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On today's episode of the Real Foodology podcast.
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In many cases, when women implement these changes, they tend to start cycling more predictably and can even conceive on their own.
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Hello, friends. Welcome back to another episode of the Real Foodology podcast. On today's episode, I sat down with Sasha Hockman who works for HRC Fertility in California. They have a lot of locations. Sasha is a board certified OB gyn. She's a board certified reproductive endocrinologist and a medical advisor. We do a deep dive into fertility, but through the lens of egg freezing and ivf. Some of y'all may remember if you follow me on Instagram or if you've been listening to this podcast for a while. I froze my eggs a couple years ago at 36 and they've just been kind of chilling for the last couple years and I didn't really know what the next steps were. I'm wondering if I'm gonna have to use them. I'm hoping to be pregnant by the end of this year. So I'm on my fertility journey, as many of y'all know, and I really wanted to know what the whole process looked like as far as I already have my eggs frozen, what next? So we dive all into that. The process of egg freezing. We talk about, do you really need to take birth control while you're freezing your eggs? Because this was something that I opted not to do. We talk about how many eggs you get and is that a marker of your fertility, what it really means, what you can do about it, things that you can do to better your fertility. So hopefully this answers a lot of questions that you might have around IVF and egg freezing and the whole process. It helped me tremendously. So I hope it helps you and hope you enjoy the episode as always. If you are loving it, if you would take a moment to rate and review, it means so much to me. Your support means the world and it really does help the show. So thank you so much. We spend about a third of our lifetime sleeping. That's kind of wild when you think about it, right? One of the things that I have been really concerned about was making sure that I am sleeping on a natural mattress. I got a birch mattress. They are stylish, they're comfortable, and most importantly, they're crafted with responsibly sourced materials. I love knowing that the mattress I'm sleeping on is made with organic raw materials sourced straight from nature, which are both comfortable and durable. They also offer a 100 night risk free trial to see how your body adjusts to it. It's shipped directly from their facility to your door for free. The mattress comes rolled up in a box and it's super easy to set up to Birch Living b I r c-living.com realfoodology for 20% off sitewide plus two free eco rest pillows with mattress purchase I have something for you that I personally have been taking for over a year now and that is Mitopure from Timeline. It is a supplement on the market that's clinically proven to target the effects of age related cellular decline. It is quite literally food for the mitochondria which can equate to better fertility health. It also helps with muscle building, it helps with recovery if you're working out. And Mitopure is a precise dose of the rare postbiotic Urolithin A. It works by promoting an essential cellular cleanup process that clears out dysfunctional mitochondria AKA your cell's battery packs. Plus it's shown to deliver double digit increases in muscle strength and endurance without a change in exercise. That is crazy. So if you would like to try Mito Pure today and join me in taking this every day, timeline is offering 33% off your order of Mito Pure while supplies last. Go to timeline.com real foodology33 Sasha, thank you so much for coming on today.
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Thanks for having me here. I'm excited.
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Me too. So I actually haven't done a podcast about this specifically because you are a rei. What does that stand for again?
B
Reproductive Endocrinology and Infertility Specialist.
A
Amazing. Yes. So I want to talk all about egg freezing and IVF because I haven't done a podcast about this. I've done a lot of podcasts about fertility in general. It's something that I'm personally very invested in right now because I froze my eggs when I was 36. I'm getting married in June, I just turned 40 and I'm like holy, I need to get this figured out because I would love to be a mom. But I haven't talked about the IVF side at all. So a lot of my conversations, just so you know, have been around like optimizing your fer, making sure you have really good high quality eggs, when to freeze your eggs and all that. So let's dive into. Well first of all, explain a little bit about what that means. Like I've never even heard that term before. So what does that mean and what.
B
All does that entail to be an REI.
A
Yes.
B
Yeah. So basically we are OBGYNs by training who then subspecialize for an additional three years after the four years of residency. It takes after med school, residency, fellowship, and then board certification about 15 years to get there.
A
Wow.
B
So we have as much training in terms of length of time as a neurosurgeon.
A
Wow.
B
People don't realize this. We are trained in several different types of surgeries that are gynecologic, pelvic, but then you just really subspecialize primarily in infertility. But reproductive endocrinology involves a number of different disease processes as well, like disorders of sexual differentiation. Most private practice physicians, like myself, we are really just focused on infertility, fertility, preservation, even other things, like just a fertility evaluation for natural reproduction and just helping people with their family building goals.
A
Amazing. I wish we. We were actually texting last night and I was telling you this, but I wish I had known you before when I was freezing my eggs.
B
I know.
A
I even went to the same, like, facility that you work at, just in a different loc. And I'm so bummed. I'm like, oh, would have loved that. I know, because there's so much. I feel like. So we hear a lot of stuff on the surface about this, like, okay, freeze your eggs as early as you can, and. But. And then like, ivf. There's a lot of conversation about ivf, but to be honest, like, I feel pretty undereducated in all of this. And I even went through the egg freezing process, so maybe we can talk about that, because we were even talking about it last night, where I was like. I felt like I didn't even fully understand the scope of everything I needed to know. And I went through it because, one, I think it's kind of a wild process. You're also emotional. Like, you have to have a major surgery. It was, like, kind of uncomfortable. And then, like, looking back on it, I'm like, oh, I don't. There was so much I didn't even know. You know, like, first of all, okay, so let's talk about this. So when you freeze your eggs, you have two different options, which is like freezing your eggs, or if you already have a partner, you can freeze your embryos.
B
Yeah. We call that embryo banking.
A
Okay, and what would be the benefit of freezing embryos over freezing your eggs?
B
Great question. So there's actually this misconception that freezing embryos is better than freezing eggs because the embryos are more viable. There's, like, somewhat some truth to that. But the biggest difference is when you go to freeze eggs, you have some advantages and disadvantages the advantage of simply freezing eggs that are not fertilized is that you have full autonomy on what happens to these eggs.
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Yeah.
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Should something happen in a relationship and you created embryos, most of the time, the resolution to that dispute is discarding the embryos. And it really sucks for the female partner, because then if they're much older, they have nothing preserved.
A
Yeah.
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And their options are a lot more limited or things may be a lot more difficult, especially if they're past their 40s.
A
Yeah.
B
So that's the. That's sort of the biggest disadvantage of creating embryos with someone, even if you feel like that is your lifelong partner, especially if you're going to really hold off on using them for a very long time. The other thing about eggs is that they. Nowadays, with our technology, we do something called vitrification, which is flash freezing of the eggs. So a slow freeze process, because it's filled with so much fluid, you can end up getting these ice crystals, and then when you go to thaw them, it just really damages the eggs. So when you hear about people who froze their eggs back in the day, when it was still considered experimental, they'll often say, it's really not that successful. It's not that good. Good. They don't do as well as embryos. So before vitrification, that is true. But now the way that we freeze them, it's basically like freezing time. And so they're in this glass, like, state because we put the embryos in these straws, they go in liquid nitrogen, and it's essentially frozen in like a fraction of a second.
A
Wow.
B
So it's. Yeah, it's pretty impressive. So with that, the thaw survival rates are so much better, but you still expect to lose maybe a certain percentage of eggs. If we look at the averages for women under 37, the average survival rate of eggs that are being thawed is 95%. If you're over that age. So over 37, then you're looking at about 85% survival rate on average.
A
And is that because as we age, are they just like. Are they more like fragile or what is that?
B
It's probably correlating to egg quality, which we expect that that does decline with age. I would say the biggest or the sharpest decline in egg quality really starts to happen around 37, 38.
A
Okay.
B
And then it just sort of accelerates after that.
A
And I'm curious, from your lens and what you've seen, do you think that there is any correlation with. Because I've had a lot of podcasts where we talk about nutrients and how well those can improve your egg quality or like, if you focus on mitochondrial health, things like that. Have you ever, have you seen a difference in, like, if somebody's actively working on nutrients, lifestyle, maybe toxin exposures, and maybe that has effect on the egg quality?
B
Anecdotally, I have not. I know that there are conflicting studies. So some studies are pretty impressive where they show that if you do certain supplementation with antioxidants, for example, CoQ10 being the most commonly used supplementation that we recommend, in addition to things like NAC or N acetylcysteine, there's pretty good evidence backing how it can improve equity quality. That being said, it's a little more nuanced because there's. It depends on the person's overall health status, their prognosis, their age. And I truly believe that there's always this genetic underlying component to how well your eggs are going to perform. And it's not necessarily something that's inherited, but it could just be like some random variant and there's no data to prove this. This is just my theory. It's something I would love to see researched is just how our genetics can really impact or how specific genetic variants could impact your egg quality and how they perform. So, I mean, that's really the biggest thing. I think that if you're in a certain age category, like if you're in your 30s and you want to postpone, say for three to six months to really improve egg quality, especially if you're someone who has an unhealthy lifestyle, nutritionally, lack of exercise, you have insane exposure to environmental toxins, we know that that truly negatively impacts things. So possibly by supplementation and improving overall lifestyle, we can see an improvement in that quality. And maybe in a handful of cases, I have seen that happen. Now, being in la, it's kind of hard to gauge that because I feel like the majority of my patients are very conscientious of this and most of them really work hard to take care of their health. So it's. Yeah, it's tough to gauge with this particular population. I think that when you're seeing a more unhealthy population, then it's easier to have more actionable things that they can do to improve that equality. But if you're already someone who's really on top of your game, it's a little bit harder to fix that for sure.
A
See, this is where I feel like the. And we don't have to spend a lot of time talking about this, but Just the insidious nature of like the pesticides that are being sprayed on our food, the stuff that's ending up in our air and water that I'm just like, there's no way. It's not having an effect on us. And that's the kind of stuff that like, we like. We don't really. We can't control it.
B
Right. We know it has an effect on us. I mean, it's been well established in our field now that even if you look at endocrine society or the American Society for Reproductive Medicine, it's often talked about how there are endocrine disrupting chemicals everywhere, that they're really affecting our overall health, our reproductive of health or risk for cancer long term. So it's really tough because all you can do is reduce exposure by eliminating certain things like perfumes we know are super toxic. Big one.
A
Honestly, that makes me feel so much better. I'm so happy to hear that that is a topic of conversation and something that they're recognizing because that is a really big one. And also that's a really easy one.
B
It's an easy one.
A
That's an easy one to take out.
B
Yeah.
A
Just stop spraying the perfume. If you want to wear something like find, you know, an essential oil or like something natur role. Obviously not when you're in the or, but like. Yeah. In your everyday life.
B
No, but it's funny, even as an ob gyn, I didn't know that until I started my fellowship. And then I happened to find this out, you know, my first week and after I got scolded, but rightfully so. But now after eliminating all fragrances, I can smell fragrances from a mile away and I hate it.
A
It just.
B
It gives you a headache. It makes you feel awful.
A
Yes.
B
Which says a lot.
A
Yes. Yeah. And I. Oh, I just. Yeah. I have such a pet peeve with like the scented or the not deodorants. The laundry detergent where you can smell people from a mile away with their clothes.
B
It's just so bad. Yeah.
A
Because I just think about their endocrine disrupt or their endocrine systems and I worry for them. One thing I've realized is that there's so much confusing information out there and it's hard to know who to trust. That's why I was really excited when I found Sepco. It's a new app for managing your supplement stack. It analyzes your entire routine, rates it based on data they have on over 180,000 products, and gives you real tips on what's working and what's not. Subco showed me how many products rank across their trust score, quality rating system, how much I'm spending, and they even gave me doctor Built supplement plans that I could follow. Here is the best thing about it. Sepco doesn't care whether you buy any supplements or not. They're not an e commerce company. In fact, they'll often tell you not to use a product anymore if they think that it's not right for you. Sepco is currently in beta, but my listeners can get 100 free access today at sepco.com realfoodology that's s u p p.com real foodology definitely check it out now because it won't be free forever. I've already tried the whole app. It's incredible. I'm sure you've heard of nad, but did you know that it's in every living cell of your body? It helps to keep us young, repairs, damage, detoxifies, and also gives us energy. But did you know between ages 20 and 50 our NAD levels are cut in half? No wonder we start having less energy, less vitality, and we just start simply feeling old. So unless you want to feel old and run down, you're going to want to boost your nad. And this is where Qualia NAD makes it super easy. It's a simple supplement clinically studied to boost your NAD levels by an average of 74%. It's vegan, gluten free, non GMO, and it's packed with ingredients to help naturally boost NAD production, to help you feel at your peak and in your prime way deeper into life. Trust me, your future self is going to thank you for that. Personally, I feel amazing and I want to feel 30 when I'm 60. So if you want to join me and boost your NAD levels up to 74, go to qualialife.com real foodology for up to 50 off and use code Real Foodology at checkout for an additional 15 off. That's qualiolife.com real foodology for an extra 15 off your purchase. Okay, so for the egg freezing process. So another thing, I was actually asking you about this a little bit last night because I was concerned because I didn't get as many eggs as some of my girlfriends did and I was one. I was horrified. I was embarrassed. I debated even if I was going to share it on the podcast because I was like, it, it feels like it's like a marker of like your fertility and, and your worth. And I could go into all the things that we judge ourselves for as women. Right, but let's talk about that a little bit, because you. You brought up a really good point that I'd never thought about before. And you said that, you know, sometimes you'll. You'll see someone who gets a lot of eggs, but they don't actually have that many that are viable. And I think at the end of the day, it really does matter about the quality over the quantity. Of course. Right, yeah. But where is that kind of like, is that a marker of, like, how good your fertility is, or. Can we talk about that a little bit?
B
Yeah, of course. So, yeah, that's another misconception. Oh, I have a lot of eggs. That's really reassuring for my fertility. Now, like I said before, the disadvantage of egg freezing is that you have no idea what the potential of that egg is. We haven't fertilized it yet. We don't know what it's going to do. And if you've never tried to get pregnant in the past, and you're electively choosing to freeze your eggs because you're single and you're getting older or whatever it is, then we just have no clue what the journey it will take is. Now we use data from previously frozen eggs that are thawed and fertilized to help predict the likelihood of having a child or a live birth from the number of eggs that are retrieved. Right. But those are averages, and some people do much better and some people do much worse. So that's just what we have to work on. But it's not the be all end. All right, so oftentimes what we see in an IVF cycle, very different than egg freezing. We actually see the whole journey. So if I walk you through an IVF cycle, the biggest difference is, first, to get your eggs, we give you injectable medications, typically in order to help stimulate your ovaries. Your ovaries are comprised of follicles. Now, you have follicles in the resting stage, which is where the majority of your eggs lie. A follicle is a sac that contains an egg. Every egg has its own follicle, and most of them are in the resting stage. Some of them have left the resting stage, and they are now antral follicles. That's what we call them, a normal number. What's considered normal is about 6 to 8 per ovary. Could be as much as 14 per ovary, and that's now considered normal. And those are the follicles that are available for stimulation. We cannot tap into future follicles. They're in the resting Stage, they are not there. They will not respond to medications. It is just the bigger follicles, which are fluid filled sacs that can be seen on ultrasound that are available for that stimulation. Once we start the injections, which takes an average of two weeks to really get those follicles ready, then we prepare to get you ready for an egg retrieval. And that egg retrieval is the procedure that you underwent where you go in with a needle into every single follicle, you suction the content, it goes into a tube and it's handed to the embryologist, who then kind of dumps it in a dish and looks under the microscope and is able to count the eggs out loud so that by the time the patient even wakes up, we know how many eggs there are. Now when you're freezing your eggs, we just freeze the mature eggs and so that the listeners understand the difference between an immature egg and a mature egg. Immature eggs have both copies of the chromosomes. A mature egg has sort of ejected out one of the copies so it could accept a copy from sperm.
A
Got it.
B
Those are the only eggs that we can actually fertilize in a lab. The immature eggs cannot be fertilized. It's got too much DNA. So when we are able to see which ones are mature, those get frozen and then that's the end. Right, but for ivf, it doesn't end there. During the egg retrieval, we're getting the male sperm, whether it's partner sperm or donor sperm. It is basically they're preparing it in by cleaning it out and, you know, then you go to fertilize the eggs. There's two main ways of doing that. There's something called icsi, which, which stands for intracytoplasmic sperm injection. This is where it's a mouthful. Yeah, but you're basically looking for the best looking sperm. You inject it directly into the egg to try to. The goal is to try to attempt a higher fertilization rate. There are specific medical indications for doing icsi, and then for like male factor infertility, for example, or previously frozen eggs is another indication. But I'd say 90% of IVF clinics are just using it for everybody. The other type of fertilization is conventional. You put sperm and egg in a dish and then you look the next day to see what happens.
A
Oh, wow.
B
Like, so I guess a more natural way to fertilize it. Yeah, it's kind of fallen out of favor mostly because in about 10 to 15% of cases you will have total fertilization failure and nobody Wants to be in that situation. No, that's a really hard phone call to have with a patient. So that's primarily why most clinics just do icsi, because, you know, nobody wants to call patients, say, yeah, almost none or none have fertilized after that. You culture the fertilized eggs for a duration of about five to seven days, I would say. Most big labs will culture until seven days. Some will just stop at six. And usually by day five or six, you should have what's called a blastocyst. So that's a day five embryo. Some take a little bit longer. But there have been babies born from day seven embryos, which is why a lot of labs will culture to day seven. Because even if it only gives us a handful of babies every year, that's a big deal. Yeah, that's many lives.
A
When you think about that one individual couple, that's really weird, Right?
B
It changed their life.
A
Right, Exactly.
B
So at our practice, we do it for everybody. And from there, the ones that do develop into blastocyst, you have the option to then biopsy some of the outer cells and send them out for genetic testing, which is known as pre implantation genetic testing.
A
Okay.
B
So we're testing the embryo before we transfer it back to the uterus and it implants.
A
Okay.
B
And that gives us an idea of is this embryo chromosomally normal or not? And based on that, we have prognostic indicators of what is the likelihood of that embryo becoming a baby. So PGT is not perfect. It does not exclude a lot of things like small deletions or duplications. And this is why it doesn't yield 100% pregnancy rates. In fact, a chromosomally normal embryo gives you a 65% chance on average. So that's sort of the process, right?
A
Yeah.
B
So when you're doing ivf, when you get to that final euploid embryo number, now you really know what you're working with.
A
Yes.
B
I have had patients where we only get three to four eggs, and they end up with two euploid embryos. Amazing. I mean, they really defied all odds, because if we look at the national averages for statistics of fertilization, on average, 70% of eggs will get fertilized. And of those fertilized eggs, only half of them are expected to become embryos. Of the embryos, the percentage that are chromosomally normal depends on age. So if you're under 35, you should have 50 to 60% that are normal. But as you get older, that percentage, you know, naturally drops.
A
Yeah.
B
But I have seen patients where they have a ton of eggs retrieved, 30 plus, and we end up with no normal embryos. And when that happens, sometimes I'm like, this one cycle might be a fluke. Let's try again and see what happens. And when it happens again, that's when you know, okay, there's something seriously wrong either with egg quality or sperm. But there are ways to sort of test to see is this aneuploidy source from the sperm or from the egg.
A
So I'm curious because I had another podcast where we were talking about this, where we don't really talk about men a lot in this whole process and how much the sperm actually plays a role in the overall infertility. If you're struggling, it's on the woman, right?
B
Yeah.
A
So when y'all are doing this process, is there testing of the sperm too, to make sure that it's viable before? I mean, I'm assuming they have to be, right?
B
Yeah. So what we do is we always start with a semen analysis. So what we're looking at are different parameters from the sperm in that sperm sample. So what is the volume of semen? To start with, it should be at least 1.5 milliliters. And then we look at the concentration of sperm, and, you know, typical concentrations that we like to see is above 15 million, 1,5 million per milliliter. And then you look at the motility, which is the swimmers. You know, what percentage of the sperm that's there are. Swimmers should be at least 40% motility. But a more important marker of motility is something called progressive motility, because motility just indicates that they're moving. But we want to know which ones are the straight shooters and how many of them are there. And so in most andrology labs, you want to see at least 32% of progressive motility. That's really important. And then finally the morphology, which is the percentage of normal shaped sperm. But if you're using really strict criteria of how the sperm looks like, we only expect to see 4% or more appearing normal. Really, because the majority of sperm is just vastly abnormal.
A
Really? Is that. Is that. Has that always been the case? Is that normal? Always.
B
It's always been the case.
A
Okay.
B
So human reproduction is actually quite inefficient.
A
Y'all may remember that I had Mark Hyman on the podcast last year, and we talked about Function, which is a company that he helped found. And it's an all in one health platform that starts with over 100 advanced lab tests covering Your entire body, heart, hormones, liver, kidneys, thyroid, autoimmunity, cancer signals, toxins, nutrients. They also have some new tests now outside of the 100 advanced lab tests that they're already testing for. And they can test for things like BPA exposure, pfas, mtf, hr, Alzheimer's, early detection, brain injury, bone health, chronic inflammatory response, extended autoimmunity, Epstein Barr, heart and metabolic, extended hormone, extended thyroid, food sensitivities, and so much more. Also Lyme, which is amazing. I think you and your family should join function. In fact, I'm getting my parents on it this year. I got my fiance on it. If you want to skip functions wait list, go to www.functionhealth.com realfoodology. That is functionhealth.com realfoodology. Which is so weird.
B
It's so weird. Yeah. It's really inefficient. I mean, if you look at the most fertile couples, the chance of conception in a given month, if you're under 25, is at most 25%.
A
That's so wild to me. I just have to believe. I'm like, it has to be because of what's happening in our environment. There's no way that we have always been like, in my opinion, well, the.
B
Infertility rates are rising, for sure. I think it's multifactorial. I do think our environment plays a huge role. I also, I mean, I know for a fact that a big part of it is we're waiting longer to have babies. Right. So that's a huge variable. But if you control for age and you still look at younger women, the age infertility rates are significantly higher than they used to be. Yeah. The biggest question I sometimes ask myself is, well, is it because we're more educated and people are seeking out treatment as opposed to just suffering in silence, or is it. I think it's probably a combination of many things, But I definitely do believe that our environment plays a massive role. We just have so many environmental toxins. There are are many different researchers who are looking at the different pesticides, for example, and how that's affecting sperm. And we know that, you know, sperm parameters have declined quite significantly in the last 50 years, particularly for men who live close to sort of big farms that spray pesticides and that are exposed to things like glyphosate.
A
Yeah, that's a big one that I like to talk about a lot. I mean, well, it doesn't give me joy, but it's just. I think it's a really. It's an invisible Insidious one.
B
Yes. And that's the hardest part. It's kind of like an invisible disease. You don't see it. You think, okay, well, I'm mostly eating vegetables, fruits, whole foods, as much as possible. In terms of my protein sources, I'm not, you know, my carb choices are really healthy. Low glycemic index, high fiber. And yet here we are. And it's the most frustrating thing for patients that are stuck doing all these repeat IVF cycles, and they're just like, what? I've done everything in my life to stay as healthy as possible. So that's definitely a big part of it, for sure.
A
There's also the phthalates piece, too. Have you heard of Dr. Shanna Swan? Yes, yes. Heard the countdown. I had her on my podcast a couple years ago, and she was talking about. I mean, it's. Yeah, it's horrifying the phthalates and what she's seeing with dropping sperm rates. And also, like, even when the babies, they're being born with smaller.
B
She talks about the analogenital distance.
A
That's what it is. I was like, what's the word for it? Yeah, yeah.
B
Really interesting study. I read about it, too, and I've heard her on many podcasts as well. And her work's amazing. It's also kind of depressing.
A
I know. I know it is. It's one of those things that, like, I. I say this often where I'm like, if. If your house is on fire, wouldn't you want somebody to tell you? It's like, if we know this is happening, we gotta sound the alarm so that we can start creating policies. Like, the more that we know about this, then we can start creating policies and not allow these companies to maybe use plastic anymore. And we need to create other options outside of plastic. If now we know what it's doing to our body, you know?
B
Right.
A
But until that, I mean, it's up to us to. I mean, I. I buy all my water and glass. Like, I try the best I can, and then, you know, there's only so much we can do, too. We can't just.
B
Right.
A
Live in a bubble.
B
Right, Right. And that's the hardest part. And I try to always reinforce, like, I don't want you to become paranoid.
A
Exactly.
B
Want you to be knowledgeable and then make the best choices you can when it's feasible.
A
Yeah, for sure. You know, so. Okay, so let's go back to. So I, obviously, I froze my eggs when I was 36. Now, you were telling me that I could actually turn those into embryos, which I never knew that I thought I was gonna have to go back through another IVF or not ivf, whatever. Like an egg freezing through the whole thing, the hormones and the retrieval and all that, to create the embryo. So what does that process look like? Because I. I think I want to do that.
B
Yeah. So it's so much easier on you this time, because really all it involves is basically getting a semen analysis, making sure that sperm looks good. If for whatever reason it doesn't, this is where additional testing really happens for the guys.
A
Okay.
B
So the guys have it fairly easy in the beginning where they just do the semen analysis. If it comes back normal, their job is done.
A
Yeah.
B
Meanwhile, the women are getting, you know, all the pelvic imaging, the tube testing with the X ray, and that is not a fun test, the hsg.
A
I have a friend that just did that and she said it was really painful.
B
Oh, yeah, it can be. There are ways to make it less painful, but that is not universally done, unfortunately.
A
Yeah.
B
So, yeah, the women have to go through a lot. And then, of course, the ovarian stimulation, if you're gonna go freeze your eggs, plus the egg retrieval, all the things. But once we make sure that sperm looks good, then you basically just schedule a time to thaw the eggs and you go to fertilize them that day. So once the eggs get thawed, essentially every patient has some sort of barcode on the straw, and in the chart, it's labeled which canister. And so the embryologists are able to easily locate exactly where they are. When you have, you know, thousands plus samples, you go to get it out, and then there's a whole thaw process. And basically then you look under the microscope to see which ones actually survived the thaw. And that. That looks good. Then you go to inject the sperm directly into the egg and you. Most practices, most embryology labs will have these bench top incubators. They're teeny tiny, they're incredible. You basically culture the egg in there and you check the next day, and you're able to tell which ones fertilized and which ones didn't. Okay, so you're physically doing nothing aside from just coordinating dates with the clinic.
A
Okay, so I'm gonna ask you a question that I might regret, but I'm curious because Hector asked me this one time, and I'm so curious. How do they actually go about getting the sperm? Is it literally like in the movies when you go to a doctor's office and they have magazines or, like, can he do that at home? You don't have to give, like, major details, but, like, what is the process look like for that? Do they go into the office to.
B
Do that so you can actually drop it off?
A
Okay, so you can do it at home.
B
You can do it at home. We were very curious about that sterile cup from the clinic.
A
Yeah.
B
Before I. And then usually you'll get, like, a whole sheet of instructions. You need two to three days of abstinence. Do not use any saliva lotions, anything that will affect the sperm. And for guys that have a really hard time with that, sometimes the lab will provide mineral oil that they use in the lab that's safe for the sperm.
A
That's so amazing. I just love to know all of this because literally Hector was asking me. He's like, what's the process for that? And I was like, I have no idea. And you see movies and they make it in this whole thing where they're, like, awkwardly at the doctor's office and they're giving them magazines, and I'm like, surely they're not doing that still.
B
Some places do.
A
Really?
B
Yeah, some places do. They will still have the guys come during the egg retrieval, and they will put them in a room, in the ejaculation room. And poor guys, you know, usually, like, it's a. It's a screen now, but the feedback I got from my husband is, that room's disgusting. Like, I'm not touching anything in there.
A
Literally, though. That's why I'm like, that's just. Yeah, that's really.
B
After we did ivf, he was like, nobody asked me how my part was. No offense. I don't think anyone cares.
A
No, literally, like, babe, you're fine. Like, that's so. That's so funny. Okay, so. Okay. I'm so happy to know that I wouldn't have to go through the hormones and all that again. Because when I froze my eggs, I thought. Because they did give me the option, they're like, would you want to do embryos? And I was like, well, at the time, I didn't have a partner, and so I just didn't want to do that. And I thought at the time it was one or the other, that you couldn't go do the embryos later.
B
Yeah. I mean, the whole point of freezing the eggs is that they're there and they're available for when you need them.
A
Yeah.
B
And depending on the number of eggs you have, if it's a smaller number, I always recommend my patients thaw all of them to fertilize, don't split it. But if you have, like, for people who have a ridiculous number of eggs, I'm just like, yeah, if you want to split it and keep some back.
A
Yeah.
B
Just in case that makes sense. Because you just never know where life takes you. And then there's also, like, the ethical considerations for couples where they feel very strongly about not discarding embryos. So a lot of people do feel very attached to their embryos, and then once they're done having their kids, if they have extras, they're kind of like, well, what do I do now? I don't want to just discard them, because I saw the result of these embryos, which is, like, the people I love most in this world. How can I go and discard these other embryos? So for those who really feel very attached, or they, you know, I would say probably are my more religious couples, I say, let's just start more conservative. We just saw a certain number that makes sense based on your age and then go from there. So that there are. There isn't this, like, crazy abundance of embryos that you don't know what to do with.
A
I mean, that's fascinating. I'd never even really thought about that before.
B
Yeah, it's. It's tough predicament, and sometimes you don't even think you're gonna feel that way until you have your first child from an embryo. And you're like, well, you're like, wow. Yeah, I kind of love these other embryos.
A
Oh, okay. So let's say that I do the embryos, and then I decide to move forward with wanting to actually turn one into a viable pregnancy. What does that process look like? Do I have to take hormones in order to do. To finish that process off in order to get pregnant?
B
So there are different ways of doing this. So this is the embryo transfer process. And oftentimes people will sort of clump that with an IVF cycle and call that ivf. But this is an fet, a frozen embryo transfer, totally different than ivf. It is the continuation of it. So once the embryos are made and they are cryopreserved, and I'd say the majority of people now are probably doing genetic testing on their embryos, although many do opt not to do that. Once you have those results and they're still cryopreserved, those embryos are just waiting for you. You sort of pick a time. I'd say the most common time that people will pick is, you know, immediately after the embryos are created, especially for Couples dealing with infertility. But for those who are doing, you know, fertility preservation, or let's say in your case, you're like, well, I want to wait until after my wedding. So then you just sort of like, set this date where once you get your period, you start the process of prepping for an embryo transfer. And this is after additional evaluation of the uterine cavities is done.
A
And is that the HSG test?
B
That's one of them. The probably most common option that doctors will use is. Is called a saline sonogram. So it's a similar process where you place a catheter in the uterus. Not very fun.
A
Yeah, that sounds awful.
B
Yeah, you should take meds before to really help with the cramping. And then sterile water is pushed into the uterus under ultrasound guidance. And then this is where you get nice images of the uterine cavity to make sure that there aren't any polyps, which are benign tissue growths inside the cavity, or fibroids, which are benign tumors of the uterine muscle that can grow in the cavity. Scar tissue, or an abnormally shaped uterus that some women are born with that may need to be corrected. So these are all things that can negatively impact the success rate of an embryo transfer or result in a miscarriage. So these things are done first in the cycle prior to getting ready for an FET frozen embryo transfer. Sometimes additional testing will also occur, like an endometrial biopsy if it's indicated. When you start the process of actually prepping for the transfer, what you're trying to do is mimic the post ovulatory stage, because five to six days post ovulation is where you have that implantation window. So you need to mimic that hormonally or you do it naturally. So the two most common protocols that we use is one is a medicated one, which is called a programmed FET protocol. This is where you get estrogen pills or patches or shots, and then you come in for monitoring. The ultrasound is to see how your lining is responding to the estrogen. Estrogen helps to thicken the endometrial lining, so we need it to be nice and thick prior to any progesterone exposure. Then once that lining looks good, you start progesterone, and then the progesterone is really what starts the clock. So in a programmed protocol, you're getting estrogen. Once the lining is ready, you start progesterone, and then five days after that start is when you have your transfer. Sometimes there will be variations in the Timing depending on specific scenarios for patients. And that's a whole different conversation, super complicated, so I won't get into that. But that's sort of the timing of. It takes an average of about, you know, two and a half to three weeks to get to that point of transfer. So usually the clinic will say, okay, you're going to start your progesterone, and on this day, on this time, is your transfer. And the embryo transfer is a painless process. This is where you have a catheter with the embryo loaded in it. It's placed in the uterus. You should not feel cramping with it. So I always tell my patients, if you are feeling anything, I need you to tell me, because it should be a very painless process. I would say the most uncomfortable part of it is you need a full bladder, and everyone just really wants to pee. So that's probably the most uncomfortable part. The natural FET method is my personal favorite. I'm all about keeping it as natural as possible. I just think that the body does it better. Statistically speaking, in our data, they seem to have the same pregnancy rates. I do think that as more practices do natural cycles more frequently, we're going to start seeing a little bit of a shift where I think the pregnancy rates will be improved. But, you know, verdict is still out, or the jury's still out. So with the natural cycle, it basically relies on you ovulating. So you come in, we track your ovulation, and once I see that your follicle is ready, then the large majority of us will do, I guess, what's called a modified natural cycle, where we give a trigger shot. So you probably remember taking this trigger shot right before your retrieval to mature your eggs. In this case, the trigger shot is to actually help ovulate. And then typically, a week after that is where you'll have your transfer. I have had patients who say, I want absolutely no medications whatsoever. The only thing I'm willing to take is the progesterone suppository just to make sure that I'm giving that extra support for my baby. And in those cases, we've done it successfully. So it's a pretty nice protocol. It just requires a little bit more monitoring sometimes, especially if it's completely natural. And then it also depends on age. So someone who's perimenopausal obviously can't really do that because they're really high likelihood.
A
Yeah, yeah, enough.
B
They're probably gonna get canceled, and it's probably not going to be as successful. The uterus does not age. So if you're older and having an embryo transfer or programmed FET is probably the way to go.
A
Okay.
B
Yeah.
A
Wow, this is really fascinating. I always thought that I was gonna have to go through an actual, like, IVF process if I wanted to use my embryos.
B
No.
A
But it sounds like I could do the all natural way, which makes me feel so much better. Yeah, like, so much better.
B
Yeah. If you ovulate regularly, then you're a great candidate for it.
A
Yeah.
B
Yeah.
A
And like clockwork. I'm like clockwork every month, like, very. Because I track everything with my natural cycles and all that. And yeah, I'm like clockwork. That's great. So. Oh, my gosh, that makes me so happy because I was texting you last night. So another reason. So the reason why I went to this doctor that I went to to freeze my eggs was because I was asking around, and I don't even remember now who referred me, but I was really to do the egg freezing process because I. I have a very, like, volatile reaction to doing synthetic hormones my whole life. Like, the first time I ever tried synthetic birth control was when I was 21. I couldn't even finish the pack. I was an insane person. I just did not like the way that I felt. And then another time I took them for, like, a couple weeks. I had the exact same reaction. It changed my period for literally, like, 10 years. Like, I had never had a heavy period. And these hormones, like, literally messed up my cycle. Like, I just. My body is so sensitive, and so I was worried that I was gonna have to do that. But after I got my egg retrieval and I didn't get as many, I was concerned that, like, oh, should I have just, like. Like, just done it? Like, sucked it up and done the birth control anyways? Do you think the birth control makes that much of a difference before when you retrieve the eggs?
B
So, yeah, this is.
A
And you can be honest, it's okay.
B
Yeah, no, this is the part that's called priming. So it's actually quite controversial whether priming is really even necessary or not. Especially with birth control pills specifically.
A
Yeah.
B
So some data shows it makes absolutely no difference, and then some shows it does. Now, the advantage of taking birth control pills prior to starting is that the theory behind it is you're kind of keeping the follicles small, similar in size. And the hope is when you stop the pillow, the follicles will grow more in synchrony so that you have more mature eggs available all at the same time, maximizing the egg count. That being said, I have had plenty of patients not wanting the pill who have been very successful in their cycles as well. And I know many doctors who don't do it and they have really great outcomes. I would say my favorite type of priming is starting in the luteal phase. So one week after you ovulate and with an estrogen pill in particular. I don't do this for women with really high ovarian reserve because the concern with them is that they're going to hyper stimulate. But with the estrogen pill, this is called an estrase prime that has been shown to improve the response to the injectable medications and potentially yielding to higher number of eggs retrieved. So that is my preferred method. That being said, there have been many cases where I do what's called just like a straight start. So at the beginning of the menstrual cycle, but you can really tell on ultrasound when the follicles are all various sizes. This is where I tell those patients, like, listen, you have a good number of follicles, but some are way bigger than the others. I don't think they're going to grow in synchrony and we're not going to get a high number of eggs.
A
Yeah.
B
If you want reconsider, we don't start today and with the next cycle we start priming you, we do the birth control, we do the estrase prime and then we start in hopes of getting a higher yield.
A
Yeah. Which I wonder now looking back if. Because that was never a conversation that was had with me and I wonder now if if that was. Yeah. Like if I had been told that, I probably would have been like, okay, I'm just gonna suck this up and just do.
B
Could also be the type of birth control pills that you've been taking too. Because sometimes. And we talked about this too last night where I said, well, estrase has a lot of side effects, the most common one being just really intense nausea. And that was my personal experience with it too. But if you administer it vaginally, then you're bypassing that first pass effect of it being metabolized by the liver, which leads to a lot of side effects. So if you place it vaginally, it has really great absorption. You're bypassing some of the side effects and you're only on it for a week.
A
Yeah. Okay. In a week. That's like pretty manageable. Yeah, I just was, I was so I, I like joke that I have like PTSD from my experiences on synthetic hormones that I just like, I Was.
B
It's a thing.
A
I, like, almost didn't freeze my eggs because I didn't want to have to take the birth control. It really. It did. It, like, scarred me. I. I really, like, did not. Not have great experiences on birth control.
B
Yeah, it's. It's really interesting with the birth control pill how two women can feel vastly different.
A
Oh, it's wild.
B
Yeah. For me, it's the opposite. I feel like my best when I'm on it. And then I've had many patients who are like, I will not do it. I literally go nuts.
A
Yes.
B
And I say, okay, no problem. We'll. We. We do something else. Yeah.
A
I'm like, I will not be getting married in June if I get put on these synthetic hormones because I turn into a monster. Like, I'm. I don't recognize myself. So it just is, like, not. But it's interesting because I have another girlfriend who. Same thing as you. It's like she thrives. She's like, I have never felt better. Like, wow. We have had vastly different experiences. It's crazy. And we're all just. We're all so bio. Individual, you know that? It's like. Yes, absolutely. Okay. This is so fascinating. God, I have so many questions for you. Okay, so this is really interesting, and I hope you don't mind that I'm, like, bringing this up, but I think you've talked about this before, but you have. Or had. Or have pcos.
B
Yeah. So it's a funny story, actually.
A
Okay. And you were able to have kids, too. There's a big concern for that for women. So let's talk about that.
B
PCOS does not mean that you can't get pregnant. A lot of people think that with pcos, it's really just an ovulation issue. PCOS is actually diagnosed of exclusion, and it involves two out of three of the following things. So that's like the primary diagnostic criteria, which is you have irregular periods or no periods at all. You have signs of hyperandrogenism, whether it is high testosterone levels on blood draw, or you're dealing with really bad cystic acne, hair loss on your head, hair growth on body areas that are just more male patterns, as well as polycystic appearing ovaries on ultrasound, which are not cysts, by the way. So polycystic ovary syndrome has nothing to do with cysts. It just is a lot of follicles in the ovaries. So I kind of hate the name of it. I wish we would rename it. Yeah, it's an endocrine disorder, a metabolic disorder, that really the true cause is not fully understood. But we're starting to understand that there's obviously a disconnect between the brain communicating with the ovaries. The ovaries are producing lots of androgens, and that is due to preferential release of luteinizing hormone, lh, which is more commonly known as your ovulation hormone. You get that LH surge before you ovulate, but what LH really does is it helps rev up androgen and testosterone because that's the precursor to estrogen. But when you have too much lh, you get too much testosterone. No, fsh, which is follicle stimulating hormone. You don't get stimulation of the follicles, so they never really grow a follicle to then release an egg. So you have all of these follicles that are hanging out in the ovary and they're just not doing anything. Yeah. And it presents really, really differently from woman to woman. And I always thought that I had PCOS because, you know, I met the criteria and other endocrine tests, tests came back normal and negative. And I had polycystic ovaries in appearance, high ovarian reserve. And not that it ended up changing management, but I just recently did an expanded genetic carrier screen, and it turns out that I have something very uncommon called congenital adrenal hyperplasia. So it acts like pcos, but it's more of a genetic disorder. So this was inherited from my parents?
A
Yeah.
B
I don't know if it's two from one. Yeah, it's really rare. But if you pass it on to your children, you could have a child that's really ill. So, you know, lucky for me, my husband's negative, and so we don't have any affected kids. But that is, you know, it's likely why I was also able to conceive on my own as I got older. But in general, with pcos, you definitely can get pregnant without treatment. But I always tell women who are anovulatory, if you're actively trying to get pregnant, don't wait for the random ovulatory event. You should be on meds that will help you ovulate in a more predictable manner. There should be additional workup like testing for pre diabetes or insulin resistance, because other metabolic disorders that happen with pcos, they. They should be managed before pregnancy occurs, for sure. Yeah.
A
Well, because oftentimes when you manage that, you also are able to lessen the symptoms of, like, the pcos because they usually come hand in hand. Absolutely. Not always. But.
B
But, yeah, but it is, like, really high association. And so if you improve insulin sensitivity, and this is where also lifestyle plays a massive, massive role. So I always tell these patients, like, you have to lift weights. You just have to.
A
You do.
B
Got to do resistance training, build muscle mass. It's going to help improve your metabolism, all other metabolic parameters. And then, of course, nutrition is a really key part of all of it, too. And, you know, that's a whole separate topic. But, yeah, there's a lot of different lifestyle things that are important. Supplementation, that's important for pcos. But in many cases, when women implement these changes, they tend to start cycling more predictably and can even conceive on their own.
A
That's amazing. It's so funny. I was talking about this on my podcast earlier that. That I've started doing all these little things that feel like. Like it was almost subconscious that I wasn't, like, I wasn't consciously being like, this is going to be good for my fertility. And I've been doing all this stuff lately, one of them being weight training. And I've been hearing for years. I mean, we all, you know, like, I've been. I've had all these guests on my podcast that say, like, you need to be weight training. And I just was so resistant to it for so long. I don't even know why. I just don't. I'm not a huge. Like, I just don't love, like, gym culture.
B
Yeah. The intimidation factor in the gym.
A
Yeah.
B
The bro culture. Like meathead, so to speak.
A
Yes. And. And if I'm being honest, I just. I love walking. Walking is my favorite form of exercise. It's meditative for me. I have dogs. It's like a great time for me to bond with my dogs. I just love it so much. And there's something about, like, the actual act of lifting weights that I just. I just don't really enjoy it that much. But I found this gym near my house a couple months ago because, like, I have the flattest butt ever. And I was like, I need to get this under control. I was like, I need to work on my butt. And they had this class, a booty camp class that I started going to. And then I became friends with one of the trainers there, and I decided to start doing personal training with her. And I'm actually really starting to enjoy it. I'm actually really starting to enjoy it.
B
I know, isn't it?
A
It is. I used to really hate it, but now I look forward to it. I see this Trainer a couple times a week. And I've also been going to the Booty Camp and like, you know, we're doing, like, smaller weights, but she's helping me kind of move up. But, like, she's been helping with my form. And it's just so interesting because I've had all these conversations recently about how much weight training can really improve your fertility too, and just your overall health. Right. And, like, with things like pcos and. Yeah. And I know you're a big proponent for weight training.
B
Yeah, I'm obsessed. I pre kids. God, I lived in the gym.
A
Yeah.
B
Like, when I wasn't at work, I was in the gym. And I would be there for two to three hours at a time.
A
I don't know how people do that.
B
Yeah, I just. It was really my happy place.
A
That's amazing.
B
And, yeah, I mean, I think it's great. Obviously, I can't afford anywhere close to that time anymore, so it's gotta be really efficient. But, you know, you just get in there, you do the thing. And I would say, like, for people who are tight on time, even just two to three sessions a week is really something. I think people always often feel like, okay, well, if I am not as consistent as humanly possible, there's no point in going today day because I haven't gone in a week. And that's the worst mentality. Even if you just get one session in a week, that's way better than nothing.
A
Well, and let me tell you that I started out only doing two sessions a week. I was just doing booty camp on, like, Tuesdays and Thursdays. And after like, two months, my fiance was like, holy shit, court. Like, I can see a difference in your butt.
B
That's amazing.
A
I was only going twice a week. And so it really has made me feel like, okay, I only need to do this, like two or three times a week. I don't need to be going every. Every single day.
B
No, you don't. I wanted to go back to one thing that you asked me before, and I. I think we kind of got sidetracked. But when you asked about the number of eggs and the likelihood of pregnancy.
A
Oh, yes.
B
This is a really important thing that people need to know, that your egg reserve does not predict likelihood of pregnancy.
A
Amazing.
B
So anti mullerian hormone levels does not correlate to likelihood of pregnancy. You could have diminished ovarian reserve and still have the same likelihood as someone your age who has very high egg reserve. So having high ovarian reserve is really cost effective for egg freezing. But is not like it could be falsely reassuring.
A
Yeah.
B
And on the other hand, a diminished ovarian reserve can lead someone to feel like they're never going to get pregnant. And there's no way that they're going to get pregnant naturally. When in reality, there's probably a lot of women out there with diminished ovarian reserve of getting pregnant on their own, and they have no idea. Cause they've never tested their fertility because they just get pregnant.
A
Yeah.
B
So.
A
Oh, my gosh. Thank you so much for saying that, too. I'm sure everyone listening is probably feeling better. I'm feeling better, and I'm glad that you brought that up. I guess. Before we wrap up, is there anything else that you feel like women need to know that we didn't cover in any of this area?
B
I guess the other big takeaway is that female age is the number one predictor of reproductive success. So if you are younger and you're even thinking about it, just go for the consultation. It doesn't commit you to anything. But just like, go see a fertility specialist, see what it's all about, understand your numbers, what things look like for you, and then make a plan accordingly. The most common thing that I see in women that come to see me, the number one regret is, I wish I froze my egg or I wish I froze more eggs.
A
Yeah.
B
And the people who have that, that have the eggs, they never regret it. There are people who end up having leftover embryos, and they're like, you know, I did what I needed to, and now I have the family I wanted. But the worst is seeing the regret. And I hate to see that for women to go through when they want a specific family size. And it becomes a lot more difficult, especially as you. You start to increase in your 40s. So it's important to talk with your doctor. How many kids do you see yourself having? What does that look like for you? Just get in and have a consult.
A
Yeah, I think that's really important. I wish. I know I can say, and I think I told you this last night, that at 36, I wish I had not waited that long. But it was. It was not even something that was like, that was crossing my mind before then. Right. Like, I always knew that I wanted to be a mom. And I always just. Just felt like, oh, this is just gonna happen someday. And of course it did. It happened later than I had hoped and that I had expected for it to, you know, and thank God I found my person. But I just. I wish that I had started thinking about this when I was, like, 28, 29, and maybe did it when I was, like, 32. And look, I don't live in regret. I don't believe in living regret. Because you're just. You're gonna, like, torture yourself, but just if you're younger. I think it's just like you said, going for a console, just, like, poke around. If that's something that you want to do, just look into it earlier than you think you would. Because also, it comes in a blink of an eye.
B
It does.
A
I feel like I'm 29. Like, I can't believe that I'm 40. And so I just look back at all those years where I'm like, I just, like, all of a sudden, I blinked and I'm 40, and I'm like, okay, should have been focused on this a little bit more, but it's fine.
B
Yeah, it.
A
It's working out the way that it's supposed to. And, you know.
B
Yeah. And 40 isn't the end for most people. For some women, it just takes a little more work. But plenty of women get pregnant in their 40s. But, you know. But, you know, it's really interesting. I would say that almost every fertility doctor I know has frozen her eggs or has frozen embryos. There's very few that I know. I think I can only think of one person who didn't do fertility preservation. And so. And this is because we understand it so well. And so all of us in our early 30s were like, all right, it's time. Egg freezing, embryo banking, whatever it looks like. You know, some people who are married did embryo banking. I was one of those people. And we ended up needing to use an embryo in order to get pregnant. So, you know, it worked out. So, yeah, it's always a good idea to just understand it.
A
I agree. I agree. Well, thank you so much for coming on today. Please let everyone know where they can find you.
B
Yeah, so you can find me on Instagram at Sasha Hackman MD or my website, Sasha Hackman.com. and I. Am I allowed to say where I work? Yeah, of course. Yeah, you can find me at. Yeah, you could find me at HRC Fertility in Beverly Hills.
A
Amazing. Thank you so much. This was awesome. I learned so much from this.
B
Yeah, I'm so glad.
A
Thank you so much for listening to the Real Foodology podcast. This is a Wellness Loud production produced by Drake Peterson and mixed by Mike Fry. Theme song is by Georgie. You can watch the full video version of this podcast inside the Spotify app or on YouTube. As always, you can leave us a voicemail by clicking the link in our bio. And if you like this episode, please rate and review on your podcast app. For more shows by my team, go to wellnessloud.com see you next time. The content of this show is for educational and informational purposes only. It is not a substitute for individual medical and mental health health advice and doesn't constitute a provider patient relationship. I am a nutritionist, but I am not your nutritionist. As always, talk to your doctor or your health team first.
Realfoodology Podcast Episode Summary
Title: The Truth About Egg Freezing + IVF No One Tells You | Sasha Hakman
Host: Courtney Swan
Guest: Dr. Sasha Hackman, REI Specialist
Release Date: February 18, 2025
Produced By: Wellness Loud
In this enlightening episode of the Realfoodology podcast, host Courtney Swan engages in a comprehensive discussion with Dr. Sasha Hackman, a board-certified OB/GYN and Reproductive Endocrinologist at HRC Fertility in California. The conversation delves deep into the intricacies of egg freezing and in vitro fertilization (IVF), providing listeners with valuable insights into fertility preservation and assisted reproductive technologies.
Courtney introduces Dr. Sasha Hackman, highlighting her extensive credentials:
Quote:
Dr. Sasha Hackman explains her specialized training, "[...] it takes after med school, residency, fellowship, and then board certification about 15 years to get there." (04:49)
Courtney shares her personal experience of freezing her eggs at 36 and expresses her curiosity about the subsequent steps in her fertility journey. She emphasizes the need for a deeper understanding of egg freezing and IVF processes, especially for those contemplating fertility preservation.
Dr. Hackman clarifies the differences between freezing eggs and embryos:
Quote:
"When you freeze embryos, [...] it really sucks for the female partner, because then if they're much older, they have nothing preserved." (07:14)
Key Points:
Age is a critical factor affecting egg quality. Dr. Hackman discusses how egg viability declines significantly after age 37, impacting survival rates during thawing.
Quote:
"For women under 37, the average survival rate of eggs that are being thawed is 95%. If you're over that age, then you're looking at about 85% survival rate on average." (09:12)
Insights:
The conversation explores whether lifestyle factors such as diet, exercise, and toxin exposure influence egg quality. Dr. Hackman acknowledges anecdotal evidence but notes the complexity due to genetic factors.
Quote:
"Some studies show that supplementation with antioxidants like CoQ10 can improve egg quality, but it's more nuanced depending on individual health status and genetics." (09:59)
Recommendations:
Both hosts express concerns about environmental pollutants like pesticides and phthalates, which are known endocrine disruptors affecting reproductive health.
Quote:
"Endocrine disrupting chemicals are everywhere, really affecting our overall health and reproductive health." (13:10)
Discussion Points:
Dr. Hackman provides a detailed walkthrough of an IVF cycle, highlighting the steps from ovarian stimulation to egg retrieval and embryo culture.
Key Steps:
Quote:
"An IVF cycle involves injectable medications to stimulate the ovaries, followed by egg retrieval where eggs are aspirated from follicles." (20:05)
The discussion emphasizes the often-overlooked role of sperm quality in fertility. Dr. Hackman explains the parameters assessed during a semen analysis.
Parameters Assessed:
Quote:
"Human reproduction is actually quite inefficient—with only about 4% of sperm appearing normal under strict criteria." (25:08)
Insights:
Dr. Hackman describes the technical aspects of egg retrieval and the subsequent embryo transfer process, including genetic testing.
Process Highlights:
Quote:
"PGT is not perfect. It does not exclude all genetic abnormalities, but it provides prognostic indicators of embryo viability." (22:55)
Dr. Hackman explains the protocols for FET, distinguishing between medicated (programmed) and natural cycles.
Medicated Protocol:
Natural Protocol:
Quote:
"The embryo transfer is a painless process, [...] the most uncomfortable part is having a full bladder." (37:18)
Recommendation:
The role of birth control pills prior to egg retrieval, known as priming, is debated. Dr. Hackman discusses the pros and cons.
Key Points:
Quote:
"Some data shows it makes absolutely no difference, and then some shows it does." (45:28)
Dr. Hackman delves into Polycystic Ovary Syndrome (PCOS), clarifying misconceptions and discussing its impact on fertility.
Understanding PCOS:
Quote:
"PCOS does not mean that you can't get pregnant. [...] lifestyle changes can lead to more predictable cycles and even natural conception." (53:10)
Personal Insight: Dr. Hackman's own diagnosis of congenital adrenal hyperplasia, which mimicked PCOS symptoms, highlights the complexity of endocrine disorders.
Courtney shares her journey with egg freezing, her challenges with synthetic hormones, and her gradual embrace of weight training for fertility improvement.
Key Experiences:
Quote:
"I can see a difference in your butt," highlighting the unexpected but positive physical changes from consistent training. (56:55)
Dr. Hackman emphasizes the importance of early consultation with fertility specialists and understanding individual fertility profiles.
Key Recommendations:
Quote:
"The number of eggs does not predict the likelihood of pregnancy. Your ovarian reserve is a cost-effective marker but not a definitive predictor." (57:24)
The episode concludes with a heartfelt exchange between Courtney and Dr. Hackman, reinforcing the crucial steps women can take to secure their fertility future. Dr. Hackman encourages listeners to consult with fertility specialists to make informed decisions tailored to their unique circumstances.
Final Thoughts:
Quote:
"The number one regret is wishing you had frozen more eggs. Don't let that be you." (58:57)
For more information, listeners are encouraged to visit Dr. Sasha Hackman's Instagram @sashahackmanmd and her website SashaHackman.com. Additionally, trending resources like Sepco and Qualia NAD are mentioned as tools for managing supplement stacks and boosting NAD levels, respectively.
Additional Resources:
This episode serves as an essential guide for anyone considering egg freezing or IVF, offering clarity on complex processes and encouraging proactive steps towards reproductive health.