Hear leading UK clinical operations experts tackle today’s most critical challenges in clinical trial outsourcing, CRO selection, and site optimization—insight essential for any trial leader planning or delivering studies across the UK and global markets.

Speakers

Episode Overview

This episode features a candid panel discussion recorded live at COG UK. Senior clinical operations leaders from industry, biotech, NHS, and patient advocacy discuss the evolving landscape of clinical research in the UK, with direct implications for clinical trial outsourcing, CRO selection, and study delivery optimization.

The panel explores why, despite a growing number of clinical trials, recruitment rates are falling and UK sites are receiving lower enrollment allocations. Experts dissect how conservative site targets, performance metrics, and resource constraints are impacting site selection decisions and sponsor strategies - a topic critical for clinical operations, outsourcing, and vendor management professionals handling global studies.

Key areas include how to build more resilient and accountable sponsor–site partnerships, approaches to decentralizing trial delivery, tailoring CRO selection and outsourcing models to increase reliability, and deploying operational best practices that enable faster site activation, improved patient recruitment, and consistent protocol delivery. Patient advocacy and the unique role of NHS/industry collaboration also feature prominently, offering perspectives on how to bridge structural gaps and better utilize the UK’s world-class data sets and patient diversity for clinical study optimization.

Key Moments

00:02 – UK clinical trial landscape: why are trial numbers up while patient recruitment falls?
00:04 – How conservative site targets and accountability metrics created a downward cycle in UK site enrollment
00:06 – Industry and NHS perspectives: site reliability, consistency, and the barriers to delivering clinical trial outsourcing at scale
00:09 – Site activation delays, site resourcing challenges, and why “winner” sites dominate CRO selection
00:12 – The role of site resources: how local limitations shape CRO/vendor selection and operational risk
00:14 – Linking UK’s data resources to clinical operations: innovative models and the potential for pre-screened “virtual waiting rooms”
00:15 – Cross-department bottlenecks in the NHS: pharmacy, imaging, IT, and their impact on sponsor/outsourcing models
00:20 – Accountability frameworks: how stronger governance and direct engagement are reshaping site and sponsor performance
00:25 – Public vs. private sites: operational differences, business-model thinking, and implications for clinical trial outsourcing strategy
00:34 – Phase 2/3 trial expansion and later-phase access, but persistent resource and recruitment hurdles
00:37 – Global benchmarking: incentives in Germany, site performance metrics (e.g. CRDCs), and lessons for UK outsourcing

Top 3 Takeaways

Site Selection and CRO Selection Must Go Beyond Track Record:
Both industry and patient advocates agree, defaulting to the same high-recruiting “winner” sites creates systemic access barriers. Effective clinical trial outsourcing requires nuanced CRO selection and site engagement to widen participation while balancing quality and speed.
Operational Resource Gaps Drive Underperformance:
Resource and cross-functional support deficits (in pharmacy, imaging, IT) are major blockers to timely site activation and successful outsourcing outcomes. Top-performing sites, public or private, function with strong business-like governance and clear lines of accountability.
Collaboration and Accountability Are Key to Clinical Study Optimization:
Breakthroughs in UK delivery now hinge on true partnership: flexible, site-by-site support models; integrated data utilization; transparent performance measures; and shared responsibility among sponsor, site, and CRO. This is the path to accelerated timelines and sustainable clinical operations best practices.

Links & Resources

Quotes

“Conservative site targets and performance metrics have led to sponsors giving UK sites much smaller allocations—the more conservative we are, the less opportunity we get.”

— Sarah Dealey

“We go to the same sites because they have the expertise and resources, but to unlock UK potential, industry must think outside the box—linking rich data assets to new trial delivery models.”

— Fiona Shields

“Sites that succeed act like a business: clear accountability, strong timelines, and a customer-focused approach. That’s true globally, not just in the UK.”

— Divya Chadha Manek

“To make trials truly accessible, we must involve patient advocates deeply—from trial design to targeted outreach—ensuring protocols and trial models fit real patient needs.”

— Janette Rawlinson

“Accountability and true partnership are what will raise UK performance. Sites and industry must align, with clear expectations and shared responsibility for outcomes.”

— Suki Balendra

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Further content and agendas: hhttps://thepbcgroup.com

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Further content and agendas: hhttps://thepbcgroup.com