, does it mean we should?–Highlights(5:57) Into the bat cave: tracking evolution in the Solomon Islands with Dr. Lavery(11:18) The peppered moth survival story(20:18) Dr. Longrich explains how humans are evolving in the modern age–Resources:1. Charles Darwin: History’s most famous biologist - Natural History Museum2. Bat Beauty Contest: Vote Now To Crown The Best-Looking Bat Of Them All - Forbes3. Parallel evolution in an island archipelago revealed by genomic sequencing of Hipposideros leaf-nosed bats - Oxford Academic4. Bats Are Going Through a Rare Evolutionary Phenomenon - Newsweek5. The Peppered Moth - Age of Revolution6. A continuous fish fossil record reveals key insights into adaptive radiation - Nature7. Study of 17,000 years of fish fossils reveals rapid evolution - Science.org8. How long does evolution take? It happens on two different timescales- New Scientist9. Future evolution: from looks to brains and personality, how will humans change in the next 10,000 years? - The Conversation10. Ancient Urbanization Predicts Genetic Resistance To Tuberculosis - Oxford Academic
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The Wasting Game
Dec 3, 202400:30:27Tap to summarizeManaging an Invisible DiseaseIs there a Zombie moose on the loose?! Not quite... But there is something lurking in the woods that has our “deer” friends shakin' in their hooves. Chronic Wasting Disease (CWD) is a 100% fatal illness that’s creeping its way through cervid populations, and it’s nearly impossible to spot. Luckily, wildlife biologists like our guest Cait Nelson from the BC Ministry of Water, Lands, and Natural Resource Stewardship are on the case.In this episode host Dr. Kaylee Byers and Cait Nelson talk about the clever scientific tools that are helping us track CWD– from grapefruit spoons to genomics! We’ll also hear from Alfred Joseph from the ʔakisq̓nuk First Nation and member of the Ktunaxa Tribe, who explains how CWD is more than just a threat to wildlife, but also has deep implications for community and food sovereignty.Join us on a pun-packed hunt to find out how we can get ahead of this deadly and stubborn disease, one dead head at a time.Special thanks to Jeff Berdusco, CWD Coordinator in the Kootenay region for providing field recordings for this episode.–Highlights(4:46) What is CWD?(13:10) A threat to cultural independence.(17:48) Tracking a silent killer.–Resources:1. Chronic Wasting Disease - British Columbia2. To Fight Chronic Wasting Disease, BC Begins to Harvest Deer - The Tyee3. “It’s important to know about this” - risk communication and the impacts of chronic wasting disease on Indigenous food systems in Western Canada - Environmental Science & Policy4. Chronic Wasting Disease: Prevention, Surveillance, and Response - BC Wildlife Federation
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Lost but Found
Nov 19, 202400:27:22Tap to summarizeForensic Methods in Disaster RecoveryContent warning: this episode discusses forensic science and the identification of human remains that may not be suited for all audiences.Natural disasters can strike without warning. And when they do, they can leave destruction, displacement, and loss of life in their wake. First responders rush to help those in need, while forensic scientists face the difficult but incredibly important task of identifying human remains– a process known as Disaster Victim Identification (DVI).In this episode, we’re going back to 2004, to the largest DVI event in recent history. Host Dr. Kaylee Byers sits down with Chief Forensic Odontologist Dr. Dirk van der Meer as he shares his first-hand experiences of helping identify victims following the devastating tsunami in Thailand. Then, how are genomics reshaping forensic identification today? We head to Australia to hear from Dr. Dadna Hartman about a new tool that’s offering answers—and closure—to families, faster than ever. Join us for a behind-the-scenes look at the important and fascinating world of forensic science.–Highlights(6:51) On the scene after the tsunami(16:01) A speedy genomic tool(23:00) Beyond the science–Resources:1.2004 Indian Ocean earthquake and tsunami: Facts and FAQs- World Vision2. The 10 most significant natural disasters worldwide by death toll from 1950 to 2022- Statista3. Disaster Victim Identification (DVI)- Interpol4. Forensic odontology in DVI: current practice and recent advances- Forensic Sciences Research5. Rapid DNA from a disaster victim identification perspective: Is it a game changer?- Forensic Science International
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Slipping Through the Spectrum
Nov 5, 202400:32:39Tap to summarizeRethinking the Divide in Autism DiagnosesDr. Hannah Belcher was already studying autism she found out she herself was Autistic. Getting her diagnosis felt like everything suddenly clicked… but why did it take so long to get answers?In this episode, Hannah shares her journey and talks about how many Autistic people, especially women, learn to mask their true selves to fit in– causing them to slip through the diagnostic cracks. Then, we invite Dr. John Constantino to break down the genetic underpinnings of Autism Spectrum Disoder and related conditions like ADHD—and how science is shaking up the genomic picture of what we thought we knew about this male-female bias.From outdated theories to “refrigerator mothers,” join hosts Dr. Kaylee Byers and Dr. Rackeb Tesfaye as they comb through the tangled web of sex bias and ask whether our current methods of studying neurodiversity is actually addressing the questions the people with ASD want answered?A Note on Language:When talking about Autism - semantics matter. So, it’s important to recognize the nuances of language. Many people in the Autism community prefer identity-first language, such as "Autistic person," as it centers Autism as a core part of their identity. Others, however, may prefer person-first language, like "person with Autism," which places the individual before the condition. We’ve used both forms of language in this episode, and we encourage respecting individual preferences by asking what each person is most comfortable with. For more on this, check out resources like the National Institutes of Health’s guide on writing respectfully about identity and the Autistic Self Advocacy Network’s explanation of identity-first language.Additionally, when we refer to ‘Autism risk’ in the context of academic research, it typically means an increased genetic likelihood of receiving an Autism diagnosis. However, we recognize that "risk" can imply a negative connotation (which we do not support.) Instead, we aim to discuss Autism in ways that honour the neurodiversity of all individuals.Lastly, regarding sex differences in Autism diagnoses, in this episode, we’re talking specifically about sex assigned at birth. Although we mention gender, we want to be clear that we aren’t exploring how Autism diagnoses may vary by gender identity—that area remains understudied! So, our conversation is focused on differences between males and females, and we look forward to seeing more research on the richly complex interactions between gender identitiy and neurodiversity in the future.Highlights:(6:32) Growing up undiagnosed(18:52) The genetic underpinnings of Autism and related neurodiverse conditions(22:20) Debunking the “female protective effect”(26:37) A biased assessmentLearn-A-Long: https://bit.ly/4g9kCRaResources:1. ‘Taking off the Mask: A Practical Guide for Managing Autistic Camouflaging and Mental Health‘ - Dr. Hannah Belcher2. Inherited Risk for Autism Through Maternal and Paternal Lineage - National Institute of Health3. 'Decade of data dents idea of a ‘female protective effect’- The Transmitter4. How ADHD Gender Bias is Slowly, Steadily Harming Females - ADDitude Mag5. Refrigerator Mothers - A Discredited Cause Of Autism- Autism Help6. Study challenges idea that autism is caused by an overly masculine brain- Science.org7. Autism Spectrum Conditions In Women: Diagnosis, Mental Health, And The Role Of Camouflaging- Research Gate (source?)
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