B (3:39)

So that's really key to definage. So the technology in definage is based on the defensin molecule. So defensins are natural messaging molecules in our body. And what they do is they wake up a dormant stem cell called the LGR6 positive stem cell that for most of our life just remains dormant except when we need it during the wound healing process. And when activated, this stem cell creates new basal cells at the base of our epidermis, or top layer of skin, which then creates new fresh skin cells. And so Definage has patented these age repair defenses which when applied to the skin, trigger this process to create new fresh skin. And this can then help address the appearance of fine lines, coarse wrinkles, textural irregularities, sagging, excessive pigment inflammation and pore size while promoting cell renewal. I love about it is it's one product that can address global anti aging.

A (4:47)

The wound healing is a very interesting topic I think, for all of us, you know, because we often hear about, you know, like micro traumas and just things that are affecting our skin daily, you know, whether it's environmental triggers or, or anything. And to be able to then repair that with, you know, skin care that you can take home with you, that's huge. Love to actually talk about some of the other products in the range though, because I know that there's obviously there's the hallmarks of the serum and the moisturizer that are pretty famous. And I mean, I've tried them myself, I use them pretty regularly. But I know that in terms of like nail health, Definage also has products in this category. And I'd love to talk about, you know, what made the brand or inspired the brand go in this Direction.

B (5:31)

Yes. So, you know, historically they had two products, a face cream followed by a bio serum. And then they expanded, really cover the whole skin with like an eye cream, neck cream, and body cream, over which that serum can be applied. And they also have a mask and cleanser. And then they looked at other needs in the body that are, you know, in dermatology we see a lot, which is hair loss. And so they developed a hair serum followed by problems with, you know, nail splitting, nail growth, which they developed this nail serum and then they recently just lost a lip serum. So really now we have all the products where Defensin can wake up the stem cells and address the skin, the hair follicles, and the nails to regenerate all of the skin and its appendages. So that's kind of how we landed at hair, nails and lips after the skin, which I think is kind of a nice journey to think about and see how their innovation has kind of followed patient need.

A (6:34)

That's interesting. Yeah. I mean, with nails, I mean, what is the role of defensins in nail health?

B (6:41)

So what they have found is that LGR6 stem cell that activates the skin is also in the nail matrix or nail root to generate your nail. So Definage and its founder, Nikolai Turvitz, was able to figure out how to trigger the stem cells in the nail root to grow using the defense ends. And so that's why this product has been so effective, innovative. Prior to the Deafenage product, the current products on the market only had chemicals to go into the existing nail plate and try to like, temporarily cosmetically fix an old damaged nail or just moisturize cuticles. But this product actually stimulates the nail matrix, produces a fresh new nail plate, and then actually improves the quality of the nail from the origin, creating a new, fresh nail.

A (7:44)

Oh, wow. So that actually explains a lot because there was. I want to share a little story for all of our listeners. I had a, you know, when I first tried the nail product, I, you know, I kind of like broken my nail and it was very painful. And I remember thinking, I'm like, you know what? This would be the perfect time to test out, you know, some of the PR I've gotten. And I was looking at, you know, definite product, and I was like, let me try this. And literally in two days, like, I noticed a difference not only in, like, the pain response I was experiencing, but also, like, I started to notice that it is actually healing.

B (8:18)

Yeah. And. And I can tell you one of the things when I, I never had bad nails, but I get that like split brittle nail. And so it really helps with that. And then a lot of times, you know, all of our nails look good and then one just breaks off and then you're like, man, now I've got to cut all my nails back so it doesn't look bad. But when, if you apply it like let's say twice a day to that one broken nail and maybe once a day to the others, you will really see the rapid growth and that nail catch up much faster than if you just let it be and try to catch up on its own.

A (8:48)

I want to actually talk about the clinical studies if, if you could like kind of tell us a little bit about some of the studies that were done on the nail root serum and the results that we're seeing.

B (8:59)

Sure. So they conducted a pilot clinical study that was independent by a third party in a US based clinic. And there were four participants, three mal males and, excuse me, three females and one male. So if you take four patients times 10 nail plates, that was 40 nail plates that were analyzed. And they evaluated this high concentration of defense and product at baseline months 1, 2 and 3. And they looked at four clinical parameters in particular nail plate smoothness, nail plate strength, speed of growth and skin quality around the nail plates. And at the end of the study they found that people had up to 92% smoother nails, up to 54% stronger nails, and up to 78% more hydration around the skin of the nails. And that a regeneration mechanism was triggered which made the nails grow faster. And people saw an initial result within 30 days. So at about a month you should start seeing results and that this continued over the three month period. So with continued use you should have continued results.

A (10:18)

That's really interesting. Now you know, that makes me think of a lot of people who we go and we get our nails done. Right. Like a lot of people love to get manicures. And I know acrylic nails, I mean back when I was like in college and high school, acrylic nails were the thing, you know, everybody was getting them and I remember it would just make your nails so thin, the nail bed, so, so thin, like paper thin. And I'm just curious, you know, in terms of anyone who does get nail treatments, you know, it can just help with that, like in terms of like the paper thin nail and like the, the brittleness that you see and all of that.

B (10:55)

Well, so the one thing that is nice about this product, regardless of what type of polish you have on, you can actually Apply it around and behind the nails, like at the cuticle, because the product will go down into the matrix matrix, even with polish applied. So that is one nice thing. You don't have to stop if your nails or toenails are polished now with acrylic and some gels. If they're grinding your nail down, it can't fix that part distally. But you know, it's going to work on regenerating the nail back at the base. But like, if you're just using regular nail polish where they're not grinding down your nails, it can actually make a huge improvement as well. But what I always tell patients, and I do myself follow this because I do paint my toenails, is I do recommend at least once or twice a year, taking at least depending on how fast your nails or toenails grow, you know, a four to six to eight week polish holiday. Because you'll find your nails regenerate actually really quickly. And then a lot of the like hyper keratotic material like that looks like white crust on your nails, which isn't fungus, but some people think is that will come off and your nails actually look a lot healthier. And I'm doing my polish holiday right now for my toenails. And I mean, within two to three days of applying the definage, my toenails were growing faster by nail like color and quality and ridging improved. And so it is really nice to see, see just really how quickly the nail responds to such, you know, a rejuvenating product.

A (12:34)

Right now I watch it on Tick Tock all the time. You know, young women are going and getting their nails done almost every week, you know, and it's, I always wonder, I'm like, gosh, the damage that we're causing, you know, in terms of between treatments or between manicures, like there's got to be something that we can use that is going to strengthen the nail and keep the integrity, you know, in terms of just, I guess, overall nail health. Right. So that's very interesting and I feel like this product is so perfect for that. I'm gonna talk about like just normal aging though. I would love to actually discuss this topic with you because I think there's not enough education around, you know, what happens to our nails as we normally age? I mean, what are some things that we can experience or signs and symptoms that we can, you know, notice as we're getting older?

B (13:18)

You know, some of the things that can happen, you know, as we age. And you know, some people are just more genetically predisposed to have these earlier than others. But you know, any patient can, you know, be more prone to brittle or fragile nails that easily split, break or peel. And you know, brittle nail syndrome, which is just, you know, increased fragility of the nail plate that causes these kind of things, you know, affects 20% of the population and women are affected twice as often as men. And so, you know, especially if you're predisposed to this, you know, you want to watch out for things like occupational and environmental exposures like frequent contact with water, chemical agents, recurrent trauma to the near nail that may be from either your job or hobbies you have. And then of course, like we just mentioned, frequent manicures. All of this will exacerbate an underlying tendency for nail brittleness. And then, you know, some people just have really slow growing nails. You know, we tend to say nails fully out in three to six months and toenails in six to 12. But you'll often find people grow much slower and that's just them.

A (14:30)

That makes sense. I, and I want to actually, you know, just get your opinion on this in terms of. Because you don't hear a lot about nail health. Like, I feel like there's not nearly enough information out there as compared to something like, you know, facial skin care, which we hear about literally everywhere and every day. What is Definage doing to like kind of raise awareness from the education standpoint around all this?

B (14:53)

Well, I mean, the one thing, you know, cosmeceutical companies can't make medical claims. So I think, you know, that that's important to say. And there are a lot of medical conditions that can cause nail problems. And so I think the one thing I would say is if people have had significant chronic nail problems, they should see a board certified dermatologist to be sure there isn't an underlying medical condition, you know, causing a brittle nail, a split nail, a pitted nail, you know, onycholysis, like a lifted nail. I mean, there can be medical problems, infectious diseases and things like that. So I think that is, we don't want to treat everything as a cosmetic problem, but I think there are many, so many underlying systemic and infectious diseases that can call nail disease. You want to make sure to rule all of that out and seek medical treatment as appropriately before, you know, using a cosmeceutical.

A (15:49)

That makes sense. So in terms of like using the nail root serum, what are some of the best ways to incorporate it into our daily routine to see like the optimal results?

B (15:59)

It's actually very easy to use and ergonomically very well designed. So the recommended use is twice daily, once in the morning and once in the evening. It has a little built in brush made from horse hairs at the tip. And you would apply one pump of the serum on the tip of the nail and you would start with your first finger like your thumb, and then brush the serum from the cuticle forward to the nail end and make sure it is distributed on the skin around the nail. And then continue to brush on the remainder of the remaining four nails in that hand. And sometimes one pump is good for all 10 nails. And if you need another pump, then you would do it on the, let's say the thumb of your other hand brushing from cuticle to tip and then continue on the remaining four fingers on the other hand. And generally I find because most people's toes and toenails are smaller, that one pump is enough for all ten toes.

A (17:01)

That's interesting. I guess you could do it at night just to make sure you're not wiping it off during the day. Yeah.

B (17:07)

And I would say make sure your hands are washed like you finish everything else because it does either need to stay on a minimum of 30 minutes without contact with water or overnight in.

A (17:16)

Terms of like, you know, I mean, definage is just really leading the way. I feel like in a lot of ways, you know, when it comes to innovation and the science of all of their products, I mean, I'd love to learn what's next for the brand. Is there anything that's on the horizon or anything new that's coming up?

B (17:31)

Sure. So you know, they just released their lip serum for like rejuvenation and anti aging. So people may not know it's out, but it just launched. So that's really exciting. I'm someone, I feel like I always have dry lips and so it's a nice serum that you can apply twice daily. It's not an ointment like, like, like a Vaseline type ointment. So you know, you use it twice a day. So I always tell patients, you know, you don't want to use it 15 times a day. It's not going to work better. But you may need something like a Vaseline or Aquaphor type product in between and that's okay. But you know, it lasts on about, I'd say 90 minutes to two hours without you eating and drinking. So you don't want to be, you know, put that on and then drink your coffee because it's going to come off. But it really does make the lips feel A lot better, especially people struggling with like colitis or lip inflammation. So that's a wonderful product. And then coming out next year, they're going to be expanding into the post procedure space with an exciting post procedure product for, you know, like things like microneedling, lasers, both ablative, non ablative. So that's really exciting. It's the more products that we have that can, you know, help patients minimize, you know, red redness, stinging, burning post procedure, even if, you know, if you're not making holes in the skin. Really is improved quality of life post procedure and then, you know, reduced healing times and improved wound healing post procedures also. Excellent.

A (19:00)

Absolutely. Well, I'm excited to see all the new products and you know, I really, really love the brand. And for everyone listening, if you guys haven't checked out Definage, you definitely need to. I literally don't know a single product in the range that I don't love. I mean, I, I really, really enjoy them. And you know, the nail serum I think is definitely a game changer in that space because I haven't seen anything else like it, honestly. I mean, I see, like I said to you, doc, I, you know, I've seen a lot of the nail oils like for cuticles and whatnot, but they don't really often do too much. So to see something that's really backed by science that's actually helping nail health, I mean, that's huge. So definitely check it out. Let us know what you guys think. But doctor, thank you so much for your time. It's been wonderful hosting you.

B (19:42)

Thank you. And I just want to say Definage really, really has the science to back up the products and there's so many lines that don't. And that's why I carry all of their products because they're scientifically sound and their clinical results are amazing.

A (19:54)

Yeah, absolutely. No, they're. I mean, it speaks for itself because the products I've used, I've actually seen real results. You know, it's really rare to do, to see that with topical solutions. You know, I think at the end of the day results speak for themselves and I've definitely experienced them. I know a lot of people that have tried it have felt the same way. So it's a very solid brand and they're definitely doing something right.

B (20:16)

And people come back over and over again. Most people stop something, want to try something else, but once people see the way they look with Definage, they never stop. I mean, I won't stop.

A (20:26)

I love it very much. But thank you so much. This has been so wonderful to chat with you and tonight.

B (20:30)

Thank you for having me. It was a pleasure.

A (20:32)

Yes, likewise. Thank you.