Dr. Monty Pal welcomes Dr. Enrique Montero, research professor within the Arthur Riggs Diabetes & Metabolism Research Institute, to discuss his global journey in immunology and the pioneering work underway at City of Hope. The episode dives into the significance of the CD6 molecule on T cells - how its overexpression drives inflammation in conditions like type 1 diabetes and graft-versus-host disease (GVHD). Dr. Montero shares early insights from the first-in-human clinical trial of CAR Tregs for GVHD, noting promising safety and signs of durable benefit in patients who had exhausted other treatment options, and outlines the vision for expanding this technology to tackle type 1 diabetes and other autoimmune conditions.