In this episode, I sit down with Dr. Katrin Dreissigacker, a plastic surgeon turned longevity architect and founder of Epigenedit, to explore why hyperbaric oxygen therapy may be one of the most overlooked tools in longevity science.

We talk about her journey from a small village in East Germany to becoming known as the “Queen of Needles,” how she reversed markers of biological aging, improved her VO2 max in midlife, and why oxygen, mitochondria, skin health, resilience, and reinvention are all deeply connected.

Key Topics:

* Hyperbaric oxygen therapy and its role in longevity

* Innovations in aesthetic medicine and needling techniques

* The impact of oxygen saturation on aging and skin health

* Biomarkers of aging and how hyperbaric oxygen influences them

* The use of peptides and biohacking for healthspan extension

Timestamps:

* 00:00 – Reversing Biological Age? The Power of Oxygen

* 00:30 – From East Germany to Elite Medicine

* 02:30 – Why She Chose Medicine (Unexpected Path)

* 02:57 – What Is Aesthetic Medicine (Beyond Vanity)

* 05:14 – “Queen of Needles” & Revolutionizing Fillers

* 08:46 – First Encounter with Hyperbaric Oxygen Therapy

* 11:24 – From Pandemic to Longevity Innovation

* 12:43 – Why She Built Her Own HBOT Chamber

* 16:22 – Can HBOT Really Improve VO2 Max?

* 18:02 – How HBOT Actually Works (Simple Explanation)

* 20:11 – Mild vs Medical HBOT: What’s the Difference?

* 21:23 – What It Improves: Sleep, Recovery & Aging

* 24:00 – How Often Should You Do HBOT?

* 26:17 – Risks, Side Effects & Common Fears

* 30:40 – The Real Benefits (Why You Don’t Feel It Immediately)

* 33:29 – Skin, Collagen & The ‘Glow Effect’

* 36:04 – Who Should NOT Use HBOT?

* 38:22 – Peptides: Hype or Breakthrough?

* 42:48 – Biggest Misconceptions About HBOT

* 44:24 – Most Overused Aesthetic Treatment Today

* 47:10 – Daily Habits for Longevity & Energy

* 48:08 – What Shows Up on Your Skin the Most?

* 49:49 – Reinvent Yourself at Any Age

ABOUT DR. KATRIN DREISSIGACKER: Physician, pioneer in aesthetic medicine and Co-Founder of EpigenEdit, believes ageing is not something to fight but something to design. After three decades at the forefront of aesthetics, she now focuses on longevity science, using tools such as mild hyperbaric oxygen therapy to support cellular regeneration, performance, and vitality from within.

RESOURCES MENTIONED:

* www.epigenedit.com

* Instagram: @epigenedit_europe / @katrin_dreissigacker

* LinkedIn: www.linkedin.com/in/katrin-dreissigacker

* Katrin’s individual practice: www.katrin-dreissigacker.com

ABOUT NINA’S NOTES: Nina’s Notes explores the intersection of longevity science, neuroscience, and human optimization. Hosted by Nina Patrick, PhD in pharmaceutical sciences and longevity researcher, each episode translates cutting-edge research into actionable insights for living longer, better.

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