Nausea is a common side effect when ingesting psilocybin mushrooms, usually most pronounced during the “come up” and typically leveling out for the remainder of the trip, although the extent and duration of nausea can vary greatly among individuals.

Today, we’ll look at a few different perspectives on why nausea can happen, as well as some tips for avoiding it. We’ll also share how nausea played an integral part in one client’s intentional psychedelic experience, so tune in for a comprehensive conversation surrounding nausea and psilocybin!

Key Takeaways

Diverse Biological Triggers: Nausea is primarily caused by the interaction of fungal compounds (like indigestible chitin, tannins, and beta-glucans) with the human body, as well as the activation of 5-HT2A and 5-HT3 receptors in the gut.
Physiological vs. Psychospiritual Lenses: Identifying the specific causes of discomfort is essential for choosing the right approach; symptoms may stem from physical digestion or from "somatic resistance" and emotional baggage.
Strategic Remedies: Depending on the trigger, the transition can be managed through remedies like lemon tekking and dietary preparation, or by intentionally "leaning in" to the experience as a beneficial psychospiritual purge.

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