← The Human Upgrade: Biohacking for Longevity & Performance
The Human Upgrade: Biohacking for Longevity & Performance
This Nobel Prize Discovery Reverses Aging In 72 Hours : 1432
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How many nights have you stared at the ceiling counting the hours until morning? Maybe you tried a sleep supplement, but it knocked you out and left you groggy like you traded one problem for another. Poor sleep doesn't just make you tired, it kills your performance, slows your brain down and speeds up aging. Kill Switch from Switch Supplements solves that problem. It works with your biology instead of against it. It contains five gut friendly extensively researched ingredients like GABA magnesium glycinate and tart cherry extract to help you fall asleep naturally, stay asleep and wake up clear. And it's in the form of a delicious sugar free, no BS hot cocoa drink. Sleep tracking data proves how well it works. People consistently hit 90 plus sleep scores and more than double their REM sleep in only three days with kill Switch. If you're ready for the best sleep of your life, order now@switchsupplements.com and use code DAVE for 20% off. If you don't sleep better, you get your money back. Kill Switch works with your biology. Your body does the rest. Imagine waking up with tons of energy fluid joints and absolutely no pain in your body. What if you knew it was as simple as making a few easy food swaps? Oxalates. They're defense chemicals and plant foods and they slowly wreck your health when you eat them. They steal your minerals and form razor sharp crystals in your body and those can cause joint pain, muscle stiffness, fatigue, even kidney stones. And they stress your mitochondria. In multiple studies, most people eat way more oxalates than their body can handle and they have no idea because you've been told all these things are good
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for you when they're not.
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So I'm running low ox 30 this January for 30 days. I'll send you one short email every morning. You'll learn how to lower your oxalate load step by step without giving up real food or adding stress to your body. You'll know exactly what to eat, what to swap and how to support your body as it clears oxalates. By the end of the month you might feel like a different person. Lighter, clearer and more energized and maybe with better skin. If you want in, it's a gift. Just tap the link in my bio and sign up@daveasprey.com
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a Nobel Prize discovery proved that your body has a built in anti aging switch that controls how fast you age. Because if aging was really about time, then people the same age would all all feel the same. But you and I both know that's not true. Some 50 year olds run marathons. Others can barely get out of bed. And the difference isn't genetics. It's not even expensive treatments or miracle supplements. It's a switch already built into your body that restores energy and reverses one of the real drivers of Aging. In 2016, Dr. Yoshinori Osumi won the Nobel Prize for discovering that switch and explaining why triggering it can can extend lifespan. But modern life keeps that switch turned off. And most people who try to activate this repair switch never reach deep repair. I reactivated that switch and did reverse my biological age. So I'm substantially younger than my calendar age. And today I'm going to show you exactly how to turn it back on. But first, you need to understand how aging actually works. The problem starts with how the FDA and Big Pharma have conditioned us to think that aging is mostly about genetics or how many birthdays you've celebrated. They made you believe that fatigue, brain fog and wrinkles are just part of getting older. You turn a certain age, your energy drops and your memory slips. And that's why most anti aging advice focuses on surface level fixes. Wrinkles get creamed and skin gets injections and faces get tightened. Those solutions are easy to sell. But aging doesn't begin on your skin. It begins in how your body's functioning. It's the difference between chronological age and biological age. Chronological age measures exactly how many birthdays you've had. Biological age measures how old your cells behave. Lab tests can now measure DNA methylation, telomere length and cellular markers of aging. And the results of those lab tests predict how fast you recover, how sharp your mind stays, how resilient your immune system is, ultimately how long you're likely to live. And this matters because two people can share the same birthday and live in completely different biological reality. One 50 year old can have the cellular function of someone in their 30s with strong energy and clear cognition and rapid recovery. And that's the person who's figured out how to trigger their anti aging switch regularly. Another 50 year old can show the biological profile of someone decades older with chronic inflammation, metabolic dysfunction, and just a brain that doesn't work. Their calendars match, but their internal biology doesn't. And that means their long term risk is higher. The reason this gap exists has nothing to do with luck or genetics alone. Aging accelerates when damage inside your cells outpaces your body's ability to recover. And when scientists talk about aging at the cellular level, they don't mean gray hair or wrinkles. They mean the slow buildup of dysfunction inside cells that interferes with normal, youthful biological processes. Proteins inside your body are constantly folding into precise shapes to perform their jobs. Over time, things like stress and toxins can cause some of these proteins to misfold or break. And when the repair systems work properly, your cells identify those damaged proteins and then recycle them. But when your cell repair slows down, those broken proteins pile up like junk in a factory, and they interfere with normal function. At the same time, your mitochondria start to lose their efficiency. Their job is to generate ATP, which is your energy currency. It powers every thought, every muscle contraction, every repair process in your body. But as your mitochondria get more damaged, they make less ATP. And you feel that as being tired. You don't recover from workouts, you can't tolerate stress like you could. Your cells are still functioning, but they're just functioning at a lower voltage. And oxidative stress makes the problem worse. So every day, your DNA absorbs damage from just metabolizing oxygen and food, and from environmental toxins and from inflammation. And a healthy repair system will monitor and correct the stress. But when your repair starts lagging behind, your DNA integrity weakens and waste builds up in your cells. Your immune system starts to recognize that debris as a threat and responds with inflammation signaling. And over time, inflammation shifts from short term repair signaling into chronic background noise that further damages your tissues and makes you age even more quickly. And even worse, your brain is not immune damaged. Proteins accumulate in neurons and neural signaling slows. And you will feel this as brain fog. You can't remember things, you don't have focus, and you have these little subtle memory lapses. It doesn't happen overnight. It emerges gradually as your repair falls behind damage. That's why time isn't the problem. The repair backlog is a problem. And this is exactly why, if you want to trigger your natural anti aging switch, you need to restore this repair deficit. And you do this by fixing your mitochondria. It's the foundation for everything else. If you want better sleep, better hormones, better memory, Just want to live longer and be healthier for as long as you want. You start there. And there are three ways to upgrade your mitochondria, Starting with number three, which is rehit. It's the most efficient way I've found to trigger mitochondrial biogenesis, which is a process of creating new, stronger mitochondria to replace old, weak ones. A rehit session takes just five minutes. And here's how you do it. You cycle, or even walk really slowly with no Resistance for two minutes slower than you want, then you instantly turn up the resistance or you sprint at maximum effort for 20 seconds. You should be fully cooked. At the end of the 20 seconds, it has to be high resistance and then you instantly turn that resistance back down and you walk or cycle really slowly for two more minutes and then you do another 20 second sprint and then walk really slowly and that's it. This works better than high intensity interval trainings. But specifically for this one anti aging process we're talking about, the second trick is to support cellular energy production with fuel. That means eating a diet that helps your mitochondria and they thrive on clean fuel. And the best fuel for mitochondria is healthy fat. Grass fed butter, MCT oil, avocados and wild caught fish are all great sources of healthy fat. If you're not eating carbohydrates at the same time, they'll provide clean burning ketones which give your brain and muscles stable energy without tons of metabolic waste. This is because fat has more calories than sugar on a gram by gram basis. So if you were to burn a little bit of fat and you got more calories, more energy out of that than you did by burning the sugar, you had extra energy without more waste. But there's one secret way to upgrade mitochondria that's more effective than the rest. And it's hidden in your own body. When you trigger it, your cells start recycling broken parts and your body starts cleaning away those misfolded proteins. Gets rid of dysfunctional mitochondria, can even get rid of precancerous cells before they become a real problem. And that process literally rejuvenates your tissues from the inside out. It sharpens your brain because it gets rid of plaque like buildup, improves muscle recovery and immune function. So exercise starts working again, reduces systemic inflammation. And studies show that when you trigger this thing regularly, biological age markers improve. But modern life shuts that switch off too. Most people are constantly snacking, eating ultra processed foods and scrolling Instagram till midnight. Keeps your insulin high. And high insulin signals your body to store energy. You add in some bad sleep and some extra stress, your entire body gets shut down. So it's not going to fix itself. So if you want to truly heal your body and reverse your age, you've got to trigger the switch regularly. And the switch is called autophagy. Autophagy means self eating. But the word itself undersells what it really does. Dr. Yoshinori Osumi won the 2016 Nobel Prize in Physiology for Medicine for Discovering the fundamental mechanisms behind autophagy. He discovered that autophagy is a core cellular function that's crucial for core quality control in your cells, for energy production and the survival of cells themselves. It's not a random event. His discoveries provided the foundation for understanding how autophagy failure is tied to all kinds of conditions, like Parkinson's, Alzheimer's, cancer, even infections. And when you can activate autophagy consciously, your cells switch into a deep cleaning and recycling mode. They break down old, damaged parts, like worn out mitochondria and harmful pathogens, then reuse those raw materials to build stronger health, healthier cell structures. The process makes your cells more efficient and helps protect you from disease. And yes, it can target precancerous and even cancerous cells. Cells that grow abnormally often have damaged parts and dysfunctional mitochondria. Autophagy identifies those faulty components and breaks them down before they can become tumors. Autophagy also targets dysfunctional mitochondria through a specialized process called mitophagy. And mitophagy is something that gets rid of old dysfunctional mitochondria that prevents those broken energy factories from draining resources and generating excess free radicals. And the remaining mitochondria become more efficient. They restore ATP production. And then your metabolism works again. The most powerful way to do this is fasting. But most people who try fasting never reach deep cleanup through a standard 16 hour fast. And it's because of one common mistake. When you stop eating, your body doesn't just shut down. It moves through multiple fuel phases. The first few hours after a meal, you're in what's called the fed state. Your body's busy breaking down food, sending sugar from the meal into your bloodstream and using insulin to move the sugar into cells for quick energy, or maybe to store it as glycogen in your liver or your muscles so you can have that energy later. So you're basically running on the fuel you just ate. And about three to four hours in, you shift into the early fasting state. Your blood sugar, your insulin levels fall because there's no new food coming in. Your body starts burning glycogen stored in your liver and turning into glucose to keep your brain and muscles powered. And those stores shrink, and your body starts looking for a backup plan. And it slowly begins to break down fat, and it'll release fatty acids into your bloodstream. By 18 hours without food, your body has burned through most of your liver glycogen. And that's when your metabolism forms slowly pivots into the Fasting state at the 18 hour mark is when you actually burn more fat. And your liver turns fat into ketones, which is a super good fuel your brain can run on. So if your goal is to maximize anti aging benefits, breaking your fast too soon means you step out right as the good stuff is beginning. So let me walk you through what happens to your body when you fast for three days in a row. Like we just talked about. The first day of a fast is all about burning through the easy fuel. Your body has already stored away sugar. Your liver empties its glycogen tank, your insulin levels drop, and your body starts tapping into fat. That's also the roughest day. Feel a lot of hunger, you can have mood swings, and you might feel tired or foggy. But behind the scenes, something important is happening. Your hormones are shifting, growth hormones rising to protect your muscles. And your metabolism begins preparing for a deeper reset. By the second day, the sugar tank is empty and your body makes a powerful shift. It runs mostly on fat and ketones. Ketones are like a premium fuel for your brain. And many people notice the energy stabilizes and their mind gets really sharp when they're in ketosis. So deep inside your cells, autophagy will kick into higher gear. Inflammation starts to fall. Your body breaks down those old weak cells and replaces them with fresh ones. You might have felt deprived yesterday, but today you feel strangely calm and clear and energized. But the third, third day is when the magic peaks. Ketones are at their highest and your brain feels steady and focused and calm. Stem cells start to wake up and they lay the foundation for a stronger immune system. When you start eating again, your mitochondria just become more efficient. And in the brain, ketones help to spark the release of bdnf, which is a brain growth factor that's tied to neuroplasticity and better memory. To put it simply, it's that three day fast that causes fasting to shift from just burning fat to actually upgrading your biology. So 16 hours without food burn sugar. 72 hours without food turns on your body's anti aging switch. A three day fast can reverse aging, sharpen your brain, and activate stem cells. And it's not really in the same category as a standard fast. And I say this as the author of two major books on fasting for longevity and performance. You don't need to do a three day fast every week, you don't need to do it every month. But if you do it every quarter or every six months, you might notice a profound Shift in how your body works. But even a three day fast might be useless if you're doing it the wrong way. Because fasting doesn't automatically cause your tissues to renew themselves. If you rush into a long fast and you have no preparation, your body is going to experience more stress than repair. If you don't prep your body right, the nervous system looks at starvation as a threat and it'll flood your body with cortisol. And you get low electrolytes, you get headaches, you get tired, you get cramps, even heart palpitations. These are all signs of stress signaling. Also, over training during a fast accelerates your muscle loss and elevates your cortisol even more. So if you're doing a three day fast, you might be able to do a hard workout every day. It's just not the right thing to get the most results. And getting low quality sleep during a fast suppresses growth hormone and it blunts the autophagy that you're fasting to achieve. You also don't want to break a fast with sugar because that's going to spike your insulin and your inflammation. So instead of emerging younger, if you don't fast in the right way, you can feel depleted, inflamed, or just discouraged. So if you want to get the anti aging benefits of autophagy, which is one of the major reasons you fast, structure is really important. The goal is deep repair with minimal stress. So start about two days before your fast. Gradually lower your carbohydrates to drain your glycogen. Gently finish your last meal early in the evening to extend the overnight fasting window. Have more minerals through salt, magnesium and potassium. And control your caffeine carefully. Although caffeine in the morning will help you on a longer fast, don't have coffee right before bed. Whether you're fasting or not fasting, because it will raise cortisol and disrupt your sleep, which is even worse. When you're fasting, keep your movement light, make sure to move, but you don't want a heavy workout. Walking, gentle mobility support, lymphatic drainage, things like that. The goal for this three days is recovery and reset, not performance. So go to bed a little earlier, dim the lights at night, keep the room cool. Fasting can amplify growth hormone, but deep sleep can also amplify growth hormone. So do them both at the same time. And breaking the fast matters as much as the fast itself. Start with a small serving of something like bone broth or a light protein just to wake up your digestion. Wait for an hour or so before you start eating again. And have protein, have fat, have some carbohydrates. Unless you're aiming to end ketosis, avoid lots of sugar and ultra processed foods for at least a day. And remember, a three day fast is really powerful, but you only want to do it maybe every few months and that gives your body time to rebuild stronger between the resets. Doing a three day fast even once a month is a lot of burden on your body. So be kind to yourself and throughout your fast. Just monitor how you feel by paying attention to your energy, your heart rate variability or your mortality. Morning readiness score on your ring and look at your mood and pay attention to how you feel because what your body can do is pretty miraculous. People respond differently to fasting. Some people feel a rush of energy on day two, others feel calm and centered, and a few people just feel weak and restless. And then on day three they feel amazing. None of those responses are wrong, they're just signals your body is showing you where it's healing and what it's struggling with and how it's adapting. And we spend our whole lives adding things. Supplements, routines, superfoods and biohacks, which I'm kind of a fan of. I invented biohacking. But sometimes the most powerful biohack of all is to subtract. Just remove food for 72 hours and watch your body remember what it was designed to do. It's designed to heal and rebuild and regenerate and the answer isn't out there, it's already inside of you. Autophagy is something your body was built to do and we just forgot how to turn it on in modern society. But it's not that hard. You just learned how to do it. You just have to get out of the way and let your body do what it's meant to do.
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The Human Upgrade, formerly Bulletproof Radio, was created and is hosted by Dave Asprey. The information contained in this podcast is provided for informational purposes only and is not intended for the purposes of diagnosing, treating, curing, or preventing any disease. Before using any products referenced on the podcast, consult with your healthcare provider carefully read all labels and heed all directions and cautions that accompany the products. Information found or received through the podcast should not be used in place of a consultation or advice from a healthcare provider. If you suspect you have a medical problem or should you have any healthcare questions, please promptly call or seek your healthcare provider. This podcast, including Dave Asprey and the producers, disclaim responsibility for any possible adverse effects from the use of information contained herein. Opinions of guests are their own and this podcast does not endorse or accept responsibility for statements made by guests. This podcast does not make any representations or warranties about guest qualifications or credibility. This podcast may contain paid endorsements and advertisements for products or services. Individuals on this podcast may have a direct or indirect financial interest in products or services referred to here in this podcast is owned by Bulletproof Media.