In this video we look at primary sclerosing cholangitis and primary biliary cholangitis (previously known as primary biliary cirrhosis), and the differences between them. This includes pathophysiology, risk factors, signs and symptoms of primary sclerosing cholangitis and primary biliary cholangitis as well as their diagnosis (including autoantibodies!) and treatment.

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Timestamps:
0:00 What does cholestatic mean?
0:59 Primary Sclerosing Cholangitis - Definition
1:31 Primary Sclerosing Cholangitis - Risk Factors / Epidemiology
2:02 Primary Sclerosing Cholangitis - Pathogenesis
3:48 Primary Sclerosing Cholangitis - Signs and Symptoms
4:26 Primary Sclerosing Cholangitis - Diagnosis
5:11 Primary Sclerosing Cholangitis - Treatment
5:59 Primary Biliary Cholangitis - Definition
6:19 Primary Biliary Cholangitis - Risk Factors / Epidemiology
6:42 Primary Biliary Cholangitis - Pathogenesis
7:58 Primary Biliary Cholangitis - Signs and Symptoms
8:34 Primary Biliary Cholangitis - Diagnosis (Criteria)
9:25 Primary Biliary Cholangitis - Treatment

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References

Cleveland Clinic, 2025. Primary biliary cholangitis (formerly primary biliary cirrhosis) and primary sclerosing cholangitis. [online] Available at: https://my.clevelandclinic.org/departments/digestive/medical-professionals/hepatology/primary-biliary-cirrhosis-primary-sclerosing-cholangitis. Cleveland Clinic
National Center for Biotechnology Information (NCBI), 2015. Primary biliary cholangitis and primary sclerosing cholangitis. PMCID: PMC4521232. [online] Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521232/. PMC
National Center for Biotechnology Information (NCBI), 2020. Primary sclerosing cholangitis: pathogenesis and clinical features. PMCID: PMC7132015. [online] Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132015/. (If exact year differs, use the one on the article page)

Disclaimer: Please remember this video and all content from Rhesus Medicine is for educational and entertainment purposes only and is not a guide to diagnose or to treat any form of condition. The content is not to be used to guide clinical practice and is not medical advice. Please consult a healthcare professional for medical advice.

Primary Sclerosing Cholangitis & Primary Biliary Cholangitis