Transcript
A (0:01)
Joe Rogan podcast.
B (0:03)
Check it out. The Joe Rogan Experience.
A (0:06)
Train by day, Joe Rogan Podcast by night.
B (0:08)
All day.
A (0:12)
All right, Nice to meet you, sir. Stimulated mind. A few future proof for your brain. Is that possible? Future proof? Why can't I say that? I already, I already have dementia. Future proof your brain from dementia and state sharp at any age. First of all, what prompted you to write this?
B (0:34)
So I've spent a long time working in a whole range of different spheres related to the brain. How to treat newborn brain injury, how to treat and maybe even prevent certain traumatic brain injuries and concussions. Looking at what affects long term cognitive decline in dementia, as well as working with elite professional athletes, particularly Formula one drivers, trying to help them stay on top of their game for as long as possible. And I saw across all those different areas, there are these core things that the brain seems to thrive on that are required either for development or maintenance of cognitive function. And these are things that people can apply to themselves on a day to day basis, improve their focus and well being. Now and then long term that translates to a lower risk of dementia.
A (1:27)
So is dementia and is it a genetic thing or is it a function of atrophy? Is it a combination of those things?
B (1:40)
It's a combination of those things. Certainly there's a genetic component. So maybe I will zoom out to start with and just think about like what is dementia? Dementia is the clinical diagnosis of losing so much cognitive function that you're not able to take care of yourself on a day to day basis. There are several different types of dementia. The most common is Alzheimer's disease. That's something like 60 to 80% of cases of dementia. The next most common is vascular dementia, something like 10 to 20%. And then there are others like frontotemporal dementia, Lewy body dementia, dementia you get with Parkinson's disease. But those first two, something like 70 to 90% of dementias, they are directly tied to lifestyle and the environment. And right now it's estimated that somewhere between 45 and maybe even 70 or more percent of dementias are preventable. And most of those fall into those two categories. There is a genetic component. So Alzheimer's disease has two broad types. There's early onset Alzheimer's disease, that's caused by a single mutation in a single gene, something like the amyloid precursor protein gene or one of the pre Snedin genes. Those people get Alzheimer's in their 30s to 50s. It's a very predictable and quite rapid decline sometimes. But that's maybe 1% of Alzheimer's the vast majority. Like when we think about Alzheimer's, we think about an age related dementia and this is much more related to the environment. So there is a genetic component you might have heard of. ApoE4.
