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SUPPORT OUR WORK: OTPLinks.com 💉 Story 1 — Fractyl Health’s One-and-Done Gene Therapy for Obesity Fractyl Health just dropped preclinical results showing their GLP-1 + GIP gene therapy candidate RJVA-002 produced almost 30% weight loss in mice after a single dose. I sat down with Dr. Harith Rajagopalan, CEO of Fractyl Health, to talk about how this new Rejuva® platform works, what it means for people living with obesity and type 2 diabetes, and why gene therapy might be the future of metabolic care. 🏛️ Story 2 — Medicare Coverage for GLP-1s? Dr. Oz Drops a Hint At the Aspen Institute, CMS Administrator Dr. Mehmet Oz said even a comment on GLP-1 coverage would be “market moving.” We break down what that means, why the Trump administration shelved a rule that would’ve added obesity meds to Medicare coverage, and how that decision might now be a bargaining chip to lower drug prices in exchange for tougher enforcement on compounding. ⚖️ Story 3 — The Retatrutide Ruling and the Future of Compounded Access A federal judge ruled the FDA acted “arbitrarily and capriciously” when it rejected Lilly’s bid to classify retatrutide as a biologic. That may sound technical, but if the FDA changes its stance, it could have huge implications for tirzepatide (Zepbound, Mounjaro) and semaglutide (Wegovy, Ozempic)—especially when it comes to compounding and patient access. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

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Send us a textBuy The BooK!https://amzn.to/3Bzs4Ggro.co/OTPSupport the showOur Book Has Been Released!Decoding GLP-1: A Guide for Friends and Family of Those On The PenBuy Here: https://amzn.to/3Dc66d4DNF10 Peptide Supplement I Use: https://integrativepeptides.com/AFFILITATES/OTPUSE CODE "OTP10" to save 10%. A small commission is paid back to support On The Pen!MY WORK RELIES ON YOUR GENEROSITY, WAYS TO SUPPORT:Venmo: OnThePenCa$h App: ManOnMounjaroBECOME A MEMBER:https://www.youtube.com/channel/UCDocQ-4IhVS3ihy_dW7nSKw/join👉 My Amazon Affiliate Store:https://www.amazon.com/shop/manonthemounjaroonthepenMORE COMMUNITY!📺 Watch Our Weekly Live Show: onthepen.tv 🆕 Discord: https://discord.gg/u4Ea8qqP🤝 Visit Our Sponsor!GLP-1 Ro Body Plan: https://www.ro.co/otpReport The Shortage: https://www.ro.co/supply-trackerDoes your insurance cover GLPs? https://www.ro.com/checker📲 Contact Me: dave@onthepen.comThank you for tuning in! If you found this content valuable, make sure to like, share, and subscribe to my youtube channel for more updates on GLP-1, obesity, type 2 diabetes, and... Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Send us a text#ReleaseTheVialshttps://www.onthepen.com/post/eli-lilly-to-releasethevials-of-zepboundEli Lilly has released single-dose vials for ZepBound to stabilize higher dose supplies and removed all Mounjaro and ZepBound doses from the FDA shortage list, though tirzepatide remains in shortage. Novo Nordisk is seeking FDA approval for Icosema, a combination of insulin and semaglutide, with a favorable safety profile.Lilly Sends Tirzepatide Compound Cease and Desist Lettershttps://www.onthepen.com/post/it-begins-eli-lilly-fires-off-round-of-cease-and-desist-letters-to-tirzepatide-peddlersEli Lilly is taking legal action against GLP-1 compounders, particularly targeting ZepBound. Cease and desist letters have been issued to smaller prescribers and med spas, potentially pressuring the FDA on tirzepatide’s shortage status.#ReportTheShortageRo.co/supply-trackerPatients are encouraged to report ZepBound or Mounjaro shortages to the FDA. Ro has introduced a supply tracker tool to notify patients of nearby availability and launched RoBody, a program connecting patients with doctors to manage obesity and achieve significant weight loss.Insurance Checker TollRo.co/checkerRo's new GLP-1 Insurance Coverage Checker allows users to check insurance coverage for obesity medications and is integrated with the supply tracker. Despite financial struggles, 23andMe is launching a GLP-1 telehealth service. The ‘Opt-in for Obesity’ campaign encourages employees to request obesity coverage from their employers.On The Pen LiveZ Reitano from Ro will discuss the GLP-1 Insurance Coverage Tool on the upcoming On The Pen Live session, airing on YouTube this Thursday at 9 p.m. Central.#OptInForObesitySupport the showOur Book Has Been Released!Decoding GLP-1: A Guide for Friends and Family of Those On The PenBuy Here: https://amzn.to/3Dc66d4DNF10 Peptide Supplement I Use: https://integrativepeptides.com/AFFILITATES/OTPUSE CODE "OTP10" to save 10%. A small commission is paid back to support On The Pen!MY WORK RELIES ON YOUR GENEROSITY, WAYS TO SUPPORT:Venmo: OnThePenCa$h App: ManOnMounjaroBECOME A MEMBER:https://www.youtube.com/channel/UCDocQ-4IhVS3ihy_dW7nSKw/join👉 My Amazon Affiliate Store:https://www.amazon.com/shop/manonthemounjaroonthepenMORE COMMUNITY!📺 Watch Our Weekly Live Show: onthepen.tv 🆕 Discord: https://discord.gg/u4Ea8qqP🤝 Visit Our Sponsor!GLP-1 Ro Body Plan: https://www.ro.co/otpReport The Shortage: https://www.ro.co/supply-trackerDoes your insurance cover GLPs? https://www.ro.com/checker📲 Contact Me: dave@onthepen.comThank you for tuning in! If you found this content valuable, make sure to like, share, and subscribe to my youtube channel for more updates on GLP-1, obesity, type 2 diabetes, and... Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.