Anaphylaxis explained including anaphylaxis pathophysiology (immunologic vs non immunologic), clinical features, diagnosis, and treatment. Includes recognition of airway compromise, use of intramuscular adrenaline (epinephrine), biphasic anaphylaxis, refractory anaphylaxis, and the immunology underlying type 1 hypersensitivity reactions.

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Timestamps:
0:00 What is Anaphylaxis?
0:32 Anaphylaxis Pathophysiology
4:08 Anaphylaxis Causes
5:28 Anaphylaxis Symptoms
7:44 Anaphylaxis Diagnosis
8:32 Anaphylaxis Treatment

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References

BMJ Best Practice (2025) Anaphylaxis – Symptoms, diagnosis and treatment. Available at: https://bestpractice.bmj.com/topics/en-gb/501
British Society for Immunology (2021) Anaphylaxis. Available at: https://www.immunology.org/public-information/bitesized-immunology/immune-dysfunction/anaphylaxis
RCEMLearning (2023) Anaphylaxis. Available at: https://www.rcemlearning.co.uk/reference/anaphylaxis/
Simons, F.E.R., Ardusso, L.R.F., Bilo, M.B., El-Gamal, Y.M., Ledford, D.K., Ring, J., Sanchez-Borges, M., Senna, G.E., Sheikh, A. and Thong, B.Y. (2018) World Allergy Organization anaphylaxis guidance 2018. Journal of Allergy and Clinical Immunology, 141(2), pp. 419–420.e1. Available at: https://www.jacionline.org/article/S0091-6749(18)30571-2/fulltext
Turner, P.J., Worm, M., Ansotegui, I.J. and El-Gamal, Y.M. (2024) IgE and non-IgE-mediated pathways in anaphylaxis. Available at: https://pmc.ncbi.nlm.nih.gov/articles/PMC12350582/
Cardona, V., Ansotegui, I.J., Ebisawa, M., El-Gamal, Y., Fernandez Rivas, M., Fineman, S., Geller, M., Gonzalez-Estrada, A., Greenberger, P.A., Sanchez Borges, M., Senna, G., Sheikh, A. and Tanno, L.K. (2020) ‘World allergy organization anaphylaxis guidance 2020’, World Allergy Organization Journal, 13(10), p. 100472. doi:10.1016/j.waojou.2020.100472.

Please remember this podcast and all content from Rhesus Medicine is meant for educational purposes only and should not be used as a guide to diagnose or to treat. Please consult a healthcare professional for medical advice.