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Dr. Nicole Safire
Welcome to Wellness Unmass. I'm Dr. Nicole Safire and this is your weekly rundown. Now let's catch up on what's happening this week because there are two stories that while they seem totally unrelated, they actually say a lot about how we're approaching medicine right now. Let's start with the uk. I mentioned it last week. I talked about that there was a slight uptick in meningitis B cases, specifically in an area of Kent, mostly affecting university students. And it definitely raised some concern. Here's the good news. Cases are now starting to come down. We've gone from mid 30 cases to about 20 confirmed after further testing. So they actually thought they had more cases than they really did. That's good news. Now that might not sound too dramatic that they said that there were 30 cases and there were 20 cases. But in infectious disease, that shift absolutely matters. And it means that response is also working too because of the confirmed cases. They aren't seeing new cases or more cases because public health officials, they moved quickly, getting the antibiotics, making sure they were diagnosing it, getting close contacts. Yeah, I remember contact tracing with COVID even more important. Well, that wasn't even that important at all with COVID but definitely important when it comes to meningitis. They also increased their vaccination campaigns. We were talking about the meningitis vaccine here in the United States at the CDC ACIP meeting last year. It caused a bit of an uproar because instead of mandating it or putting it on the formal recommendations in kids going off to college, they said they really wanted it to be a conversation with the doctor. And risk based? Well, meningitis is the most lethal in infants, but the vaccine is not improved for infants. So obviously you're not gonna recommend it for infants. But it's the second highest risk is kids specifically like older adolescents, college age kids who are all congregating together in dorm rooms. That's why there's a recommendation for that vaccine to be given before kids are going to college. Especially, especially, especially if they are living in the dorms or they are living in apartments with other kids. Meningitis is no joke. It is not a common cold. It is not like the flu. It is very serious and should be taken seriously. Happy to hear what's going on in the UK and really hope that we don't see any upticks come late summer here in the United States because fewer people are getting vaccines. That is definitely the trend that is happening here and not just here is happening across the world as well. Okay, let's shift gears because the second story is a different kind of health issue, but not surprising, one we're dealing with every day here in the United States. GLP1 medications. You know, the weight loss medications, WeGovy, Manjaro, all whatever the other name brands are that people are taking. You know, these drugs. You know, the other, the actual names are like semi, glutide, Tirzepatide. They've really changed the conversation around weight loss and metabolic health in general. And to be clear, they work. They absolutely work. I think we all know that. All you have to do is turn on the TV and all of a sudden, Hollywood. They've always been skinny. They're just even skinnier now. But it's not just people in Hollywood. Everyone's on them and you see it. You kind of see the wasting away of the phases. And yeah, I mean, a lot of people are losing weight. It is helping to tackle the obesity crisis. Do they have side effects? Absolutely, they have side effects. I think we don't talk about the side effects enough. But the reality is there are benefits to these medications, not only just losing weight, but all the benefits that come with losing weight. One specifically has been heart health, and this is well documented. People who are on these medications and are losing weight, they have decreased heart attacks and strokes and just overall better heart health. Well, I hate to burst your bubble, people, but just like I have told you, most of these medications, for most people, you have to stay on them forever. Because the majority of people, over half, I think it's even 2/3. I don't know what the actual number is now, but when people stop the medication, oftentimes they gain the weight back. Some people gain the exact same amount of weight back. Some people gain even more weight than when they started out to begin. Well, this new study raises an important question or kind of answers it for us. What happens to all of those health benefits when you stop the medication? Well, the answer is it's not great. What researchers are seeing is that many of those cardiovascular benefits, they fade, and they fade fairly quickly within about six months. In this one study, the risk factors for heart disease started creeping back up. By a year, more significant changes are happening. And by 18 months of stopping the medication, all the benefit of being on those medications, they're gone. Some experts are even calling it kind of like a medical whiplash. And that is not healthy for your body because now you're putting your body in a state of strock. You're shocking it by depleting its nutrients, and then you're shocking it again by taking the medication away and adding all the weight loss or adding all the weight back. And so I think this is where we need to pause and be honest about what these medications are and what they aren't. They're not a quick fix. They're not something you can take for a few months and move on. And for many patients, they're looking more like long term, possibly probably lifelong therapies. And that comes with real considerations. Cost. They're expensive. You can get some, I believe, on Trump Rx for a lower cost, but they're still expensive. Access who can get them and then staying on the medication. And what happens if you can't? Especially as we start talking about using these drugs in younger people. That's right. There are clinical, clinical trials for kids under the age of 10 taking these medications. It's already approved for teens and preteens. I mean, that's crazy. We need to be teaching these kids good, healthy lifestyle behaviors and not necessarily giving them medications. We need to make sure that they have long term success. Yes, they can be incredibly helpful, but they don't replace the foundation of health, nutrition, physical activity and addressing underlying metabolic issues. That's the answer. Those stings still matter and they matter long term. Thank you so much for listening to this week's rundown. I'm Dr. Nicole Safire. Listen to Wellness on Mass on iHeartRadio, Apple Podcasts or wherever you get your podcasts.
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Hey, it's Covino and Rich struggling to see up close. Make it visible with viz. VIZ is a once daily prescription eye drop to treat blurry near vision for up to 10 hours. The most common side effects that may be experienced while using VIZ include eye irritation, temporary dim or dark vision, headaches, and eye redness. Talk to an eye doctor to learn if this is right for you.
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Date: March 26, 2026
Host: Dr. Nicole Saphier (featured guest host for Wellness Unmasked segment)
This special “Wellness Unmasked” installment, hosted by Dr. Nicole Saphier, zeroes in on two major health stories: a meningitis scare in the UK and the latest research on wildly popular weight loss drugs (GLP-1 medications). With her signature blend of clarity and candor, Dr. Saphier examines what these stories reveal about modern medicine—especially our readiness, and reluctance, to address root causes versus quick solutions. The episode packs in fast-breaking health news, underlying context, and pressing questions about our societal approach to wellness.
Initial Concern & Response
Clarification of Severity
Public Health Interventions
U.S. Vaccination Policy Comparisons
Key Recommendation & Caution
Game-Changing Drugs
Side Effects & Critical Perspective
Cardiovascular and Other Benefits—With a Catch
Temporary Gains, Long-Term Challenges
Critical Reflection and Societal Questions
Youth, Access, and Ethics
“Meningitis is no joke. It is not a common cold. It is not like the flu. It is very serious and should be taken seriously.”
—Dr. Nicole Saphier (05:10)
“These medications, for most people, you have to stay on them forever. Because the majority of people, over half—maybe even two-thirds—when people stop the medication, often they gain the weight back. Some...even more than they started out with.”
—Dr. Nicole Saphier (08:07)
“They don’t replace the foundation of health: nutrition, physical activity, and addressing underlying metabolic issues. That’s the answer.”
—Dr. Nicole Saphier (09:20)
Dr. Saphier delivers her insights with clarity, concern, and an accessible, matter-of-fact tone. She balances scientific rigor with practical advice and societal critique—particularly with respect to quick fixes versus long-term health habits.
This episode is invaluable for anyone curious about evolving health threats and therapies, especially as they intersect with social trends, public policy, and our collective attitudes toward wellness.