In this episode, host Shikha Jain, MD, speaks with Amy Comander, MD, about incorporating lifestyle medicine into cancer care, exciting advancements highlighted at the 2025 San Antonio Breast Cancer Symposium and more. • Welcome to another exciting episode of Oncology Overdrive 1:02 • About Comander 1:16 • The interview 3:42 • How do you find time to do everything that you do? 4:06 • When you started on your path, did you see your journey taking you to breast cancer, lifestyle medicine and authorship? How did you get to where you are today? 4:34 • Jain and Comander on the shifting mindset toward holistic patient care. 6:36 • Jain and Comander on the importance of lifestyle interventions in cancer care. 7:50 • Jain and Comander discuss optimizing survivorship. 9:04 • Tell us more about your latest book, PAVING Your Path Through Breast Cancer and Beyond […] What are you most excited about sharing from this book? 9:50 • Do you feel like this is a book for physicians, patients, caregivers or everyone? 11:47 • Is there anything related to lifestyle medicine, or breast oncology in general, that you are looking forward to hearing about at this year's San Antonio Breast Cancer Symposium? 14:38 • What are your thoughts on ESMO's latest press release regarding mRNA COVID vaccines and improved response to immunotherapy? 17:29 • Jain and Comander on specific lifestyle interventions to improve quality and quantity of life, as well as "guilty pleasures". 20:23 • How do you train for all the marathons you run, and when do you find the time to train regularly? 21:43 • What are the things that you are looking forward to seeing in the breast cancer space over the next decade in cancer care? 25:24 • If someone could only listen to the last minute of this episode, what would you want listeners to take away? 27:37 • How to contact Comander 28:45 • Thanks for listening 29:42 Amy Comander, MD, DipABLM, FACLM, MSCP, is a breast oncologist and medical director of the Mass General Brigham Cancer Institute in Waltham, director of the lifestyle medicine program at the Mass General Brigham Cancer Institute, and an instructor in medicine at Harvard Medical School. You can get a copy of her new book, PAVING Your Path Through Breast Cancer, here.

We'd love to hear from you! Send your comments/questions to Dr. Jain at oncologyoverdrive@healio.com. Follow Healio on X and LinkedIn: @HemOncToday and https://www.linkedin.com/company/hemonctoday/. Follow Dr. Jain on X: @ShikhaJainMD. Comander can be reached on Instagram @dramycomander, LinkedIn, or via email acomander@mgh.harvard.edu. References • Grippin AJ, et al. Nature. 2025;doi:10.1038/s41586-025-09655-y. • PAVING the Path to Wellness. https://www.massgeneral.org/cancer-center/patient-and-family-resources/supportive-care/paving. Published 2021. Accessed November 11, 2026

Disclosures: Jain and Comander report no relevant financial disclosures.