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Host/Interviewer
Well, I do want to talk about the medications that you said cause sexual dysfunction. So SSRIs, which are antidepressants, are given widely like water.
Dr. Irwin Goldstein
So how do people add to people who are minors?
Host/Interviewer
Yes.
Dr. Irwin Goldstein
This is a nightmare. These are people who say it's 1 to 3% of all users will have this PSSD thing, which is a disaster. SSRIs raise serotonin, so like depression, which leads to suicide, and we can stop suicide. So it's a fabulous drug. Right. But its effect on the neuron and on the synapse and on neurotransmitters. In about 1 to 3% of people are irreversibly changed.
Sponsor/Advertiser Voice
Why is it irreversible?
Dr. Irwin Goldstein
Well, we're writing the paper on this right now. We're deep, deep into it. And you just have to study the animal studies that they do. They provide it and they find neuronal synapse and neurotransmitter changes that you don't ever get back. So there's something about the drug in genetically susceptible people that irreversibly changes their function. So that's a problem because we have tons of people who have taken this drug because they were unhappy changing schools and the parents gave them an SSRI so they would have less stress. Okay, but without the knowledge that for the rest of their lives they would have no pleasure during orgasm. Give me a break. And you have to put the risks and the benefits together.
Host/Interviewer
Well, I mean, yes, I think if someone's severely depressed and suicidal, that's an absolute. I mean, you gotta weigh the risks and the benefits, Right? I tell my patients all the time, look, you have to weigh the risks and the benefits.
Dr. Irwin Goldstein
But it's stressful at school. No suicidality.
Host/Interviewer
Just need to be very, very thoughtful.
Dr. Irwin Goldstein
Or broke up with someone who's 14 years old, you know? Yeah, they had their first love. I don't know, because I see the people who said, I did not make this decision and I'm never going to have a sex life again. Wow. WO is me. I mean, we see that over and over again.
Host/Interviewer
Okay.
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Host/Interviewer
Have you seen patients where they've just taken it for a short period of time and it's like, how long does it take for this neuronal activity?
Dr. Irwin Goldstein
So this is the weird part of pssd. It could take three years for this to happen and it could take a month or, or a few weeks on this drug. So who knows, right? It has definitely seen patients where they've
Host/Interviewer
been fine for years and then three years later they've started noticing that their whole, you know, their whole sexual milieu has changed.
Dr. Irwin Goldstein
Yeah. And it's not like, like when we studied ed, we had patients who had ed, they had normal libido, normal orgasm, normal sensation, normal pleasure during orgasm. It was an ed Soul sexual dysfunction. Boy, oh boy. Pssd, it's this bizarre multi dimensional thing. No libido, poor sensation, anhedonia erectile dysfunction, I don't know, whatever you can think of, it's not working. It's awful. It's so broad. So it's so individual how people present.
Host/Interviewer
But some people get Better. Right.
Dr. Irwin Goldstein
So what I tell patients, because we see a lot of PSSD now as our paper is coming out. It's like this paper, paper. It's kind of like this thing that has been gone for like six years. We've been developing this thing. But whatever the. The. Each person has a unique presentation of pssd. It's not a, you know, like a cookie cutter. All PSSD people are the same. They are not. They're. They're way. Some people have no ed, and some people. Their prime thing is ed. Some people, it's. They can't feel their genitals, but it's not that they can't feel it because if you touch it, they can feel it, but they can't. They don't get this. You touch your genitals and it's supposed to be a pleasurable thing. It's supposed to be different than touching your arm. It's like touching their arm.
Host/Interviewer
Right.
Dr. Irwin Goldstein
And it's not like this special thing and on and on, it just keeps going. But we'll address each issue. So I'm not going to cure people with psst. They're not going to be back like they once were if they ever had, which is like the minor people have never had, which is very frustrating. But like people who are 25 and 30 who make the decision to go on, but they've had sex, they're not going to get back to the way they were, but they're going to be way more functional. We're so good with erections. We can really help people. I mean, they may have to take a pill or a shot or something, or a subcutaneous injection, something. But we can get them functional that way. As we talked about orgasm issues, we can do that. We can help their libido because, you know, straight up.
Host/Interviewer
But you think that they're on their own. Like with time, things won't improve.
Dr. Irwin Goldstein
Well, that's why they're presenting, because things on their time are not improving. It could be that there's a subpopulation of people who do improve, but we're not going to see them. So our bias is we're getting the other population. The. No. Improved version. Yes. So beyond SSRIs, there's these five alpha reductase inhibitors. Boy, are they bad.
Sponsor/Advertiser Voice
Yeah.
Host/Interviewer
Finasteride being the most common, Finasteride being
Dr. Irwin Goldstein
the most common, Dutasteride being. And then you have the Accutane group, and then you have the minoxidil group. They're kind of all the same. They. Well, they influence so the way it's proposed to the physician by the pharmaceutical groups are that this 5 alpha reductase is designed to impact negatively on the synthesis of dihydrotestosterone, period. Like, nothing else is bothered. But there's like 10 biochemical reactions that depend on the activity of 5 alpha reductase, including stuff in the brain, for which we get back to the PSSD thing. There's a kind of an interesting similarity between what we call PFS post finasteride syndrome and PSSD post SSRI sexual dysfunction. Because of the influence negatively of SSRIs on the brain and five alpha reductases on the brain. There is a lot of biochemical reactions that would otherwise be used that can't be used because of 5 alpha reductase. And then we get into the reality that dihydrotestosterone is really an important hormone for the corporal. The penis, smooth muscle cell. Without it, apoptosis or cell death happens, which turns into scarring, which turns into erectile dysfunction. That becomes permanent, or we can't really change the collagenization of the erectile tissue that leads to this thing called venous leakage. And it's very frustrating, you know, and these are people who are 16, 18, they look at themselves. Their father's bald, their uncle's bald. They don't want to be bald. And they just go to the Internet because you don't need to see a doctor for five alpha reductase inhibitors. They're not given any information on side effects or just briefly.
Host/Interviewer
Yeah.
Dr. Irwin Goldstein
And they end up with this PFS thing.
Host/Interviewer
Is that also permanent in your experience?
Dr. Irwin Goldstein
I believe it to be the exact same kind of concept.
Host/Interviewer
Reversible neuronal changes.
Dr. Irwin Goldstein
Well, let's just say that in many cases their DHT remains low despite them being off the drug. So they have changes to the enzyme that may be irreversible. Yes. So the thing is, like, Viagra is an enzyme inhibitor, but it's a reversible one.
Host/Interviewer
Okay.
Dr. Irwin Goldstein
The five alpha reductase inhibitors are irreversible enzyme inhibitors. They cause suicidal changes to the enzyme.
Host/Interviewer
Gosh.
Dr. Irwin Goldstein
Yeah.
Host/Interviewer
So there's a lot of. I'm sure physicians listening to this that are going to say, you don't. This is all false.
Dr. Irwin Goldstein
Oh, it's all false.
Host/Interviewer
Yeah.
Dr. Irwin Goldstein
Well, that's fine. I have no problem with them saying that. It's just they don't take care of these people.
Host/Interviewer
Right, right.
Dr. Irwin Goldstein
And they may be invested in the value of the drug. For example, psychiatrists see the suicide.
Host/Interviewer
Yeah.
Dr. Irwin Goldstein
I see the side Effects. I see the sexual dysfunction. So my perspective, bad drug. Their perspective is good drug.
Host/Interviewer
Yeah.
Dr. Irwin Goldstein
And then there's these hair people. You know, people want hair, but I. They're saying how fabulous the drug is and I say, whoa, I'm seeing all the sexual side effects.
Host/Interviewer
Right.
Dr. Irwin Goldstein
So I know it's just on. The reality is the drugs cause these
Host/Interviewer
things and there's just no way for us to predict who's going to be the.
Dr. Irwin Goldstein
Yeah, that's the problem.
Host/Interviewer
Right. Because it's a small subset of people, like less than 1%, probably.
Dr. Irwin Goldstein
It's just that millions of people are on these products.
Host/Interviewer
Right, right. It's given out like candy. A lot of these medications.
Dr. Irwin Goldstein
So if 50 million people are on these products, you know, and 1% are. Have them, that's a lot of people.
Host/Interviewer
Yeah, it really is. That fibrosis thing is really crazy to me. That's really scary.
Dr. Irwin Goldstein
Yeah. So we have a brand new ultrasound strategy. So there is. Urologists perform intracavernosal injections and then you get an erection and then you do what's called a Doppler ultrasound. So it looks at the blood flow, but ultrasound, that's Doppler, that's blood flow related, is a sort of a nuance. It's sort of a new thing. The old ultrasound was grayscale. Black, white, gray. You looked at a baby, you didn't look at the blood flow to the baby. You looked at the facial features, you looked at the shape of the head, the arms, the legs. That's grayscale. So for reasons unclear to me, grayscale has been ignored by the urologic community studying this stuff. So we purchased a device that is a very high frequency. It's 15.4 MHz. So it has amazing resolution with the probe touching the penis. Like when you examine a baby, you put the probe on the pregnant abdomen and you're like a foot from the intended target.
Host/Interviewer
Yeah.
Dr. Irwin Goldstein
So you don't need fancy equipment for that.
Host/Interviewer
Right.
Dr. Irwin Goldstein
But when you want to get high resolution with 1 millimeter from the contact point of the probe to the erect penis, you need a fancy piece of equipment. And not everybody has that.
Host/Interviewer
Yeah.
Dr. Irwin Goldstein
So we have probably no one. Probably. We have the ability. We bought this $150,000 thing that allows us to get high resolution grayscale of the erect penis. So if you can get people in a rigid sustained erection with intracavernosal agents and you do grayscale with the device, if it's all gray, perfect. That's where blood goes everywhere. That's erectile tissue. If you take a person with five days of priapism and he's got kind of a dead penis and you ultrasound that, you see basically black.
Host/Interviewer
Yeah. Just for clarity, a priapism is an erection that doesn't go away. When you've had it for five days, it means that there's no more blood flow going in or out. And all the tissue is probably fibrosed and scarred.
Dr. Irwin Goldstein
And if you're listening and you have it for more than four hours, get your body to an emergency room.
Host/Interviewer
Yes, please. It's not fun. Go to the ER immediately.
Dr. Irwin Goldstein
Okay. Having said that, in the state of priapism for multiple days, which is just an awful state, the tissue's basically dead. So it's all basically scar tissue at this point. So no blood goes to those regions. So on grayscale you'll see dark, like black. Okay, so we have now a discrimination between healthy, healthy tissue, gray and black tissue, which is sort of non healthy tissue or dead.
Host/Interviewer
Yeah.
Dr. Irwin Goldstein
Okay. So we have these thing called the erection hardness scale. I spent like multiple years on this crazy thing. You push down on a series of rods. One rod, when you push down, does not buckle. And we call that 4 out of 4 erection hardness scale. And that's like the normal physiologic boner version erection. And then three out of four, you press down on it, it buckles a little bit, but it's still able to have penetration. You press down on the 2, there's even more buckling, and you can't really proceed. But it's close to being good. Just not good enough. And then one out of four is this nightmare. Like, you press down and it's has no rigidity.
Host/Interviewer
Like a noodle.
Dr. Irwin Goldstein
Like a noodle.
Host/Interviewer
Okay.
Dr. Irwin Goldstein
So there we go. So what we've now done is divide the gray scale by the erection hardness scale. So the 4 to 4 erection is all gray. The complete horrible thing is pretty much all black.
Host/Interviewer
Yeah.
Dr. Irwin Goldstein
And then there's gradations of gray and black on the. The tweeners, we call them. So grade three out of four is mostly gray, but a little bit of black. Two out of four is little more. So we now are doing ultrasound on our PFS patients and our PSSD patients.
Host/Interviewer
Yeah. And what do you say?
Dr. Irwin Goldstein
So now we're finding that they get scarring.
Host/Interviewer
Wow.
Dr. Irwin Goldstein
Which is the scary part. Their ED is the irreversible version. It's not the psychologic one. It's the irreversible. So from the 5 alpha reductase community, the apoptosis the cell death that leads to the scarring is due to inability to synthesize DHT dihydrotestosterone, which is the goal of the drug. So you don't have acne in one end or you don't lose hair on the other end, but you don't have penis smooth muscle in 1 to 3% of patients who are susceptible wild. So that's horrible. And then the PSSD community, we've identified oxygen radicals. So O2 is the normal oxygen. If you make it O3 negative, it's really an aggressive chemical or molecule and it goes after smooth muscle causing apoptosis. So it's the same concept as 5 alpha reductase. Hurting tissue as SSRIs hurting tissue. So yeah, SSRIs is supposed to act on the brain. Guess what? They also act on penis. Gosh, we're stuck in craziness. Right?
Host/Interviewer
Well, let's take it back a little bit. You were actually the senior author on the Viagra paper.
Dr. Irwin Goldstein
Yes. 19. It was May14. I can tell you exactly that.
Host/Interviewer
That's amazing. First of all, such a huge accomplishment. But that changed the game for men's sexual health.
Dr. Irwin Goldstein
Yeah, I mean it was the first ever oral product. It wasn't designed for patients. This was to get the word out to practitioners. We haven't ever published the Phase 2 and Phase 3 data from the multi institutional Phase 2 and Phase 3 trials that the FDA requires. So that was the first time it was published.
Host/Interviewer
So what was.
Dr. Irwin Goldstein
By the way, there's a whole story to this.
Host/Interviewer
Yeah, I want to hear the story.
Dr. Irwin Goldstein
So I submit. I was first author and the New England Journal is in Boston. Right. So I'm in Boston. I was Boston at that time. Now in San Diego. Happy.
Host/Interviewer
Especially right now where it's snowing in like negative.
Dr. Irwin Goldstein
Could not be any more pleasant to be here. So we submitted it and we said okay, a no brainer. Everyone would realize how important this was. It got rejected.
Host/Interviewer
Really?
Dr. Irwin Goldstein
By the New England Journal. They wanted this, so we changed this and then we resubmitted. Seven rejections. Seven consent. It took us, I don't know, but seven, eight months to get it through the New England Journal editorial board. I have to tell you, they are not easy.
Host/Interviewer
I'm sure not.
Dr. Irwin Goldstein
But what happened with the New England Journal is really fascinating because what they required at the end of the day was our data was based on the iief. We talked earlier on the FSFI Female Sexual Function Index. But the International Index of Erectile Function was developed by Pfizer to Get it through the fda, which required a questionnaire, had to be validated. That takes another few years to do a few dollars. But it was a validated questionnaire, the iif. And we passed all the standards of placebo this way, sildenafil that way. Statistically significant difference. And the New England Journal said, there isn't a doctor on earth that didn't know what the F you're talking about with an improved iif. If you want get this through, you're going to have to go back to each and every patient's diary, find out. Because we had their erection hardness data. I took the pill and my erection was almost hard. That would be three. Or my erection was really soft and couldn't be used. That was the one. Or my erection was this boner thing and that was erection four. But we had all that data. But we never used that data. It was just, you know how that they collected that. So we had to go back to the thousands of people, all their uses of the medication, and get their diaries to identify when they had a two, you know, to be in the triad of ed. So a lot of people were onesies and twosies, but then on the drug or placebo, they could be a three or a four. So we took people who had a three and a four as the people who were able to have sex and how often that happened on active drug and how. And with that we got approval. But boy, oh boy, that was an issue. But actually it made it more real. I think it was. I think, I think the New England Journal. Is the New England Journal because it is the New England Journal. Yeah.
Host/Interviewer
Yeah.
Dr. Irwin Goldstein
So do you know what, do you know the. I'll never forget this. What was the percentage of active drug users Sildenafil, to get them from a 1, a 2 to a 3 and a 4?
Host/Interviewer
60%.
Dr. Irwin Goldstein
69. It was a great number, of course, 69%. And I said, you know, this was made to happen.
Host/Interviewer
It was so true.
Dr. Irwin Goldstein
And it was only like 23% for placebo, something like that.
Host/Interviewer
What was the response by one, the medical community and then patients.
Dr. Irwin Goldstein
Yeah, So I was the first author. So I was the communication person. Yeah, we didn't have cell phones and stuff then. It was phones.
Host/Interviewer
Yeah.
Dr. Irwin Goldstein
So our office was insane.
Host/Interviewer
Yes.
Dr. Irwin Goldstein
I mean, my poor staff hated me. But we fielded every call and. But they were from women. That was the crazy part. Yeah, I assumed everything would be men, men, men. But the women were saying, okay, Viagras for them, I don't have orgasm, I have pain when I Have orgasm. I have arousal problems. I can't. I have no. Boy, it really hurts when it penetrates me. I mean, all the gamut of female sexual dysfunction things were brought up, and my response was, hey, I'm a urologist. I deal with men. Go to your gynecologist. Someone will help you.
Host/Interviewer
Yeah.
Dr. Irwin Goldstein
And inevitably, most phone calls came back and were saying, gynecologist says go see you. I don't deal with this stuff.
Host/Interviewer
It's so interesting to me because I also mistakenly thought for a long time that gynecologists dealt with all the menopause issues. And there is.
Dr. Irwin Goldstein
I thought you were going to say sexual health.
Host/Interviewer
Well, that too. But you already addressed.
Dr. Irwin Goldstein
They do not.
Host/Interviewer
But so that was what put the onus on me to really start learning all this stuff. Because I was like, well, you know who is.
Dr. Irwin Goldstein
Well, the AUA has guidelines now.
Host/Interviewer
Now they do. But even when I trained, there was not.
Sponsor/Advertiser Voice
There was not anything.
Dr. Irwin Goldstein
We just lectured in the government. Kimbrough thing. I gave the whole menopause thing. That's great, because the AUA has guidelines now.
Host/Interviewer
Yes.
Dr. Irwin Goldstein
Well, just for the general, Gynecology does not have guidelines.
Host/Interviewer
Yes. Yeah.
Dr. Irwin Goldstein
Isn't that weird?
Host/Interviewer
That's crazy.
Dr. Irwin Goldstein
That's pretty weird. Anyways, the phone calls from the Viagra led to the realization that we had to deal with women, that the parallel tract urology is a tract in sexual medicine. At this presentation, there's a sexual medicine group of abstracts presented and talks given. They have stones, they have cancers. But there's a track called sexual medicine, and that comes from 1970s, when we started doing penile implants. It became a part of urology. There's no part of gynecology in sexual medicine. It's so weird. So it's just like a big hole in teaching and understanding and education in gynecology.
Host/Interviewer
Well, I've always believed that the people who do fellowship in female pelvic medicine,
Sponsor/Advertiser Voice
like urogynecology, they don't get this.
Host/Interviewer
They should, though, right?
Sponsor/Advertiser Voice
We're taking.
Dr. Irwin Goldstein
Should I get.
Host/Interviewer
I mean, we're literally operating in the vagina China. And we're.
Dr. Irwin Goldstein
But, you know, it's like radical prostate patients. They don't necessarily want to know what evil they're doing.
Sponsor/Advertiser Voice
If you guys like that clip with Dr. Irwin Goldstein, make sure to check out the full episode right here.
Episode: Moment: They Took This Medication… and Lost Pleasure During Orgasm (PSSD?)
Host: Dr. Rena Malik
Guest: Dr. Irwin Goldstein
Release Date: May 20, 2026
In this candid and highly informative discussion, Dr. Rena Malik speaks with Dr. Irwin Goldstein, a renowned expert in sexual medicine, about the serious sexual side effects caused by certain commonly prescribed medications—specifically SSRIs (antidepressants), 5-alpha-reductase inhibitors (like finasteride), and others. The central focus is on Post-SSRI Sexual Dysfunction (PSSD) and related syndromes, their permanence, mechanisms, and the often-overlooked fallout for affected individuals. The episode aims to provide science-backed answers to questions patients may be too embarrassed to ask, challenge medical orthodoxy, and encourage thoughtful prescribing practices.
SSRIs and Sexual Dysfunction
Weighing Risks and Benefits
Timing of Onset
Symptoms are Broad and Individualized
Recovery Prospects
5-Alpha Reductase Inhibitors (Finasteride, Dutasteride) & Accutane
Irreversibility Explained
Awareness Gap & Dismissal
Advances in Imaging
Erection Hardness Scale
Biological Mechanisms
Viagra’s Publication Story
Unexpected Fallout: Female Sexual Medicine
On the scale of PSSD/PFS populations:
On PSSD symptoms:
On advances in imaging:
On the toughness of publishing Viagra’s clinical trial:
On gender gap in care:
This episode offers a rare, unvarnished look at the persistent sexual side effects of SSRIs and similar medications, challenging the medical status quo and advocating for better patient education, targeted research, and multidisciplinary care. Dr. Goldstein and Dr. Malik deliver both hard science and heartfelt concern, equipping listeners with knowledge that could profoundly influence their medication choices and spur crucial conversations in clinical settings.