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Show Notes:

Selective sweep on human amylase genes postdates the split with Neanderthals

Comparison with ancestral diets suggests dense acellular carbohydrates promote an inflammatory microbiota, and may be the primary dietary cause of leptin resistance and obesity

Onnit - Alpha Brain

Thesis | Personalized nootropics for every brain

Questions:

The Carnivore Connection

Jim writes:

Long time, first time.

I want your understanding of the Carnivore connection hypothesis; the PubMed links are included:

https://pubmed.ncbi.nlm.nih.gov/22235369/.

https://pubmed.ncbi.nlmThe 'carnivore connection'--evolutionary aspects of insulin resistance - PubMed.nThe 'carnivore connection'--evolutionary aspects of insulin resistance - PubMedih.gov/11965520/.

I am a layperson researching why my insulin resistance has gone up while my A1C, weight, waist, and everything else have seemed to improve. I have adopted a largely meat-based eating habit, with some fasting included. Yes, as a 5'11" male with an ideal body weight of 180-200 lbs, I average at least 200 grams of protein daily. I expected my IR to lower, but it has gradually increased as my A1C has decreased. You can explain this hypothesis better than I can write here, and I want to hear whether I understood the paper. Suppose I have understood the paper(s), again, being a layperson. In that case, I hope someone will look into gestational diabetes and see if it is the body's natural reaction to become more IR for a reproductive advantage.

Thank you for continuing to educate me.

Jim

Nootropics for kids

Kate writes:

Hi Robb and Nicki

Wondering if you have any suggestions for a nootropic that would be safe for kids? My 13 year old daughter struggles to stay focused on her schoolwork. We've tried caffeine, but was thinking it might be helpful to give her something more? Would love your thoughts.

Kate

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