Kawasaki Disease is a systemic form of vasculitis that primarily affects children. In this video: Kawasaki Disease pathophysiology (proposed), Kawasaki Disease symptoms (and a mnemonic to help remember them!), as well as the diagnosis (including Z scores) and criteria for Kawasaki Disease!

PDFs available here: https://rhesusmedicine.com/pages/paediatrics

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Timestamps:
0:00 What is Kawasaki Disease? Kawasaki Disease Epidemiology
0:53 Kawasaki Disease Pathophysiology
2:26 Kawasaki Disease Symptoms / Kawasaki Disease Signs and Symptoms (Acute Febrile Stage)
3:42 Kawasaki Disease Symptoms (Subacute + Convalescent + Chronic Stage)
4:40 Kawasaki Disease Diagnosis - Kawasaki Disease Crtieria
5:27 Kawasaki Disease Diagnosis - Echocardiography + Z Score
6:47 Treatment of Kawasaki Disease

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References

MSD Manuals Professional Edition (2025) Kawasaki disease. Reviewed/Revised Feb 2025; Modified Jun 2025. Available at: https://www.msdmanuals.com/professional/pediatrics/rheumatologic-disorders-in-children/kawasaki-disease
BMJ Best Practice (2025) Kawasaki disease: symptoms, diagnosis and treatment. Last reviewed: 9 Dec 2025; Last updated: 7 Nov 2025. Available at: https://bestpractice.bmj.com/topics/en-gb/236
NICE CKS / NHS England (2021) Kawasaki disease – diagnosis and management. NHS.uk content reflects CKS-informed guidance based on NICE protocols (e.g., fever in under 5s) with key diagnostic features and cardiac follow-up. Available at: https://www.nhs.uk/conditions/kawasaki-disease/diagnosis/
American Academy of Family Physicians (AAFP) (2015) Diagnosis and Management of Kawasaki Disease — long-term cardiovascular follow-up stratification by coronary involvement (incorporating AHA guideline guidance). American Family Physician, 91(6).
Arch Dis Child (2014) Management of Kawasaki disease in the convalescent phase: long-term cardiac management and risk stratification, Archives of Disease in Childhood.

Disclaimer: Please remember this podcast and all content from Rhesus Medicine is for educational and entertainment purposes only and is not a guide to diagnose or to treat any form of condition. The content is not to be used to guide clinical practice and is not medical advice. Please consult a healthcare professional for medical advice.