The Tudor Dixon Podcast: Ozempic Era Explained—GLP-1 Risks, Weight Loss Truths

Summary

The Tudor Dixon Podcast: Ozempic Era Explained—GLP-1 Risks, Weight Loss Truths

Release Date: April 8, 2026
Host: Tudor Dixon
Guest: Dr. Tom Lavin, Weight Loss Physician and Founder of Your Era

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Episode Overview

This episode dives into the explosive popularity and medical reality of GLP-1 medications like Ozempic and Wegovy, used for weight loss. Host Tudor Dixon, prompted by the dramatic thinning observed at glamorous events and celebrity culture, explores the science, medical guidelines, and societal implications of this “Ozempic Era.” Featuring expert insight from Dr. Tom Lavin—a veteran in weight loss and founder of the nationwide Your Era clinic— the discussion demystifies how these drugs work, who should use them, what risks exist, and why responsible medical oversight is crucial.

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Key Discussion Points & Insights

1. Society’s Swinging Attitudes on Weight

• Tudor opens with an observation about Hollywood’s current extreme thinness, contrasting it with past cycles of dietary advice (low-fat in the 1980s, body positivity in recent years).
  • “When I was young, I was like the 80s snack well generation…we all got really fat still. And then...body positivity…because we didn’t know how to get rid of it. And now we have GLP-1s and we’re like, you have to be as skinny as possible and there’s no rules. So what is happening?” (03:16, Tudor Dixon)

2. What Are GLP-1 Drugs? Medical Breakthrough or Quick Fix?

• Dr. Lavin: GLP-1s (glucagon-like peptide-1 receptor agonists) are “the first time we’ve had a medicine that can actually change our set point in our brain to make us want to live at the correct weight." (03:38)
• These drugs help balance brain chemistry evolved for scarcity, now challenged by an overabundance of food.
• Not a miracle or replacement for healthy habits—muscle mass can be lost if not managed with diet and resistance training.

3. Medical Indications and Dangers of Overuse

• Not just for “the sick”—being only 20 or 30 pounds overweight can have negative health effects due to chronic inflammation.
  • “There is a good clinical medical indication [for use], but if you’re at ideal weight or already thin and just want to go on it to get thinner…[there’s a risk of] muscle wasting unless you’re lifting weights and doing resistance training.” (06:18, Dr. Lavin)
• Risks when used unsupervised include excessive weight loss, muscle wasting, potential loss of bone density.

4. The Need for Comprehensive, Ongoing Medical Oversight

• Many get these drugs through cursory online clinics or quick doctor visits, without education or followup on diet, exercise, or side effects.
  • Dr. Lavin: “To just go on the medicine with no clinical oversight and just think this is going to be magical…I don’t need to do anything is very naive and can be dangerous.” (11:17)
• Real programs should emphasize building/maintaining muscle, adequate protein, sleep, and minimizing processed foods.

5. The Black Market and ‘Boutique’ Dangers

• GLP-1s are sometimes dispensed by salons or aesthetic clinics, even those lacking medical credentials, or smuggled from overseas—posing real risks.
  • Tudor on unlicensed providers: “It’s almost like the same place you’d go to get your eyelashes done…How is that possible?” (16:10)
  • Dr. Lavin: “There’s also a black market…if it says ‘not for human use’ or ‘only for animal use’, stay away.” (17:13)

6. Muscle Mass, Longevity, and the Real Health Picture

• Longevity depends on muscle mass—drugs that reduce muscle may actually shorten life.
  • “Muscle mass is one of the key things in longevity. So to lose that is not a good thing over time.” (12:53, Dr. Lavin)

7. GLP-1s’ Surprising Impact on Addictions and Impulse Control

• Early evidence and anecdotes suggest GLP-1s reduce cravings for alcohol, gambling, even compulsive phone scrolling. This is due to their action in reducing dopamine reward spikes in the brain.
  • “GLP-1s drop that dopamine spike, so you don’t have that drive…that goes for narcotics and alcohol and tobacco and gambling and scrolling on your phone.” (21:24, Dr. Lavin)
• “Microdosing” is being explored for these uses, with some staying on ultra-low doses after weight loss.

8. How GLP-1s Work: The Science

• GLP-1s are “incretins”—gut hormones that regulate blood glucose, insulin, gastric emptying, and influence hunger.
• Human body’s natural GLP-1 lasts only 1-2 minutes, but engineered ones can last up to a week.
  • “We’ve been able to engineer the new GLP-1s where they last a week now, not just a minute.” (29:08, Dr. Lavin)

9. Broader Medical Promise

• Early data (mostly animal/short studies) suggest possible benefit in autoimmune diseases like Crohn’s and rheumatoid arthritis.
  • “We’re finding in clinical practice that it does improve people’s health…a lot of kind of chronic disease processes…we might be able to impact at…an inflammatory basic level.” (30:04, Dr. Lavin)

10. Side Effects: The Good, the Bad, and the Manageable

• Short-term: Nausea, heartburn, diarrhea, constipation, typically within the first month or two. Often dose-dependent and resolve with time or lower dose.
• Long-term: Muscle wasting, bone density loss if not countered by nutrition and exercise.
  • “If your dose is too high, you’re in this red zone where you’re getting nausea, really bad heartburn…You just need to drop the dose down.” (31:05, Dr. Lavin)

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Notable Quotes & Moments

“GLP-1s are…the first time we’ve had a medicine that can actually change our set point in our brain to make us want to live at the correct weight. First time ever.”
(03:16, Dr. Lavin)

“To just go on the medicine with no clinical oversight…and just think this is going to be magical…I don’t need to do anything is very naive and can be dangerous."
(11:17, Dr. Lavin)

“There’s also a black market…and if it says ‘not for human use’, research only, or animal use...stay away.”
(17:13, Dr. Lavin)

“My wife always says you’ll never look as good as you do today as much as you criticize how you look today.”
(18:56, Dr. Lavin)

“GLP-1s drop that dopamine spike, so you don’t have that drive…that goes for narcotics and alcohol and tobacco and gambling and scrolling on your phone.”
(21:24, Dr. Lavin)

"Muscle mass is one of the key things in longevity. So to lose that is not a good thing over time.”
(12:53, Dr. Lavin)

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Timestamps for Key Segments

• 00:39 – Tudor introduces topic: viral weight loss, Ozempic, and Dr. Lavin’s experience
• 03:16 – Societal trends in weight, early GLP-1 medical explanation
• 04:40 – Medical need versus cosmetic use, obesity as chronic disease
• 06:18 – Who should get GLP-1 and why excessive thinness is dangerous
• 09:12 – Special concerns for older patients with joint replacements, muscle loss
• 10:25 – Frustration with healthcare: lack of follow-up, missing patient education
• 11:17 – The case for responsible, physician-led oversight
• 15:01 – Should obesity have specialist care like other conditions?
• 16:10 – Dangers of unregulated, boutique, and black-market GLP-1s
• 19:05 – Hollywood and media’s role in unhealthy thinness ideals
• 20:59 – Non-weight-loss effects: addiction and impulse control
• 21:24 – How GLP-1 affects reward pathways and cravings in the brain
• 22:59 – Microdosing and post-weight-loss maintenance
• 24:44 – Debunking social media myths about irreversible weight loss
• 28:41 – The science: what GLP-1s are and how they’re engineered
• 30:04 – GLP-1s and potential for treating autoimmune disease
• 31:05 – Side effects (short & long term), tips for minimizing
• 32:38 – Your Era as a national resource for safe, personalized GLP-1 care

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Closing Thoughts

The “Ozempic Era” represents a seismic shift in medicine and culture, but it brings both tremendous promise and serious risk. GLP-1 drugs must be paired with education, proper nutrition, exercise, and careful medical oversight. Without that, dangers—from muscle wasting to black market scams—are real. Their value in treating more than just obesity—possibly even addictions and autoimmune conditions—is still unfolding science. But as Dr. Lavin insists, “nothing comes without consequences.” The goal isn’t just thinness, but healthier, longer living.

For more, visit yourera.com for clinical advice and resources.

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For more content, subscribe to the Tudor Dixon Podcast on your favorite platform or visit TudorDixonPodcast.com.

Transcript

[A]

This is an iHeart podcast. Guaranteed Human.

[B]

It's happening across America. Men are being allowed to compete in women's sports, robbing girls of scholarships, medals, titles and safety. For the first time in history, the U.S. supreme Court heard two cases that could decide the future of women's sports nationwide. Alliance Defending Freedom needs your voice today. Visit joinadf.comdixon or text DIXON to 83848 to add your name and side with truth and fairness. That's joinadf.com Dixon paid for by Alliance Defending Freedom.

[A]

Welcome to the Tutor Dixon podcast. Today we are going to be talking all things weight loss because we just saw recently the, I think it was what, the Oscars, that everybody looked incredibly thin. Like, really some people looked really thin. I think some people were even saying, were some of these people too thin? Like, what's going on? And we have a lot of questions about the Ozempic era. What does that mean? What does healthcare look like? So we found a guy who's been in the weight loss industry his whole life, like medical, weight loss, surgery, all of this. And I find his story really interesting because he's gone into a more holistic approach of medicine and how to take care of ourselves. And he's going to explain the rules to us around some of these GLP1s. And I say that because I was like researching before this podcast and I thought, and I've had people who in my life have taken these and I thought it was just kind of like, I don't know, you like the way you go home with an antibiotic where they're like, okay, take one every 12 hours and then, you know, you'll be better. So that was the experience that people I have in my life had with this. It's like, here's a shot. You give it to yourself this many times and then you'll be thin. And so I talked to Dr. Tom Lavin about it. He's like, no, this is not the way. So we have him here right now. He actually leads an organization called Your Era. It's a nationwide network that provides personalized physician led GLP1 care. So he can tell us everything. Dr. Lavin, thank you so much for joining us.

[C]

Great, great to be here. Tudor. I'm very, you know, happy to have this discussion because I feel it's so important.

[A]

Well, I think it's important too, because I think that we have an unhealthy relationship with people gaining and losing weight, just in general, because we had years of, when I was young, I was like the 80s snack well generation where it was like, we're not going to eat any fat, but we're going to load up on carbs and sugar and that's somehow not going to affect our lives. And yet we all got really fat still. And then we went into the like, I feel like my kids have grown up in the body positivity era where it's like, doesn't matter how much weight you gain because you look beautiful no matter what. And then. But I think that was really because we didn't know how to get rid of it. And now we have GLP1s and we're like, you have to be as skinny as possible and there's no rules. So what is happening?

[C]

Yeah, it's been a roller coaster. Obviously the, the American Heart association came out with low fat diets somewhere back in the 80s. And so we went low fat, which meant high carb and we. Our obesity rate skyrocketed. And then we realized, well, that's not good at all. Obviously you have to eat the right fats, but you definitely want to go on a lower carb diet. But really it's just a balanced diet. And these meds with the proportion proper clinical oversight are extremely effective. It's the first time we've had a medicine that can actually change our set point in our brain to make us want to live at the correct weight. First time ever. But of course they can be abused like anything else and they need clinical oversight.

[A]

So I think a lot of us look at this and we're like, this is just a quick way to get skinny. And it's all about, you know, look what we look like. But when I read about your story and what you've helped people with, I mean, we're talking about a lot of medical conditions that are connected to being overweight. And there is there for, for people who are suffering from hypertension or diabetes or heart disease, this is kind of a lifesaver, right?

[C]

No question about it. Obviously, obesity is a complex neurohormonal chronic disease. So this whole idea of the willpower just push away and walk more is such a naive kind of understanding. We have very complex pathways. Just think of hundreds of thousands of years of evolution where food was scarce and now suddenly over the past hundred years, you know, we have food, so our brain is not regulated. So what these GLP1s do actually level the playing field and help people from, you know, when people are overweight, be able to regulate down to a weight that is more healthy. So they're very effective as far as that standpoint. But once again, if people take them without any clinical oversight and get too thin and have muscle wasting, that's the other side of the problem.

[A]

So that's what there are, there are like, if you go to one of these websites, you always have to put in your age and your weight or some, some judgment where the computer goes, okay, you are eligible or you are not eligible. But I would argue that we've seen celebrities who seem like they started in the ineligible category and they are still taking this. So what? So why are you, why is there a point where it's like you're not heavy enough? What happens? Why shouldn't you take it?

[C]

Right? So we give it to help people lose weight. And even people that are 20, 30 pounds overweight, we say, well, they're not sick. There are bad things going on in your body. At 20 to 30 pounds overweight, with chronic inflammation, which has created our whole kind of chronic diseases, are all from this inflammation. So it, for people 20, 30 pounds overweight, there is a good clinical medical indication. But if your ideal weight are already thin and you just want to go on it to get thinner, you know that because every time you have any kind of weight loss, you have muscle wasting, unless you're actually lifting weights and doing resistance training. So once again, the whole program we have is to make sure people are doing something to maintain muscle mass, getting their protein. And we even take a, a bigger holistic approach to, I want you to get your regular sleep, eat appropriately, to avoid ultra processed foods, get your protein, minimize alcohol and things that hurt you. And so in that you just become so much healthier and have better vitality.

[A]

So even if you, even if you are in the category of yes, you fit this, this medication and you should take it, there are still things that you have to monitor. You, you be trying to have a healthy lifestyle, you should still try to work out. These aren't. It's not like this is just a miracle. And you don't have to do any of that.

[C]

No, of course not. So, you know, I tell everyone that's

[A]

what we're looking for. Just to be clear, I'm not gonna lie, we don't want to do all that stuff.

[C]

I tell everyone you're not a child, okay? So nothing comes without, you know, consequences. And I also tell people the programs that existed before GLP1s didn't work because they didn't change that internal set point in our hypothalamus to make us want to live at a lower weight. This does that so it gives you the tool to change that internal set point and let you live at a lower weight. But at the same time, it comes with responsibilities that you need to know about. As far as, like I said, you want to live healthy. So you have to do resistance training, you have to do, make sure you get your adequate protein, get your vitamins, you know, and it's important to give people all the tools so they know what they need to do and they can pick and choose, you know, what they do. But losing weight without taking protein or doing any kind of exercise is going to involve losing muscle mass. And like you were saying, as we get older, that's a bigger problem.

[A]

So that's what I'm wondering, because I see people that I know who have had knee replacements or hip replacements or shoulder replacements, and those areas to me are already weak. They've already had to do. They've already had to do physical therapy to build that area back up. And when, for me, when I watch people that I know that are in their 70s, it's hard to even get back to square one after you've had that surgery. But then I think there's a real temptation to say, okay, now, because I've had this struggle and I've gained weight, I Wanna take this GLP1. How does that affect you if you already have a problem where you have weakened muscles in a certain area of your body?

[C]

Yeah, no question. Going back a little bit, the reason a lot of people need hip replacements, knee replacements, is because they carry too much weight on those joints for too long a period of time. So the problem can be looked at both ways. But at the same time, if you go through the. Any kind of joint replacement at an advanced age and don't work on rehab and maintaining muscle mass, certainly that's going to put you at a disadvantage.

[A]

That's. So that is where I feel like these things kind of come together. And I think my experience has been that I. I feel, I will say in the entire health care industry, maybe it's just the area that I live in. I know, I mean, I've had loved ones, I've had friends that go in, whether it is a psychiatric medication, a weight loss medication, any type of, like, allergies, it's prescribed and there's no interaction after that. And. And to me, this is a medication where there's constant changes and we hear there's side effects. We hear that can have gastrointestinal, intestinal reactions that are. That are pretty severe and they don't have a way to they're not even checked in on. That shocks me.

[C]

Right. That was one of our reasons for setting up your era because we felt like all the digital platforms didn't have the follow up that was needed with physicians or nurse practitioners that really had an understanding of how to follow patients and how to empower them with the knowledge to get their best outcomes. So no question about it, to just go on the medicine with no clinical oversight and just think this is going to be magical, I don't need to do anything is very naive and can be dangerous and that you will lose muscle mass if you're not doing some kind of exercise.

[A]

But we trust our doctors and they're not saying that. I'm telling you, I know someone that went on this and I know for a fact there was no discussion over what your diet should be, whether you should try to do any exercise. I mean, I'm reading your site, so went to your ERA and I'm reading and it's, there's like, okay, this is what you have to do to increase, make sure you, you maintain your muscle mass and then also eating correctly and add protein into your diet. Those discussions are not being had in the 15 minute visit at the office. Is it because doctors don't have time? Is it because doctors have so many medications they don't really have all the information? This came on the market pretty quickly as a weight loss drug, but. Or at least I feel like it. But now I think we're finding out celebrities have been using it since like 2018. So maybe it just feels like that. Is there not enough information? How is it that they are not passing that on to us as patients?

[C]

I think it's multifactorial. So a lot of doctors don't have a full understanding and they don't even know how this drug works, how to follow up, how do you dose it? Can you stop it? Do people take it forever? There's so many questions that doctors don't know and at the same time you have patients that just want to get on it. They don't want to hear anything, just give me the medicine. That's all I need. And that's not the right answer either. So it has to be this collaboration between healthcare provider, team and the patient, empowering the patient to know everything to optimize their health long term. We now know that muscle mass is one of the key things in longevity. So to lose that is not a good thing over time. So you need a whole program.

[A]

Let's take a quick commercial break. We'll Continue.

[B]

Next on the Tudor Dixon Podcast, it's happening across America. Men are being allowed to compete in women's sports, robbing girls of scholarships, medals, titles and safety. For the first time in history, the U.S. supreme Court heard two cases that could decide the future of women's sports nationwide. Alliance Defending Freedom needs your voice today. Visit joinadf.comdixon or text DIXON to 8384 to add your name and side with truth and fairness. That's joinadf.com Dixon paid for by Alliance Defending Freedom.

[A]

So this is your specialty. You're a weight loss professional. I mean, that's, you're a weight loss healthcare professional. So, so my question is why, why is it if I have a knee problem, I have to go to a specialist? If I have a foot problem, I go to a specialist. If I, you know, all, if I have a heart problem, I go to a specialist. But if I have a weight problem too often, even though there is, there are specialists, I just go to my gp. What shouldn't they be referring everybody to a doctor who specializes in this?

[C]

That's complex because it's a matter of access. So, you know, you really want to make sure that the general public that needs this has access to the medicine so they can be taken care of, but they, they have to understand, you know, how to take it optimally for their own health, their long term health. And the side effects aren't, you know, essentially life and death like a lot of other areas. But optimizing your health, maintaining your muscle mass, you know, feeling better about life are critical. So, you know, we're trying to make people aware that you really need a full plan when you're on GLP1.

[A]

So, so, I mean, you say not life and death, but you did just say that muscle mass is related to longevity. And I'm assuming you're talking about like how long we're gonna live.

[C]

Correct.

[A]

So then if you're taking these and you're not aware of that, I mean, you really could be potentially hurting your body. And I know, I know that. I have people that I know in their 20s who are not heavy and

[B]

how are they, how are they getting this?

[A]

They, I mean, is there, I guess there's no rules. If you, if you just, just say you really want it, you can get it. Because I know a young woman who is scarily thin. Scarily thin. It does not make any sense. She is, she does not need this. And there's like a boutique, almost like the same place you'd go to get your eyelashes done. And they're giving out what they say is a. A. An injection of GLP1. I don't even know that they have a medical license. How is that possible?

[C]

Yeah, that it's not regulated. Well, at the. You know, every state regulates their physicians and how they practice. And so, you know, you're. You're going to get that. And there's also a black market of GLP ones that might be made in Mexico or China or, you know, and they say, not for human use or only for animal use. And. Yeah, and if it says that you need to run, like, don't take things that are not for human use, that

[A]

feels like a pretty natural reaction to run from that. But maybe it's just that you want to be thin so bad that you're like. I mean, I guess I would also feel like, oh, they must have cleared it for human use. It just still says that because it's clearly here for me.

[C]

Right, Right. I don't know. I think it's more a matter of people are desperate, they want to lose whatever amount of weight, and so they're willing to accept things that say not for human use or for research only. And once again, there's no oversight as far as sterility or purity. Even if it says purity on it, it doesn't matter if it says not for human use, research only, or animal use. You know, stay away.

[A]

That is so scary. When I was just thinking the other day when. Yeah. You know, when we were little, you would watch all those movies that would find the Fountain of Youth, and, like, they'd be searching their whole. The whole movie for the Fountain of Youth. And. And when I was a kid, I thought that was just like, oh, these people just want to live forever. You know, now that I'm old, I'm like, oh, no. I know what they were looking for. They wanted to get rid of this, and they want to get rid of this, and, you know, like, they wanted to look young again. But that's why we make movies about it, because there is such a desire to go back to. To grasp what you used to have. I mean, I. Clip from that show Schitt's Creek, where she's like, take pictures of yourself now naked, because when you get old, you'll look back with much kinder eyes. And I'm like, you know, that's not a lie. I mean, but it is true. You look back and you're like, I really look good. Then when I thought I was fat, because we're constantly looking for that.

[C]

Right. My wife Always says you'll never look as good as you do today as much as you criticize how you look today. So.

[A]

But we always think that we can, there is better and, and there's reasons we think that. I mean you look at just these, these images and these videos that recently came out of Oprah and Demi Moore and they, they are, they're very thin and they look very young, but they look like you could blow them over with a feather. I mean they, they looked very. And I don't know if that, obviously I don't know their stories. So people were saying, oh, this is a GLP one, but can it, can you get to the point where you' so thin that you are shaking? I mean there you can see they're kind of tremors. They have kind of tremors as they're walking.

[C]

Yeah, I, I really worry when people get below a BMI of 20. What are you doing? But like you said, it's that infatuation with being so thin. Obviously we're about being healthy and living your life at the highest level is from a physiological standpoint and that's in optimal weight range with, you know, if you need a GLP one obviously there's a lot of microdosing working work going on today in research on the inflammatory pathways and the addiction pathways, cardioproductive pathways. So many things going on. So these drugs are peptides that are far beyond just diabetes or weight loss. There's so many other long term benefits, you know, not to put aside addiction. The impulse, you know, reductions are great for gambling or narcotics or alcohol or cigarettes. So many different things have research going on today. So the GLP1s have really changed the landscape on so many different therapies.

[A]

No. Okay, so that is interesting because I have heard people and I just recently started hearing this, maybe I'm behind the times or something where people are saying, you know, you, you can knock GLP1s but I was an alcoholic and I'm totally cured. Or I mean, other addictions, even weird things like the desire to gamble. Like it's. Is that possible? Is it possible that a drug can take that off?

[C]

How does that work in your brain? You have these mesolimbic and mesocortical pathways. And the mesolimbic pathways are these Q induced dopamine spikes. Meaning I see a pizza, my dopamine spikes, I need to eat the pizza. So the GLP1s drop that dopamine spike. So you don't have that drive to eat that pizza. And that goes for. It appears for narcotics and alcohol and tobacco and gambling and scrolling on your phone and so many different things that, you know. So it's kind of that executive control over impulse control, which we all want. But GLP1s appear early on to really impact these areas.

[A]

That's very interesting because we see people on all of these different medications to try to control those things. And I, in just the. I mean, what you're saying kind of reminds me of that add mind, where it's like, I'm going to start this, I'm going to move that. I'm going to start this, I'm going to move to that. And. And then you get put on a stimulant, which I never understood. I'm like, why is the person who is like, I should do 14 things at a time, Then it's like, let's make that. Take that to the next level. Which I guess there's some medicine behind that. But when I hear about what. What this does, what is the. How do you know a microdose? Like, I. Because this is not like you're taking the full shot every day for this kind of stuff.

[C]

Right, right, right.

[A]

How does that work?

[C]

There's a lot of research going on in those areas, but it kind of goes to the. What happens when I get to my goal weight? Like, can you just stop it? And we know there's some weight regain if you stop, you know, cold. So some of our patients stay on the same dose, Some go to a. A very low amount. And that seems to handle most patients. And you can call it microdosing, call it whatever you want. Microdosing kind of got trendy, but you're just going to a much lower dose of the medicine, which, with all these other pathways and benefits, makes sense. But it also seems to help people maintain the weight loss. And there are certain people, and there are not many that can go cold turkey. They get there, they're fine, they're done, and they can maintain that weight loss. And it does come back to the hypothalamic set point that I was talking about earlier, where, you know, we have this, and there's a lot of research that has gone into this, where the hypothalamus is really the hunger center of our brain, and there's a weight. You know, you could think of it as a thermostat where there's a weight, where your body feels comfortable every time you try to go below it. You know, you can, you know, with sheer willpower, do it for a while, and then you go right back to that weight. And that was before GLP1s that actually lower the set point. So GLP1s are the first med and they're peptides that can actually lower that set point, which is why people are having long term weight loss with GLP1s, whereas before that, nothing happened.

[A]

Let's take a quick commercial break. We'll continue next on the Tudor Dixon Podcast. I saw this thing on social media the, the other day that I actually think was not true. But you know, you read these things, you're like, is this actually, is this a true thing? I think this was not a true thing, but it was. But I want to ask you about it. It was a celebrity who claimed that they couldn't get back to, to like they lost too much weight and then they couldn't regulate their body. Even though they got off, they couldn't regulate their body back.

[C]

That'd be hard to believe because once you get off the GLP1s, you're going to have, you know, some trending upwards, particularly if you're below your ideal weight. Your body's gonna want to get back there. But once again, you know, there's anorexia nervosa and other, you know, psychiatric diseases that could have played a role in that. You know, that's, you know, so many personal factors that we don't know about that could have been involved there.

[A]

There. Is there anyone who is coming to you now and saying, I have this addiction and I want to. And they, and you just start them at the microdosing to test that.

[C]

Oh, addictions? Yeah. Yes. There's, there are a lot of patients that, you know, they have chronic disease. Like we're seeing patients that have different autoimmune diseases where it really impacts or gets, gets them off their, their other meds and helps them control it. So definitely there are patients that, you know, have alcohol problems or other problems that we will try because the side effect profile of the GLP1s is so low and there is mounting biomarker evidence and clinical evidence that they impact so many disease processes, including addiction. The addiction and the way we found that is everybody was losing weight, but then they, they didn't really want to drink alcohol anymore. They didn't have that drive to Netflix and a bottle of wine every night. So the, you know, they broke that weekly habit where they still, you know, can enjoy alcohol if they want to, but they don't have that cue induced drive to grab the bottle of wine.

[A]

Is it something that we already have in our systems? I guess this Some is this it, does it replicate something natural? Or how do, how do some people have these issues and some people don't?

[C]

There's a lot of genetics and evolution that is involved in all of our different, you know, mental pathways of why are certain people overweight and certain aren't. And I always say it's genetics plus environment. I mean people that we used to operate on families and you know, I'd operate on the husband, wife, they'd lose £150 each and I'd see the little 10 year old one year Christmas picture, he's way overweight. The next year's environment changed because they quit eating so bad. He's a thin guy now. So. So it's a combination of genetics and environment and I think this evolutionary dysregulation of all of our pathways where, I mean, think about it, up until about 100 to 150 years ago, there was no food. I mean you were a hunter, gatherer, you were always in search of food. So our pathways were driving us eat when you find food, eat well. The last 50 years there's food everywhere and the ultra processed food industry has exploded. So, so these pathways just imploded and, and so patients got, you know, over the past 50 years obesity has just gone rampant.

[A]

It, but, but what is the medication? Is it something that we, is it something totally foreign to our systems? It's something we are.

[C]

I'm sorry. Yeah, yeah, so that's. So GLP1s are something called incretins and they're, they're gut derived hormones that have effects on the body. And the big, in fact effects are they decrease your, your insulin or they increase your insulin, decrease your blood glucose after you eat, slow the stomach gastric emptying and they have all these impacts we're talking about on the brain to decrease your set point, decrease hunger drive. And so the problem with our endogenous meaning the GLP1s in our body, they only last a minute because they have this enzyme DPP4 that breaks it down. Well, we've been able to Engineer the new GLP1s where they last a week. Now not just a minute, one to two minutes. They last an entire week. The half flight's like five days. So now these, these incretins can, can have all these impacts all, all day, every day instead of just after eating.

[A]

Interesting. All right, so the last thing I want to ask you, you mentioned autoimmune disorders. Is that like Crohn's and things like that, is this improving those disorders?

[C]

Rheumatoid arthritis, Crohn's different. And once again there's no long term clinical research. There's just the biomarker animal studies and shorter term studies. But we're finding in clinical practice that it does improve people's health and getting some people off their medicines or on lower medicines and improving their symptoms. So there are a lot of kind of chronic disease processes that we've been treating forever in our, you know, like I said, our disease treatment healthcare system that we might be able to impact kind of at a inflammatory basic level.

[A]

Interesting. Actually I said that was my last question. But what are the side effects? Like what are the bad things that can happen? Because I know a lot of people get on it and they don't know what they're experiencing. I've heard, I've heard constipation, I've heard diarrhea, I've heard all kinds of things.

[C]

There's kind of short term and long term and we were kind of talking about the long term, you know, the loss of muscle mass, loss of bone density, which is why we really stress nutrition, protein and resistance training. That's kind of long term but the short term that people feel, you know, in the first, you know, week of taking therapy are the GI symptoms and they're somewhat self limited but can be nausea. And once again we kind of talk about this yellow zone, green zone, red zone concept where if your dose is too high, you're in this red zone where you're getting nausea, really bad heartburn and you just need to drop the dose down usually on those symptoms. But diarrhea and constipation are other symptoms that patients will have and they're usually self limiting and over time they resolve patients accommodate to those symptoms. But it's that first one to two months where you're trying to get in the right dosing range and tolerate the medicine before if you can make it through one to two months. Patients seem to have really good results. It took the first month that they really have challenges.

[A]

Great, great. So people want to know how to find out more. If they go to your era, if they go to your site, is that something that you can go from any state, from any place? Is that like local or how does that work?

[C]

Yeah, yourera.com we're national, we're able to provide care in all 50 states and, and we're, we'll provide information and oversight. Once again our goal is to empower people with the knowledge to optimize their health, lose their weight, but lose it in way and maintain it long term.

[A]

Wonderful. Thank you so much. This has been very informative. So anybody who wants to go there, check it out. Dr. Tom Lavin, thank you so much for being on today.

[C]

Thanks Tutor. It was my pleasure.

[A]

And thank you all for joining the Tutor Dixon Podcast. As always, you can [e-mail], the iHeartRadio app, Apple Podcasts, or wherever you get your podcast. You can also watch watch on Rumble or YouTube uteRdixon. Just tune in and right now go off and have a blessed day. This is an iHeart podcast. Guaranteed Human.