In this episode of the Fueled & Free Podcast, Margaret shares her personal experience with microdosing GLP-1 peptides, and observations she’s had having coached clients who are microdosing GLP peptides.

She breaks down how microdosing can minimize side effects, support appetite regulation, and improve metabolic health, while emphasizing that it’s not a one-size-fits-all solution when it comes to fat loss.

Margaret also dives into the nuances of insulin resistance, hormone balance, and gut health — explaining why each person’s response to GLP-1s is unique, i.e. why some need a higher dose to get their body to respond.

This episode challenges the misconception that needing a higher dose means failure, and instead reframes it as part of a personalized journey toward better health.

Episode Recap:

What microdosing really means and why it’s a smart, gentle starting point {01:42}
Why microdosing can fall short for fat loss if deeper metabolic issues exist {03:47}
Five reasons your body may not respond on a low dose (insulin resistance, receptor sensitivity, thyroid, undereating, gut health) {09:18}
How to know when it’s time to move from microdosing to a therapeutic dose {17:09}
Why needing a higher dose is not failure—it’s feedback from your body {24:44}
The importance of flexibility over rigidity in your dosing journey {31:21}
Why the microdosing phase still matters, even if you eventually titrate {32:00}

Links & References:

Connect with me on Instagram @margaretannpowell

**Disclaimer: The information shared in this podcast is NOT meant to be taken as individual or medical advice. Please seek the guidance of your physician or healthcare provider regarding any medical condition or treatment.

80. When Microdosing GLP-1s Isn’t Enough For Fat Loss: Why Needing a Higher Dose Isn’t Failure