This episode explores what NAD is, why it matters for cellular energy and metabolic function, and why measuring it accurately has historically been so difficult. Guest Jari Närhi explains that NAD is essential for mitochondrial ATP production, DNA repair, inflammation response, and hundreds of metabolic processes, but that low NAD is usually more a consequence of illness, inflammation, or depletion than a root cause on its own. The conversation unpacks the nuance around supplementation, including niacin, NR, NMN, and NAD IVs, while emphasizing that more is not always better and that raising NAD without clear need may not be beneficial. Leigh Ann and Jari also discuss the limits of conventional NAD testing, noting that measuring only NAD+ offers a very incomplete picture compared with looking at multiple NAD forms and their ratios. A major focus of the episode is how NADMED’s technology makes it possible for clinical labs to measure several NAD metabolites more reliably and at scale, opening the door for better clinical use and research.

Product Discount Codes + Links

Juna: Website (Discount Code: LEIGHANN)
Broc Shot: Website (Discount Code: LEIGHANNLINDSEY)
Hoolest: Website (Discount Code: THEACCRESCENT10)

Guest Info

NADMED - Website
Jari Närhi - LinkedIn

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233. Jari Närhi (NADMED) - NAD Explained: Energy, Inflammation, and the Future of Testing