Neuroscientist Paul Nuyujukian likens the brain to a stadium full of people. To eavesdrop on the crowd you could put a microphone in the middle of the stadium. But to understand the conversations you need to record individual people. He thinks about the brain the same way. To understand brain disease, he studies neurons—one at a time. And his insights are shedding light on a big global issue—stroke. The World Health Organization predicts one in four adults will have a stroke in their lifetime. Strokes can cause death, or lead to paralysis or speech problems. But there’s still a lot researchers don’t know about how the brain recovers from an event like a stroke. Nuyujukian directs a lab at Stanford University that studies how the brain controls movement, including after neurological events like stroke. We get into how he does this, and why he hopes his research could eventually help people who’ve been paralyzed.

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A new approach to brain health, one neuron at a time