← The Human Upgrade: Biohacking for Longevity & Performance
The Human Upgrade: Biohacking for Longevity & Performance
The Secret to Staying DANGEROUS After 50 : 1422
01:00:34
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- [00:00]
A
One of the compounds I've been the most excited about for years and years is a longevity compound that goes down linearly with age is. Well, it's a longevity compound, but it's
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B
also a massive improvement in endothelial function. So tissue sensitivity increases, brain speed increases, vascular protection, kidney protection. I mean, it's really an amazing compound. My wife and I have been using it since the end of August and I would say it's subtle, but the one thing that you notice the most right away is again, sex is improved, right? You have better oxytocin in delivery. Literally within the first week of her and I taking it, it was like we were having sex and we were a brand new couple. We've been together for 14 and a half years. 76 year old woman started chloroquine within five days, started menstruating. It's restarting and making you younger.
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A
You really want to be long lived. Your body needs to believe at a very basic level that you're still capable of having babies. And if you do that, then your body says, well, there's no way I'm going to age out for the next generation because I might have more. If you start as a man, you wake up and you're like, man, my morning kickstand is getting in the way. That's good. And if you're a and saying I feel fertile again, that's good. That's actually a profound sign that you're reversing your age and that you're therefore extending your life. You're listening to the human upgrade with Dave Asprey. Ready to unlock razor sharp focus, sustained energy and next level cognitive performance. It starts with understanding how to use one of the most misunderstood biohacking tool on the planet. The tool nicotine. When you use the right form in the right way, it's a nootropic powerhouse. Most people are using it completely wrong or avoiding it entirely because of outdated propaganda and fear mongering. Most people hear nicotine and picture lung cancer. Wrong. Target cigarettes contain 7,000 chemicals. Pure nicotine in low doses works completely differently. Clean nicotine enhances mitochondrial function, sharpens focus, improves reaction time and supports neuroplasticity. Numerous studies show that it improves cognitive performance and protects your brain. But you need the right form, the right dose and the right protocol. So I'm presenting this clean nicotine roadmap. It's a five day program designed to help upgrade your brain and performance the right way. For five days, I'll send you a power packed email each day you'll learn exactly which forms of nicotine to use and which ones are toxic, how to dose for your goals, and how to stack it with other nootropics for maximum effect. You'll get the science, the protocols and the resources you need to make nicotine work for you, not against you. By the end of the program, you'll have a roadmap to enhanced cognition, better focus, and unstoppable mental energy. Enroll for free Sign up for my Clean Nicotine Roadmap and receive the information and biohacking resources you need to sharpen your focus and improve cognitive performance. Delivered straight to your inbox. Here's something even the most dialed in biohackers miss. You can look great and feel fine, but you could still be aging fast on the inside in one area but not another. That's because each of your organ systems ages at its own pace and systemage from Generation Lab can show you exactly how each of your internal systems, your brain, your hormones, your mitochondria, your immune system are holding up over time. This goes deeper than just blood sugar or cholesterol testing. It tells you what's working and what's not. Is the daily supplement stack you're taking actually making you younger? Well, now you can know. And you don't just get raw data, they give you an action plan to improve. What nutrients is your body missing? What to eat? More of where your body needs extra recovery. Best part? It's a five minute pain free blood test you do at home and it gives you a level of data most people never see, even with a functional medicine team. Go to generationlab.com, use code DAVE20 to get $20 off and see what your body's really doing behind the surface. This episode is going to be a ton of fun and we're going to go deep on peptides. You've heard a lot about peptides, probably from every influencer ever these days. And there are incredible capabilities for peptides, to the point that even when I was interviewing our FDA commissioner, interviewing the head of the fda, I actually did that. And he's he was actually very pro peptide, very friendly, and so is Bobby Kennedy. So this is interesting. If you'd asked me five years ago, is it ever likely that the FDA would be in favor of peptides, I would have said unlikely. In fact, the only thing more unlikely is that I would be interviewing that of the fda. So there's been a change in leadership. That doesn't mean that every one of the tens of thousands of FDA employees is a fan of these things because they do compete with pharma, and sometimes they are pharma products. And our experts today are coming back on the show. We have Josh Felber and Jay Campbell, and these are some of the smartest guys in the space. I've worked with Josh for years at one of his previous companies, and he's also runs a big podcast called Making bank. And just a serial entrepreneur in the health space who's very passionate about peptides. And then Jay Campbell, who is one of the. I was gonna like, like fist bum high five grab you, like, it's just far enough away that it's off. So Jay, you've seen him online, and he's one of the OG peptide guys. And I've been using peptides for about 15 years, wrote a lot about them, including the Russian bioregulator peptides in my big longevity book. And I've just enjoyed the slow awareness in society of peptides. But anytime that happens, you get people who are really not experts in the space, and then they're creating these products from China that might work but aren't really tested. So there's a lot of safety problems. So I thought, let's bring in a couple of guys who really know what's up. And let's talk about two things. One, peptides 101 for you, and the other one is like, what's. What are the things no one knows about yet? Because that's why you listen to the show. Anyway, so, guys, welcome to the show.
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B
Thanks for having us.
- [06:33]
A
Yeah, thanks for having us. Now, first question. Are you guys in a choir together?
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B
We did. We did.
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A
We did coordinate this morning.
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B
Black or white? Yeah, I did change my head recently.
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A
It might have looked funny too. We all in black, but then we'd
- [06:51]
B
have been blue, though. And mine are like black. I'm black. And what you.
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A
Good deal. So we have a good range of colors here, man. So many questions. I want to ask for a sneak preview of some of the new products, and I'm. I'm really stoked on those. We're going to talk about those. First one, though, for listeners who maybe have heard of peptides, but they don't really know what they are. This. This is going to be a big challenge for you. Can you tell me what peptides are? In plain English?
- [07:17]
B
Of course. They're just basically organic signaling molecules. You know, I like to call them fractionated proteins or chains of amino acids. And as you were talking about bioregulators, right? Like, the shorter the chain, the more likely you can orally ingest it, the longer the chain has to be injected. Right. Injectable peptides, for people who are new to this, are the highest impact delivery system for two reasons. One, they cross the blood brain barrier the fastest, and two, they get into portal or parental circulation the fastest. So systemically they're delivered that way. But as you know, there are many different delivery systems. And the cool thing is, you know, we happen to work with some of the companies that are delivering new technologies. One of them is a Velcro patch, which you will be seeing very soon. Right now they can deliver about 10 different peptides. But when they can get to like 80 little tiny micron needles, all peptides will be able. And it'll just go on like, wow. Yeah. So no more. Oh, my God, I'm scared shitless of needles. I can't inject myself, which is, by the way, 80% of the public.
- [08:14]
A
You know, one of the things that's changed my life in the last year is, and for many years, I've been taking little insulin syringes. And you draw the right dose and you put a little sticker on there and then you inject. I kind of inject the top of my butt because I have a lot of extra skin there for when I was fat.
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B
Yep.
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A
Makes it easy.
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B
Yep.
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A
It's. It's like, what are those things? The honey badgers stick it in there and they're tiny needles. But I bought a. A peptide pen. Yeah.
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B
Greatest thing of all time.
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A
Ten of them.
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B
Exactly.
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A
So explain what a peptide pen is and why people who use peptides might want to switch.
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B
So I have a cooler, he probably does a little insulin cooler that I carry around with me all over the world that has literally 10 pens in it.
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A
Right.
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B
So like every peptide that I use, and they're basically just like you said. The best way for most people to understand is they're like insulin pens. Right. So people that are familiar with insulin syringes or little insulin auto injectors, they now have these for peptide pens. And so you can basically, like you said, instead of reconstituting in a vial, you can now put. Most of the pens are 3ml, so you can put almost a half a vial, a vial and a half into your pen carrier pen around. And all you have to do is switch the top of the little, you know, call it red eject needle and inject it on the go all the time. And they're like you said, they're tiny needles so you can inject. My wife injects GHKC in her face, like. Right. It hurts. No, it doesn't, because she's using a 2mm micron needle, so you can't feel it. But, yeah, they're. They are, to me, a revolution in peptide usage, because all the people like us in the know who use peptides are carrying pens around now, so.
- [09:46]
A
So what it looks like is a Sharpie. Yeah. And instead of filling your. Your little vial of peptides with sterile water and then drawing each time, you just take all of the thing and you put it in a new little vial and it goes inside the pen, and you just dial the back of the pen to the dose you want. So it's a little numbered thing. And then you can't feel the needle going. You just stick it in. It's much less waste, and it's. It's just an easier way to get them in. Although I'd rather do a patch.
- [10:14]
B
Yeah, it's three. Well, so it's a three milliliter. Most pens are three milliliters. So for most people, depending on what you're using it for, and you're not critically injured or acutely injured, you can get about four to six weeks with each pen, you know, before you have to refill it. And they. They make international travel.
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A
Right.
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B
It's amazing. Right, because now you don't have to carry vials and syringes and all that stuff. Bacterial cyanic water. You just carry the pen in a cooler.
- [10:35]
A
Yep. And the. The TSA guys don't even know what pens are, so that's probably good. No, actually, that's not true. There's a lot of TSA guys who listen to the show. Definitely. I was just saying, they fungo E. No, they recognize.
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B
They know what it is. They'll take it.
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A
We're always chatting. I go through. Go through security, like, hey, yeah, you should do that peptide. It's kind of cool. All right, so that's a new delivery system, and I'm going to restate what you were saying. And even plainer English, like I would on Dr. Oz or something, but basically steak or eggs. Those are big proteins. Yep. And all proteins are made out of basically amino acids. So think of those as letters in the Alphabet.
- [11:14]
B
Exactly.
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A
And if you were to take three letters and make the. Or.
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B
If.
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A
Or. And. Or. But those are little peptides. Right. In their words. Or you could have one that's more like superstition. Ooh, that's a big fancy word. And that's a longer chain peptide. So you'd have to Inject the peptide. That's longer chain because you would digest it otherwise. But the very short ones, like GHK.
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B
Exactly.
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A
Or someone like BPC 157, you can just take those orally because they're so small, the body doesn't try to digest them. They just soak in through your gut lining.
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B
Wow, you really know about peptides, bro. Unlike 95% of the influencers on the Internet.
- [11:51]
A
You know, that's a popular thing these days. It's that, that's, that's the issue. Right. And you know, I love seeing people talk about peptides, but I do have concerns. Yeah, One of the biggest concerns is that someone's gonna say, well, we have to regulate all these things. And bottom line is anytime someone says they're going to control access to your ability to control your biology, they're probably not working for your best sense. Exactly. So we should be allowed to do stupid things like go downhill skiing. I mean, you might hit a tree, right? Exactly. Oh no. How risky are peptides? Sure. Actually we just kind of went through this a little bit back in December. That potential of having all of the peptides wiped out, you know, unavailable from, you know, direct access. But I mean, from a safety perspective, I mean, it's just like taking a vitamin B capsule or anything else, you know, they're the worst ace you do is you might get the runs if you took way too much like a whole vial of something.
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B
Right?
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A
Yeah. But from a health standpoint, it's not going to affect you.
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B
So I've been using peptides for 24 years, literally since 2003, and I've never seen a single person. Odd. Now obviously if we talk about GLPs, which are recent phenomenon, last four years, five years, there are complete buffoons who inject way too much and don't eat for two weeks. Right. And they may become constipated, they may have gallbladder issues, pancreatic issues, et cetera. But that is just from a overdosing way. Super physiologic levels that don't even apply to a normal person. So as Josh said, I mean, the risk is so nominal. And again, they're organic signaling modes and
- [13:25]
A
I mean, okay, you guys do sell peptides, right? BioLongevity, you know, US manufactured high quality stuff and things that I actually used that said insulin is a peptide. Exactly. You get OD on insulin, it'll kill you.
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B
Yep. Right.
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A
And.
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B
Yep.
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A
You ever OD on PT141?
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B
No. But if you do, you're probably going to have to go to the hospital
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A
for Prio prism well and nausea. So. So what I would say here is don't go nuts with your peptide usage. You actually want to get good advice. And what's really unfortunate in the US right now is you can go to most even well educated, functional doctors, even if they're peptide aware. You can say, I want to try this new peptide. And they're not allowed to tell you to do it because it's not standard of care. There isn't enough research. So a few of them will say, well, you can kind of use this. I can't sell it to you. You might be able to do it and it might have these effects on, on your molecules. But I can't professionally recommend it. Right, Yep. So I would just say practice caution. And if you go to ChatGPT and you've told it the right thing so that it won't act like an idiot, it'll give you decent advice. But what you want to do is take that advice and then put it into Claude and just say shoot holes in this advice. Right. And so make sure you get at least two AIs if you're going to try to do that. Or I think you have something.
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B
What does Jay Campbell say about this peptide?
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A
Jay's AI character? Yeah. Do you have an AI out there? That's.
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B
I do.
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A
Okay, what is it?
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B
It's just custom built one.
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A
I mean, is it one that the jbot, can everyone use that?
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B
Yeah.
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A
Yeah. How do you use it? Just go to the website jcambel.com jcambel.com all right. And get the JBOT. Yeah.
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B
I mean, but as you know, AI, we play the game with it all the time between Claude Perplexity, Grok and Chat gbt and you get six different answers from the same question. Right. So yeah, very. Buyer beware. Be very concerned that you're not, you know, getting bad information. Because there's a lot of bad information for sure.
- [15:26]
A
But now we're going to break the third ball. I'm going to ask this next one and I want like this for a sound bite. So you got to give me the punchline first and then give me the details after. Okay? Okay. Everyone's into mitochondria these days. What is SS71?
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B
Peptide 31.
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A
But does say you should 70 actually
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B
say a llama pre tide because they'll come after us. Now you can't say.
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A
Yeah, you can't say. Really?
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B
Yeah, they literally FDA approved. It's called a lama pred now.
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A
Okay. That's A mouthful. Bama Pred. All right. Fixing your mitochondria. There's a peptide that is exceptionally powerful. What is it? How does it work?
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B
It's called a Lama Pre Tide, formerly SS31, and I call it the amplifier peptide, because what it does is it improves signaling and cellular cascades. So everything that you're doing, whether you're on therapeutic hormones, whether you're living insulin controlled, whether you're taking this supplement, that supplement, it improves and amplifies everything that you're doing. So it's honestly in one of the most profound peptides I think of in existence.
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A
You might have heard me talk about mitochondria just once or twice, three times. My hypothesis has been since the late 90s, that these are foundational to longevity and cognitive performance and health. And the more research has come out over the last 15 years, everything comes down ultimately to mitochondria. And you might say, no, it's my hormones. Who do you think makes the power production to make your hormones a fixed mitochondria? All sorts of crazy improvements happen throughout the system. And in the mitochondria, there's a membrane, which just means it's tiny droplets of fat, and it contains a compound called cardiolipin. What is ss? Sorry? What is olama Prettide? Olama. What?
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B
So it strengthens the cardiolipin. So it strengthens the actual. The fatty acid membranes around the cellular walls. So cardiolipin being very powerful in extending life, you know, is the stronger the cardiolipin, or the more you produce, the more amplified and charged your card, your mitochondria will be. So SS31 is actually improving. Caught the mitochondrial density of all those connective tissues. Right. Or, you know, it's really just cellular signaling, but it's an incredible peptide. I mean, I've been using it personally for four years myself, like right when it first came out. And I think what we're seeing now, especially in the clinical space, is they're actually using it in much higher doses than people that are critically injured, which is incredible because I've always just used it as a very small microdose. Like on the weekends, if I was taking, like, you know, mitocharge or one of the awesome mitochondrial supplements, I would take SS31 on Saturday and Sunday. But now a lot of the clinical literature, at least in the people working in functional health, are seeing taking 4, 5, 6 milligrams a day of this and dramatically improving again, all of the cell signaling and processes that people who are critically injured Autoimmune impaired. So it's an amazing peptide for that. But like, for us life extension people, I think it's something that you actually have to have in a pen that you carry around with you at all times.
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A
I'm running 20 milligrams a day for six weeks.
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B
Wow, that's awesome. What do you notice when you take it?
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A
Do you feel cellular charge instantly just starting it? I've never felt a big boost from it.
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B
Yeah.
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A
And it's, it's more foundational. Yeah. Right. And then if you want the boost, you use MOT C, which is another peptide. Tell me about MOT C. So we
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B
actually, it's funny you just mentioned that. So we actually have a blend at Bio Longevity Labs that has MOT C NAD plus and five amino injectable. And I took that this morning. And that for people like us, is noticeable. And what I mean by that is, is that like within 30 minutes of taking it, you have energy. Right.
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A
Wow.
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B
So it's a very, very powerful blend. But MOT C is, you know, just call it another mitochondrial regulator super optimizer. I mean, it basically enhances NAD plus or not nad, but just increases ATP synthase and you have more, you know, ATP nad. Cellular signaling for heavy people who are, you know, obviously not mitochondria optimized, they notice a much better response with MOTC than people like us. Now, not to say that it doesn't help us, but the heavier, more insulin resistant, more metabolically deranged a person is, a high dose of MOT C really turns the mitochondria on and really gives them that cellular energy. In fact, people that use MOT C who are normally like not energized or just don't have the energy to train or exercise, when they start using MOT C that have that energy, they want to start doing it. So it's also a very powerful peptide.
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A
For our high end longevity clients at Unlimited Life who are into these sorts of things. I usually recommend that you run for a couple months. Yeah.
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B
Eight weeks.
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A
Yeah. That you do the Olama pre tides. 31. Dude.
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B
Yeah.
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A
Anyway, they changed name. Olama Pre Tide. Yeah. All right.
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B
That says 31.
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A
So I just say that. Do that for a couple months, especially if you're heavy or, or if your mitochondrion working, because you want, you want the engine in good shape before you turbocharge it. And Matt sees the turbocharger.
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B
Yep.
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A
And the other question, a lot of the functional docs I've worked with are not recommending blending peptides. Together because of cross linking. What's your take on that? Is there research? Have you done it?
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B
Yeah, so, so, so it's a good, it's a good point because a lot of people are talking about it. I won't mention a influencer who talks about this a lot.
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A
I don't even know who that is. I haven't done anything. I talk about doctors.
- [20:46]
B
It's like my arch nemesis or enemy. But in truth, the studies show that if you put, you know, three separate substances and you let them sit there and they're not actually blended from a standpoint of like injecting, could they render one of the other substances inert? Yes, technically, theoretically, yes. But in practice and real application, like in people who have been using these blends for a long time, everybody who uses them seems to say that they still work. And you know, Brian Moscow, our chief science officer, you know, just did a gigantic thread on Instagram about this and looking at the data, looking at the studies and the truth is, is that if they are doing any kind of cross chain linking or rendering one substance inert after a time, it's not affecting the efficacy of the peptides in a blend. And I'm specifically talking about Glow and CLO, right? Which is GHKCU, what is it? KPV and then TB500 and BPC. And then that's obviously Gloom, sorry, that's CLO and then Glow is just GHKCU, TB500 and BPC157. Again, people who have been using these products for years, you know, all rave about them. Right? So like if that's true, then why would be people getting results in the marketplace? So I, I, I, I say, you know, be cautious, don't throw the baby out with the bath water when you hear stuff like that. Because nobody from a chemical standpoint or a formulation standpoint would have ever putting those blends in the to mix together if that was really happening. So yeah, maybe over time, if you live in your refrigerator for six months, it may, one may become less efficacious than the other, but it's not ruining all of the blend.
- [22:22]
A
Well, even with our, we've sent them out for testing. We do all of our series, we have them, we redo the test in the six months and they're still stable. Yeah. Oh, they're still saving their, yeah. I mean, obviously there's always a little dip because it's sitting in a fridge, in a liquid, in a liquid.
- [22:35]
B
And by the way, I've had really smart biochemical engineers because as you know, I've been in the space for a long time. Say that because this is a question people ask, like, hey, I reconstituted my peptide, it's sitting in my fridge. At what point does it lose efficacy? And the smartest people that I know who have, you know, answered this question for me, always say that over time it loses some efficacy, but it never goes below a certain amount as long as it's not exposed to obviously incandescent, you know, high grade light or temperature variance. Right. So if you keep it in the fridge. So my guess is, and again, this is from other people who are way smarter than me, they say it goes down to about 76 to 78% of efficacy from right when you opened it, which was 99.9. Okay, right. So what does that mean? It means if you had it in your refrigerator for six months, you need to use more.
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A
Okay.
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B
Because it's not the same.
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A
This is really important. So there's perfection versus getting it done.
- [23:25]
B
Exactly.
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A
And choice one, inject three different times, throw away three different needles and deal with all that.
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B
Exactly.
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A
Or have one vial inject and maybe it's 10 or 15% left less efficacious. But because you actually injected, because you want to avoid sticks. So convenience is actually something that's under undervalued in literature and in medicine because I've had times where there's 10 peptide vials and I have, you know, a box of needles.
- [23:54]
B
Exactly.
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A
And some days you wake up and you're like, I just don't feel like sticking myself 10 times. And it takes time and energy. Pens make it easier, blends make it even easier. And if the data you're showing is well backed up, and it sounds like it is, then okay, fine. So you have some mixed. What would happen though if I just took all the peptides I like and I just mixed them all together in a sterile vial and had 1, 1 pen to rule them all.
- [24:18]
B
So that's when you're gonna have cross chain linking. Like I always say, use peptides that are for the same application. Right. So it's like TESSA and ipa, ipa, CJC growth hormone agonist peptides together, healing peptides together. Now, again, it's not to say that if you separated the injections and injected them in different parts of your body over a 24 hour period or even a 12 hour period, that you still wouldn't have efficacy. But I kind of look at it as a bleeding neck syndrome. Right. Like, what is your biggest issue? Focus on that first, you know, then People will say, but, Jay, I'm. And I sprained my ankle. Right. So, okay, well, then take your BBC and TB500 six hours later, after you use your, you know, mitochondrial or your GH agonist peptides. But I don't think. And again, this is from an application standpoint. I don't think anyone should be thinking about, you know, the shiny object syndrome. Oh, my God. This peptide, that peptide, this peptide. I want to use them all together. Don't do that. Focus on what is the biggest thing that is in your life right now. Solve that and then process accordingly.
- [25:14]
A
That is the most profound advice. And it's true of supplements. Exactly. Pick a goal, do everything to meet the goal at the same time. And then, oh, look, now I got my energy back. Or whatever your goal is, and then move on to the next one.
- [25:26]
B
Exactly.
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A
And the fearful. Or I'm afraid that I might do something that. That wasn't helpful. That perspective.
- [25:33]
B
You mean Peter Atia's office audience.
- [25:35]
A
Oh, I think he's afraid of. He's afraid of a lot of things going on. But, yeah, never met a longevity doctor who said, you can't extend human life. But, hey, have you ever seen him
- [25:45]
B
with a shirt off, by the way?
- [25:47]
A
I, I couldn't unsee that. By the way, as a guy, I weighed 300 pounds. I have extra skin. You see me with my shirt off. So I'm not, I'm not judging.
- [25:56]
B
You look amazing. But I mean, no, but it's crazy because, like, there's been, you know, somebody posted on Instagram. You probably saw it. I mean, by the way, great job on going after him. But there was a. There was a post somebody did just like a week ago about, like, oh, he's this great longevity doctor. And people were like, I think this is bad timing.
- [26:14]
A
I mean, aside from all the Epstein stuff, which is.
- [26:17]
B
Which is gaslighting is the highest quality,
- [26:19]
A
it's just terrible stuff. But the idea that, that you can go out there and say hormone replacement therapy isn't safe. Take stats, get vaccinated. Vaccinated.
- [26:29]
B
I know.
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A
And still have. Like, how do people think it's longevity? I don't know. It's weird.
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B
It's insane, bro. So I'm glad that you took a stand on it, because I've been saying I've been going after him for years. Him and I have been fighting for years, too. But I, when I saw that, I was like, really awesome that you did that.
- [26:42]
A
Yeah, I've been talking. Is just a failure of his longevity advice for a long Time. Yeah, exactly. In fact, at a. At a longevity conference full of doctors, someone said, what's the biggest risk to the longevity movement? And I said, fake longevity doctors like Peter T. Exactly. Like he's true. Misleading the public.
- [26:58]
B
And he always has. You're right. It's not just because he's in the Epstein files. He's always been wrong.
- [27:02]
A
Yeah.
- [27:03]
B
Literally always wrong.
- [27:04]
A
Yeah. In fact, maybe I should launch a book like the Anti atia Diet, Just do the opposite of what he's look at.
- [27:10]
B
Who would pay that guy $150,000 a year for advice? Can you imagine? Yeah.
- [27:16]
A
You know, we're.
- [27:17]
B
We're waiting for Sergeant.
- [27:20]
A
Some of his clients are now with Unlimited Life, which is my concierge longevity program.
- [27:25]
B
That's awesome. It.
- [27:27]
A
It's funny, though, when. When I look at. At people's labs and $40,000 worth of lab work per client, like, it's. It's really fun. And I would say maybe 60% of clients have. They have problems with growth hormone. And this is something that happens as you age. Of course, taking growth hormone is not necessarily a good idea, but the. The fearful people of the world will say, well, if once you go on growth hormone, you can never go off. And I'm just gonna tell you that is straight up bullshit.
- [27:55]
B
That's bullshit.
- [27:56]
A
The reason is I had zero growth hormone eight years ago.
- [27:59]
B
Yeah. Because you were fat.
- [28:00]
A
Not just because I was fat. I also had, you know, toxic mold poisoning.
- [28:03]
B
Yeah.
- [28:03]
A
And have some weird genetics and thing and things like that. So I did the full on glucagon challenge and like, wow, you have zero. So I was on growth hormone for five years.
- [28:12]
B
Yeah.
- [28:13]
A
And I said, you know, I think I'm done. It's. It's expensive. It's a pain in the ass. So I tapered off of it, and I had absolutely normal growth hormone levels after that.
- [28:22]
B
Nice.
- [28:23]
A
Just like people have been going off of testosterone for years and getting their testosterone natural production back up.
- [28:28]
B
Yeah.
- [28:28]
A
And so what you can do now, though, is you can use these signaling molecules, peptides, to raise your growth hormone. What are the two peptides that are most effective at getting growth hormone levels up?
- [28:42]
B
Well, should we talk about FLGR242 first? We gotta get to that. Well, so, no, I mean, traditionally, for sure.
- [28:49]
A
Tessa.
- [28:50]
B
You got Tessa. Morellin. And then probably a combination, you know, between how you feel or how you individually biochemically do on it. Ipamorellin and CJC. Right. So those are your three most powerful column growth hormone agonist peptides. You know, one is a GHRH one is a GnRH. Tessa is, as you know, an FDA approved drug called Agrippa. Right. They give it to men with lipodystrophy. They have like wasting illnesses or HIV diagnosis, whatever, and they get that really hard visceral body fat, and so it tears through it. So from a longevity standpoint, for men that have belly fat, there's nothing better, right? Exactly. Yeah. So IMPA is really good for women and it's good for men, too. It's a little weaker than Tessa, but it doesn't increase endogenous or it doesn't actually block endogenous release. Right. So you can inject it too. No, I said. I said women take IPA better. I said women take IPA better because they don't have side effects like Tessa does, because Tesla is a very powerful pulse. Right.
- [29:48]
A
I appreciate you calling out the difference in biology between men and women.
- [29:53]
B
You like that?
- [29:54]
A
Just clarity. It's actually important. Yeah. You know, dosing is different, peptides and all for sure. And growth hormone starting around in your 40s, it goes down in everyone. And some people, if you've had metabolic dysfunction like I have, it goes down a lot more.
- [30:07]
B
Right.
- [30:07]
A
So that stack can be really powerful. It is, yeah. There's also a compound called MK677. It's not a peptide. What do you think about that stuff?
- [30:16]
B
I don't like it. It does increase appetite. It massively increases IGF1, but inside, in people that use it, especially in the dose of high, it also increases cortisol, prolactin. It does a lot of negative things. I think it's great, though, for people that have really difficult ability to eat enough food to build musc, because it does stimulate appetite. Right. And it's cheap. And, you know, it's. It obviously is a very powerful secret dog. But there's just better options. Right. Like Tesla and IPA are way better options. So is CJC.
- [30:45]
A
I like MK677 because it's oral and just take a pill.
- [30:49]
B
Yeah.
- [30:49]
A
Take it at night and. And think things are better. But you're right, it will make you hungrier. Yeah. It's not been an issue for me because I can eat as much as I want and I don't gain weight at this point. My biology is. Is. Yeah, it's kind of crazy.
- [31:02]
B
Yeah.
- [31:03]
A
All right, that's helpful. So there's our growth hormone conversation. You don't have to take growth hormone in most circumstances because you can simulate it with the compounds you just mentioned. And all this stuff will Be in the show notes for you. If you're scrambling for a pen, don't worry about it. We have daveasbury.com and this, this will be there for you. Let's talk about the new peptide on the block, flgr.
- [31:26]
B
So, so we bought for you. So I, I'm saying this because I know I've been using it now. This is my 17th week on it. I'm not gonna take my shirt off right now, but I'm more muscular and leaner than I've ever been in my life. And I've been on this product since the end of. Thank you. Since the end of October. And it is, Dave, it's profound. We actually think that it's going to change the world. We have thousands of people using it right now. And so what it does is it's a recombinant folletin. Now your audience and you know have heard of follistatin 314-377-381. And all of those products prior to our products had a very short half life. So if you were going to get any benefit, you'd have to literally like bodybuilders would inject it three or four times a day before workout after workout. Because again, it was such a small or, I'm sorry, the, the half life was so small and so tiny you had to inject it all this time.
- [32:20]
A
What does falsetin do?
- [32:21]
B
So basically it govern. It removes the governor for myostatin. And myostatin is what prevents us from like becoming over muscular. Remember the bowls and the pictures, the, you know, the giant Red Bulls or whatever and they became these like mutant bulls. So if you remove myostatin or remove the governor from myostatin, you can become more muscular, but not only become more muscular, you'll become leaner because it's actually inhibiting or increasing lipolysis and inhibiting activin. So our designer chemist created a 19 day albumin binding construct with a PK curve of like 14 days. So basically what that means for those that didn't know what the fuck I just said.
- [32:59]
A
Yeah.
- [33:00]
B
Is it literally when you inj, it stays active in your system for 19 days.
- [33:04]
A
Wow.
- [33:04]
B
So it's, it's insane. Now we. How many vials did we bring him?
- [33:08]
A
Two months worth. Two, four. Sweet.
- [33:09]
B
And we'll send you a lot more because you're going to want to be on it, I mean it within four weeks. You, you're pretty lean already, but you're going to be more muscular, you're going to have more force Production, you're going to be stronger, more energetic. If you were fatter, which you're not, you would notice fat loss. So women who are taking this right now who are using GLPs are preventing muscle loss, which as you know, is the number one problem for GLPs and increasing, you know, basically lean tissue. And it works in everyone. Like I said, we have thousands of people using this and we have all these people who have been on it for six to seven weeks now because we were able to actually ship what, second week of December, third week of December. So they've been on it for six, seven weeks. Dude, they're sending us pictures. 67 year old women are sending us pictures and we're like, holy. You know, like we got to control the supply chain of this. We got to be able to scale this production. So again, it's a research molecule molecule right now. But we can see where it goes that there's going to be a lot of pharmaceutical companies, especially in obesity research that probably want to have access to the patent, maybe even license, maybe even develop it.
- [34:09]
A
I'm sorry, do you have the patent on it?
- [34:10]
B
Oh yeah, we have two CAS numbers. It's amazing. I mean. And then the other product, which we should talk about too is Clotho, which you're already familiar with.
- [34:18]
A
We're going to get to Cloth in a minute. I got to go deeper on flu. Okay. For sure.
- [34:20]
B
Please.
- [34:23]
A
Longevity starts inside your cells. If you want top 1% performance, every input matters. And that's why I added Nanducka by peak to my daily ritual. Nandaka is a ceremonial cacao nootropic and I take it because it supports cellular resilience, it supports my metabolic balance and it helps to regulate stress. One of my favorite ingredients is Pu erh tea which is a great source of antioxidants and it's got a high concentration of of full spectrum Reishi spore powder for calm and focus. And of course it's got lion's mane for your brain and chago for immunity and a lot more. Peak uses only the fruiting bodies of the mushrooms, which is important. So your cells get the bioactive compounds that actually drive your resilience. What sets Nandaka apart is the synergy. The cacao butter acts as a fat based delivery system so that the adaptogens actually can get into your cells. What I feel is steady mental focus and calm energy. So get ready to meet your new delicious ritual for all day focus. You get 20% off@peaklife.com. that's P I Q U E life.com Dave give it a try. Right now, your body might be wasting energy on stress instead of healing. That's why your gut feels off, your brain feels dull, and your immune system keeps letting you down. What if you could switch your healing state back on? On? Without meds, stimulants, or guesswork, Vibrant Blue Oil's parasympathetic essential oil blend is a powerful, non invasive way to activate your nervous system and shift your body into healing mode just through scent. A drop behind your ears can help switch off your stress response, calm inflammation and support digestion, detox and immune function. And it can even help clear up your stubborn brain fog. It's natural, easy to use, and thousands of happy customers already love it. And right now, the Human Upgrade podcast listeners can grab a full size Bottle for over 50% off at vibrantblueoils.com Dave that's vibrantblueoils.com Dave don't wait to start feeling like yourself again. So flgr seems like it stacks well with the glp is to stop muscle loss.
- [36:36]
B
Exactly.
- [36:37]
A
Now, Follistatin is a really interesting longevity compound and it's one I've written about. And it's, like you said, really hard to do something about it. Yep. So I did two rounds of mini Circle Follistatin gene therapy, which turns on natural folletin production. Not at the high levels you're talking about, but it does it for about two years each each time you inject. And the injections are pretty expensive.
- [36:58]
B
Yeah, but what is it, like 75k?
- [37:00]
A
I know it's 25k. I'm sure it's. No, I don't think it's ever been 75, but I'm sure the prices will come down over time.
- [37:06]
B
Well, they have to now. Well, yeah.
- [37:08]
A
And what I noticed was I was already really lean. I lost about 1% body fat, which I probably didn't want to do.
- [37:16]
B
Right.
- [37:16]
A
But I'm already reasonably muscular and I could probably spend more time at upgrade labs if I wanted to put on more muscle. But I'm on. I'm flying like 75 of the time. I'm on the road. It's. It's brutal.
- [37:26]
B
Yeah.
- [37:27]
A
So I did notice, you know, easy maintenance of muscle mass and like an improvement in energy.
- [37:34]
B
Yeah, for sure.
- [37:35]
A
Yes. Which I didn't expect from Fall of Satin. So that, that was positive. So I'm really stoked to try your new flgr. You're gonna love it. And you just inject once every.
- [37:45]
B
Well, so. So this is A good point. So originally the chemist was like, inject once every two weeks, which is the same thing as the PK curve, by the way. Our Clotho shares the same album and binding construct, 19 day half life. But what we're finding now, and you already know this from just your years in biohacking and understanding PK curves, if you inject it weekly versus twice weekly, you kind of have that, that from a nadir standpoint versus a, you know, falling. So twice a week again you, that's what I'm doing now. But I would say the average person should start for 8 to 10 weeks. 132 weeks progress. Notice what you, your response to it, muscle, fat loss, etc, and then if you really want to get more anal, more involved in it, weekly. And then when you get to like you and I are, it's like, oh, I'm gonna inject on Tuesday and Friday because I'm gonna remember in my mind those are the days I'm lifting, et cetera. Those are the days I'm doing. That's what I'm doing right now. But again, it's designed for a 19 day half life, so technically you can, you can inject it once every two weeks.
- [38:42]
A
Wow.
- [38:43]
B
It's amazing, dude. I, I, I'm, you know, I'm going out on a limb and you know, I don't people, I think this is one of the greatest performance enhancement products in the history of science.
- [38:52]
A
Amazing.
- [38:53]
B
Yeah. It's going to change the world for sure.
- [38:55]
A
If you're wondering what a PK curve is, I'm going to explain that for you is pharmacokinetics. And one of the things that, that's just driven me nuts in the supplement world for a long time and in the peptide world is you say, oh, it's got, you know, 500 milligrams of this in it. It doesn't matter. So if you take that and it doesn't absorb well, then you could have just taken a rock and saved some money. As long as it's not too big because then you couldn't rip it out. That's like a. Peter, it's your problem. Did I say that? Oh man, that was my outside voice. Anyway, actually, you know what, I just was, I apologize, Peter. That was a Lane Norton problem there. There you go.
- [39:36]
B
You had to get him in too.
- [39:37]
A
Yeah, exactly.
- [39:38]
B
Yeah. I haven't heard from him. Is he still around?
- [39:40]
A
I don't know. But every time he talks about me, I sell a lot of stuff.
- [39:42]
B
There you go.
- [39:43]
A
Yeah, but last time he, he did it. I sold more than $10,000 using Bio Lane as a discount code on my website. So thanks, Lane. I love you, brother. And your mom says hi.
- [39:55]
B
That's good.
- [39:57]
A
I love bullies, man. I know. I had a bullies. So back to PK curves. I got distracted by my bad sense of humor.
- [40:05]
B
It's all good if you were to
- [40:06]
A
take something and all of it entered your system right away, it go boing. And then. But if it drops off right away, so maybe that's useful. Maybe you wanted a really strong peak, or maybe you wanted it to come on really gently and then stick around for a long time. Right. Which is what you guys designed. And so a lot of the supplement companies I've had on, the inventors and the creators, they're modifying how a supplement goes into the body. And the one you've heard about most would be something like glutathione. Because if you take a glutathione capsule, the PK curve is very, very flat because your body digests it. Not much goes in. So then they make it in liposomes or in other forms, and that means it actually goes up. So it has a better curve. But then how long does it last? How long does it stick around? So playing with this can be the difference between spending $20 on a generic supplement that doesn't do anything and then spending 55 bucks on someone who spent 10 years of research, and all of a sudden it has magic powers. So PK curves are underappreciated. And if you're saying, how the hell do I know what the PK curve on anything is? Well, you could ask your favorite expert who's any of the AI engines right now. Like, describe the PK curve for this compound in this form. Form. And that'll tell you how often you should take something. There's also the issue of circadian timing.
- [41:19]
B
Yep.
- [41:20]
A
So a lot of peptides are peptides that are associated with our light and dark cycles. And we're all missing dark anyway. Unless you're like me and your house is pitch black with red lights at night and your neighbors think you're a vampire. But how do we know when to take our peptides?
- [41:35]
B
It's a great question. I mean, I think in that conversation, we probably should talk about melanin cortoid receptors, complex stimulators. Right. Like Melanitan one. You know, I think Melanitan one is the most under utilized and underappreciated peptide that we know of. Right. Because, you know, in my studies of it and I've been using it since 2008. I've permanently darkened my skin. I live in, obviously, Florida, and I travel like you a lot. And I don't have to worry about, you know, altering my skin color anymore because it's done that. But also, when you go deep into, like, melanin cortoid receptor complexes and understand what it does, there's consciousness component. Exactly. So I personally have been recommending that people microdose melanitan one, two or three times a week. And obviously, when you're in tropical, exotic locations where the sun is coming down, you can do it every morning. Right.
- [42:23]
A
But what's the microdose?
- [42:25]
B
That's a good question. I think it depends on the person because, as you know, melanin cortoid receptor complex peptides can create nausea in some
- [42:32]
A
users and profound arousal, too.
- [42:34]
B
Absolutely right. Melanitan, too. We could talk about that. I think it's somewhere between 0.3 and 0.500 micrograms, so like less than a milligram, you know, two or three times a week. But, you know, seeds and other people out there have higher dose, you know, for arousal and stuff like that. But honestly, to your question, I. I think it's, you know, daylight. I mean, if we just observe the ancients, right? Like, they ate during the day and they never ate at night. So it's like, if you're gonna give your peptides. I mean, for me, again, living in Florida, I get a lot of sunlight. I get a lot of sun gazing in the morning. I mean, everything is right when I wake up. Up, right? And then I'm out in my backyard and I'm sungazing. I'm. I'm grounding.
- [43:12]
A
Do you do butthole sunny?
- [43:13]
B
Do I do butthole sunning? No, I don't do testicle sunning either.
- [43:16]
A
You never tried it?
- [43:17]
B
I have never tried it, no. Is it awesome?
- [43:19]
A
I. You'd have to ask, actually. I was in the New York Post. The headline was Biohacker Bro burns bum.
- [43:28]
B
We have.
- [43:29]
A
But it was a humor post. Not. Not for health post.
- [43:32]
B
Well, I've seen, you know, we've seen. We did a. We did a debunk testicle tanning or whatever, you know, on my website a couple years back.
- [43:38]
A
But I do know red and infrared really do work.
- [43:41]
B
Oh, there's no doubt. I mean, there's no doubt. I mean, look, the. Depending on the time of the day, the red light gradient of the sun's rays are amazing. Right? Like, if you do that every morning and you're like, at the beach with the ocean and you're on the sand, I mean, there's some really powerful, powerful stuff that you're getting from that, you know, But I don't think most people living in giant cities have any idea about any of that.
- [44:01]
A
Right. What's deeper on melanin?
- [44:04]
B
Yeah.
- [44:05]
A
So this is, this is stuff that gives you dark skin skin. So if you are blessed with naturally dark skin, as some of my friends will say, black don't crack. Right, right, right. And the first time I heard that, I'm like, really? They're like, oh, yeah, of course our skin doesn't age. And it's true. You look at an old white dude and an old black dude, totally different skin quality. Because melanin is protective.
- [44:25]
B
Yeah.
- [44:26]
A
So if you come come from genetics that are optimized to be able to eat wheat and survive dark, cold, shitty winters, which is most of Europe up, eating wheat's still bad for you. But if you can darken your skin, it actually improves your health. No doubt. And here's the consciousness angle, and I think this comes from my cognitive enhancement book, but it could have been the longevity one. So inside your brain you have melanin. And melanin was called junk melanin by scientists because they know what it did. Anytime scientists say something is junk, you
- [44:55]
B
know that's the opposite. Yeah.
- [44:56]
A
It means we don't know what it is and we're too arrogant to tell you that. Exactly. And inside the back of your eye, where sun doesn't get you, have a ton of melanin. And two guys who are strangely, dentists in Mexico, I think they were dentists, maybe eye doctors. I wrote about their study a long time ago. They're like, why is this in the eye? And they went on this obsessive 10 year journey of research to figure it out. And it turns out that melanin acts as a capacitor.
- [45:22]
B
Exactly.
- [45:23]
A
And what capacitors do electrically is you put electricity into it and it holds onto it and releases it in a big spark. Like Ark of the Covenant is probably a capacitor. And you can make them at home enough to kill people by just taking aluminum foil and epoxy and making many layers of it. So this is something we know about in electrical engineering, but people fail to understand that we have semiconductors throughout our body. They're just organic semiconductors. And melanin as a capacitor in the back of the eye. It's because sometimes your eye needs a lot of energy quickly. It's in the brain because you Need a lot quicker, quickly.
- [45:55]
B
Yep.
- [45:56]
A
So if you can get better melanin by being in the sun and being in the dark or with a compound. I've noticed a difference cognitively as well.
- [46:04]
B
To me it's life changing. I mean I wrote about that in my, my tot Bible book back in 2017. And by the way, I'm glad you mentioned those two guys. There's another guy we should mention who's also been Google. How did. What do you call that when Google deletes you now when they just remove your information being right. Yeah, exactly. His name was Dr. Frank Barr. The listening audience please look up this guy. But he was a Berkeley researcher and he was suicided off a Building in 1972. But he was the guy that was looking into all the research into melanin and like you said as a capacitor into this like, I mean it was like a self regulating system. He was looking into how powerful melanin is. Whoever governs this planet. And if we want to go there, I'm sure we can talk about that too. Is not wanting people to understand what melanin is as you said said because it is very powerful molecule.
- [46:50]
A
Who do you think are the anti Melanin Illuminati?
- [46:53]
B
Good question. Good question. But they do not want us researching melanin. And I've been telling you that guy again his name was Dr. Frank Barr. He was a Berkeley researcher and he was the guy in studying melanin and he just literally was thrown off a building in 1972. And you know what's so crazy about this is when I was doing research, this is back in 2015 and 2016, it was readily available. Somebody like two years ago sent me a thing and there's like, there's nothing about Frank Barr. Who the is Frank Barr? And I was like what are you talking about? And I had to go to my book.
- [47:20]
A
Wow.
- [47:21]
B
In the paperback and all of his research and his links which by the way are now deleted.
- [47:26]
A
Wow. Yeah.
- [47:27]
B
So they've. He's been disappeared.
- [47:29]
A
Google is one of the most anti functional health companies on the planet. It's. It's actually kind of evil. Even their.
- [47:35]
B
It's demonic.
- [47:36]
A
Yeah, it's demonic is a good report. It. It doesn't make sense. All right, slight diversion here. So when people are at 40 years of Zen, which is right near here for the last 10 plus years, we teach them how to write an intention that you can actually manifest. Right. And this is kind of rewriting code for your subconscious. And there's actually A science to it. And one of the things to understand is that your subconscious and your mitochondrial networks, which have consciousness, that's very dumb, but still conscious, they don't understand negative operators. So the word no or not, not, it doesn't work. And as an example, don't think of an elephant. How'd that work? All right, so pick the elephant.
- [48:19]
B
If you're.
- [48:20]
A
If your tagline since the days of formation is don't be evil, the way that's processed unconsciously is directly be evil. And yes, I'm talking about Google's slogan for many years. And I don't think Larry and Sergey had any intention of doing it that way. In fact, when they were two guys and two computers, they came to a company that I helped to get started, started, and we held their servers for a long time until they built their own data centers and took over the world. So, like, without intention, you can do that. So mindfulness is important. Maybe we need more, more melanin for that, probably. Okay, let's switch gears. One of the compounds I've been the most excited about for years and years is a longevity compound that goes down linearly with age. And I wanted to use it. So. So I found a guy who was making it in a vat in basically a small research lab, I think in Vegas. And I wrote about him in Superhuman. And it turns out it was hard to make and hard to keep it from sticking together, but the compound is called Clotho. And the reason I'm interested in Clotho is, well, it's a longevity compound, but it's also a cognitive enhancer. And until very recently, you couldn't buy Clotho because it wasn't available. So what are you doing with Clotho?
- [49:35]
B
So same. And we should name him. You know, Mike Farber is his name. And he's one of the world's most brilliant chemists. He's got 160 drug delivery patents. Amazing guy. Short story on how he came into our ecosystem is he's been in my audience for like five years. And he sent me his crazy email back in March or April of last year, and he was like, we should do some stuff and help the world together. And I wrote him back with question marks, like, you know, who are you, bro? And then he sends me his link to all of his patents. And then that's when I called these guys. I said, holy, we need to talk to this guy. And so then he explained to us, he's like, look, I've developed this revolutionary 19 day album and binding construct, and I can do this with this, this and this molecule and we can change the world. And so we're all like, okay, bro, what does that mean for us? And hence, six months later, he created Clotho and he created FLGR242. So Clotho, as you said, is really an endocrine protein or an endocrine hormone that is now synthesized as a peptide. As you know, there are many people in the universe right now, especially on planet earth, that are making forms of Clotho though. The problem again in the synthesis of it is that it degrades rapidly, it doesn't stabilize in light. If you don't build it in a construct, in a binding construct like our chemist Mike has, it just doesn't last long. And also it's very expensive, very cost prohibitive. It's very difficult to manufacture, as you already said. So our guy took it and he put the same 19 day half life again. It's an album and binding construct. And he's very, very knowledgeable about how much inter individual Clotho is in a cell of a 40 year old aging person over time. Right. And we assume it's somewhere between 8 and 13 micrograms a week circulating. And it's obviously, as you said, going down. Right. So our dose is 10 micrograms to be injected every two weeks. So essentially if the PK curve again is the same, it's very small. But as he has explained to us, there's a lot of risk in overdosing with Clotho for the kidneys, you know, there's a lot of bad things that can happen. So you're only taking a tiny microdose dose that's like 5 micrograms every two weeks. And for an aging person, 40, 50s, 60s and 70s, what we notice is you already kind of mentioned it. Massive improvement in endothelial function. So tissue sensitivity, $0.05 sensitivity increases, brain speed increases vascular protection, kidney protection. I mean, it's really an amazing compound. My wife and I have been using it since the end of August and I would say it's subtle, but the one thing that you notice the most right away is again, sexual is improved. Right. You have better oxytocin delivery, I would say better pair bonding and calfin. I mean, literally within the first week of her and I taking it, it was like we were having sex and we were a brand new couple again. We've been together for 14 and a half years. Wow. So I can't wait for you to start using this. But I also think that this product is also going to really do a Great job. And by the way, we need to mention this. Mike is a humanitarian. He is not a pharmaceutical giant where he wants to just keep this in the hands of the elite. He wants people to be able to experience this. So, as you know, we sell it at a very cost, affordable rate.
- [52:33]
A
What does it cost?
- [52:34]
B
I mean, like, with most at a discount when we have a sale, it's like 360 bucks for a month supply.
- [52:40]
A
Okay, got it. And that's really hard.
- [52:41]
B
So it's not expensive? No. There's people in the clinical spaces, you know, selling it for $3,000 a month. And it's not the same molecule, by the way. It doesn't have the same half life. It's not going to work as well. I mean, I don't want to degrade anybody else, but it's amazing. And again, right now it's 10 micrograms. You inject it once every two weeks.
- [52:57]
A
Weeks.
- [52:58]
B
The newest, as I was telling him as we were driving in the city this morning, is that a lot of people in my inner circle are taking half the dose and injecting it weekly. And again, if you understand, again, the pharmakinetics and the plasma dynamics, two shots over once every two weeks is probably gonna again, be more like that versus kind of like that. Right. So not a huge difference from a longevity standpoint, but in a feeling efficacy standpoint, you'll probably notice better endothelial function injecting twice versus once every two weeks. Weeks.
- [53:26]
A
One of the things that isn't well known about Clotho is that at the right doses, it's profoundly kidney protective.
- [53:33]
B
No doubt.
- [53:34]
A
And I wrote about the four killers in my longevity book because I thought calling the four horsemen was kind of douchey. And if I'd added a fifth, it would have been kidney dysfunction. Because what happens to most of us is you get diabetes. Yes, Right. And then diabetes triggers the other major killers, which would be cancer and cardiovascular and Alzheimer's. And it also does hypertension, which is cardiovascular, but it's also kidney toxic. So if you can get your chlothal levels up to those of a healthy young person, your kidneys are likely to last longer and then all the other diseases that are all tied to endothelial dysfunction. Anyway, your risk of those logically ought to go down. And the studies show that people with more Clotho do age better.
- [54:18]
B
Better 76 year old woman, to add to what you're saying, started clotho and within 5 days started menstruating. Hadn't blamed.
- [54:25]
A
Holy crap.
- [54:26]
B
27 years. Was freaked Out. But we're like, well, you know, biologically, theoretically, this is what it would do. It's restarting and making you younger cellularly.
- [54:34]
A
And this is, this is going to be controversial. So I do a lot of work, especially with unlimited life, with women who are at perimenopause or menopause. And I've had so many experts on the show like Anna Kabeca and you're triple board certified obgyn and, and it's because men have their own set of issues that happen with andropause and our curve is different and women have theirs. And biohacking has been about 58% women since the beginning of the movement. So like this is, what's the operating system for all humans? Where's the manual for us? Yeah, and with women, man, they, they get into this, I hate my life at perimenopause. And if we're managing their hormones correctly, it's very manageable. Right? And then I'm finally free. I just take my bhrt and then I got my life back, I got my brain back, everything is stable and smooth.
- [55:23]
B
I can fuck my husband, things are good.
- [55:25]
A
Yeah, exactly. And it can be relationship saving for sure. Doubt. But if you read Superhuman, you really want to be long lived, your body needs to believe at a very basic level that you're still capable of having babies.
- [55:41]
B
Exactly.
- [55:41]
A
And if you do that, that then your body says, well, there's no way I'm going to like age out for the next generation because I might have more. So there are hormone replacement modalities like the WY method where women, 60s, 70s, 80s, you change the amount of hormones you take every day in order to mimic a normal curve of menstruating. So then you do have a one or two day cycle even in your 60s or 70s. Now right now, a lot of women friends and, and menopause, they're like, Dave F you, I don't want to do that. It's a pain in the butt. Right. I respect that. Same time, if it's going to give you the energy you had when you were 30, would you do it? And the answer may be yes. So either one's okay. But if you start as a man, you wake up and you're like, man, my morning kickstand is getting in the way. That's good. And if you're a woman and saying I feel fertile again, that's good. That's actually a profound sign that you're reversing your age and that you're therefore extending your life.
- [56:43]
B
And by the way, that is what is noticeable for most of the people that have been using Clotho. And again, it's a small sample size. There's thousands of people using both products. But it was, it's been like since the second or third week of December that most people got it. So most people, like I said, are in their sixth to seventh week of using both products. But that's what they noticed. You know, know again, better sexual function, better tissue function. A lot of people's sense of smell is massively improving. Hearing is improving. So again, it's the little things. But again, it's endothelial tissue sensitivity.
- [57:11]
A
That's crazy.
- [57:12]
B
Yeah.
- [57:13]
A
And, and guys, I should mention biolongevitylabs.com you can use code Dave. Right. And this is a sponsored episode and all that kind of stuff. They. I always like to disclose that. And also you guys have been friends for a long time. I was on your board of directors at your last. Yeah, for many years. My rule is really straightforward. I don't have anyone on the show show unless I want to interview them. Awesome. So appreciate it that that code's important to me. This feels like the, the golden age of biohacking where I have access to things that I want. I don't need a permission slip from someone to get it. I don't have to fly out of the country to get it or, you know, have my, my peptide smuggling vest on or whatever. And it, it, it used to be pretty crazy for this stuff. Sure. So how does it work from a regulatory perspective? I mean, these are research chemicals.
- [57:59]
B
Yep.
- [58:00]
A
And there's no law that says I can't inject any research chemical I want. Right, Right. So how do you navigate the legalities of offering.
- [58:08]
B
It's an awesome question. So my newest book is coming out and this is when I shill metabolic awakening with GLP peptides. It comes out literally in a week. I don't know when this will run, but you know, it's basically end of February. And it's my Magnum opus. It's 770 pages, 1400 scientific references. I have an entire chapter discussing research, the regulatory situation, the gray market aspect of it. Like what is, what can you do? What can't you do? And the truth is. And this comes from our attorney, you know, shout out to Jeff Cohen, as you said, any person is allowed to write to research on themselves. Right. In the state of Montana, they have the right to try.
- [58:43]
A
Right.
- [58:44]
B
Any drug you can get irb, phased study, you can start stuff there. And through the state of Montana you can get a clinician to write you a script and you can do whatever you want, any drug, experimental research, molecule, et cetera, etc. But like in our world right now, the, the pharmaceutical industry sees the research industry as the direct to consumer model. And the legal opinion of all the attorneys that have ever been in that space call it the direct to consumer model because again, it is a competitor to the pharma model, right? Which as you know, has to go through a doctor, get a script, et cetera. And the truth is, and a lot of people don't even know this in the functional health space, no peptide is illegal to prescribe. It is written as a off label medication if a functional well doctor wants to do it. They have obviously Since September of 2023 been listed as Class 2 a lot of the peptides. But very soon, according to people in the MAHA movement and the people that advise us legally, everything is going to be moved back to phase or class one. Which means that peptides will be open season. Any doctor can write a script for them.
- [59:45]
A
Right. The fact that you can write a script for it doesn't mean that your insurance company and your medical licensing board won't bully you.
- [59:51]
B
Exactly. And they will go after it.
- [59:53]
A
Do you think, you think that we're going to see something like a RICO lawsuit against the ama?
- [59:58]
B
I think it's already happening. I think what you're seeing is the 503A and 503B compounders are being attacked right now by the major pharmaceutical giants, which Dave is, you and I both know. Let's just say it's a scam because these are the same people who two years ago or three years ago were commissioned by the same pharmaceutical giants to make their product when they couldn't keep up with the demand. And now they're going after them and saying, oh, you don't have the right to sell this or make it, even though we gave you that express right previously. So it's all really, to me laughable. I don't know, it's the great question. And again I, I analyze this in the book and I, but you know, to what you were saying, we are in a golden age. I have a whole chapter, it's a bonus chapter about everything that's in the pipeline, right? And we didn't talk about Reticutide or Trizatide or any of these amazing books, I mean these amazing GOP products. But dude, those products, as amazing as they are, Dave, and the expectation, you know, you heard Huberman recently talking about Road True Tide is Going to be a trillion dollar product shocking in two years. I don't even know if any of those products will even be relevant. That's how amazing this golden age that we're in is. And so. And again, this chapter in the book has all of the drugs that are already in phase two and phase three that are a couple years out. Right. And by the way, we need to mention this. The whole FDA approval for a drug process is outdated and antiquated and ridiculous. It doesn't even apply at this point.
- [61:17]
A
I can't actually agree with you anymore.
- [61:19]
B
Why not?
- [61:21]
A
For studies I went to dc. Yeah. And I talked with Marty, the commissioner. Yeah, yeah.
- [61:28]
B
Shout out to Marty.
- [61:29]
A
Yeah. Jim o' Neill was just on the show and we talked backstage about Peptides and on stage Marty said, you know what, our approvals process is ridiculous. It's held people back. We're going to fast forward.
- [61:41]
B
So he agrees with me then that's what you're saying? Because that's what I'm saying.
- [61:44]
A
I don't know if he agrees with everything you're saying, saying. But, but he straight up said in front of 500 people when I'm interviewing him, he said it is antiquated. Yeah. We are going to fast track high likelihood candidates and it doesn't matter if they're drugs or anything else. So that we're just going to get rid of this process because the process was there to make money for people.
- [62:03]
B
Exactly.
- [62:04]
A
Exactly. The number of people who've died waiting for something to be legal.
- [62:08]
B
Insane.
- [62:08]
A
It's, it's unconscionable. It is.
- [62:10]
B
And think of all the women that couldn't get hormones from the wheel.
- [62:13]
A
God, it's, it's just crazy pants. So the problem is people have a hard time getting good advice. For 25 years, since I've been in the longevity field, I've made it a practice of finding trustworthy people. And I'm not always right. I did have Peter on the show before he had his show. So guys, I apologize for that. We all mess up one time is okay. Yeah. But I didn't get any, any new knowledge from that, so it's okay. But, but I mean here, here's the thing. There are a group of people who have access to these things because they know the right people. And those are the people who feel better, have more energy and live way longer than everyone else. And that, that's been my, my job is like hey, let, let me introduce you for a very long time. And now that I'm doing it directly with Clients with unlimited life. I've seen even more of the results just up close and personal. It's been very satisfying. And the reality is like you're saying you can do anything you want with your biology and it may be really dumb and it may be really smart, so don't be really dumb. And one of the funniest things, just as an example of what's allowed, a long time ago I had a 80 year old doctor in practice tell me about urine injection therapy, which is now known as Biolane therapy therapy. And this kind of therapy, it's ridiculous, but you're taking immune molecules from your urine and using them to turn off really powerful allergies, right? Sounds gross. It's a lot less gross than drinking it, that's for sure. But, well, okay, is there a law against that? There cannot be a law against that. Right. So anytime a regulator anywhere in the world says you're not allowed to do something you want to do to be healthy, that regulator is not your friend. They're not working on your side. And where we're running into problems here, if you go to your average doctor here and you talk about peptides, they'll say dangerous, don't understand, no studies. So you gotta hire the right expert. That's why I don't hire the guy who paints my house to change the oil of my car. Not the same skill set. So you gotta find the right people. It's really important. I do think you have an enormous body of knowledge like you've, you've really devoted more than a decade made of only doing peptides, which is really cool. And so biolongevitylabs.com, use code Dave and check out jcampbell.com to get some of this info directly. Use the JBOT. And look, you might do something and it might not work. I've done lots of things that don't work, okay? It's called an experiment. And Thomas Edison tried 10,000 light bulbs that didn't work before he found one that did. It won't take that long. With peptides you should feel a difference on the things that matter most to you. You. And same thing with supplements, Same thing with changing your diet. Same thing with turning out your freaking lights at night. It's all a stack and we just want the recipe that works for you. Thank you for listening and for your time and your attention and for considering like wow, the world is really interesting right now. Maybe that thing that is weighing me down, whatever it is, maybe there's something you can do that felt like it was impossible 10 years ago because it was. That's. That's how it is right now.
- [65:21]
B
Now.
- [65:22]
A
See you on the next episode. See you next time on the Human Upgrade Podcast.
- [65:32]
B
The Human Upgrade, formerly Bulletproof Radio, was
- [65:35]
A
created and is hosted by Dave Asprey.
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B
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