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Gwyneth Paltrow
Acura's all new adx. A compact SUV that isn't just built for one thing. It's precision crafted for everything. To escape the grind. With available all wheel drive to go with your flow. With available Google built in.
Dr. Dan
Hey Google, turn it up.
Gwyneth Paltrow
Okay.
Dr. Dan
Turning up the volume.
Gwyneth Paltrow
And crafted to be heard. With an available Bang Olufsen premium sound system. The all new Acura adx. Crafted to match your energy. Acura precision crafted performance. Google is a trademark of Google llc. Travel has always been such a big part of my life, and in a way, it's really what inspired me to start goop. I love discovering new places, new experiences, and finding those really special stays that make a trip even more memorable. Hosting on Airbnb is a great way to make the most of your time away. It's a wonderful option if you have extra space, own a seasonal home, or tend to travel at the same time every year. Hosting is incredibly flexible. You set the dates, welcome guests on your terms, and create memorable stays that reflect the warmth and uniqueness you seek in your own travels. If you've ever thought about hosting, your home might be worth more than you think. Find out how much@airbnb.com hosting when you are pioneering anything or introducing new ideas to the culture, you get criticized. You do. Yeah, did you hear about that? I didn't find the one.
Dr. Dan
I found someone I respected and we made it the one. In the sort of longing kind of view of love, people understand each other as if by magic.
Gwyneth Paltrow
Nothing in itself is addictive on the one hand. On the other hand, everything could be addictive if there's an emptiness in that person that needs to be filled.
Dr. Dan
I now know that nobody changes until they change their energy. And when you change your energy, you change your life. Gwyneth.
Gwyneth Paltrow
I'm Gwyneth Paltrow. This is the GOOP Podcast, bringing together thought leaders, culture changers, creatives, founders and CEOs, scientists, doctors, healers and seekers here to start conversations. Because simply asking questions and listening has the power to change the way we see the world. Here we go. Welcome back to the GOOP Podcast. I'm Gwyneth Paltrow, and today I'm thrilled to be sitting down with Dr. Dan, who is the Chief Medical Officer and co founder of well Bell, a brand I personally love and use every day to maintain maximum hair health. Dr. Dan is a renowned expert in the field of nutritional and holistic health with a focus on how what we put into our bodies impacts not just how we look, but how we feel. So Dr. Dan thank you so much for joining us. And I'm so excited to hear more about, you know, your connection with beauty, wellness and the brain. It's an intersection that I'm very, I'm very interested in, as you might know.
Dr. Dan
Absolutely. They're all, you know, it's also interconnected brain health, overall health. It all starts with self kindness and making good decisions for yourself, even small, little good decisions for yourself.
Gwyneth Paltrow
So can you tell me a little bit about your background? Because you're kind of a hardcore md, and then you've kind of adopted this idea of a more holistic approach, which. Which seems to be the trend I've noticed. You know, when I started talking about wellness, most MDs were like, what the fuck is she talking about?
Dr. Dan
Right. That's true. So, you know, I went like a very conventional path. I went to Harvard for college. I was a psychology major. I thought I was going to become a psychiatrist. Went to Cornell for med school, Ended up doing internal medicine and cardiology and running the intensive care unit at a hospital in New York City dealing with heart attacks and sudden cardiac death and these really acute issues. But I realized that I love taking care of patients holistically. So I did a fellowship in functional medicine and age management. And then my career took a detour from there. So I really focused on overall wellness, mind body medicine and precision medicine, which I'm very, very passionate about.
Gwyneth Paltrow
Yeah. And I. So this is kind of a new emerging field, precision medicine. Will you tell us about. How do you define it and what does it look like in your.
Dr. Dan
The way that I think about it is every individual is different. So when we're looking at what we're going to put Gwyneth on, or my sister on, or a patient that walks into my office, it's based on three things. This is how I think about it. The first column is, what does Gwyneth want? Like, what are your goals and aspirations, health wise? Because anyone, anytime someone walks into an office, they have things that they're thinking about. Maybe their mother had breast cancer, maybe their grandfather had Parkinson's, maybe they want more energy. So that's column one. Two is where does the data lead us? So that could be different biomarkers, it could be gene sequencing, epigenetics. So where does the data lead us? And then three is what does Dr. Dan want for Gwyneth? You know, I want you to be on top of your health maintenance, be on top of your mammograms. Make sure from a cardiovascular and brain health standpoint, you're optimized and then those three things come together. And that's what I think precision medicine is. It's a marriage of those three things.
Gwyneth Paltrow
Mm. And so are you finding that? Because I think, you know, it is really interesting. I remember even, you know, wearing a continuous glucose monitor for a while just to see what was spiking my blood sugar. And I was doing it in conjunction with a friend, and we had completely different reactions to a bowl of pasta or oat milk. And so is it true that our, like, even the foods that we can tolerate like that. For some. For some of us, certain foods are inflammatory or will spike the glycemic index, and for certain people not. And what are the factors that determine that?
Dr. Dan
It's such a good question. I love that question. And the absolute answer to that is yes, every patient and person is different and their reaction to food, environmental factors is going to be different. You know, so there's a relationship between our genetics, our metabolism, and how it reacts to food nutrition. So one person might eat beets and their blood sugar is fine. Another person might eat beets, which is otherwise healthy, has a lot of health benefits, and their blood glucose and insulin might spike.
Gwyneth Paltrow
Right, right, right. So, like, how, how available is this? I mean, do you see this approach becoming more pervasive or is this still, like, for the 1% right now? Like, can. Can regular people kind of have access to this kind of approach?
Dr. Dan
We're seeing more and more businesses start out sort of focusing on precision medicine that are going to scale more and more. One of them is Function Health, and they do all sorts of biomarkers. And we'll see in the next decade, we're going to move from just population based medicine where we have recommendations for, okay, you're above 50, this is what you should do to, okay, this is your genetic blueprint. These are your genes, this is your blood work, and this is exactly what you should be on for optimal health outcomes. And I can't wait to see that happen at a sort of, like, at a mass level so that people have access to that and also have more agency. You know, really can pull the levers, whether it's sleep, nutrition, diet, meditation, supplements. How do you sort of make good decision? I think we need to do that with data.
Gwyneth Paltrow
Yes, absolutely. And also it needs to be, I think, sort of with anything. And at least from my point of view, what I've observed is that, you know, consumers really shape these markets. Right. And if. And if patients want to have more agency, as you say, and be able to take steps that are more directly like within their control to impact their health positively. It's so nice that there are these, you know, as you say, startups or companies that are going to fill the hole in that market.
Dr. Dan
It's undoubtedly going to happen. I think the next 10 years of medicine, there's going to be quantum leaps in terms of genetics and, you know, breakthroughs, but the focus is going to be really on preventative medicine. This idea of like, Alzheimer's is not a disease that you really want to diagnose when someone's 80 and has memory loss. But sort of look at people's genetics, like, what's their APOE gene status and how can we optimize people ahead of time? And I can't wait for that shift to happen. It's happening right now and I think we're bringing it to the surface so that people know about it.
Gwyneth Paltrow
Yeah. And how, how much kind of, you know, if we get a genetic profile back, like how much of the genes that, like that code is determinative and how much can we impact through the lifestyle choices that we make? Like, I have the Apo 3, I have double copy, I think. What are you not. I don't have the worst one. I have the second to worst one.
Dr. Dan
Well, the second to worst one is what most people have. It's the normal one or the most common one, I should say. So that's a three. Three. If you have a copy of the four or two copies of the four, it increases your risk of developing Alzheimer's and also cardiovascular disease. So that's a way that genetics sort of points to how we can risk, stratify and really double down on those people who carry that specific gene. In terms of, like, how much control we have. We have a whole lot of control. And the research that people do on Alzheimer's alone, It looks like 50 to 60% of people who have or develop Alzheimer's can prevent it through lifestyle, through blood glucose lowering, you know, body mass, exercise, having relationships, continuing education, connection with community. So I think both of them play a role and we try to make an impact wherever we can.
Gwyneth Paltrow
I read somewhere that they said that Alzheimer's, I believe Alzheimer's is like also a disease of inflammation. I mean, obviously there's a genetic component to that, but does that mean that it's, you know, there's a kind of downstream impact. If you, if you have the gene and you have high inflammation, you're. You're then more likely to develop Alzheimer's?
Dr. Dan
I think those models are being figured out. There's no question that if you have the gene, your risk of developing Alzheimer's is increased. But there's different factors like inflammation might be one of them. And we can measure inflammation in the blood through something called C reactive protein, crp. So if you're globally inflamed, all disease models, you know, whether you look at Alzheimer's and memory loss, cancer, heart disease, inflammation is not your friend, it's a foe. So if we're looking to optimize and someone has a gene, we may want to look at their CRP and say, okay, your CRP is elevated. What can we do nutritionally to get you your CRP down? What interventions can we put into place to make you as in optimal health as possible?
Gwyneth Paltrow
Mm. So in terms of. I guess I'll start. I'll start here. So we've, we've talked a lot and learned a lot and read a lot about these, these class of the, the GLP1 inhibitors and how, how much they can impact, you know, first weight. Right. That's how we all heard about it. And now, like, I have friends who are working with functional doctors who are microdosing it to control inflammation. And I'm dying to get your point of view on this. Like, how safe are these drugs? Are they really like the miracle drugs that they're being touted as? Like, I'm just dying to have your take. I would. I almost just called you just to talk to you about this, just because I was curious. But then I was like, I'll ask him on the podcast.
Dr. Dan
First and foremost, you can call me any time, answer any questions, have me on speed dial. GLP1s are a field that I'm really passionate about. So they're GLP1 receptor agonists, and basically they help curtail appetite and help with weight loss. And they were studied on people who had morbid obesity, cardiometabolic disease, diabetes, to try to get massive weight reduction so that they don't have the complications related to obesity and being overweight. And then the GLP one started to be used off label just for weight loss. There's some real benefits to GLP1 receptor agonists, and we're talking about the Ozempics, the Manjaros, the wegovies of the world. And for those patients, it's really a life changer. It's really, really impactful. There's research in the cardiovascular community and also the Alzheimer's community that can actually improve outcomes in some of those patients. There are concerns. One of the concerns is that 40% of the weight loss from the GLP1s is from muscle mass.
Gwyneth Paltrow
Right.
Dr. Dan
So my biggest concern is, let's say I have a 70 year old who comes in, if they lose 40% of their muscle, it's going to be near impossible to get it back on. And then what happens if they lose their muscle mass? Their gait imbalance is off, their strength is off, their basal metabolic rate is off. They can develop insulin resistance over time because they don't have, you know, so they're going to have to be on Ozempic forever. So I think when it comes to these things, it's not like one size fits all. It comes back to that sort of precision medicine. And who's the right candidate for those medications?
Gwyneth Paltrow
But is there, are there things that you can do to mitigate that muscle loss when you're on Ozempic or one of these class of drugs?
Dr. Dan
Definitely weightlifting and focusing on the big muscle group. So your, your quads, your glutes, your hamstrings, I think that's important, increasing your protein intake. And as a founder of Wellbel, one of the things that we're Also seeing with GLP1s is that it does precipitate hair loss. So the first sort of wave of hair loss we saw as a company was during COVID and Covid related hair loss. And now we're seeing a lot of people who are on GLP1s with hair loss. So oftentimes we preventatively put them on Wellbel to prevent that hair loss from happening. There are systemic side effects, but it's really like you need to weigh risk when it comes to these medications.
Gwyneth Paltrow
Right. And we're going to talk all about Wellba, which I'm very excited to talk about. But what about this? Do the GLP1s like inherently lower global inflammation in the body as well?
Dr. Dan
I haven't read that research yet. I'd have to look at it. I wouldn't be completely surprised because a lot of that has to do with glucose and insulin regulation. So if you're more regulated. And the other thing is obesity in and of itself causes inflammation. So if it's not necessarily the GLP1s, it might be the weight loss where the, the weight loss going away reduces inflammation. So I think that's more the likely mechanism. So it goes back. So if I see a patient and I'm trying to think of GLP1, are they overweight, are they obese, or are they just trying to lose five pounds? So when the people are using it, just, you know, as a shortcut, I think the long term benefits are not there. But if it's for someone who, you know, really has high inflammation, they're overweight, they sort of fit the right profile. This is where the whole precision medicine comes in. It's no one size fits all. You have to look at biomarkers, you have to look at their body mass index, their percentage body fat, and then use all those markers to make the right decision for that patient.
Gwyneth Paltrow
Oh, yeah. So let's, let's, let's talk about Wellbel for a little bit because this is a product that you and your, your sisters co founded it and, and it's a product that I use and love so much that I asked if we could carry it on the, on the goop shop. Can you tell me, was it, it was, it was your sister's hair loss that sort of incited this whole business idea. Is that right?
Dr. Dan
Yeah. I have two sisters. I'm the old eldest of three. My middle sister was postpartum and then my other sister was going through some stressful life events and they both had pretty extensive hair loss. And at the time I really didn't like what was out there on the market. So I was like, you know, heck, let me put my functional medicine fellowship to use. And I formulated Wellbel. They were my first guinea pigs and they had really great outcomes with the supplement. And one day I remember we were like in Tribeca at some sushi spot and my sister's like, Dan, you're not going to understand. Like, I've knew like baby hairs coming in and they were so excited. And it sort of morphed into company wasn't the intention. It was sort of just like, you know, older brother rescue, younger sister sort of situation. And five years later, it's an actual company and we're super proud of it and we're super proud to be working with GOOP and working with you. It's, it's a real honor, I should say.
Gwyneth Paltrow
Oh, that's so sweet. Thank you. Acura's all new avx. A compact SUV that isn't just built for one thing. It's precision crafted for everything. To escape the grind. With available all wheel drive to go with your flow. With available Google built in.
Dr. Dan
Hey, Google, turn it up.
Gwyneth Paltrow
Okay.
Dr. Dan
Turning up the volume.
Gwyneth Paltrow
And crafted to be heard with an available bang and Olufsen premium sound system. The all new Acura adx crafted to match your energy. Acura precision crafted performance. Google is a trademark of Google llc. So I, when I first met you and we were talking about the product. I was skeptical, you know, because I've tried different hair supplements before. And by the way, I always had like the thin, thickest, craziest hair. Whenever I got a haircut, I was like, can you thin it out? It's like so, you know. And then after Covid, I really did lose a lot of hair when I, when I got Covid. And then of course, perimenopause is just not a friend to hair, et cetera. So why, why, how does it work and why does it work so well?
Dr. Dan
So I think there's a couple of reasons. There's a couple of hero ingredients in Wellbel that I think really, really allow it to work for a lot of different people. Works for men, works for women. There's one product specifically for Perry and postmenopausal women, and we can get into that later. But in terms of the hero ingredients, I would say we have biotin at a much more physiologic dose. Some of our competitors have as much as six times as much biotin. And you can end up with biotin overload, which can cause cystic acne, nausea, abdominal pain, and more. Frighteningly, it can actually interfere, interfere with thyroid assays and cardiac troponin assays, which I as a cardiologist used to figure out in the emergency room if someone's having a heart attack. So, you know, having physiologic doses of things is really important. It has msm, which is a natural form of sulfur. MSM is anti inflammatory for the scalp. It also provides the bonds needed for healthy hair. And it's a precursor for keratin and elastin. We included a little bit of betaine hydrochloride. And betaine is something that increases your stomach acidity just enough to help you break down foods. So you're absorbing your micronutrients better systemically. You're just healthier because you're getting the micronutrients you need to produce healthy hair. And lastly there's saw palmetto. So a lot of hair loss is hormonal and the main hormone is testosterone. So testosterone gets converted to its mean cousin, dihydrotestosterone. And so we block that conversion with saw palmetto, which is natural so that you have less dht. And DHT is, you know, responsible for miniaturization of hair follicles. And I think we have a very compact list. I hate supplements that have like 35 ingredients. It's very concise, high yield, you know, vegan, non GMO. I formulated it using, you know, research and doing literature searches on PubMed. And I think it just seems to, for lots of people, it does take time. It's not overnight, but it takes about two or three months. But people usually have increase in hair density, better hair quality and decreased shedding. And there's been so many stories, I never thought, Gwyneth, going into this, that I would be hearing from post chemo patients or people with autoimmune diseases. And you hear these stories about how much of your identity is related to, like, your appearance and your hair. And like people with, you know, not wanting to go on dates or not wanting to, you know, socialize because they're embarrassed from their alopecia. And the fact that we can make an impact in those customers has been so fulfilling.
Gwyneth Paltrow
Yeah, it, and it really is, you know, you're right when you say it's, it's such a part of identity. And you know, I, I still have a ton of hair, but I don't have like, I probably have a quarter of what I used to have. And it's like you feel sort of naked. You know, you're like, where, where did all my hair go? Is this a symptom of a larger problem? Like, it's startling.
Dr. Dan
It's startling. Yeah, it's. It gives you a feeling of feeling maybe exposed or, you know, vulnerable in a little way. And then. Exactly. Like, what's wrong? Do I have something wrong with my thyroid? Or is this a product of aging and reminding that, you know, all of us are getting older? Like, those thoughts do come up.
Gwyneth Paltrow
Yeah. And what about. Or do you, do you ever recommend that, like, people have put, you know, topical minoxidil or. I heard there are certain lasers for your scalp or PRP for the scalp. Like, are there other things that people who are really struggling with hair loss that want to attack it from a multi pronged, you know, way.
Dr. Dan
You stole the words right out of my mouth. I love multipronged. Yeah. So I think in some complicated patients and patients with really difficult hair loss, you need, you know, a multi prong approach. You know, even like a medical dermatologist who specializes in hair loss and alopecia. Sometimes I have patients who've needed scalp biopsies to try to figure out what's going on their hair loss. But those things can help. Minoxidil can help. Lasers toxic.
Gwyneth Paltrow
Is it okay to use?
Dr. Dan
I think topical minoxidil safe and I think oral minoxidil at low dosages is usually pretty well tolerated. So we have plenty of patients on Wellbel, who are on other modalities and interventions to try to help them with their alopecia.
Gwyneth Paltrow
Right. Because presumably if you get PRP in the scalp and it's helpful or like, you know, you're keeping more hair, you want to make it as healthy as possible and keep it on the scalp and.
Dr. Dan
Absolutely. I think some of it is hair health. And then I don't think scalp health really gets enough attention. Scalp health, everything that's good for your skin is good for your scalp. So you want to sort of get inflammation down at the scalp level. So a lot of the modalities sort of work on that, making sure that the circulation to the scalp is good because the follicles need nutrients, they need oxygen, they need blood, they need nutrients. So you have to sort of think about that. And some of these ingredients help promote circulation to the scalp as well. So it's the hair follicle and the scalp that are both important.
Gwyneth Paltrow
What is vitamin K2 that's included, just out of curiosity?
Dr. Dan
So I slipped in vitamin K2 for the women's plus, because I'm also really. Osteopenia and osteoporosis are very important to me. I have a lot of women who are over the age of 40, 45 who struggle with bone loss. And I was like, you know what, If I'm going to create a supplement for that age group, why don't I slip in something that's good for their bone health and their hair health? So we know that vitamin K and vitamin D and calcium are great for your bone health. Vitamin K actually is improved circulation to the scalp and it's a pre. Helps with elastin and collagen production for hair. Like a little secret ingredient we put in there, address all those issues.
Gwyneth Paltrow
That's awesome.
Dr. Dan
Yeah.
Gwyneth Paltrow
And can be used in conjunction with estrogen replacement as well for bone protection.
Dr. Dan
Totally. Yeah.
Gwyneth Paltrow
That's good to know. So you often talk about, like, nutrition as a whole and kind of what we eat and how it impacts, how it impacts how we age. But can you talk from your perspective a little bit about how it impacts mental health?
Dr. Dan
So in my mind, the way I think about nutrition and overall health is that it's all connected. So if you're, you know, if you don't have a happy gut and your GI tract is inflamed and you're bloated and eating things that don't agree with you, sometimes those patients have mental fog. They don't have mental clarity. Their wake sleep cycles can be set off. So they're not really sleeping well at nighttime. So I think nutrition is super important. Feeling good, I always say happy stomach, happy patients. So there's clearly a connection between the GI tract and the gut and the brain. And getting patients optimized from that standpoint is something that I often focus on. There are things, for instance, like omega fatty acids, like from salmon, that are great for your skin and also great for your heart and your brain. And I love including those sort of things. When I wake up in the morning, I do intermittent fasting. I'll have a tablespoon of flaxseed oil, and then that's sort of one of my morning routines. That's how I get my day started. And interestingly, keeps me super satiated. And we want to have good, good alpha linol, alpha linoleic acid levels. And flaxseed oil is fabulous for that. It's anti inflammatory and it's great for your gut.
Gwyneth Paltrow
You break your fast with that or. It doesn't break the fast. It's under the.
Dr. Dan
Yeah, I think it's fine. It's just a tablespoon of alpha linoleic acid. And that's. That's it until I, I break my fast.
Gwyneth Paltrow
How long do you fast for?
Dr. Dan
On average, like 18 hours.
Gwyneth Paltrow
Oh, wow, that's a, that's a, that's A hefty fast, Dr. Dan.
Dr. Dan
Yeah, you get used to it. You get used to it.
Gwyneth Paltrow
And, and, and why do you find that it works for you?
Dr. Dan
I feel like I have better mental clarity, more energy in animal models when they look at intermittent fasting or, you know, that kind of calorie restriction, it promotes autophagy, which is a way for your immune system to sort of prune and get rid of, like, bad cells. And I just feel, I just feel good. So I listen to my body. I don't do it all the time. You know, with these routines, we don't have to be 100%. Are there weekends where my kids have, like, French toast and I like, totally scarf it down? 100%?
Gwyneth Paltrow
Yeah. I mean, yeah, the French toast is hard to resist. I got to tell you, I have very dry lips. So I've always been something of a lip balm and lip mask connoisseur, if I do say so myself. So I wanted to make the best, best ever lip mask. Like, better than anything on the market, better than anything I had ever tried, because it's what I needed. That's why I'm excited to share our newest GOOP product with you, the Nourishing repair Lip mask. Formulated with high performance clean ingredients, this mask delivers clinical grade results, increasing hydration by over 160% with just one swipe. The result, smoother, softer and more protected lips that look as good as they feel immediately and over time. At Goop, we believe in beauty as wellness. That's why our products are carefully crafted to be clean, holistic and results driven. To try our nourishing lip repair mask or any of our Goop Beauty products, use code goop lips@goop.com for 15% off your first Goop Beauty purchase. I'm really excited for you to try our products and I hope you love them as much as I do. So some things that I hear a bit conflicting is like some cardiologists will say, you know, watch your red meat intake if you have cholesterol issue. And then the people that I speak to on the more functional side say if you're having grass fed grass finished beef, it doesn't impact your cholesterol as negatively and grass fed beef is actually a superfood and the organ meats, et cetera. Where do you land on this?
Dr. Dan
So I sort of, you know, I'm a functional medicine doctor and a cardiologist, so.
Gwyneth Paltrow
Exactly that's how I'm asking you.
Dr. Dan
The first thing I would say is sort of goes back to this end of one sort of practice of medicine. Like not everyone's the same and not everyone responds the same to red meat and their cholesterol metabolism. Also it depends on like if someone has coronary plaque, my targets and goal for that person, if they did a calcium score and it's positive, is going to be very different than someone who has high cholesterol and has no plaque at all. So I really need to get to know the patient first. That's my first answer. And like my intuitive sort of responses, like every person's different and their response to red meat and where they, they are on the spectrum of heart disease is different. And then the second thing I want to say is like sort of like everything in moderation. If you're having red meat a couple of times a month, I don't think that that's going to be really negative on your health if you're sourcing, you know, really good grass fed meat. So that's, that's my stance on it. So if someone asks me, that's usually what I say.
Gwyneth Paltrow
Okay, do you eat red meat sparingly?
Dr. Dan
So it's not completely out of my diet, but I tend to eat get protein from other sources prior to red meat. But A couple times a month I will have red meat.
Gwyneth Paltrow
Okay.
Dr. Dan
Yeah, so it's like a special occasion, you know, like nice, you know, nice steak dinner maybe. You know, there's a restaurant that just opened up in my building that has grass fed hamburgers. My kids love it. So like, we've hit that spot up a couple times, so it's not a no. And I think that goes for everything in life. Like, I think people really want a schedule and things to be super binary, like yes to red meat, no to red meat, and there's like a comfortable in between where you can say, okay, there's enough evidence that maybe red meat shouldn't be the primary source of protein, but I can still include it in my diet. And taking the stress away from those kind of decisions, I see people getting really into like a tailspin about, you know, what supplements should I be on and you know, what should my diet be. And I think if you have a generalized philosophy of what works well and you're good 80% of the time, 85% of the time, I think that's okay.
Gwyneth Paltrow
Presumably it also changes with different chapters, right? I mean like, I'm hardcore perimenopausal. I wish it would just stop already before I, like, I can't take it anymore. But I noticed that, you know, after I was, I had long Covid and was dealing with sort of chronic inflammation for a long time and I went really paleo. It felt great and I had more clarity and more energy and my, my C4A was going down a bit and all that. And then in the past like year I feel like I need more carbohydrates and more fiber. You know, like I've really been craving legumes, lentils and, and like great, you know, homemade organic sourdough bread, that kind of thing. So I've been sort of experimenting with just eating, you know, in more instinctually. And I have to say, like, I feel good right now having like a, some sourdough, great quality sourdough bread, like a really nice glass of organic unsprayed grapes, you know, like glass of red wine. So I don't know, do you think it's bad to sort of follow your, what your body is kind of craving.
Dr. Dan
And if it's like Dunkin Donuts every morning, probably I would say let's, let's revisit that question. But in general, I think people know like what their body needs and carbs are important. You just need to get good carbs, you know, and like have enough healthy carbs. Enough protein and fiber, enough healthy fats. I think most people know, like, what feels good. If you eat something and you don't feel good afterwards, it's probably something that's not really meshing well with your body. And what do I mean by not feeling well? You might feel bloated, you might have some brain fog. Sometimes people break out in allergies or just feel slowed down. Those are foods that are inflammatory. Your body's telling you, hey, I'm not happy. And interestingly enough, if you look at the small bowel, the highest concentration of immune cells is in your small bowel. So your small bowel is a huge immune system. It's like a giant immune system. So if it's not happy, it's going to like, sort of set off and then you get the systemic effects of it and, you know, feeling brain foggy and slow and sluggish. And I try to eat towards a certain feeling.
Gwyneth Paltrow
Right.
Dr. Dan
If you eat towards that feeling of like, feeling good afterwards, you're probably making good decisions.
Gwyneth Paltrow
Yeah, that's a great, that's a great distinction. And I, I think that's right. And I've just been surprised that, like, you know, putting some of these foods back into my diet has made me feel really good, you know. But again, like you say, we're all sui generis, completely unique and one of a kind. And so maybe, you know, a diet that works for every, you know, that I find that really interesting as well and that the thinking really evolves there around precision medicine.
Dr. Dan
That's why no diet has ever been like the forever diet for society. There's common trends. I would say the closest thing is a Mediterranean diet. Probably fits most people.
Gwyneth Paltrow
Yeah.
Dr. Dan
Just because it's high in, like, the healthy fats and, you know, phytonutrients and vegetables and those things time and time again seem to be beneficial for us. But there are certain vegetables that some patients absolutely can't tolerate that give them, you know, they're going to be bloated and miserable. So there's no one diet that fits everybody. And I think we're going to get to a point in medicine and wellness where we'll be able to look at people's DNA, we'll be able to do blood tests and really know exactly what you should eat based on your metabolomics, your genes, your epigenetics, etc. I don't think that's at prime time, but the best sort of thing now to do is figure out what foods make you feel good and what foods make you feel keep a food journal. Like what makes you not feel good and if it doesn't, put it on the maybe avoid list.
Gwyneth Paltrow
Right. And like you know, not. Or not sleeping well. Like for me that's, that's a clue. Always like if I. Because I tend to eat dinner early so that I'll digest before I go to sleep. And if I still don't sleep well, it's that I ate something that my body isn't loving 100%.
Dr. Dan
I think your body will tell you. Will tell you something to sign. I've had patients who've developed migraines from eating foods that don't agree with them.
Gwyneth Paltrow
Yeah, it's really interesting. And what about alcohol? Do you ever have tequila or a glass of wine or. Never.
Dr. Dan
It's again, not never. I'm. I'm usually there's very seldomly am I in the never category. There are a couple. There's certain things that are in the never category.
Gwyneth Paltrow
What's in your never category? If you feel comfortable.
Dr. Dan
I've never done any drugs.
Gwyneth Paltrow
Oh, you're missing out, Dr. Dan. No, just kidding.
Dr. Dan
I've never done any drugs. Gosh, I think that's probably one of them. I've never tried a cigarette. Never had an interest in it.
Gwyneth Paltrow
Honestly lucky I was so addicted back in the day. Oh my God.
Dr. Dan
Never had an interest. So I think those things are definitely like the. No, there's never really upside.
Gwyneth Paltrow
Yeah.
Dr. Dan
Evidence that there might be a use case for like hallucinogens in certain people with mental health issues. And that's being researched. So that.
Gwyneth Paltrow
Or like trauma. Mdma.
Dr. Dan
Yeah, trauma, mdma, ketamine. Like I think there's a use case for that. But sort of self medicating with drugs to help yourself when you know things don't feel right can often, you know, a bad direction. But when it comes to alcohol, I mean I'll have a drink like I would say like once or twice a month, you know, at a friend's dinner or a birthday party, you know, New Year's kind of at the same frequency. I have the red meat.
Gwyneth Paltrow
Right.
Dr. Dan
Maybe I just need to have red meat and alcohol at the same time.
Gwyneth Paltrow
Just going back to what you were saying around psychedelics and like mitigation techniques or modality for like how much does stress and trauma impact our cellular health, our metabolic health?
Dr. Dan
So so much that I don't even know where to start. Gosh, you know, the first thing I think about is cortisol. So cortisol is a stress hormone that our body was designed to Produce when like a grizzly bear was coming. After that we can like save ourselves and you know, jump into fight or flight. Nowadays that hormone is more maladaptive, meaning we produce it because we're in traffic or we get into an argument with a co worker.
Gwyneth Paltrow
Right.
Dr. Dan
I think chronic cortisol and inflammation really, really can be to at the molecular level. An interesting study that I looked at a while ago in Asia was that they looked at people who had good relationships, like healthy work relationships and healthy marriages, and they measured these inflammatory markers called interleukins.
Gwyneth Paltrow
Yeah.
Dr. Dan
And then they chronicled the same interleukins for people who had toxic relationships. So they were in a bad romance, you know, they didn't like their boss. And those pro inflammatory cytokines that are known to cause cancer, heart disease and brain disease were all elevated in those people. And it just leads you to think that your outer world and what you interface with directly impacts your inner biology. And that's when like being aware and having agency and thinking about these things, that we're not separate from our environments and that decisions about what we eat, the thoughts we maintain, the people we keep around us, that all affects you. I just met with a woman the other day who had metastatic eye cancer. You don't really hear about that that often.
Gwyneth Paltrow
Wow.
Dr. Dan
Primary eye cancer. And we're talking about her health. And we went through her nutrition and what supplements she should be on. And I said to her at the end of it, I said, do you have any toxic relationships? And her husband nearly fell off his chair. And she said, sort of like I told you so. And I said, whatever is going on with that toxic relationship that needs to end. Because if we're looking to keep you around for as long as possible, those stressful situations need to, you know, completely not exist. So I think that's a beautiful question. It's a very insightful question, Gwyneth, and one that I really appreciate and feel strongly about.
Gwyneth Paltrow
Is it called like something like morphic resonance, like that you're internally resonating with those external energetic factors that can impact you positively or negatively.
Dr. Dan
100%. We're where it's all energy.
Gwyneth Paltrow
Yeah.
Dr. Dan
One source of energy impacting another energy. So if you have those toxicities in your life, toxicity can be food toxicity can be the thoughts that you feed yourself. And toxicity can be the relationships you have will have a direct impact on your biologic and molecular health. And it's not spoken about enough.
Gwyneth Paltrow
No, it's true. And it's. And we normalize the toxicity. You Know, we, we normalize being in toxic situations. You know, I have been in my life, you know, thankfully, like I'm too old now to sustain anyone or anything toxic, but, you know, I did for many, many years and you know, like throughout my life. And you know, I think we're also sort of sometimes even a little bit shamed in the culture for, or at least in the past, you know, couple of decades for wanting to abstain from certain things that are toxic, like, like, you know, hyper processed foods or, you know, or alcohol, you know, having like the culture judge you for that or, you know, which I also find really interesting that there's this sort of sociological acceptance for us in, for that toxicity on whatever level is acceptable or normal.
Dr. Dan
I, you know, there's a lot of social pressures in that. And what I would want to tell people is to think about your own self kindness and self love. When you're tuned into that, you really don't. Those sort of external factors of judgment or what society perceives matter less. And one of the things that I said recently that, that I liked was that every decision you make is a micro contract with your DNA, little micro contracts, you know, how you treat the mailman, what you have at the restaurant, and you don't have to get it perfect, but they're little micro contracts. And I think when you think about longevity and health span, it's the accumulation of those micro contracts that make an impact in our lives. So there's a lot of agency here, and that's what I want to tell the people who are listening to this podcast. You have a lot of agency in terms of what your life can look like, who you surround yourself with, the decisions that you make. And as soon as you become aware that you have that agency, the external factors cannot have that same control and come from self love and self care, and you'll always land on top.
Gwyneth Paltrow
And I think you make a really interesting point about being guided by, you know, you sometimes say like your body speaks to you, right? And I think if we can move out of the model of like tolerating stuff and move more into the model of like, how does this make me feel? How does this food make me feel? How does this person make me feel? How does this coworker, you know, that, that, that the agency has to start there, right? With real honesty around how you relate to yourself, how you're, how you're really feeling. Like you have to be able to let the information bubble up in a real way.
Dr. Dan
100% awareness, but awareness without necessarily the Victimhood of it. So if you all of a sudden, you know, awareness becomes the poor me, then that poor me is going to be its own kind of toxicity. So it's being curious about how things make you so without judgment. So how can you be curious about how this food makes me feel or this person makes me feel without judgment and without putting yourself in that poor me victim category because that in and of itself can increase cortisol levels and make you feel lousy. And all of a sudden you, you develop an identity of someone who's everything's wrong and then you what do you attract wrong? More and more wrong. So it's doing it in a way that's still again with a self kindness and saying, well, this doesn't really work out for me. Let me, let me marinate over this. Let me think about this.
Gwyneth Paltrow
Yeah, yeah. So a Wellbel you can take with all your other supplements that your, you know, doctor or nutritionist or whatever has given you or is it important to take it and sort of let them, let people like, do doctors want to know more holistically the supplements that you're taking?
Dr. Dan
I would recommend that. I always think it's good to keep your healthcare practitioner in the loop of what you're taking just so that they're aware. Make sure that doesn't interact with any of your medications, that you're not on anything that might be a duplicate. So I think that's a really good practice to keep your healthcare practitioner, your holistic practitioner plugged into what you're doing and taking.
Gwyneth Paltrow
I don't know if you're developing new products for Wellbel, but even for the existing SKUs that you have, like how did you, are they. Did you put like clinicals behind them? Did you. How can you talk a little bit about the product development process?
Dr. Dan
Yeah, so I put my super nerd hat on, put on my glasses like mad scientist and then I started researching like ingredients that were clinically validated. And you know, early on in the company we didn't have enough money to like launch a clinical trial. Those are really expensive.
Gwyneth Paltrow
Yeah.
Dr. Dan
Luckily we, we've grown to the point that we hired our own CRO and we're running some clinical trials with dermatologists. So we'll, we should have some excite exciting double blind placebo controlled data within the year. But the early days, we're really looking at safe. You know, the first thing they teach you in med school is do no harm.
Gwyneth Paltrow
Yeah.
Dr. Dan
So important to me. I was like, it would be great if it works, but I definitely don't want to cause any harm. What can I put together that's going to be safe for most people? And it took a lot of research and time and trial and error to find that formulation. And now we really want to get it substantiated through a clinical trial and that process, the enrollment for that clinical trial is happening as we speak.
Gwyneth Paltrow
That's really exciting. I mean even anecdotally you have so many incredible stories and before and after pictures that I'm sure the results of the clinical trials are going to be impressive.
Dr. Dan
Thank you. Yes, we're excited. I feel encouraged.
Gwyneth Paltrow
Yeah. Do you feel like on some level the kind of wellness industry that has gotten so popular now, it's so funny. I look back and like when I think about what the things that we used to ask questions about it back in the day, it's like so much of it is mainstream now, which is so funny to me. But there's also, I mean it's kind of a great thing about social media is that it's this great democratizer and people can find an audience and find people who they resonate with, et cetera and get good information. But presumably there's also not good information. And I hear all the time from my kids about I'm not on TikTok but I hear like there's all these wellness trends on TikTok. Does this concern you at all? And are there ways to sort of fact check these? You know, because you we spoke about cortisol for example on this call and apparently there's a whole thing on social media about cortisol face and how to get rid when you have it and how to get rid of it. So what's your sort of take on like the, you know, social mediaization of wellness information?
Dr. Dan
In some part I like it because it's bringing health and wellness to the forefront and allowing people to be aware about the importance of it. So it's a bit of a double edged sword in that respect. I think it's great that people are interested in these things, wanting to understand it and wanting to share with other people to help them. The problem is a lot of the people who are posting don't necessarily have health and wellness background. You know, misinformation can be propagated really easily. So it's sort of like a double edged sword. I'm hoping that at some point maybe AI or some platforms will be able to help us really, you know, fact check against like journal articles and like clinicians and thought leaders who maybe are experts in cortisol or cholesterol, so that if you hear something great and then maybe you'll take the opportunity to just fact check it before you take it as, you know, as gospel. So I know I didn't answer it as a yes or no. It's sort of a yes and no. But that's what I would recommend. Be curious, be your own self advocate. Try to find a couple of doctors or health experts that resonate with you. So as opposed to like jumping from one TikTok channel to another where you're just going to hear all sorts of random facts and there's no way to really validate it and it becomes information overload. Pick a couple of people that resonate with you who seem like they're well, credentialed. Another way to know if someone is really knows what they're talking about. Those people tend to tell you I don't know when they don't know. So I look for those people. I love when someone's smart says I don't know because it makes me feel that when they do know, they really understand the concept.
Gwyneth Paltrow
Right. Right. Yeah.
Dr. Dan
Pick your pick. Your people are going to inspire you and seem to know what they're talking about.
Gwyneth Paltrow
Right. Right. Can I ask you a couple of questions? Just heart related, since I have a cardiologist on the podcast here for a minute, so I have recently discovered that I have a tiny bit of plaque, which is really surprising to me because I'm super healthy. And I.
Dr. Dan
Guilty. This guy also felt a little bit crazy. Tiny speck.
Gwyneth Paltrow
Me too. Tiny, tiny bit. And I think I also, I'm not unconvinced that it was, you know, some, you know, I've been reading a lot about COVID and heart disease and stuff like that. And so I don't know if it's because of that or just because I'm 52 or what. Because genetically, like I don't, you know, nobody in my family has ever dealt with like any heart disease at all. So it's kind of, it's a little bit of a mystery. But I wanted to ask you about, so protocols to really keep that in check. Like there's a drug called Repatha that I've heard of. I wanted to ask your opinion on that. Your opinion on the efficacy of statins, which seems to be a real hotbed topic these days.
Dr. Dan
We're going to need a whole separate podcast management. But love this category. You just like, I was excited to be on this podcast. Now I'm like through the roof. So you know, I think once you have any demonstrable plaque, you should be on a low dose statin if you can tolerate it. The reason statins are important are that they stabilize plaque. Obviously, we know that they lower cholesterol, but we don't really care about cholesterol. We really care about the effect of cholesterol on plaque, on the actual thing that we're judging. And there's different kinds of plaque. I sit on the board as an advisor for this company that does plaque analysis. It's called clearly. I don't know if you've had a clearly scan. If you haven't, we should probably get you one.
Gwyneth Paltrow
I'd love one.
Dr. Dan
It uses AI to look at your plaque and determine if it's vulnerable high risk plaque or low risk calcified plaque. And statins can help move plaque from that vulnerable plaque to the more stable calcified plaque. If I have someone with high cholesterol and their calcium score is a zero and their carotid ultrasound is normal, and they have no evidence of heart disease or plaque, I'll manage it with supplements and diet and exercise and nutrition. So we'll look at, you know, bergamot extract and berberine and red yeast rice. I'm on a statin myself. As soon as I realized I was on, you know, had plaque, I started on a statin. But I think the efficacy of statins is at its lowest dose, meaning that if you increase the dose, you don't really get that much more benefit, but you get much more side effects. So, for instance, I'm on Crestor Rosuvastatin, 5 milligrams, I take it every day. My cholesterol is beautiful now. It's a lot better than it was. Also, there's a couple of new kids on the block with cholesterol that we never talked about. It used to be like hdl, LDL, and triglycerides, and that's it. Now there's lp, little A, lipoprotein A, apo B, different inflammatory markers that have to do with the heart. And so we've moved from those basic cholesterol panels to these more advanced cholesterol, you know, cardiac biomarkers. So if you haven't done that, we should do that as well.
Gwyneth Paltrow
Okay. Okay. And what about repatha?
Dr. Dan
I use repatha in patients who are statin intolerant or patients who are really high risk, where statins are not really getting them to goal. Repath is an injectable. It's a monoclonal antibody that works to lower Cholesterol, it's very, very effective. But I think most people who have heart disease and coronary plaque don't need repatha. But it's great to have it to use in addition to statins or in replacement when people are statin intolerant.
Gwyneth Paltrow
Thank you so much. Yeah, I do want to ask you a little bit about detoxification. You mentioned early autophagy. So the process whereby the body, when it's not digesting, starts to kind of gobble up these unhealthy cells and. Right. Sort of like gets the toxins out of the body. That's our part of our natural detoxification system, of course, sweating, et cetera. We live in a super toxic environment. Obviously, you know, our bodies were not designed to detoxify, you know, these forever chemicals with great ease. And so there's a lot of discussion around helping the body detoxify some of these substances. And especially, you know, right now we're dealing with this kind of post. I don't even know what to call it. Apocalyptic fire in Los Angeles. And I have so many friends that are so worried about VOCs and benzene and you know, all of these incredibly toxic things that could potentially be in the air or the water, asbestos that burned, you know, lithium and car batteries, et cetera. So I guess in your opinion, you know, what, what are some of the things to, you know, sort of generally like, do we need to help our body with its detoxification processes? And then if so, you know, especially in a more extreme event like post fire, what are some of the things that we can do to help the body with that process?
Dr. Dan
So the first thing I would say is even after sort of like a post apocalyptic disaster where a lot of chemicals and molecules are put into the air, there's no, no need to short term panic. Do you know what I mean? So like a lot of these effects that take time to accumulate and really cause damage in terms of like detoxing, there's ways to sort of help with like liver. Your liver is very important for detoxification. So there's things that can upregulate liver detoxification. There's antioxidants. For instance, the number one, you know, antioxidant for the body is glutathione. I think glutathione is like a master antioxidant. So you know, glutathione, there's transdermal glutathione. If people are really worried about toxic exposures or if they feel like they're symptomatic There are specialty labs that can check for these, you know, like in your urine or your blood. You can check for benzene and toluene and these different, you know, chemicals. And then, you know, we can figure out ways of detoxing the body from those. So it really depends on what the exposure is, you know, increasing your antioxidant support. Antioxidants neutralize free radicals. So our concerns with a lot of these chemicals is that they produce these free radicals that can cause DNA damage. So we want to neutralize the free radicals. What neutralizes free radicals? It's antioxidants. What's an antioxidant? Vitamin C is an antioxidant. You know, eat the rainbow. You know, you're going to get a lot of phytonutrients, a lot of antioxidants just from your food. If you're worried about the air quality, you know, maybe investing in a good HEPA filter in your bedroom is a way to hedge against some of the toxicities of the air and, you know, clean your HEPA filter often. So these are sort of things that you can do that are simple, that can, you know, combat, you know, toxicity and promote, you know, body detoxification.
Gwyneth Paltrow
And what about things like, like saunas or taking binders, like charcoal binders and sitting in a sauna?
Dr. Dan
I have had patients who've done that and they found it really helpful. What I do is like, I use like spirulina and broken chlorella extract, and I put those in my smoothie. That seems a lot easier for me. I love the sauna. There's a lot of health benefits for sauna separate of detoxification. But if you want to sort of use like something natural that you can put in a smoothie, Spirulina and broken chlorella extract and moringa extract are things that I, I add to my smoothie probably two or three times a week. I don't, I don't think I get to it every single day, but I try to do it a couple times a week and that really helps. I'll even get broken chlorella extract, little capsules, and I'll just take them when chelates and hip and gets rid of toxins. Really good for mercury. Also, if your heavy metals are high, that's another way of getting it down.
Gwyneth Paltrow
So are there interesting wellness modalities or ways of thinking about things that are emerging now that you feel excited about implementing or researching further?
Dr. Dan
Gosh, there's so many. There's some in the very sort of Basic science, medical world. And then there are things that are more in the functional medicine. I think the things in the biotech world that I'm really excited about are like liquid biopsies where we can detect tumors in the blood before that cancer becomes clinically manifest. There's a company called Galleri which does the grail test and they look for circulating tumor DNA and are able to evaluate whether you have one of 50 different cancers. I think that AI is going to take healthcare and medicine to the stratosphere in terms of, like, the use for plaque analysis and, you know, making sure that you're not going to have complications from medicines and even over reading mammographies and ultrasounds to make sure that breast cancer is not, you know, not missed. On the functional medicine side, I think this concept of precision medicine for the masses is what I'm the most excited about. And really seeing that come to fruition is something that is going to be part of my life's mission.
Gwyneth Paltrow
That's so exciting. Thing I did want to ask you was there's Wellbel women, Wellbel Women plus, and Wellbel men. Can you talk a little bit about the distinctions between each one of those three products?
Dr. Dan
Yeah. I'll start with the timeline. We started with regular Wellbel for all women, and then we did Wellbel men's only because men have more testosterone and we needed to have more solid palmetto to block the DHT conversion for them. And then we realized that the hormonal needs of Perry and postmenopausal women also are different. When women go into perimenopause, their estrogen and progesterone drop more than their testosterone does also have relative androgen excess. So they have more testosterone compared to estrogen and progesterone. So they also needed more Dharma DHT blockade. And then I added the vitamin K2 for the osteopenia and osteoporosis and some copper and zinc to help with hormones and testosterone metabolism. The core of the, the different products is very similar with slight nuances for each one of those groups.
Gwyneth Paltrow
That's great. And you said your, your hair, like completely changed after.
Dr. Dan
I have more hair now than I did in college. It's insane.
Gwyneth Paltrow
This is not an ad, by the way. This is like, I, we. We really were. This is like from the heart. This is, this is amazing product. I'm. You know, when I find something that really works, like, I always want to share it. That's kind of like the, the foundation of our, my whole business really is just like trying to connect people to good things. So I'm. I'm just. I'm really thrilled that you have made a product that's so efficacious and, you know, like. Like, won't. Doesn't disappoint. And it's done so thoughtfully, especially with, like, a holistic and scientific lens.
Dr. Dan
Thank you. Yeah, it's a merger of, you know, science, beauty, and overall wellness. Like, even the betaine hydrochloride that we put in there to increase the absorption of micronutrients was an ingredient that was specifically put there from a holistic standpoint that other, you know, other supplements don't have is. I knew betaine would help with overall hair, skin, and nails. So, yeah, we're really proud of the results and again, super honored to be working with you and Goop on this product.
Gwyneth Paltrow
Thank you.
Dr. Dan
And I had. I had so much fun on this podcast. I can't believe the hour went by so quickly.
Gwyneth Paltrow
Right? It was like 10 minutes. I couldn't believe it. Thank you so much for being here today. The connection between what we put into our bodies and how we feel, not just physically, but mentally, is critically important. And the work you're doing at Welbelle is really making a difference, at least in my life, for the health of my hair. If you want to learn more or try Wellbel for yourself, you can find it now in Goop stores and@goop.com. thank you all so much for tuning in and see you next time. This has been a presentation of Cadence 13 Studios. I hope you'll listen, follow rate and review all of our episodes, which are available for free on Apple Podcasts, Spotify, Odyssey, or wherever you get your podcasts.
The GOOP Podcast: Dr. Dan on Hair Health, Hormones, and the Science of Feeling (and Looking) Your Best
Release Date: February 11, 2025
Host: Gwyneth Paltrow
Guest: Dr. Dan, Chief Medical Officer and Co-Founder of Wellbel
Gwyneth Paltrow welcomes Dr. Dan, a renowned expert in nutritional and holistic health, to discuss the intricate connections between beauty, wellness, and brain health. Dr. Dan shares his journey from a conventional medical path to embracing a holistic, precision medicine approach.
Dr. Dan [03:07]: "It's all interconnected—brain health, overall health. It all starts with self-kindness and making good decisions for yourself, even small, little good decisions."
Dr. Dan elaborates on precision medicine, emphasizing the importance of individualized healthcare based on personal goals, data-driven insights, and medical expertise.
Dr. Dan [04:29]: "Precision medicine is a marriage of what the patient wants, where the data lead us, and what the doctor wants for the patient's health maintenance."
He explains that precision medicine moves beyond one-size-fits-all approaches, using genetic sequencing and biomarkers to tailor healthcare strategies uniquely to each individual.
The discussion shifts to how individuals respond differently to various foods, highlighting the role of genetics and metabolism in these reactions.
Gwyneth Paltrow [05:23]: "I remember wearing a continuous glucose monitor and having completely different reactions to a bowl of pasta versus oat milk."
Dr. Dan confirms that personalized responses to food are common, influenced by genetics and metabolic processes, making personalized nutrition a cornerstone of precision medicine.
Addressing the scalability of precision medicine, Dr. Dan is optimistic about its growing accessibility.
Dr. Dan [06:47]: "We're seeing more businesses start out focusing on precision medicine that are going to scale more and more."
He envisions a future where precision medicine becomes mainstream, empowering individuals with data to make informed health decisions.
Gwyneth brings up GLP1 inhibitors, drugs commonly associated with weight loss, and seeks Dr. Dan's insights on their safety and efficacy.
Dr. Dan [11:51]: "GLP1s can be life-changing for certain patients, but they're not one-size-fits-all. For example, 40% of weight loss from GLP1s can come from muscle mass, which is a concern, especially for older adults."
Dr. Dan emphasizes the importance of using GLP1 inhibitors judiciously, recommending muscle-strengthening exercises and proper nutrition to mitigate potential muscle loss.
Dr. Dan discusses the inception of Wellbel, a supplement designed to combat hair loss, inspired by personal experiences with his sisters.
Dr. Dan [15:53]: "I formulated Wellbel using my functional medicine fellowship to create a safe, effective supplement that promotes hair health without unnecessary additives."
He details the key ingredients—biotin, MSM, betaine hydrochloride, and saw palmetto—and their roles in enhancing hair density, quality, and reducing shedding.
The conversation delves into the profound connection between nutrition and mental well-being.
Dr. Dan [24:28]: "If you don't have a happy gut and your GI tract is inflamed, it can lead to mental fog, poor sleep, and overall reduced mental clarity."
Dr. Dan highlights how a well-balanced diet rich in omega fatty acids and antioxidants supports both physical and mental health, citing his personal routine of intermittent fasting and flaxseed oil consumption.
Gwyneth raises concerns about the influx of wellness trends on social media, questioning their reliability.
Dr. Dan [46:08]: "It's a double-edged sword. While it's great that more people are interested in health and wellness, misinformation can spread just as easily."
He advises listeners to seek information from credible sources and consult healthcare professionals to verify the validity of wellness claims encountered online.
As a cardiologist, Dr. Dan provides insights into managing heart health, discussing plaque formation and the use of statins.
Dr. Dan [49:12]: "Once you have any demonstrable plaque, you should be on a low-dose statin if you can tolerate it. Statins stabilize plaque, reducing the risk of heart attacks."
He also touches upon newer treatments like Repatha, an injectable medication for patients who are statin-intolerant or require additional cholesterol lowering.
The discussion covers strategies to enhance the body's detoxification mechanisms in response to environmental toxins.
Dr. Dan [53:25]: "Glutathione is the number one antioxidant for detoxification. Incorporating antioxidants like Vitamin C and using HEPA filters can help reduce toxic exposures."
He recommends natural binders such as spirulina and chlorella extract to aid in removing heavy metals and other toxins from the body.
Dr. Dan expresses excitement about advancements in liquid biopsies and AI-driven healthcare solutions.
Dr. Dan [56:27]: "Liquid biopsies can detect tumors early, and AI will revolutionize plaque analysis and disease prediction, making precision medicine accessible to the masses."
He underscores his commitment to integrating these innovations to enhance preventive healthcare.
Explaining the various formulations of Wellbel, Dr. Dan highlights the tailored approach for different demographics.
Dr. Dan [57:43]: "Wellbel Women, Wellbel Men, and Wellbel Women Plus each have specific ingredient profiles to address unique hormonal and physiological needs."
He emphasizes the importance of targeted supplementation to effectively support hair health across different groups.
Gwyneth and Dr. Dan conclude by reinforcing the importance of personalized health decisions and the transformative potential of precision medicine.
Dr. Dan [41:24]: "Every decision you make is a micro contract with your DNA. Awareness and self-kindness empower you to make choices that enhance your health and longevity."
Gwyneth commends Wellbel's thoughtful formulation and its positive impact on her own hair health, expressing enthusiasm for the collaboration between GOOP and Wellbel.
Dr. Dan [03:07]: "It's all interconnected—brain health, overall health. It all starts with self-kindness and making good decisions for yourself, even small, little good decisions."
Gwyneth Paltrow [05:23]: "I remember wearing a continuous glucose monitor and having completely different reactions to a bowl of pasta versus oat milk."
Dr. Dan [46:08]: "It's a double-edged sword. While it's great that more people are interested in health and wellness, misinformation can spread just as easily."
Dr. Dan [49:12]: "Once you have any demonstrable plaque, you should be on a low-dose statin if you can tolerate it. Statins stabilize plaque, reducing the risk of heart attacks."
Dr. Dan [57:43]: "Wellbel Women, Wellbel Men, and Wellbel Women Plus each have specific ingredient profiles to address unique hormonal and physiological needs."
This episode of The GOOP Podcast offers a comprehensive exploration of personalized health strategies, the science behind hair health, and the evolving landscape of precision medicine. Dr. Dan's expertise provides valuable insights into how individualized approaches can significantly enhance both physical appearance and overall well-being.
For those interested in exploring Wellbel products, they are available at GOOP stores and online at goop.com.
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