
Hosted by Nina Patrick · EN

In this episode, I sit down with Dr. Katrin Dreissigacker, a plastic surgeon turned longevity architect and founder of Epigenedit, to explore why hyperbaric oxygen therapy may be one of the most overlooked tools in longevity science.We talk about her journey from a small village in East Germany to becoming known as the “Queen of Needles,” how she reversed markers of biological aging, improved her VO2 max in midlife, and why oxygen, mitochondria, skin health, resilience, and reinvention are all deeply connected.Key Topics:* Hyperbaric oxygen therapy and its role in longevity* Innovations in aesthetic medicine and needling techniques* The impact of oxygen saturation on aging and skin health* Biomarkers of aging and how hyperbaric oxygen influences them* The use of peptides and biohacking for healthspan extensionTimestamps:* 00:00 – Reversing Biological Age? The Power of Oxygen* 00:30 – From East Germany to Elite Medicine* 02:30 – Why She Chose Medicine (Unexpected Path)* 02:57 – What Is Aesthetic Medicine (Beyond Vanity)* 05:14 – “Queen of Needles” & Revolutionizing Fillers* 08:46 – First Encounter with Hyperbaric Oxygen Therapy* 11:24 – From Pandemic to Longevity Innovation* 12:43 – Why She Built Her Own HBOT Chamber* 16:22 – Can HBOT Really Improve VO2 Max?* 18:02 – How HBOT Actually Works (Simple Explanation)* 20:11 – Mild vs Medical HBOT: What’s the Difference?* 21:23 – What It Improves: Sleep, Recovery & Aging* 24:00 – How Often Should You Do HBOT?* 26:17 – Risks, Side Effects & Common Fears* 30:40 – The Real Benefits (Why You Don’t Feel It Immediately)* 33:29 – Skin, Collagen & The ‘Glow Effect’* 36:04 – Who Should NOT Use HBOT?* 38:22 – Peptides: Hype or Breakthrough?* 42:48 – Biggest Misconceptions About HBOT* 44:24 – Most Overused Aesthetic Treatment Today* 47:10 – Daily Habits for Longevity & Energy* 48:08 – What Shows Up on Your Skin the Most?* 49:49 – Reinvent Yourself at Any AgeABOUT DR. KATRIN DREISSIGACKER: Physician, pioneer in aesthetic medicine and Co-Founder of EpigenEdit, believes ageing is not something to fight but something to design. After three decades at the forefront of aesthetics, she now focuses on longevity science, using tools such as mild hyperbaric oxygen therapy to support cellular regeneration, performance, and vitality from within.RESOURCES MENTIONED:* www.epigenedit.com* Instagram: @epigenedit_europe / @katrin_dreissigacker* LinkedIn: www.linkedin.com/in/katrin-dreissigacker* Katrin’s individual practice: www.katrin-dreissigacker.comABOUT NINA’S NOTES: Nina’s Notes explores the intersection of longevity science, neuroscience, and human optimization. Hosted by Nina Patrick, PhD in pharmaceutical sciences and longevity researcher, each episode translates cutting-edge research into actionable insights for living longer, better.CONNECT WITH NINA’S NOTESNewsletter: www.ninasnotes.xyzLinkedIn: www.linkedin.com/in/ninapatrick/Website: www.ninapatrick.xyzThanks for reading Nina’s Notes! This post is public so feel free to share it. Get full access to Nina’s Notes at www.ninasnotes.xyz/subscribe

Hey friends,Dr. Yi Song has spent her career bridging Eastern and Western medicine.What she’s found is that most people are already losing the health game before they feel a single symptom.In this conversation, Dr. Song breaks down why treating symptoms is not the same as healing, what stem cell therapy can actually do (and what the industry gets dangerously wrong), and how meditation and energy flow aren’t just ancient metaphysics - they’re measurable, teachable tools for longevity.If you’ve ever wondered whether regenerative medicine is real or hype, or how to find a clinic you can actually trust, this episode will sharpen your thinking.Key Topics:* Why early prevention is the most overlooked lever in healthcare* Stem cell types, functions, and what mesenchymal stem cells can treat* How stem cell production declines with age — and what to do about it* Navigating the unregulated stem cell clinic landscape safely* The six principles of natural longevity from The Regeneration Effect* Meditation, energy flow, and metaphysical states of consciousnessTimestamps:* 00:00 The Intersection of Eastern and Western Medicine* 08:05 The Importance of Early Prevention in Healthcare* 13:19 Exploring Stem Cell Therapy and Its Benefits* 16:18 Understanding Stem Cells: Types and Functions* 19:56 Applications of Mesenchymal Stem Cells in Treatment* 22:39 Preventative Measures for Joint Health and Aging* 28:05 The Decline of Stem Cells with Age* 29:17 Skepticism and FDA Approval in Stem Cell Therapy* 30:58 Quality Control in Stem Cell Treatments* 33:45 Identifying Reputable Clinics for Stem Cell Therapy* 35:21 The Importance of Personalized Treatment* 38:12 The Regeneration Effect: Principles for Longevity* 40:46 Six Principles for Health and Longevity* 46:24 Rapid Fire Longevity Questions* 49:52 Myths and Realities of Stem Cell TherapyRESOURCES MENTIONED:The Regeneration Effect Book — https://book.regenerationeffect.comStemCell Therapy Experts — https://stemcelltherapyexperts.comCell Therapy Experts Podcast — https://youtube.com/CellTherapyExpertsFree Regeneration Effect eBook — https://gift.regenerationeffect.comConnect with Dr. Song: https://regenerationeffect.comABOUT DR. YI SONG: Dr. Yi Song is a regenerative medicine physician and author of The Regeneration Effect. Drawing on decades at the intersection of Chinese medicine and modern science, she guides patients through personalized stem cell protocols and holistic longevity frameworks at StemCell Therapy Experts.ABOUT NINA’S NOTES: Nina’s Notes explores the intersection of longevity science, neuroscience, and human optimization. Hosted by Nina Patrick, PhD in pharmaceutical sciences and longevity researcher, each episode translates cutting-edge research into actionable insights for living longer, better.CONNECT WITH NINA’S NOTESLinkedIn: https://www.linkedin.com/in/ninapatrick/Website: https://www.ninapatrick.xyzKey Wordsholistic health, early prevention, stem cell therapy, meditation, longevity, Chinese medicine, regenerative medicine, energy flow, aging, biohacking Get full access to Nina’s Notes at www.ninasnotes.xyz/subscribe

Plant medicine is moving from the fringe into the mainstream.In this episode of the Nina’s Notes Podcast, I speak with Danny and Sarah, founders of Behold Retreats, who have guided more than 1,500 people through plant medicine ceremonies around the world.Their participants range from professional athletes and high performers to people seeking deep emotional healing.We explore what actually happens inside a psychedelic retreat, how medicines like ayahuasca, psilocybin, and Bufo are used in ceremonial contexts, and why these experiences are attracting people interested in healing, personal growth, and expanded consciousness.Danny and Sarah also explain the concept of ego dissolution, the importance of integration after psychedelic experiences, and the difference between using these medicines for healing versus expansion.Topics we discuss:• What happens during a plant medicine retreat• The meaning of ego dissolution (sometimes called “ego death”)• The biggest misconceptions about psychedelics• Why athletes and high performers explore plant medicine• Healing versus expansion in psychedelic experiences• Why integration is essential after ceremonyPlant medicines have been used for thousands of years in indigenous traditions. Today, they are becoming part of a growing conversation around mental health, consciousness, and human potential.Learn more about Behold Retreats: https://bit.ly/4rwJszzThanks for reading Nina’s Notes! This post is public so feel free to share it. Get full access to Nina’s Notes at www.ninasnotes.xyz/subscribe

Hey friends,Most longevity conversations focus on labs, supplements, and biomarkers. This week’s guest, Roderick Lambert, goes deliberately upstream of all of that.After 15 years of struggling with obesity and a doctor warning him at 35 that he could have a heart attack within five years, Roderick overhauled his life, lost 24kg in seven months, and never looked back. Today he coaches people aged 40–60 on the root causes of metabolic decline and accelerated aging.The calories in, calories out model isn’t just bad advice. It’s physically inaccurate.You’ll discover:* Why mitochondrial dysfunction is the root cause of most chronic diseases* How fat produces up to 6x more usable energy than glucose* Why the 40–60 window is your last real chance to turn back the clock* The role of light, circadian biology, and coherence in cellular health* Why “you can’t get well in the environment you got sick in”* How to build habits that stick, without willpowerCheers, NinaTimestamps:* 00:00 Roderick’s Journey: 15 Years of Obesity* 05:30 The Doctor’s Warning That Changed Everything* 12:00 Why Calories In/Out Is Inaccurate Physics* 18:00 Mitochondria: Far More Than the Powerhouse of the Cell* 25:00 Accelerated Aging and the 40–60 Window* 31:00 Food First: Fat vs. Glucose as Fuel* 38:00 Light Diet and Circadian Biology* 44:00 Fasting, Movement, and Building Habits* 50:00 Accountability as the Missing LinkABOUT RODERICK LAMBERT: Roderick Lambert is a metabolic health coach and founder of Midlife Metabolic Health. After reversing his own metabolic syndrome in his early 40s, he now works with clients aged 40–60 to address the root causes of accelerated aging through first principles nutrition, light biology, movement, and mindset.ABOUT NINA’S NOTES: Nina’s Notes explores the intersection of longevity science, neuroscience, and human optimization. Hosted by Nina Patrick, PhD in pharmaceutical sciences and longevity researcher, each episode translates cutting-edge research into actionable insights for living longer, better.CONNECT WITH RODERICK LAMBERTWebsite: https://midlifemetabolichealth.comFacebook: https://www.facebook.com/MidlifeMetabolicHealth/LinkedIn: https://www.linkedin.com/in/rodericklambert/ Get full access to Nina’s Notes at www.ninasnotes.xyz/subscribe

Living longer isn't the same as living well. In this episode, I explore a concept that might matter more than your health span or lifespan: your joy span, the years you spend actually liking your life.Dr. Kerry Burnight, professor of geriatric medicine at UC Irvine, argues that how we respond to aging determines whether we thrive or suffer. And the good news? You can lengthen your joy span at any age through everyday choices.What You'll Learn:- The difference between lifespan, health span, and joy span- Dr. Burnight's 4 non-negotiable actions: Grow, Adapt, Give, Connect- Why asking questions makes you more likeable (science-backed)- How to continue learning as you age (including free college options for 60+)- Why I believe this matters at 38, not just in your later yearsIn The Video, I Share Practical Challenges:- Journal prompts to assess your current joy span- How to adapt when life throws you curveballs- Creative ways to stay connected and give back- Dr. Burnight's quizzes to get your baseline (link below)Timestamps:00:00 Understanding Joy Span vs. Health Span01:00 The Four Non-Negotiable Actions for Thriving03:36 Adapting and Growing as we Age05:35 The Book of the Week07:15 Check this OutLinksJoyspan Quizzes: https://www.hachettebookgroup.com/wp-content/uploads/2025/07/JoyspanExtendedExcerpt.pdfCONNECT WITH ME Newsletter: https://www.ninasnotes.xyz LinkedIn: https://www.linkedin.com/in/ninapatrick/ Website: https://www.ninapatrick.xyzjoy span, health span, aging, quality of life, mental health, connection, lifelong learning, geriatric medicine, Dr. Kerry Burnight, thriving, Nina’s Notes Get full access to Nina’s Notes at www.ninasnotes.xyz/subscribe

Preventative healthcare isn’t just for the wealthy few, it can be accessible to everyone who needs it most.In this episode, Nina sits down with Emilian Popa, founder of Expand Health, for a candid conversation about democratizing longevity and preventative care. From his early days as an entrepreneur in Romania to working in venture capital and finally building his own healthcare company, Emilian reveals the critical gaps in our current healthcare system and how technology can bridge them.This isn’t about boutique longevity clinics charging $10,000 for annual memberships. It’s about making evidence-based preventative care accessible and affordable for the middle class, the people who need it most but are currently priced out of the market.Emilian explains why behavior change is the hardest part of healthcare transformation, how AI is revolutionizing patient experience and cost structures, and why the fundamentals of nutrition, movement, and sleep remain non-negotiable. You’ll discover what’s actually stopping people from accessing preventative care, how healthcare will evolve over the next decade, and why brain health deserves more attention in the longevity conversation.Timestamps:00:00 Emilian’s Entrepreneurial Journey05:47 Building Expand Health: A New Approach to Healthcare12:11 Behavior Change and Health Span20:24 Innovations in Preventative Care25:43 Scaling Preventative Health Across Continents30:57 The Cost of Healthcare and Access to Testing32:31 Democratizing Healthcare: Bridging the Gap34:59 Behavior Change: The Key to Health37:16 The Future of Work: Balancing Productivity and Health41:05 Foundational Health: Nutrition, Movement, and Sleep43:33 Emerging Technologies in Health and Longevity48:15 Advice for Individuals in the Longevity Space52:58 The Importance of Brain Health and Future InnovationsWhere to find Emilian Popa:* Expand Health* LinkedInWhere to find Nina Patrick, PhD:* Newsletter* LinkedIn* Website Get full access to Nina’s Notes at www.ninasnotes.xyz/subscribe

In this conversation, I explore a fascinating paradox in our relationship with artificial intelligence.Why do we demand absolute perfection from AI while accepting human error as inevitable? When an LLM hallucinates or cites fake sources, I get frustrated. But when a colleague misspeaks or misremembers, I give them grace. Why the double standard?I walk through the reality of human error across industries:* Diagnostic mistakes happen in 5-20% of doctor visits* 80% of aviation accidents trace back to human error* 20% of Big Four audits have significant deficiencies* Even elite professionals only achieve 90-95% accuracy.The thread tying all of this together is simple but uncomfortable: our imperfections are what make us human and interesting. AI-generated content feels soulless. You can sense it. It lacks emotion, depth, playfulness, and personality.I believe we’re heading toward an age where we’ll pay a premium for human-generated content, art, and music. We think we can scale the human experience with AI, but what we’ll find instead is an overly perfect, emotionless dark age of art and culture.The choice isn’t between perfect AI or imperfect humans. It’s about deciding which imperfections we’re willing to live with.TIMESTAMPS00:00 Hello from Australia!01:16 We Expect Perfection out of AI and Not in Humans, Why?06:41 The Paradox of Perfection in AI and Humanity07:05 Mentoring Opportunities07:26 The Book of the Week08:34 Grab My Guidebooks08:51 Check this outLinkshttps://www.who.int/news-room/fact-sheets/detail/patient-safetyhttps://www.sciencedirect.com/science/article/pii/S2666691X23000246https://tax.thomsonreuters.com/news/audit-deficiency-rate-drops-in-2024-in-sign-of-improvement/https://www.researchgate.net/publication/1907590_Thinking_is_Bad_Implications_of_Human_Error_Research_for_Spreadsheet_Research_and_PracticeCONNECT WITH MENewsletter: https://www.ninasnotes.xyzLongevity.Technology Unlocked Podcast: https://longevity.technology/unlocked/Longevity Guidebooks: https://ninapatrick.xyz/guidebooksMentoring: https://ninapatrick.xyz/startup-mentor/LinkedIn: https://www.linkedin.com/in/ninapatrick/Website: https://www.ninapatrick.xyz Get full access to Nina’s Notes at www.ninasnotes.xyz/subscribe

What if you could actually see your brain activity in real-time and learn to control it like adjusting a thermostat?In this episode, Nina sits down with Ariel Garten, neuroscientist and founder of Muse, for a deep dive into how neurofeedback technology is revolutionizing the way we train our brains. From her early work making buildings light up with brainwaves at the 2010 Winter Olympics to creating a headband used by half a million people worldwide, Ariel reveals how accessible brain training has become.This isn’t science fiction, it’s neuroscience made practical. Ariel explains how three to five minutes of daily brain training can improve focus, enhance sleep quality by 20%, and even help you fall asleep 55% faster. You’ll discover what your brain really looks like during sleep, why most of us aren’t getting “textbook” sleep, and how emerging technologies like deep sleep stimulation could change how we age.Timestamps:00:00 Introduction to Muse and Neuroscience01:50 The Journey of Muse: From Concept to Reality04:29 User Experience: Feedback and Interaction with Muse06:54 Training the Brain: Techniques and Processes09:44 Understanding Calmness: EEG Insights and Metacognition12:12 Evolution of Use Cases: Meditation to Sleep Optimization14:52 The Muse S: Enhancing Sleep Quality17:35 The Complexity of Sleep: Insights from EEG Studies22:10 Transforming Sleep Through Mindfulness24:33 Understanding Calmness and Anxiety26:06 Enhancing Focus and Productivity27:52 The Role of Muse in Daily Life29:19 Exploring ADHD and Focus31:30 The Future of Brain Diagnostics34:01 Innovations in Brain Measurement36:34 The Limits of Brain Training39:30 Best Practices for Brain TrainingCONNECT WITH ARIEL GARTENWebsite: https://choosemuse.comLinkedin: https://www.linkedin.com/in/arielgarten/Twitter: @choosemuseInstagram: @choosemuseCONNECT WITH NINA’S NOTESNewsletter:LinkedIn: https://www.linkedin.com/in/ninapatrick/Website: https://www.ninapatrick.xyz Get full access to Nina’s Notes at www.ninasnotes.xyz/subscribe

In this episode of Nina’s Notes (#164), I dive into the crucial but under-researched connection between estrogen and ADHD in women. After conversations with friends and audience questions at my recent talk, I dug into the scientific literature - and ladies, we were right, the two are very connected.KEY TOPICS COVERED:• Why ADHD gets missed in women and girls• How hormonal fluctuations impact ADHD symptoms throughout your cycle• The follicular phase advantage vs. luteal phase challenges• ADHD during pregnancy: what the limited research shows• Perimenopause and menopause: the hormone hurricane effect• Why estrogen is crucial for cognitive function and dopamine regulation• Practical symptom tracking strategies using apps like Clue or FloTIMESTAMPS:00:00 Introduction to New Podcast Launch01:40 Exploring the Estrogen-ADHD Connection03:27 How Hormones Affect ADHD04:55 Hormonal Changes and ADHD Symptoms08:27 Managing ADHD Through Hormonal Awareness09:03 Do you want to improve your health and wellness in 2026?09:31 The Book of the Week09:59 Book Review: The Secret of Secrets11:09 Mentoring with Nina11:31 Check This OutCONNECT WITH MENewsletter: https://www.ninasnotes.xyzLinkedIn: https://www.linkedin.com/in/ninapatrick/Website:https://www.ninapatrick.xyz Get full access to Nina’s Notes at www.ninasnotes.xyz/subscribe

In this conversation, I cover the emerging science on psychedelics. Not the hype, but the data.How these compounds interact with the brain, reopen windows of neuroplasticity, and appear to influence aging, neurodegenerative disease, mental health, trauma, and resilience in ways we’re only beginning to understand.I walk through studies looking at psychedelics in neurodegenerative disease, stroke recovery, and end-of-life care, specifically improvements in Parkinson’s, life extension in cells and mice, and cancer patients losing their fear of death.The thread tying all of this together is simple but uncomfortable: longevity isn’t just about adding years to the body. It’s about tending to the nervous system, the mind, and the stories we carry.If we want to live longer and better, we may need to stop treating biology and psychology as separate systems, and start designing a more integrated, humane approach to aging.Timestamps:00:00 Introduction to Epigenetics and Longevity02:42 The Intersection of Psychedelics and Longevity05:36 Understanding the Hallmarks of Aging08:51 Mental Health, Neuroplasticity, and Aging11:45 Psychedelics and Neurodegenerative Diseases14:46 Psychedelics in Stroke Recovery17:33 Psychedelics and Trauma Healing20:30 Psychedelics in End-of-Life Care23:41 The Future of Longevity and PsychedelicsCONNECT WITH NINA’S NOTESNewsletter: https://www.ninasnotes.xyzLinkedIn: https://www.linkedin.com/in/ninapatrick/Website: https://www.ninapatrick.xyz Get full access to Nina’s Notes at www.ninasnotes.xyz/subscribe