In this episode, University of Pennsylvania physician and ethicist Dr. Jason Karlawish joins host Dr. Emily Silverman to explore Alzheimer’s disease as what he calls a “disease of autonomy.” Jason shares the story behind his book The Problem of Alzheimer’s and reflects on how society’s understanding of dementia has evolved - from viewing it as an inevitable part of aging to recognizing it as a profound medical and ethical challenge. He discusses the controversial FDA approval of aducanumab, the moral complexities of scientific progress, and why he believes caregiving is a form of “mind support”, a way of helping someone rebuild identity, safety, and connection. Together, Emily and Jason examine how technology, environment, and human empathy intersect in dementia care, and why supporting caregivers is essential to sustaining autonomy, dignity, and hope for those living with the disease.

About this episode’s featured guest

Dr. Jason Karlawish is a physician and professor at the University of Pennsylvania who specializes in dementia care, ethics, and aging. As co-director of the Penn Memory Center and leader of several national Alzheimer’s initiatives, he combines clinical care with research on cognitive impairment, informed consent, and patient autonomy. His work, including the book The Problem of Alzheimer’s, highlights the ethical and social challenges of dementia while advocating for compassionate, community-centered care.

About Remo’s host Dr. Emily Silverman

Dr. Emily Silverman is an internal-medicine physician, Assistant Volunteer Professor of Medicine at UCSF. She is the creator and host of The Nocturnists, an award-winning medical storytelling program that has uplifted the voices of more than 450 clinicians since 2016 through its podcast and live performances. Her work has been supported by a MacDowell fellowship and widely published in numerous publications including JAMA, The New York Times, and NPR. Learn more about Emily by visiting her website.

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The information in this podcast is for general informational purposes only and is not the practice of medicine or any profession. It is not intended to be medical advice and is not a substitute for professional medical advice, diagnosis, or treatment.