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Dave Asprey
Foreign.
Dylan Jelli
Today's episode is sponsored by my good friends at Timeline. Timeline is now offering the world's first ever longevity gummies, powered by Might appear. You've heard me talk about the importance of cellular health and our mitochondria, which is why I have time. As my favorite and most trusted sponsor, these are the only clinically proven Urolithin a gummies for strength and healthy aging. We may be living longer lifespans, but are we truly living better lives? What if the key is not just adding years to your life, but life to your years? This all starts at the cellular level. As we age, our mitochondrial health starts to decline. And one of the keys to living longer and healthier is keeping our mitochondria healthy and strong and might appear targets. This for us. Take control your health now and live the life that you not only desire, but you also deserve. As a gift to all my listeners, you can save 20% off today by going to timeline.comdylan to get started. That's timeline.comdylan. i assure you your cells will thank you. All right everybody, welcome back to the Dylan Jelli podcast. So this has been an interview that I have been dying to get for I don't know how long and it is one of the biggest honors and pleasures that I've had. There is literally no intro that I'm going to be able to do to give this man even a fraction of what, you know, he has done or what I could say. But I am going to give a little bit of his background, which I'm sure most of you know. But I want to cover some of the bases before we get into our interview. So he is the founder of Bulletproof Coffee, the Bulletproof Diet and the biohacking movement. He's a four time New York Times bestselling author. He has a brand new book, it's in the background, as you can see, it's a bestseller. It's called heavily meditated and he is the C E O of Upgrade Labs and he hosts an amazing podcast. It's called the Human Upgrade Podcast. He pioneered online sales in the 90s, he co founded an early data center company and he later transformed his own health by losing a hundred plus pounds and improving his cognitive function. So this journey has led him to create the bulletproof diet and coined the term biohacking. And Dave runs the 40 years of Zen neurofeedback program, the biohacking conference, which was absolutely amazing and a regenerative agricultural farm while investing in biohacking startups. So as a leader in the Longevity Movement. He collaborates with medical professionals, researchers and innovators to develop groundbreaking techniques and products that enhance mental and physical performance and using science backed methods. His mission is to help people upgrade their minds to a happier, more conscious state and optimize their bodies one cell at a time. So my friends, this is Dave Osprey.
Dave Asprey
Wow, that was quite the, quite the feeding of my spiritual ego. I'm gonna have to go meditate or something. Thanks, Dylan.
Dylan Jelli
Absolutely, man. Well, first, I know how busy you are and taking any sort of time like this is a really big deal and for giving it to me, I really, really appreciate it. So thank you. Before I even get going with everything.
Dave Asprey
It is, it's an honor to be here. Anytime people are gonna invest an hour of their time to listen to something, I, I can only be grateful. So thank you for making it happen.
Dylan Jelli
Absolutely. Well, we're going to, we're going to put you in front of as many people as possible. So look, you've, you've had a major impact on I don't know how many hundreds of thousands of people. And I'm going to tell you right now, you helped me transform from being in the bodybuilding industry to making a transition into biohacking, which for me personally has changed my life and opened up a million other avenues and made me feel like I'm kind of doing God's will now. And you've, you've played a major impact in that. And so I want to get into this polarizing term, biohacking, because it, it is polarizing to some people. And I think once you get into it, you realize it's, it gets only.
Dave Asprey
Polarizing to dumb people.
Dylan Jelli
Explain what it, what it means and how you came up with it, please.
Dave Asprey
By the way, I only said that to trigger people. And we're going to talk about why you got triggered if you didn't get triggered. So I don't really believe that Biohacking is just the art and science of changing the environment around you and inside of you. So you have full control of your state, full control of your biology. And it united like kombucha moms and yoga teachers and breathwork teachers and bodybuilders and neuroscientists and Navy Seals and longevity doctors and that Let us all come together and say it's not about doing just one thing. It's about doing the right recipe with the right ingredients to get the results you want. And I've said from the very beginning of the biohacking movement that some of the best biohackers in the world are bodybuilders. Because the mindset for bodybuilding is I want a specific state, I want this amount of body fat, this amount of muscle, this amount of hydration. And here's all the levers and cranks and tools I can use. I just gotta pick the right ones and I can do it right. And then you practice and you measure. Like this is some of the heritage of biohacking. In fact, I opened Upgrade Labs, the world's first biohacking center, underneath Arnold Schwarzenegger's office in Santa Monica about 10 years ago. Today it's a franchise. We've got about 30 locations in the process of opening. About nine open and people can partner. If you go to ownandupgradelabs.com and we can open one in your neighborhood, it's like AI longevity. But if you're a bodybuilder, only 10% of the equipment has to do with stimulating muscle because it requires a small amount of AI stimulation combined with superhuman recovery and nutrition to create massive change. Whether it's VO2 Max or whether it's muscle growth, you don't have to work hard. We have this idea that working hard for long periods of time gets better results, especially in cardio. It doesn't. And even when you're training with weights, the way you load your muscle and the way you recover is more important than overloading the muscle. So I want you to save every minute of time. And if your goal is, I want to have a bodybuilder's physique, well, let's help you do that in a way that takes less time and doesn't put a strain on your cardiovascular system.
Dylan Jelli
I cannot resonate with you enough on this now. I just actually found that my ejection fraction was on the little bit lower end for where it should be. And I'm doing a hundred minutes of zone four cardio five days a week for the last 15 years.
Dave Asprey
That was kind of a mistake.
Dylan Jelli
Kind of? Yeah. And you know what I'm realizing by I, I've been stepping down and stepping away, I'm losing more weight and I'm eating more calories and I'm doing less cardio.
Dave Asprey
Isn't it so offensive? People have been telling us since I was a 300 pound, fat, young, like 22 year old that oh, if I would just do more cardio and just go to the gym more and eat less, I would lose. We straight. I believe this so fervently. 18 months straight, 6 days a week, 90 minutes a day without Fail on a low fat, low calorie, semi vegetarian diet. I never lost an inch off my waist. 46 inch waist, beginning and end, never lost a pound. Sure, I put on some muscle under my flab, but I had flabs, not abs. And I was so disillusioned. I'm sitting at Carl's Jr. With all my thin friends because there were a lot of thin people back then. You know, the, the early, this is the late 90s and they're eating double western bacon cheeseburgers. I mean the chicken salad with no dressing. Oh, no chicken because of calories. Like maybe I'm eating too much lettuce and like I work out more than all my friends combined and I eat less than the smallest of them and I'm still fat. And I thought it was a moral failing and it was that, no, this advice is bullshit. And that was one of the things that really led me to say I'm only going to do what works. I'm going to measure things and I'm going to stop following stupid advice. I don't care if some double blind study or some angry PhD troll named Lane just decides that, that they're going to yell about something over and over and over to make it true. That isn't how it works. If it does not work for you, then don't do it. Measure it with an aura ring. Early investor advisor to aura and in fact I was CTO and co founder of the first fitness tracker to get heart rate from the wrist. Like I believe in this stuff and only do what works. And if I tell you something and your HRV goes the wrong way, then don't do what I said, do what someone else said or read more details because we're not all the same. The recipe is different. And you know this as a former bodybuilder and as a biohacker. Now you take a 50 year old woman, the rules are different than a 50 year old dude. And if it's an 18 year old, it's going to be completely different, right? So you got to look at the hormonal environment, you got to look at the other environmental factors. I was working with a pro athlete the other day, a very top ranked one. And I'm not going to name the sport just for confidentiality, but you know, she had a series of three seemingly unrelated things that put her system in a sympathetic overdrive. And her doctors who don't know about biohacking, they said, oh, here, have some NSAIDs. So they gave her leaky gut which led to brain Fog. So now you got a pro athlete with brain fog. Leaky gut. Joints still hurt because of the leaky gut. And no one ever said, you know, you kind of had a head injury followed by an emergency surgery for something else, and your system never recovered. It's the recipe of how you got here. It's different for every one of us. And so I just want you to understand what I'm saying. I will tell you principles, and I will tell you what is most likely to work. But if you don't measure, you don't follow that rule. Track what you hack, you might get different results. And if you go deeply, we'll probably can tell you why in this episode. It's not that it doesn't work. It's that you are not the same as any other human on the planet. And it's okay.
Dylan Jelli
That's right. You know, I. I got into this conversation with Ben Azadi, and he. And we were talking about how I suffered from lipophobia, even being a nutritionist for 20 years. I started being a nutritionist in my early 20s, and I still, to this do about six to eight months ago, was absolutely terrified of eating fats. And I, like, you, would stall out or, like, wonder, why am I. Why do I feel like shit and why this and why that, when I'm eating 13 servings of vegetables a day and oatmeal and egg whites and just living on it, right? And you know what, Dave, man? I started to look into the. The bulletproof diet that you came up with, and I took aspects of that. And then I told my wife one day, I said, you know what? I am done. I can't do this anymore. I'm miserable. And I started following a lot of what you had in there, and I mixed some of my own stuff in there, and I went from 16, 1700 calories a day to now 2700 and fat from like 20 grams of fat to 130. And I'm thriving. Like, thriving. And I'm. I'm embarrassed to even talk that I was doing this, but I'm happy to help people and say what you said was right.
Dave Asprey
Do you know how rare of a human you are? You have more than a decade invested in an identity and a mindset and a belief, and scientists at big universities do the same thing. And then you had the balls and the audacity to say, oh, my God, maybe some of my assumptions are wrong. And instead of feeling threatened, like, I guess I'll try it, and I'll tell you one of the reasons that bulletproof and the bulletproof coffee became so famous, by the way, I am not at bulletproof anymore. Danger coffee is my new coffee company. Danger. Because who knows what you might do? But the reason became such a big deal is you know that you go to a Tony Robbins event and there's those hot coals. You're gonna walk on coals. And that first step, you're like, I'm gonna die. The first time that I came back from Tibet, where I had yak butter tea, and I took a big old hunk of butter and I put it in a blender, it was like walking on coals. I'd been a vegan. I'd been a raw vegan. Everyone had told me butter would kill me. But all of the science, all the longevity nonprofit work I'd done, it led to a different conclusion. I said, I'm just gonna try this for a little while. And I put it in there. I tested a bunch of different recipes. When I got it dialed in, everyone who drank it would feel amazing, but they'd always feel like they were gonna die. The first time they put that hunk of butter in there. It was like a step into the unknown. It's like you're risking your life. You weren't. You were actually helping. And the fact you could do it, as someone who was really in the anti fat camp, that. That says a lot about your willingness to. To question everything and to be truthful. So congratulations, man. And by the way, extra thousand calories a day. I had the same experience. I had this. This weird time where I said, I know. I've learned fat doesn't make you fat, not the way they say. And some fat does make you fat. Each fat does different things, but.
Dylan Jelli
Right, Right.
Dave Asprey
I went on an early version. I was kind of stress testing the bulletproof diet before I was willing to publish it. So I was doing 4,500 plus calories a day, and I was just gonna do this for a month. I'm like, I'm gonna just. I'm gonna set myself up. Less than five hours of sleep every night, no exercise, and 4,500 calories a day. I'm gonna do it for a month. The math says I should gain £20 or something, and I'm only gonna gain one or two or something. I grew abs. I actually felt great. I did it for months. And overfeeding is not good for longevity. I don't recommend anybody do that. You know, conservation of energy and Newton's law, All of Newtonian physics is bullshit. Reality runs at quantum level. Newtonian physics is just a story that fits pretty well about reality, but it is not an accurate story. And I love to take the trolls, the calories in, calories out, Die Hards. They're doing it like a religion. And I say, oh, if. If you're going to get fat, eat a gram of uranium that's more than a million calories. And they go, but you can't digest uranium. I go, do we need to keep going? And then they go, that's not fair. Okay, okay, how about this? Did you know that there's a drug that ranchers give to cows that's an extract of toxic mold that makes cows get fat on 30% less calories? They go, no, no. Okay. It's called zero. It's an extract of a mold toxin that's 10,000 times stronger than human estrogen, and it grows in houses. But if this mold can exist and it's a drug that ranchers spend tens of millions of dollars a year on because they have to buy less corn, you're going to tell me calories in, calories out still a thing, right? The only way you can still do that is if you're one of those people who's like, you know, if you say what I don't like, lord will strike you down from heaven with a stick of rice cake. Or, I don't even know what's going on with those people. But they're not sane.
Dylan Jelli
No, I agree. The calorie bros, they're. They're out in the wild. And this. All calories are equal and all of this, and I tell people, you're telling me that if I put this in this hand and this in this hand, these french fries that are 200 calories in this 200 calorie piece of chicken, they're the same thing. And I'm just lost as to how they're the same.
Dave Asprey
It's funny, too, because as a bodybuilder, give someone a hundred grams a day of soy protein, 100 grams a day of whey or beef protein, and you tell me who's gonna have dates, right?
Dylan Jelli
100%. I couldn't agree more. This. That people get on. I just, I. It's confounding to me. And I, you know, it's. It's easy to fall into that trap, which we all have, but when you start questioning things and doing things on your own and seeing how they work, it's amazing. And one of the things that you're big on, that I am now big on is animal proteins. And I want to know why for you? I mean, I know why, but I want the audience to hear why the animal proteins are so beneficial and so important and why they've been stigmatized.
Dave Asprey
Ooh. Well, the why we're gonna have to go into some theories that I cannot prove or disprove. That's okay. I think I know why. And why are they better? They're better because they work better because of digestibility and amino acid availability. And you see these poor, sad, weak bone density vegans, and they're like beans and rice are a complete protein. Even if you extract the proteins from the beans and the rice, you're gonna need an awful lot of it. And it still doesn't work as well. The very best plant proteins are 30% less available than animal proteins. Animal proteins have more minerals, more vitamins, and they don't come with toxins. And all of the plant proteins come with he high amounts of heavy metals. They come if they're naturally whole foods, packaged. They come with a huge amount of mineral depletion, oxalates, sometimes histamines, lectins, and omega 6 fats and a boatload of carbs. So you just can't do it. And saying something is true doesn't make it true. And you go to India where everyone's vegetarian, not vegan. Not everyone, but many people, when they're eating their traditional diet full, I mean, full of ghee with some coconut oil and lassi, which is full fat, dairy and butter and eggs, which are in many of the dishes. Oh, they're eating a high saturated fat diet with some protein. Right. They don't have obesity, they don't have high blood pressure, they don't have diabetes. It's the introduction of American seed oils and the exclusion of saturated fat, particularly stearic acid, that leads to these problems.
Dylan Jelli
A hundred percent. I thoroughly agree. And I, I, I've been on that because I had found some plaque in my arteries, which was unexplainable, honestly. And this thing of wanting me to crush my LDL down in the 30s, which is what I was being advised to do, and I, God, give yourself.
Dave Asprey
Cancer, why don't you?
Dylan Jelli
Exactly. And that's why I said that is absolutely insane. And so I, you know, I understand that. So I wouldn't take the statins and I didn't. It was an LP issue, which is a genetic issue. It's not something you can control with diet and weight loss. And so I've gone other means in doing it and hacked my way down in My score, but I thoroughly agree. And the cholesterol thing is what I want your opinion on. The LDL dropping your LDL too low. What kind of negative effect can that have? And what, why do you feel like that is being pushed on so many people, aside from the obvious with the statin markets?
Dave Asprey
Well, when we talk about why low LDL gets promoted, and we talk about why low animal protein gets promoted, there's usually an emergent phenomenon, right? And I studied artificial intelligence. I designed highly distributed high scale computer networks for a living. And what happens when you take a small rule and you repeat it an infinite number of times? You get what looks like complex behavior. So a lot of the structures of life, like flowers, plants, the way our bodies grow, it looks so complex. It's the same simple, simple rules repeated infinite number of times. Like seashells and lizards, like they're all based on math done over and over and over. Stephen Wolfram proved this about 15 years ago. So weird complexity emerges from simple rules played infinite numbers of times. Well, with both the pharmaceutical side of things, the low LDL and with the animal protein side of things, the rule is make money. So you're getting millions and millions of micro decisions made by well meaning sometimes people, people who are willing to say, I know I saw some data that says this LDL thing is something we shouldn't lower. But I'm going to ignore that data because I don't like it. So I'm going to convince myself it doesn't matter and that low LDL is the end all, be all I'm going to convince myself. I met the head of R and D at Pepsi and the former CEO of Pepsi and she said if Pepsi was a country, it would be the 17th largest economy in the world. And Pepsi at the time was entirely vegan. Right. Because that was her belief system. And so they just threw out all the data that didn't support vegan and then they fervently believed it was a good thing. Right. And I, I mean I spoke to her and her intent was how do we lower toxins? Like we're doing our best, but believing something that doesn't work is highly toxic.
Dylan Jelli
Right?
Dave Asprey
It has to actually work. Right. So what I think that's one explanation is well meaning people with profit as a motive instead of something else. The other one is, and sometimes I find myself thinking about this, but I can't prove it. If you were to design a system to make humans less fertile and weak and sick, you would do what we did. We have the worst quality Lighting. We have the lowest quality seed oils. They're putting fluoride in the water. That is. Dude, the Nazis pioneered putting fluoride in water in order to make people more docile because it poisons our thyroids. So if it was just some things were good and some things were bad. But it's almost universally the recommendations are the worst ones you can do. And then there's always functional doctors and others who are saying this stuff doesn't work, and then they get shouted down and canceled. Right? So, I mean, I would have been like, maybe I'm just being. But then I saw the behavior of the world during the pandemic, and the truth has come out. Everyone who got the jab actually has higher risk. Higher risk of dying from everything. All cause mortality. That is real and that is backed by science. And there were thousands of physicians and other people like me who were talking about this during the pandemic. I lost 95% of my reach for two years because I had the audacity to say, as the author of a major book on fertility, my first book, it is a poor idea to inject anything into a pregnant woman, whether it's tested or not, unless it's life threatening, because there's a lot of stuff we don't yet understand, especially in the first trimester. So let's not stick pregnant women with tested or untested things.
Dylan Jelli
Right?
Dave Asprey
And, man, they came after me. I got my warning letter from the FTC for one of my things I got on factcheck. Org. Now, these are some of my largest career achievements.
Dylan Jelli
Right.
Dave Asprey
Or sends you a whole post about why entrepreneur Dave Asprey, who says people make money off the pandemic and explains how that he's wrong. I'm like, you bringing it? You bring it, guys. Thank you. But that's so. I think there are some people who hate humans and they want us to die. I really believe that. And I don't think we should put sociopaths in charge. I really don't. I'm not. It's not a partisan issue. This is an evil issue. Yeah.
Dylan Jelli
Call me crazy, but I have to agree with everything that you just said there. It just. It's craziness. And. And I agree with you. And what I saw, it was some of the most troubling and bothersome things. Thankfully, you know, it appears now that there's at least more capability of being a little bit more open and talking about these things, and people are more receptive now to listening and hey, to each their own, man. If you Want to do what you do, do what you do. But I'm just thankful that there's people like you and communities like we have now where we can talk about this and put it out there, and conventions like you put on and ways that we can learn from each other and grow. It's it. That's why I'm part of this, man, and why I shifted. Everything that I'm doing is to be a part of this.
Dave Asprey
So, well, you. You're doing something that's going to help you, it's gonna help your family, it's gonna help all the people. Listen, because you're willing to evolve, and so am I. Like, I've been wrong about things, and I evolved things. And one thing where I've been very, very clear. For the past 15 years, I have not eaten any seed oils other than if they're in a nut or something. I don't even eat very many nuts anymore. And, you know, some olive oil. But you think with the amount of butter and. And lard from healthy pigs, ones I've raised, and beef tallow and all that stuff, and, you know, dairy fat, you. I'd have to see an effect. So I just gotta clearly scan. You know what that is? Yeah. Oh, yeah, yeah. So this is the gold standard to look at soft plaque in your right. Not calcified plaque. Calcified plaque isn't as dangerous as people think. Like that's stable at least. Well, I didn't have calcified plaque and I didn't have any diffuse soft plaque at all after 15 years of only eating that stuff and, you know, maybe an ounce or two of olive oil most days. Right. So I am the worst case on that. I did have two spots where there was a slight thickening of plaque. Everywhere else is perfectly clean. And the explanation for that, according to the imaging people I work with, is. Oh, yeah, you had Covid twice. That's what the spike protein does. Those are just parts of the arteries that are healing right now, and that'll go away over time. So anyone who has soft plaque, it's really not that hard to get rid of it. It's called nattokinase, something I recommend all throughout the pandemic because it also digests any foreign proteins, including spiky ones that are in you. You take 4,000 units of nattokinase and lumbrokinase, if you want to be fancy on top of it, and you do that for a couple years, it'll get rid of most plaque. It's absolutely solvable. But you can't be eating garbage the whole time.
Dylan Jelli
Yep. I've been taking 12,000 of Nattokinase since I found out I had plaque. And I'm also getting the clearly test done as well. And I've taken courses on it to fully comprehend and understand it. So like you said, gold standard if you really want to know the true amount of plaque. Because when people get a calcium score, it's only measuring hard plaque and it's still an estimate. Right. It's not real evasive or gonna give those right numbers. So I'm really glad you brought that up because a lot of people aren't aware of that test at all. And it's, it's the, it is the gold standard and it's AI driven. It's not some guy or woman reading it that can really kind of read it however the hell they want, you know. So thanks for bringing that up.
Dave Asprey
You're welcome. It's part of the advanced longevity stuff that I do and I run a, a very, very high end longevity biohacking and consciousness fulfillment Mastermind. That's your Concierge 247 longevity care and all that for a small group of high net worths along with a couple partners. And this is the kind of stuff that we put them through and then like, well, most of us aren't going to go to that trouble. And it's expensive. So for that part of Upgrade Labs, which is my franchise, we have our testing platform called Axo. You can go to upgradelabs.com and look at it and it costs a few hundred bucks and you can order the hundred plus markers that I have determined for longevity and performance that actually matter. And it includes your LP and LP PLA2, the one you talked about, and the things like homocysteine and cortisol and testosterone and thyroid and all this stuff you would need to know with AI interpretation of it and recommendations. Here's the lifestyle, here's the supplements, here's what to do. Right. And you can talk to your doctor if you want, but we're not gonna diagnose or treat anything. I just want you to live for a very long time and be abundantly healthy. And it turns out none of those are medical conditions. So weird. That's upgradelabs.com like it's, it's not very expensive anymore and you can get a longevity age out of that. You get two of them actually.
Dylan Jelli
So you're telling me you actually test the things we need to test for, not the BS that you get at the doctor's Office.
Dave Asprey
That's what I mean. I do measure LDL cuz it's just about free these days. But people with low LDL die more from all cause mortality, right? The people who are the hundred plus club, you know, the super longevity or super centenarians we call them, they have more LDL than average, not less and higher. LDL later in life is a predictor of longevity. And LDL helps your body escort toxins out of the body and be resilient to toxins. LDL is simply not bad for you. Oxidized LDL is bad for you. So what I tell people, if you're still afraid of LDL or anything else, the most important marker of vascular health that you're gonna find is LP PLA2. It's an enzyme that's released when anything damages the lining of your arteries. It could be your obsession with kale smoothies where you're getting oxalate in the blood that, that damages your arteries. It could be this mythical LDL problem, but it's not. And it could be many other things. But if anything is hurting your arteries, that number goes up. So if your LDL is. Oh no, my total cholesterol is 200. Oh, I have to get on drugs. That's just a marketing campaign, right? And you know what else is a marketing campaign? So I was co founder of one of the early fitness trackers and I tracked this down. You know where 10,000 steps a day actually came from?
Dylan Jelli
No.
Dave Asprey
In 1952, a Japanese company invented the first pedometer that counts your steps. They made up 10,000 as a goal. And there was a marketing campaign that swept across Japan in the 1950s and we've been repeating that crap ever since.
Dylan Jelli
Really?
Dave Asprey
Numbers are the same game. The guy's selling you statins. Oh, look, we have a drug that lowers something your body needs to make hormones. Let's just tell everyone that. 200, 220. I mean 200. I mean 180. As low as you can get so we can sell more of these things. It's all bullshit.
Dylan Jelli
I believe it. I totally believe it. Um, okay, so I wanna shift into some of the things that you and I both kind of take and that we talk about. And I've really kind of dug into what you've been discussing with certain types of supplements and also areas of study which would revolve around N, A D and mitochondria. So I'd like to kind of touch on both of these because I want your expertise on both areas because of the importance I have Taken a real big study into mitochondria because I started to partner with Timeline several months ago. And yes, they are the best. And so it made me study cellular health a hell of a lot more than I ever did. Right.
Dave Asprey
Have you read Headstrong, my cognitive enhancement book?
Dylan Jelli
No, I have not.
Dave Asprey
The masterclass book on understanding mitochondria. I mean, it is so detailed. It was on the New York Times Science Monthly list, which is different than normal books. And it was between Homo deuce and sapiens. I was like the meat in the sandwich. And that is like, if you want to understand mitochondria at a, like, scientific layperson's view without having to read, like, textbooks on it, it's like, here's what they are, here's the levers, and here's how to think about them. I think that would be fantastic to help you dial in. And I also. I use Timeline. I've been working with him since the very first podcast about Urolith and a was on my show. Like, that helped to make it a thing. And they present at the biohacking conference, and that's biohackingconference.com you'll be there next year, I'm assuming. I was there this year.
Dylan Jelli
I'll be there every year from here on out, man.
Dave Asprey
Steve Aoki was our DJ last year. He said, it'll come back this year. And it's. It's hard to express what happens. We have 4,500 people who care about longevity and consciousness. It's a great vibe. And it's the. It's the conference that launched the movement of biohacking. And I. It's my favorite thing every year.
Dylan Jelli
Well, I'll tell you this. I went to seven conferences in the past year, I think, and that one trumped them all. And that's even a 4M, which is the, you know, so big and so well known, but I had the most fun. I actually have a little documentary that my stepson's making me. I'm going to send you when I'm done of my whole time at the conference.
Dave Asprey
I can't wait to see it.
Dylan Jelli
Yeah, you're gonna love it. You're gonna love it.
Dave Asprey
It's funny. I've lectured there multiple times with thousands of doctors, but every year they just say the same things, like, it's become kind of an echo chamber and it's kind of old and dusty. So next year, the biohacking conference, we're offering medical education units as part of the conference so doctors can come to the biohacking conference, and they can fill out their longevity credits as they do it.
Dylan Jelli
Right.
Dave Asprey
Biohacking and systems biology is different than old school longevity stuff. Mm.
Dylan Jelli
A hundred percent. That's amazing. You're offering that. Just another testament to everything you're doing. Why is mitochondrial health so important? And what do people. What do most people not really know about it that they should know and understand and why it. It's vital to longevity.
Dave Asprey
Okay, we think about mitochondria the way we learned in seventh grade biology. Oh, they're the power house of the cell. Yeah, There are energy plants, or my favorite, we were floating around as single cells, and then we harnessed the mitochondria to be our mobile power plants. No, no, no, no. All bacteria, all single celled organisms can operate independently. They have a basic intelligence. They have an algorithm of life. What really happened is we had a cell floating around. Mitochondria infected the cell. They're like, hey, look, a mobile petri dish. Let's take over. And inside almost all the cells in your body, there's way more ancient bacteria calling the shots than your cells that you identify as you. So what's really happening in our body is in near real time. Mitochondria are talking to each other via many different mechanisms. They're deciding the state of your body and the state of the world around you. And then they're telling each system in the body what to do. And they're telling you what you're allowed to see or experience and how to feel about it. And then you believe it like it's real. And then you are your mitochondria's puppet. And. Wow. That means if they're stressed, they're gonna not make energy as much and they're gonna make inflammatory markers, they're gonna make stress hormones. Right? And if they're stressed because you have bad lighting at night in your house, or because you're eating the wrong foods cause there's not enough fat to build mitochondria, you're gonna be stressed. And if they're stressed because you're telling yourself a lot of stories about some childhood trigger trauma thing, then they're gonna be stressed. Cause they pick up stress, right? And they're just simply saying, how do I keep this body alive as long as possible? And I eventually, by studying mitochondria and studying neuroscience for 10 years, measuring the brain waves five days at a time for very high performing CEO types. More than a thousand of these and measuring what's really going on in there. I know how it works now. There's an algorithm for how our bodies and our mitochondria think. And it's different than how our brains think. And it's really helpful to understand why mitochondria health is so important, because every disease of aging ultimately comes down to your mitochondria charge of everything. Something went wrong with our system. And let me talk through how mitochondria make decisions. Cause I think it's, it's enlightening on many different levels, including like consciousness and meditation and happiness, which are part of the biohacking movement. If you join the biohacking movement to solve one problem, pretty soon you'll be a longevity guy and then you'll be a consciousness guy. That's just how it works. Like, oh, I feel so good, I wanna live longer. Like life is good. And then, oh, now I wanna live longer. Maybe I wanna be happy. It's just, it's inevitable. And I built it, right? Yeah, I tricked some people. So here's how it works. If I clap my hands, we know that it takes some time for the signal to make it across the Internet. And then it came from your speakers to your ears and then you heard it. That's what you saw, right? That's not real. If we're measuring the auditory cortex in your brain 1/3 of a second after the signal reached your ears, your mitochondria allowed the signal through after they had a chance to decide what it was and how you were supposed to feel about it, and whether you even needed to know about it. What? Okay, so, and we know this third of a second window, it's a quarter second when you're 18 years old and it drifts up to about 350 milliseconds by the time you're 25ish. And it stays there, hopefully until you die. And if it goes above that, you're getting dementia. So there's a window on reality where your body can censor what you see. It's like the old Super Bowl. You watch the super bowl and it's broadcast live. And then Janet Jackson has a wardrobe thing and magically you see that all live broadcast has an 8 second censorship window to prevent that from happening unless you pay for it. You have a third of a second censorship window on reality that your mitochondria use to manipulate how you feel about things. So it's a distributed network of trillions of tiny environmental sensors with built in compute nodes that are also manufacturing nodes. And they can manufacture heat, electricity, or a bunch of different chemicals. That's what they do. So they sense, they decide and they do. And we get what's left after that.
Dylan Jelli
Wow, I've never heard that breakdown.
Dave Asprey
Yeah, this is why it's so confusing. This is new thinking. I presented this in front of the Dalai Lama's co author Victor Chan, who's been his best friend for 50 years. And he on stage, very, very surprising to me. He said, dave, now that I just heard about these f words, everything the Dalai Lama said over the last 50 years makes a lot more sense. And multiple Buddhist scholars are now looking at mitochondria in a new way as a foundational formation of our ego. And heavily meditated. The book behind you on the shelf there yet the number one bestselling meditation and number one bestselling philosophy book in the country because of mitochondria. And if show people the COVID of the book really quick, by the way, this is the other side effect of mitochondria. I did not fast, I was not dehydrated, I did not take any kind of medication. I got off an airplane and that's just how I look. And I used to be a 300 pound guy. Like what? That's because of mitochondria. So here's how they make decisions. Number one, these are all F words. It makes it easy. Is fear. If something is scary, run away from Killer Hyde. This is why I can trigger someone by saying only for dumb people. Because if you're a dumb person, you might get kicked out of the tribe and then a lion, tiger or bear is going to eat you, right? Basically, if you have a trigger for being called dumb, then I triggered you. My finger was on your trigger. But it wasn't you, it was your mitochondria. Fear. And people who don't meditate spend nine times more energy on fear than it really needs. And people who meditate spend six times more energy on fear than anything else. Because your mitochondria know it's game over if you die, right? So you're hyper aware of threats. It's good if there's a mugger behind a pillar, you're gonna respond before you can think as you should. So it serves you, but it sucks. The next one after fear is food. Eat everything, right? Famine has been a problem, right? And this is a great thing. This is what a pig will do, it's what a tree will do, a slime mold will do it. Or even like a politician, all of them will do the same things because all life does this. And then we have fear, then we have food, and then the next Thing that all life has to do to stay alive for multiple generations. It's an F word. You know that one. So you know, all life must do this because it has to last for thousands of years. There has to be multiple generations. And it's an F word. You've got this fear.
Dylan Jelli
Food and fight. I don't know.
Dave Asprey
That's the first. You're one of the rare people who doesn't drop an F bomb. It's fertility. But it could be the other F bomb, right? Oh, I love it.
Dylan Jelli
That makes sense.
Dave Asprey
This is so critical to understand right now. While you're listening to this show, your mitochondria, without your knowledge or permission, are invisibly analyzing everything in the world around you, saying, should I kill it? Can I eat it? And can I hump it right 100% the entire time you're alive, they are doing this before you have a chance to think. And is there anything you've ever done you're ashamed of that isn't one of those three?
Dylan Jelli
I mean, there's a lot I've done I'm ashamed of.
Dave Asprey
You didn't ask the girl out. You didn't take the opportunity. You shied away from the thing you didn't say. Yeah, fear.
Dylan Jelli
Yeah.
Dave Asprey
You ate the entire pizza wrapped around the Ben and Jerry's. That was food, right? The time you went out on the date with, you know, the whole cheerleader team or whatever you did. Like, God, I know this is the wrong date, but I'm gonna do it anyway. Everything, right.
Dylan Jelli
No, it's true.
Dave Asprey
Yep. Okay. It's not you. It's an automated system to keep your body safe and make sure that we reproduce. That's installed as part of your operating system. And you're the application, not the operating system. It's designed to be invisible. And it hates it when you become aware of it because it's a threat. What if that dude living in my. In my head, who's really slow. It takes em like a whole second to figure anything out in your mitochondria. They're really dumb. They're like, dude, I got this. Like, don't get my way. Don't get my way. And here's what gives me hope about humanity, is the next F word is friend. All life on Earth forms an ecosystem. You support your own species. You support the species around you according to your ecological niche. So we're wired in our bones to be kind to each other. It's why we form family units. It's why we form tribes. It's why we Help little kids who aren't ours. We help the lady across the street. And it's why community is so nourishing when you have healthy support. And the final F word is the one that is the focus of heavily meditated and my 40 years of Zen neuroscience school. It's forgiveness. Because one thing our mitochondria are terribly good at is holding a grudge. So there's that one time in third grade, your coach yelled at you about something, and your mitochondria were like, aha. Got it. When you were in third grade, you didn't feel safe when that happened, so it basically turned on an alert, Right? And it's an alert, the same as your phone. Imagine if your therapist, your meditation teacher's like, hey, man, these TikTok alerts just keep popping up. I can't get anything done. And they're like, gently swipe left. Just set them to the side. Recognize that they're part of being human. And you go to the biohacker. Like, you swipe up and go into the system settings and just turn off the freaking alerts, okay? They're both valid techniques. So all of psychology and all of meditation is manage alerts better and biohacking and what you have in heavily meditated. People spend $20,000 a week to learn how to do that. And I put that in that book. That's what's most important. You turn this off. Now, your mitochondrial network that's constantly looking for threats, it'll stop seeing things as threats that aren't threats. And that frees up so much energy. When people go through 40 years of Zen, it's five days of really intense turning off alerts. Well, they come out and they say, everything feels easier because someone cuts you off in traffic. I mean, I used to have, like, the biggest muscles on my middle finger. That was probably my most developed musculature in my 20s. And when I finally got this, I, it doesn't matter if somebody cuts me. I'd have zero change in my heart rate. And the story used to be there disrespecting me. And I didn't even know what the story was, man. It would just piss me off. It doesn't piss me off anymore. I don't have to regulate my behavior because I don't care.
Dylan Jelli
Right.
Dave Asprey
It wasn't a threat. I just thought it was. Anytime you're angry, it's ultimately fear. It just doesn't feel like it. It's just the way your body manipulates you to make sure you do what it wants.
Dylan Jelli
Yep.
Dave Asprey
And you'll get everyone in jail. There's pretty much those first 3F words will get you in jail every single time if you don't regulate yourself very well. And you don't regulate yourself very well when your mitochondria don't make enough energy for you to regulate yourself.
Dylan Jelli
Right. Man, what a breakdown. I really appreciate that. I'm so glad that I brought that up and asked that and that we got into that, because I've never heard any breakdown like that. And I've been studying this for quite a while.
Dave Asprey
There is no one else on earth you'll hear that from. This is original work.
Dylan Jelli
It's amazing. And you. So what you just broke down was that in the book that you were talking about that you have from prior.
Dave Asprey
That's in heavily meditated.
Dylan Jelli
Okay.
Dave Asprey
I mentioned the F words before. But to. To combine them in that way with neuroscience. The. The mitochondrial proper care and maintenance of mitochondria, especially in the brain. That is headstrong. My longevity book is superhuman. And if you read any of the recent big longevity books, exactly the same frameworks that I use. Um, there are some people who are trying to say vegan diets that happen to contain collagen from cows or a longevity diet or something that is not real. No. But I tell you why.
Dylan Jelli
Beautiful. Thank you so much for that breakdown. I want to jump into the NAD side now because I've seen you talk a lot about it. I've been working with someone that you are also very familiar with, and. And I've learned a ton. I talked with Dr. Saltzman for a good two to three hours last week, and I can't even get into how much I learned. And I know you've talked to him, so I want some of your thoughts because I know and you know this craze on NAD right now is out of control. And I don't think people have any sort of grasp whatsoever about taking NAD and the need for NMN as opposed to nad. Let's just talk about importance of N A D and then why people are so misguided right now on taking straight NAD and what they need to be doing.
Dave Asprey
N A D is fundamental to mitochondrial function. And we all know why, how important mitochondria are after this conversation.
Dylan Jelli
Right?
Dave Asprey
So as you age, your NAD levels drop linearly with time. And we have less nad, you can make less electricity, less heat, and less longevity compounds in your cells. So there's a clear case for raising NAD. And I've been taking NAD precursors for 25 years. The first one was niacinamide, which is a form of niacin. And then NR nicotinamide riboside came out. And I've been taking that for a long time as a company called Elysium. I've had David Sinclair on the show a couple times and on the Human Upgrade. Just actually earlier this week I interviewed a guy named Lenny guente who has 40 years of experience working with NAD. And so nicotinamine riboside is kind of step one of raising your NAD levels. And then there's nicotinamide mononucleotide or NMN, which is the second way or I guess third way of raising your N A D levels. And the other thing you can do is you can do N A D IVs. And I popularized these like in 2015. They're a thousand dollars a pop, takes two hours and you feel like you're gonna die. Someone's standing on your, your chest. It does improve performance, it's just very expensive. And it doesn't raise levels in the cells as much as supplementation with a mixture of nmn, NR and, and, and niacinamide. So there's various companies I've worked with who make these kinds of formulas and some of them are better than others. And the, I think the first major company was Elysium. Um, I do a lot of work with Qualia. Qualia. N A D plus is a good product and I like NMN a lot and I like mixtures of precursors and I like it when they pair it with some antioxidants to block immune activation. That can happen as a side effect of raising N A D. The specific compound is called CD38. Yes. Some people, they raise N A D and then they, they feel good for two months and they start getting weird inflammatory stuff. That's because some inflammatory cells eat all your N A D if you don't block them. So if you're taking appropriate antioxidants or they're built into your formula, that's a good strategy. But raising your NAD is necessary as part of a longevity or cognitive performance strategy. Just in general.
Dylan Jelli
So with the, the C38, cuz I'm, I'm using Wonderfield and they have respiratory in there and I believe like olive, olive extract. And doesn't that address the CD38?
Dave Asprey
Wonderfield's a great brand. I, I don't, I could have easily mentioned them there as well in that list. I, I guess I was going linearly from back in time. Yes. Resveratrol is one way to do it. And having, you know, highly active resveratrols there. The olive polyphenols are fantastic. So many people are saying, oh, I'm gonna drink olive oil every day. It's the single most important thing. It's bullshit. Two tablespoons a day, 30 mils to 50 mils of olive oil, is associated with increasing your longevity, and it's good for you. More than that, you push up your oleic acid numbers, and when your oleic acid is excessive, your body oxidizes omega 6 fats much more easily through something called D5D and D6D. So olive oil overdose doesn't work. We tried that in the 90s and learned. And what does work is at least half your calories coming from healthy saturated fats, the rest primarily monounsaturated. And you can't avoid some omega 6s. And you don't need to. They're. They're essential. They just need to be 5 or 10% undamaged. So you can take olive oil polyphenols without having to drink 2 gallons of the stuff a day.
Dylan Jelli
Right?
Dave Asprey
Olive oil polyphenols like hydroxy tyrosol, that are relatively little known, those are really important. And by the way, when you read Headstrong, my book from a few years ago, hydroxy tyrosal is one of my recommended mitochondrial supplements. So there you go. There's your Wonderfield connection.
Dylan Jelli
Love it, man. Absolutely. Yeah, that's. That's another one that I started. And I really started to learn more about N A D and pairing it with mitochondria, like you said. And when they go hand, you understand how they go hand in hand. You realize the importance of addressing both areas. And so definitely. Well, I know we're getting closer to the end, so there's a few things I want to talk to you about. One, let's get into talking about oatmeal. And I, I. I warned Ben about this. When we talked, I said, the oatmeal mafia is coming for us, dude, because we're blasting it now. I spent, like, the last 15 years eating oatmeal seven days a week, literally. And once I learned that it was horrible for you and I stopped, I felt a thousand times better. And then I started wearing a CGM and seeing the spikes and going, man, what the is going on here? So let's talk about that. Why is oatmeal not good for you? And why is this gonna piss so many people off like you've already done in the past, which I found hilarious, because they weren't grasping what you were saying. But I want to know why it's bad and why. Why it's. Aside from the glyphosate, which I think should be obvious, why else is it bad?
Dave Asprey
It's not really bad. One of the things that's made humans the dominant species on the Earth is that we could survive on all kinds of food. Here's what's happened. The people who own the slaves or control the peasants, we're talking thousands of years ago of the kings, the queens, the Egyptian whatevers. They ate the meat, the butter, the fish, the cheese, even the wine, which probably wasn't good for them, but who knows? And they fed the peasants the brown rice, the oatmeal, the porridge, gruel is what we called it. This is useful because it has enough energy to go plow the fields, because it has calories, but it's low in nutrients and it's not good for you in many different ways. And we go into what those are, but it's good enough to feed the peasants so they can do the work so I can have the cheese. That means it's become like soul food. And people get so weird and religious because of their mitochondrial food connection. Like, oh, this is soul food. These are the. This is the food of my European peasant roots. Like, get over yourself, dude. Look at what it does to your blood sugar. Oatmeal. Have Ben and Jerry's. It'll have less of an effect, and it's got good fat in it. And by the way, Ben Jerry's is not a clean brand by a long shot. There's much better brands of ice cream, and I'm not saying you should eat either one of them, but if you have continuous glucose monitoring, oatmeal's terrible. And if you do overnight oats, which is even stupider because oats contain anti nutrients and anti nutrients, he at least gets rid of some of those things. So, you know, the blood sugar effects, they're quite often. Because there are grain, there's mold, mycotoxins that are in them. But worst of all, they contain avenin, which is a protein very similar to gluten that causes inflammation and leaky gut. And often they're contaminated with gluten, which probably isn't gonna affect most people unless you truly have celiac. But if I get very much gluten at all from American gluten sources, it wrecks my gut, and I know it. I can eat European gluten. So there are issues there, but that may not be the thing. But Avenin is Not gluten, but it does the same thing by poking holes in your gut. The other thing that I wrote about in the book before, this most recent one, is phytic acid. And phytic acid blocks mineral absorption. They bind, it binds to zinc, magnesium, iron, calcium. So you have these poor vegans. I was the devout vegan, or devout raw vegan. So I'm talking about myself here when I was obese and desperate. Well, look at this. This plant has all these minerals in it. My spinach has iron, the antinutrients that are present, which is phytic acid, and something called oxalic acid, which isn't as high in oatmeal. It doesn't matter if there's minerals in your plants, if you can't absorb them, because the plants are actively sucking minerals out of your bones. There you go. That's why overnight cold oats are even worse than cooked oats. But they both contain high levels of phytic acid. How do I know about this? Because I run a regenerative farm and I study what animals eat as well as what humans eat. And when you feed high phytic acid grains to chickens or cows, their hooves fall off, their beaks don't form. And these are animals that are designed to be able to eat phytic acid. Humans can't break this down. We don't make phytase, which is the enzyme that breaks it down. So farmers will add phytase to animal feed so the animals can eat things higher in phytocast than they're supposed to, but then they'll give humans that. And what does it do? It makes us have osteoporosis. It gives us mineral deficiencies. Guess what happens when your minerals don't work? Your mitochondria don't work. I make two supplements with Sup Grade Labs, which is part of one of my companies that I focus on. They're the least sexy longevity supplements, but the most broadly applicable one of them is called Vitamin D. You can go to vitamind a k e.com and the other one's called Minerals 101. Oh, and then you drink Danger Coffee. There's 22 bucks worth of trace and ultra trace minerals in every bag of the coffee. The coffee's 25 bucks a bag because of it. And it's really good coffee without mold in it. Why? Because if you just get all the minerals your body needs and you have the fat soluble vitamins at the same time which guide the minerals in, then your exercise will work, then your meditation will work, even your NAD pathways work better. So like the least sexy Vitamin D and Minerals101. It's not timeline, it's not wonderful, it's just critical and it's affordable and it's the the broadest applicable thing. I'd probably make more money if I did some fancy longevity, whatever. But I have so many companies I work with who I support. At the conference. You guys do this cool stuff. I want to get the basics to everybody. And if I put it in your coffee, that's awesome. But that's why I do it the way I do. Because oats and kale and almonds and spinach and all these superfoods, they are stuck in your minerals. And if you say, well, I'm going to be even healthy, I'm going to go to steel cut oats instead of rolled oats. They contain more lectins and they contain oxalates more than rolled oats. And this is consistent in every kind of grain. Brown rice is for very, very poor people. Every rice eating country eats white rice preferentially because the outer part of the rice, it has all the fiber. It also has all the arsenic and all the lectins. And it's not good for you. But if you're the lowest of the peasants, there's more calories in the lining of the rice so they'll give you all the toxins so you can have the calories. And if you can afford it, you eat the white rice, which has carbs, not a lot of nutrients. Rice isn't a nutrient source, it's an energy source. Right? And then you eat a little bit of meat with it. There's your nutrients, there's your protein, there's your fat. Right? And you go to wheat. The peasants eat brown bread cause they couldn't afford to throw away the brown part that had all the lectins and all the oxalates. White flour has almost no oxalate. Whole wheat flour has huge doses that cause kidney stones. Yes, right. 70% of kidney stones are caused by plants. And a lot of these superfoods and you get these influencers who just don't have a clue. The way I was in my late 20s eating, I've been there. I shattered three teeth from green smoothies. And being a vegan because I was sucking my minerals out. Kale, spinach, chard, almonds and sweet potatoes, which I didn't. I recommended those as being better than other things. I talked about oxalates in the bulletproof diet, but I didn't control it for them as strongly as I should have. And you eat those when you're young. It builds up over time and it makes you systemically weak from a mitochondrial level, from a bone level. You do not want to do that. So what do you do? Get rid of the brown parts of your grains. Blanch your nuts. If you're still gonna eat nuts, eat peely nuts and macadamia nuts. Those are really the only two safe nuts. Maybe a few walnuts here and there. That's what you do. And the rest of the stuff? Yeah, it tastes good. I don't care. I don't like it. It doesn't taste good. I'm like, are you an adult? Like, oh, does heroin taste good? Then I guess you have heroin. Like, don't be dumb and stop getting.
Dylan Jelli
Offended by a fact about a food. Like, it's like you owe it something. I just don't get it, man. It's like when I found out and I learned, I was like, well, one more thing that's gotta go. Let's make a change.
Dave Asprey
You know, I've been really doing a deep forgiveness practice on one food and I just haven't been successful. It's on kale. Like, kale is not food. And it keeps trying to pretend like it's food. And I'm getting triggered by this. Dylan, I. I need help.
Dylan Jelli
We'll talk after and I'll help you out with it. I want to tell you one more thing before we go. You turned me into a coffee snob. I. I literally started drinking coffee three years ago, only drinking K cups. And I learned about Aeropress and Danger and I found it and I drink it seven days a week. And you've made me make this an art that I do twice a day. And I hated dark roast now I love it. And when you have a special come out, like that Ethiopian one, for example, I bought like 10 tins of that. When you came out with it after, I tried it because it was incredible. So, wow.
Dave Asprey
Thank you for calling that out.
Dylan Jelli
We.
Dave Asprey
Every two months, I come out with ceremonial grade coffee.
Dylan Jelli
Yeah.
Dave Asprey
And it's like, there's $2,000 bottles of wine. This is the highest cupping score, award winning coffees. And they're lab tested for mold and they're remineralized and they come in little tins. It's called ceremonial grade because it's meant for like a conscious coffee. Sharing Saturday morning with a friend. It's not a daily drinker. Just like you might have a glass of wine every now and then, but when you go out for something special, you're going to Splurge. This is that coffee. And every tin has art from a local artist in the region where the beans are from. And so we're, you know, spreading love. That. That's a labor of love. But, man, coffee is the original longevity compound. It has controlled the evolution of science and consciousness. During the Enlightenment, coffee houses were banned by one of the kings of England because it made people think too much. And it never stopped doing that.
Dylan Jelli
It's incredible. It's been a game changer for me. I gave one up to my mom, and I kept nine of those tins of that Ethiopian one. But, man, I. I look forward to those when they come out. So I know you have to run. I. Like I said, I. There's like 500 topics I didn't get to. But I appreciate so much your time, brother. Like, it was incredible talking with you real quick. And I'll link everything in the description. What's the best way to follow you or to find you? What's some of your best ways that people can stay on track with you?
Dave Asprey
Go to dave asprey.com it's easy. Instagram or all the other accounts, dave.asprey, tikTok, and whatever your platform is. And then go to Danger coffee. Com. Yes. And you can use code bio lane if you want to save 10% or something like that. I just use that code because I love trolling trolls. It makes me so happy. I love it.
Dylan Jelli
I am so appreciative of your time. Dave, thank you so much, man. Just an honor to have you here.
Dave Asprey
Likewise.
Dylan Jelli
All right, thank you.
Dave Asprey
Sam.
In this milestone 50th episode, Dylan Gemelli welcomes Dave Asprey, founder of Bulletproof Coffee, biohacking pioneer, and best-selling author. The discussion dives deep into the fundamentals and controversies of biohacking, optimizing mitochondrial health, nutritional myths (especially around cholesterol, fats, and oatmeal), and cutting-edge longevity strategies. The episode hits both science-based analysis and personal transformation stories in a dynamic, open, and sometimes irreverent tone.
Irreverent, challenging, and deeply informative, this episode shatters widely held health and nutrition myths, making a compelling case for individualized, data-driven longevity strategies grounded in mitochondrial health. Asprey’s analogy-packed explanations and sharp humor keep the dense biology accessible and actionable. Both guests stress that true optimization is about measuring, adjusting, and thinking for yourself—not blindly following trends or dogma.